SI3042901T1 - Inhibitorji virusa hepatitisa c - Google Patents
Inhibitorji virusa hepatitisa c Download PDFInfo
- Publication number
- SI3042901T1 SI3042901T1 SI200732006T SI200732006T SI3042901T1 SI 3042901 T1 SI3042901 T1 SI 3042901T1 SI 200732006 T SI200732006 T SI 200732006T SI 200732006 T SI200732006 T SI 200732006T SI 3042901 T1 SI3042901 T1 SI 3042901T1
- Authority
- SI
- Slovenia
- Prior art keywords
- hcv
- formulation
- interferon
- imidazol
- pyrrolidinyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 2
- 241000711549 Hepacivirus C Species 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 12
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 208000015181 infectious disease Diseases 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 claims 11
- 108010050904 Interferons Proteins 0.000 claims 3
- 102000014150 Interferons Human genes 0.000 claims 3
- 229940079322 interferon Drugs 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229960000329 ribavirin Drugs 0.000 claims 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- -1 (2S) -2- (5- (4 '- (2 - ((2S) 1 - ((2S) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -2-pyrrolidinyl) -1H-imidazol-5-yl) -4-biphenylyl) -1H- imidazol-2-yl) -1- pyrrolidinyl Chemical group 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 claims 1
- 108010087227 IMP Dehydrogenase Proteins 0.000 claims 1
- 102000006674 IMP dehydrogenase Human genes 0.000 claims 1
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 1
- 108010078049 Interferon alpha-2 Proteins 0.000 claims 1
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 1
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 229960003521 interferon alfa-2a Drugs 0.000 claims 1
- 229940117681 interleukin-12 Drugs 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 229960000888 rimantadine Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (11)
- INHIBITORJI VIRUSA HEPATITISA C PATENTNI ZAHTEVKI1. Farmacevtska formulacija, prirejena za oralno dajanje, ki vsebuje metil ((IS)-1-(((2S)-2-(5-(4’-(2-((2S)1-((2S)-2-((metoksikarbonil)amino)-3-metilbutanoil)-2-pirolidinil)-1 H-imidazol-5-il) -4-bifenilil) -1 H-imidazol-2-il) -1-pirolidinil) karbonil) - 2-metilpropil) karbamat; ali njena farmacevtsko sprejemljiva sol.
- 2. Formulacija po zahtevku 1, ki vsebuje dihidroklorid metil((IS)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)2-((metoksikarbonil)amino)-3-metilbutanoil)-2-pirolidinil)-1H-imidazol-5-il) -4-bifenilil) -1 H-imidazol-2-il)pirolidinil)karbonil)-2-metilpropil) karbamat.
- 3. Formulacija po zahtevku 1 ali 2 v obliki kapsul, tablet, praškov, granul, raztopin ali suspenzij v vodnih ali ne-vodnih tekočinah, užitnih penah ali smetani ali tekočih emulzijah olja v vodi ali emulzij z vodo v olju.
- 4. Formulacija po zahtevku 3, v obliki kapsul ali tablet.
- 5. Formulacija po zahtevku 3, v obliki tablet.
- 6. Formulacija po katerem koli izmed predhodnih zahtevkov, kjer formulacija obsega oralni, nestrupen farmacevtsko sprejemljiv inertni nosilec.
- 7. Formulacija po kateremkoli od predhodnih zahtevkov, ki nadalje obsega eno ali dve dodatni spojini ki imata anti-HCV aktivnost.
- 8. Formulacija po zahtevku 7, kjer je vsaj ena od dodatnih spojin interferon ali ribavirin.
- 9. Formulacija po zahtevku 8, kjer je interferon izbran izmed interferona alfa 2B, pegiliranega interferona alfa, konsenzusnega interferona, interferona alfa 2A in limfoblastoidnega interferon tau.
- 10. Formulacija po zahtevku 7, kjer je vsaj ena od dodatnih spojin izbrana izmed interlevkina 2, interlevkin 6, interlevkin 12, spojina, ki izboljša razvoj celičnega odziva tipa 1 T celic pomagalk, interferenčne RNA, anti-sense RNA, imikvimoda, ribavirina, inozin 5-monofosfat dehidrogenaznega inhibitorja, amantadina in rimantadina.
- 11. Formulacija po zahtevku 7, kjer je vsaj ena od dodatnih spojin učinkovita, da inhibira funkcijo tarče, izbrana izmed HCV metaloproteaze, HCV serinske proteaze, HCV polimeraze, HCV helikaze, HCV NS4B proteina, HCV vstopnega (ang. »HCV entry«, sestavljenega HCV, izstopnega HCV (ang. »HCV egress), HCV NS5A proteina in IMPDH za zdravljenje okužb s HCV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83699606P | 2006-08-11 | 2006-08-11 | |
US11/835,462 US8329159B2 (en) | 2006-08-11 | 2007-08-08 | Hepatitis C virus inhibitors |
EP16153044.9A EP3042901B1 (en) | 2006-08-11 | 2007-08-09 | Hepatitis c virus inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3042901T1 true SI3042901T1 (sl) | 2018-06-29 |
Family
ID=38812845
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731764A SI2784075T1 (sl) | 2006-08-11 | 2007-08-09 | Inhibitorji virusa hepatitisa C |
SI200731498T SI2049522T1 (sl) | 2006-08-11 | 2007-08-09 | Inhibitorji virusa hepatitisa c |
SI200732006T SI3042901T1 (sl) | 2006-08-11 | 2007-08-09 | Inhibitorji virusa hepatitisa c |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731764A SI2784075T1 (sl) | 2006-08-11 | 2007-08-09 | Inhibitorji virusa hepatitisa C |
SI200731498T SI2049522T1 (sl) | 2006-08-11 | 2007-08-09 | Inhibitorji virusa hepatitisa c |
Country Status (32)
Country | Link |
---|---|
US (7) | US8329159B2 (sl) |
EP (5) | EP2385048A1 (sl) |
JP (3) | JP5235882B2 (sl) |
KR (2) | KR101475189B1 (sl) |
CN (1) | CN104447707B (sl) |
AR (1) | AR063684A1 (sl) |
AU (1) | AU2007286222B2 (sl) |
BR (1) | BRPI0716483B8 (sl) |
CA (1) | CA2660520C (sl) |
CL (1) | CL2007002327A1 (sl) |
CO (1) | CO6150171A2 (sl) |
CY (4) | CY1115594T1 (sl) |
DK (3) | DK2784075T3 (sl) |
EA (1) | EA015756B1 (sl) |
ES (3) | ES2476592T3 (sl) |
HK (2) | HK1126486A1 (sl) |
HR (3) | HRP20140737T1 (sl) |
HU (2) | HUE029145T2 (sl) |
IL (1) | IL196813A (sl) |
LT (2) | LT3042901T (sl) |
LU (1) | LU92635I2 (sl) |
MX (1) | MX2009001426A (sl) |
NL (1) | NL300713I2 (sl) |
NO (2) | NO340543B1 (sl) |
NZ (1) | NZ574805A (sl) |
PE (1) | PE20080542A1 (sl) |
PL (3) | PL3042901T3 (sl) |
PT (2) | PT3042901T (sl) |
SI (3) | SI2784075T1 (sl) |
TW (1) | TWI432426B (sl) |
WO (1) | WO2008021927A2 (sl) |
ZA (1) | ZA200900962B (sl) |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006069063A1 (en) | 2004-12-20 | 2006-06-29 | Genentech, Inc. | Pyrrolidine inhibitors of iap |
US7745636B2 (en) | 2006-08-11 | 2010-06-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7759495B2 (en) | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8303944B2 (en) | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20080193411A1 (en) * | 2006-11-21 | 2008-08-14 | Genelabs Technologies, Inc. | Anti-viral Compounds |
CL2008001234A1 (es) * | 2007-04-30 | 2008-09-22 | Genentech Inc | Compuestos derivados de heterociclos nitrogenados, inhibidores de las proteinas de apoptosis; y uso en el tratamiento del cancer. |
JP2010526143A (ja) | 2007-05-04 | 2010-07-29 | バーテックス ファーマシューティカルズ インコーポレイテッド | Hcv感染の処置のための併用療法 |
US7741347B2 (en) | 2007-05-17 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
ITMI20071012A1 (it) * | 2007-05-18 | 2008-11-19 | St Microelectronics Srl | Dispositivo di memoria migliorato a veloce programmazione |
JP4827986B2 (ja) | 2007-06-08 | 2011-11-30 | マンカインド コーポレ−ション | IRE−1αインヒビター |
NZ582692A (en) * | 2007-07-05 | 2012-05-25 | Array Biopharma Inc | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US7728027B2 (en) * | 2007-08-08 | 2010-06-01 | Bristol-Myers Squibb Company | Process for synthesizing compounds useful for treating hepatitis C |
US8629171B2 (en) * | 2007-08-08 | 2014-01-14 | Bristol-Myers Squibb Company | Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt |
WO2009049238A1 (en) | 2007-10-11 | 2009-04-16 | The Regents Of The University Of California | Compositions and methods of inhibiting n-acylethanolamine-hydrolyzing acid amidase |
ATE551337T1 (de) * | 2008-02-12 | 2012-04-15 | Bristol Myers Squibb Co | Inhibitoren des hepatitis-c-virus |
MX2010008699A (es) | 2008-02-12 | 2010-08-30 | Bristol Myers Squibb Co | Derivados heterociclicos como inhibidores de virus de la hepatitis c. |
PL2242752T3 (pl) * | 2008-02-13 | 2012-12-31 | Bristol Myers Squibb Co | Imidazolilobifenyloimidazole jako inhibitory wirusa zapalenia wątroby typu c |
US8147818B2 (en) | 2008-02-13 | 2012-04-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP2011529962A (ja) | 2008-08-02 | 2011-12-15 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8383094B2 (en) | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2346329B1 (en) * | 2008-10-09 | 2013-08-21 | Anadys Pharmaceuticals, Inc. | A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds |
MX2011005896A (es) | 2008-12-03 | 2011-09-29 | Presidio Pharmaceuticals Inc | Inhibidores de hcv ns5a. |
BRPI0922366B8 (pt) | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
MX2011006333A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8637561B2 (en) | 2009-02-17 | 2014-01-28 | Enanta Pharmaceuticals, Inc. | Linked diimidazole derivatives |
US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8420686B2 (en) | 2009-02-17 | 2013-04-16 | Enanta Pharmaceuticals, Inc. | Linked diimidazole antivirals |
US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
UY32462A (es) | 2009-02-23 | 2010-09-30 | Arrow Therapeutics Ltd | Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644 |
CA2753313A1 (en) * | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
US10752611B2 (en) | 2009-02-27 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8426458B2 (en) | 2009-02-27 | 2013-04-23 | Enanta Pharmaceuticals, Inc. | Hepatitis C Virus inhibitors |
AU2010217797B2 (en) | 2009-02-27 | 2014-02-20 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8507522B2 (en) | 2009-03-06 | 2013-08-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
EA201190224A1 (ru) | 2009-03-27 | 2012-03-30 | Пресидио Фармасьютикалс, Инк. | Ингибиторы гепатита c, содержащие конденсированные кольца |
US8709999B2 (en) | 2009-03-27 | 2014-04-29 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic HCV inhibitors |
US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9278922B2 (en) * | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
AU2010240882B2 (en) * | 2009-04-24 | 2014-10-23 | Janssen Sciences Ireland Uc | Diaryl ethers |
WO2010132538A1 (en) * | 2009-05-12 | 2010-11-18 | Schering Corporation | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
CN104211689B (zh) * | 2009-05-13 | 2017-01-18 | 吉利德制药有限责任公司 | 抗病毒化合物 |
AU2014203349B2 (en) * | 2009-05-13 | 2014-11-27 | Gilead Pharmasset Llc | Antiviral compounds |
AU2013202666B2 (en) * | 2009-05-13 | 2015-07-16 | Gilead Pharmasset Llc | Antiviral compounds |
US8772505B2 (en) * | 2009-05-29 | 2014-07-08 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis C |
JP2012528195A (ja) * | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | C型肝炎などの疾患を処置するための3つの結合アリール部分で構成された抗菌性化合物 |
US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8138215B2 (en) * | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
ES2414934T3 (es) * | 2009-06-11 | 2013-07-23 | Abbvie Bahamas Limited | Inhibidores del virus de la Hepatitis C |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
AU2012203474B2 (en) * | 2009-06-11 | 2014-09-18 | Abbvie Ireland Unlimited Company | Anti-Viral Compounds |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
WO2011015657A1 (en) | 2009-08-07 | 2011-02-10 | Tibotec Pharmaceuticals | Phenyl ethynyl derivatives as hepatitis c virus inhibitors |
WO2011015658A1 (en) | 2009-08-07 | 2011-02-10 | Tibotec Pharmaceuticals | Bis-benzimidazole derivatives as hepatitis c virus inhibitors |
CN102482260A (zh) | 2009-09-03 | 2012-05-30 | 泰博特克药品公司 | 双-苯并咪唑衍生物 |
US8344155B2 (en) | 2009-09-04 | 2013-01-01 | Glaxosmith Kline Llc | Chemical compounds |
US8703938B2 (en) * | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US9156818B2 (en) | 2009-09-11 | 2015-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8822700B2 (en) * | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8927709B2 (en) * | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8759332B2 (en) * | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011031934A1 (en) * | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8415374B2 (en) | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
AU2010324871A1 (en) | 2009-11-25 | 2012-06-14 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
US20110137633A1 (en) * | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Anti-viral compounds and methods of identifying the same |
KR101768946B1 (ko) | 2009-12-04 | 2017-08-17 | 내셔날 헬스 리서치 인스티튜트 | 프롤린 유도체 |
WO2011081918A1 (en) | 2009-12-14 | 2011-07-07 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20110152246A1 (en) * | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
CA2784646A1 (en) | 2009-12-18 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Hcv combination therapy |
BR112012014899A2 (pt) | 2009-12-18 | 2017-03-14 | Idenix Pharmaceuticals Inc | composto, composição farmacêutica, método para tratar ou prevenir uma infecção por vírus de hepatite c em um sujeito, método para tratar , prevenir ou melhorar um ou mais sintomas de uma doença hepática ou distúrbio associado a uma infecção por vírus de hepatite c em um sujeito, método para inibir a replicação de um vírus em um hospedeiro, método para inibir a replicação de um vírus |
CA2785488A1 (en) | 2009-12-22 | 2011-07-21 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
WO2011079327A1 (en) * | 2009-12-24 | 2011-06-30 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
MX2012008658A (es) | 2010-01-25 | 2012-12-05 | Enanta Pharm Inc | Inhibidores del virus de la hepatitis c. |
WO2011091532A1 (en) * | 2010-01-28 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
US8178531B2 (en) | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
BR112012022311A2 (pt) | 2010-03-04 | 2016-08-23 | Enanta Pharm Inc | agentes farmacêuticos de combinação como inibidores da replicação de hcv. |
AU2011224698A1 (en) | 2010-03-09 | 2012-11-01 | Merck Sharp & Dohme Corp. | Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases |
WO2011119860A1 (en) * | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
TW201200522A (en) * | 2010-03-24 | 2012-01-01 | Vertex Pharma | Analogues for the treatment or prevention of flavivirus infections |
AU2011232331A1 (en) | 2010-03-24 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of Flavivirus infections |
EP2609923B1 (en) | 2010-03-31 | 2017-05-24 | Gilead Pharmasset LLC | Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
US9125904B1 (en) | 2010-05-11 | 2015-09-08 | Achillion Pharmaceuticals, Inc. | Biphenyl imidazoles and related compounds useful for treating HCV infections |
US20110312996A1 (en) * | 2010-05-17 | 2011-12-22 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
WO2011149856A1 (en) * | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
EP2575819A4 (en) | 2010-06-04 | 2013-11-27 | Enanta Pharm Inc | INHIBITORS OF HEPATITIS C VIRUS |
NZ605440A (en) * | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
JP2013531011A (ja) | 2010-06-28 | 2013-08-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染の処置または予防のための化合物および方法 |
MX2012014918A (es) | 2010-06-28 | 2013-04-08 | Vertex Pharma | Compuestos y metodos para tratamiento o prevencion de infecciones por flavivirus. |
EP2593565A4 (en) * | 2010-07-16 | 2013-12-04 | Bristol Myers Squibb Co | METHODS FOR IDENTIFYING COMBINATIONS OF NS5A TARGETING COMPOUNDS THAT SYNERGISTICALLY WORK TO INHIBIT THE REPLICATION OF HEPATITIS C VIRUS |
WO2012018534A2 (en) | 2010-07-26 | 2012-02-09 | Schering Corporation | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
ES2504977T3 (es) | 2010-07-26 | 2014-10-09 | Janssen R&D Ireland | Derivados hetero-bicíclicos como inhibidores del VHC |
US20120196794A1 (en) * | 2010-08-06 | 2012-08-02 | Bristol-Myers Squibb Company | Combinations of Hepatitis C Virus Inhibitors |
EP2603080A4 (en) | 2010-08-12 | 2014-01-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
WO2012020036A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Hepatitis c virus inhibitors |
WO2012024363A2 (en) | 2010-08-17 | 2012-02-23 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
BR112013004520A2 (pt) | 2010-08-26 | 2016-06-07 | Univ Emory | inibidores potentes e seletivos do virus da hepatite c |
US8822520B2 (en) | 2010-09-22 | 2014-09-02 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic HCV inhibitors |
CA2812699A1 (en) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US8999967B2 (en) | 2010-09-29 | 2015-04-07 | Presidio Pharmaceuticals, Inc. | Tricyclic fused ring inhibitors of hepatitis C |
CA2812779A1 (en) | 2010-09-29 | 2012-04-19 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
EA201390532A1 (ru) | 2010-10-08 | 2013-09-30 | Новартис Аг | Композиции сульфамидых ингибиторов ns3, содержащие витамин е |
AU2014203655B2 (en) * | 2010-10-13 | 2016-07-07 | Abbvie Ireland Unlimited Company | Anti-viral compounds |
HUE026832T2 (en) * | 2010-10-13 | 2016-07-28 | Abbvie Bahamas Ltd | Antiviral 1-phenyl-2,5-dibenzimidazol-5-ylpyrrolidine derivative |
WO2012048421A1 (en) * | 2010-10-14 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
KR101594166B1 (ko) | 2010-10-26 | 2016-02-15 | 프레시디오 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스의 억제제 |
CA2814534A1 (en) | 2010-11-04 | 2012-05-10 | Theravance, Inc. | Novel inhibitors of hepatitis c virus |
AU2011328980B2 (en) | 2010-11-17 | 2015-07-30 | Gilead Pharmasset Llc | Antiviral compounds |
JP6069215B2 (ja) | 2010-11-30 | 2017-02-01 | ギリアド ファーマセット エルエルシー | 化合物 |
RU2452735C1 (ru) * | 2010-11-30 | 2012-06-10 | Александр Васильевич Иващенко | Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения |
WO2012083061A2 (en) * | 2010-12-15 | 2012-06-21 | Abbott Laboratories | Anti-viral compounds |
WO2012083048A2 (en) * | 2010-12-15 | 2012-06-21 | Abbott Laboratories | Anti-viral compounds |
WO2012087976A2 (en) * | 2010-12-21 | 2012-06-28 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
CN106986862A (zh) | 2010-12-22 | 2017-07-28 | Abbvie 公司 | 丙型肝炎抑制剂及其用途 |
US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
US8835456B1 (en) | 2011-03-18 | 2014-09-16 | Achillion Pharmaceuticals, Inc. | NS5A inhibitors useful for treating HCV |
US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
JP5669984B2 (ja) | 2011-05-18 | 2015-02-18 | エナンタ ファーマシューティカルズ インコーポレイテッド | 5−アザスピロ[2.4]ヘプタン−6−カルボン酸およびその誘導体の製造方法 |
LT2714036T (lt) | 2011-05-27 | 2016-10-10 | Achillion Pharmaceuticals, Inc. | Pakeistieji alifanai, ciklofanai, heterofanai, hetero-heterofanai ir metalocenai, tinkami panaudoti hcv infekcijų gydymui |
WO2012175581A1 (en) | 2011-06-24 | 2012-12-27 | F. Hoffmann-La Roche Ag | Antiviral compounds |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
WO2013016490A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Thiophene compounds |
CA2845321A1 (en) * | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
US20140378416A1 (en) | 2011-09-14 | 2014-12-25 | Michael P. Dwyer | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
KR101991298B1 (ko) | 2011-09-16 | 2019-06-21 | 길리애드 파마셋 엘엘씨 | Hcv 치료 방법 |
GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
MX2014003705A (es) | 2011-10-10 | 2014-07-22 | Hoffmann La Roche | Compuestos antivirales. |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
PT107925A (pt) | 2011-10-21 | 2014-12-03 | Abbvie Inc | Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv |
ES2529143B1 (es) | 2011-10-21 | 2015-10-26 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc |
TWI577672B (zh) * | 2011-11-03 | 2017-04-11 | 施萬生物製藥研發Ip有限責任公司 | C型肝炎病毒抑制劑 |
EA030941B1 (ru) | 2011-11-16 | 2018-10-31 | Джилид Фармассет Ллс | Противовирусные соединения |
ES2625518T3 (es) | 2011-11-22 | 2017-07-19 | The Regents Of The University Of California | Beta-lactonas disustituidas como inhibidores de amidasa de ácido N-aciletanolamina (NAAA) |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
KR20140104030A (ko) | 2011-12-16 | 2014-08-27 | 에프. 호프만-라 로슈 아게 | Hcv ns5a의 억제제 |
DK2794628T3 (en) | 2011-12-20 | 2017-07-10 | Riboscience Llc | 4'-AZIDO-3'-FLUORO-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION |
UA111761C2 (uk) | 2011-12-20 | 2016-06-10 | Рібосаєнс Ллс | 2',4'-дифтор-2'-метилзаміщені нуклеозидні похідні як інгібітори реплікації phk вірусу гепатиту c |
CA2858646A1 (en) | 2011-12-28 | 2013-07-04 | Janssen R&D Ireland | Quinazolinone derivatives as hcv inhibitors |
AU2012360905B2 (en) | 2011-12-28 | 2017-04-27 | Janssen Sciences Ireland Uc | Hetero-bicyclic derivatives as HCV inhibitors |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
NZ628515A (en) | 2012-02-10 | 2016-06-24 | Lupin Ltd | Antiviral compounds with a dibenzooxaheterocycle moiety |
US9090559B2 (en) | 2012-02-24 | 2015-07-28 | Hoffmann-La Roche Inc. | Antiviral compounds |
EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
SI2850075T1 (sl) | 2012-04-25 | 2017-06-30 | Theravance Biopharma R&D Ip, Llc | Piperazin-piperidinske spojine kot inhibitorji virusa hepatitisa C |
EP2850072B1 (en) | 2012-04-25 | 2016-08-31 | Theravance Biopharma R&D IP, LLC | Hepatitis c virus inhibitors |
US8883135B2 (en) | 2012-05-03 | 2014-11-11 | Theravance Biopharma R&D Ip, Llc | Crystalline form of a pyridyl-piperazinyl hepatitis C virus inhibitor |
US20130309196A1 (en) | 2012-05-16 | 2013-11-21 | Gilead Sciences, Inc. | Antiviral compounds |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
WO2014065791A1 (en) | 2012-10-24 | 2014-05-01 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EP2948440B1 (en) | 2013-01-23 | 2017-04-12 | F. Hoffmann-La Roche AG | Antiviral triazole derivatives |
EP3650013A1 (en) | 2013-01-31 | 2020-05-13 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
RU2507201C1 (ru) | 2013-02-07 | 2014-02-20 | Александр Васильевич Иващенко | Алкил [(s)-1-((s)-2-{5-[4-(4-{2-[(s)-1-((s)-2-метоксикарбониламино-3-метил-бутирил)-пирролидин-2-ил]-3н-имидазол-4-ил}-бута-1,3-диинил)-фенил]-1н-имидазол-2-ил}-пирролидин-1-карбонил)-2-метил-пропил]-карбамат нафталин-1,5-дисульфонат, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
KR20150114566A (ko) | 2013-03-05 | 2015-10-12 | 에프. 호프만-라 로슈 아게 | 항바이러스 화합물 |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
WO2014144547A2 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Amide derivatives of lactam based n-acylethanolamine acid amidase (naaa) inhibitors |
WO2014144836A2 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Carbamate derivatives of lactam based n-acylethanolamine acid amidase (naaa) inhibitors |
EP2990406B1 (en) * | 2013-04-26 | 2018-12-26 | Seoul National University R&DB Foundation | Benzidine derivative, method for preparing same, and pharmaceutical composition containing benzidine derivative for treating liver disease caused by hepatitis c virus |
EA201592185A1 (ru) | 2013-05-16 | 2016-05-31 | Рибосайенс Ллк | 4'-азидо, 3'-дезокси-3'-фторзамещенные нуклеозидные производные |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
NZ714927A (en) | 2013-05-16 | 2020-09-25 | Riboscience Llc | 4’-fluoro-2’-methyl substituted nucleoside derivatives |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
WO2015026454A1 (en) * | 2013-07-17 | 2015-02-26 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis c virus |
JP6333372B2 (ja) * | 2013-07-09 | 2018-05-30 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤の組み合わせ |
EP3021845A1 (en) * | 2013-07-17 | 2016-05-25 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
EP3038601B1 (en) | 2013-08-27 | 2020-04-08 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
EP3080104A1 (en) | 2013-12-11 | 2016-10-19 | Bristol-Myers Squibb Company | 4,4'-biphenyldiyl-bis-(1 h-imidazolyl) derivatives as hepatitis hcv inhibitors |
WO2015089810A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Fused tetracyclic heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
EP3125895A4 (en) | 2014-04-04 | 2017-08-30 | X-RX, Inc. | Substituted spirocydic inhibitors of autotaxin |
WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
BR112017000236A2 (pt) | 2014-07-08 | 2018-01-16 | Gima Spa | unidade de enchimento de elementos recipientes de cápsulas de uso único, máquina para embalar cápsulas de uso único e método para encher elementos recipientes de cápsulas de uso único |
WO2016075588A1 (en) * | 2014-11-11 | 2016-05-19 | Sun Pharmaceutical Industries Limited | Stable amorphous daclatasvir dihydrochloride |
WO2016089814A1 (en) | 2014-12-02 | 2016-06-09 | Concert Pharmaceuticals, Inc. | Deuterated analogues of daclatasvir |
CN105753944B (zh) * | 2014-12-19 | 2019-10-01 | 正大天晴药业集团股份有限公司 | 达卡他韦及其衍生物的制备中间体 |
WO2016102979A1 (en) | 2014-12-26 | 2016-06-30 | Cipla Limited | Polymorphic forms of methyl((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1h-imidazol-5-yl)-4-biphenylyl)-1h-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl)carbamate and salts thereof |
CN106188015B (zh) * | 2015-05-06 | 2019-10-18 | 广东东阳光药业有限公司 | 一种制备达卡他韦的方法 |
WO2016178250A1 (en) | 2015-05-07 | 2016-11-10 | Mylan Laboratories Limited | Process for the preparation of daclatasvir |
CZ2015366A3 (cs) | 2015-05-29 | 2016-12-07 | Zentiva, K.S. | Pevné formy Daclatasviru |
US20160375017A1 (en) | 2015-06-26 | 2016-12-29 | Abbvie Inc. | Solid Pharmaceutical Compositions for Treating HCV |
US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2017076358A1 (zh) * | 2015-11-06 | 2017-05-11 | 苏州晶云药物科技有限公司 | 咪唑基联苯基化合物盐的新晶型及其制备方法 |
GB2552919A (en) * | 2015-11-18 | 2018-02-21 | Azad Pharmaceutical Ingredients Ag | Stable amorphous form of daclatasvir |
CN106083829B (zh) * | 2016-01-12 | 2019-01-22 | 深圳市塔吉瑞生物医药有限公司 | 一种丙型肝炎病毒抑制剂、药物组合物及其应用 |
WO2017172476A1 (en) * | 2016-03-28 | 2017-10-05 | The University Of Toledo | Potent inhibitors of aspartate n-acetyl-transferase for the treatment of canavan disease |
PE20181920A1 (es) | 2016-04-07 | 2018-12-11 | Glaxosmithkline Ip Dev Ltd | Amidas heterociclicas utiles como moduladores de proteinas |
WO2017189978A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
US20190256498A1 (en) | 2016-07-08 | 2019-08-22 | Lupin Limited | Crystalline forms of daclatasvir dihydrochloride |
WO2018015847A1 (en) * | 2016-07-18 | 2018-01-25 | Glenmark Pharmaceuticals Limited | Process for preparation of daclatasvir and salts |
CN108069941A (zh) * | 2016-11-15 | 2018-05-25 | 广东东阳光药业有限公司 | 一种制备达卡他韦的方法 |
RU2650610C1 (ru) | 2017-02-28 | 2018-04-16 | Васильевич Иващенко Александр | Противовирусная композиция и способ ее применения |
US10392370B2 (en) * | 2017-03-13 | 2019-08-27 | Optimus Drugs Pvt Ltd | Process for the preparation of Daclatasvir dihydrochloride and its intermediates |
US10766912B2 (en) | 2017-03-22 | 2020-09-08 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Silicon-containing compound for resistance to hepatitis C virus infection |
CN109305962B (zh) * | 2017-07-28 | 2022-01-18 | 扬子江药业集团有限公司 | 一种盐酸达拉他韦的精制方法 |
AR112702A1 (es) | 2017-09-21 | 2019-11-27 | Riboscience Llc | Derivados de nucleósidos sustituidos con 4-fluoro-2-metilo como inhibidores de la replicación de hcv arn |
CN113167802A (zh) | 2018-12-04 | 2021-07-23 | 百时美施贵宝公司 | 通过多同位素体反应监测使用样品内校准曲线的分析方法 |
TW202106677A (zh) * | 2019-04-25 | 2021-02-16 | 美商貝達醫藥公司 | 用於治療c型肝炎病毒感染之ns5a的二胺甲酸酯抑制劑 |
EP4341266A1 (en) | 2021-05-21 | 2024-03-27 | Gilead Sciences, Inc. | Pentacyclic derivatives as zika virus inhibitors |
WO2024059005A1 (en) * | 2022-09-14 | 2024-03-21 | Jnana Therapeutics Inc. | Treating pku with correctors of mammalian slc6a19 function |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5654451B1 (en) | 1993-01-14 | 2000-02-22 | Magainin Pharma | Amino acids and peptides having modified c-terminals and modified n-terminals |
CA2153987A1 (en) | 1993-01-14 | 1994-07-21 | U. Prasad Kari | Amino acids and peptides having modified terminals |
WO1998027108A2 (en) * | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
MXPA03002363A (es) * | 2000-09-22 | 2004-09-10 | Bayer Cropscience Ag | Delta-1-pirrolinas. |
WO2004002940A1 (en) | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company | Inhibitors of hcv ns5b polymerase |
EP1532118A2 (en) | 2002-07-05 | 2005-05-25 | Axxima Pharmaceuticals Aktiengesellschaft | Imidazole compounds for the treatment of hepatitis c virus infections |
US20050069522A1 (en) | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
DE10243939A1 (de) * | 2002-09-24 | 2004-04-01 | Bayer Cropscience Ag | Pyrroline |
US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
US20050119318A1 (en) * | 2003-10-31 | 2005-06-02 | Hudyma Thomas W. | Inhibitors of HCV replication |
GB0326168D0 (en) | 2003-11-10 | 2003-12-17 | Arrow Therapeutics Ltd | Chemical compounds |
US7514434B2 (en) * | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
JP2007534735A (ja) | 2004-04-28 | 2007-11-29 | アロウ セラピューティクス リミテッド | 抗ウイルス剤として使用するためのモルホリニルアニリノキナゾリン誘導体 |
MX2007001029A (es) * | 2004-07-26 | 2007-04-12 | Lilly Co Eli | Agentes del receptor de histamina h3, preparacion y usos terapeuticos. |
WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
GB2438802A (en) | 2005-02-28 | 2007-12-05 | Univ Rockefeller | Structure of the hepatitis C virus NS5A protein |
US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
BRPI0615934A2 (pt) | 2005-09-16 | 2011-05-31 | Arrow Therapeutics Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, uso de um derivado de bifenila, composição farmacêutica, e, produto |
WO2007058384A1 (en) | 2005-11-17 | 2007-05-24 | Osaka University | Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same |
ES2395386T3 (es) | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Compuestos antivirales |
SG133452A1 (en) | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
NZ569703A (en) | 2006-01-11 | 2011-07-29 | Arrow Therapeutics Ltd | [quinazolin-4-yl]-(4-[1,2,4]triazol-1-ylphenyl)-amine derivatives |
WO2007082554A1 (en) | 2006-01-23 | 2007-07-26 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Modulators of hcv replication |
KR20090012345A (ko) | 2006-05-30 | 2009-02-03 | 애로우 쎄라퓨틱스 리미티드 | 바이페닐 유도체, 및 c형 간염 치료에 있어서의 이들의 용도 |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7745636B2 (en) * | 2006-08-11 | 2010-06-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8303944B2 (en) | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7741347B2 (en) * | 2007-05-17 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8629171B2 (en) * | 2007-08-08 | 2014-01-14 | Bristol-Myers Squibb Company | Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt |
US8181098B2 (en) * | 2008-06-11 | 2012-05-15 | Freescale Semiconductor, Inc. | Error correcting Viterbi decoder |
TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
US8138215B2 (en) * | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8415374B2 (en) * | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US20120196794A1 (en) * | 2010-08-06 | 2012-08-02 | Bristol-Myers Squibb Company | Combinations of Hepatitis C Virus Inhibitors |
US8552047B2 (en) * | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2007
- 2007-08-08 US US11/835,462 patent/US8329159B2/en not_active Expired - Fee Related
- 2007-08-09 PT PT161530449T patent/PT3042901T/pt unknown
- 2007-08-09 WO PCT/US2007/075544 patent/WO2008021927A2/en active Application Filing
- 2007-08-09 EP EP11171390A patent/EP2385048A1/en not_active Withdrawn
- 2007-08-09 EA EA200900298A patent/EA015756B1/ru active Protection Beyond IP Right Term
- 2007-08-09 HU HUE14168065A patent/HUE029145T2/hu unknown
- 2007-08-09 PT PT78000585T patent/PT2049522E/pt unknown
- 2007-08-09 ES ES07800058.5T patent/ES2476592T3/es active Active
- 2007-08-09 KR KR1020147010437A patent/KR101475189B1/ko active IP Right Grant
- 2007-08-09 PE PE2007001068A patent/PE20080542A1/es active IP Right Grant
- 2007-08-09 KR KR1020097004970A patent/KR101450352B1/ko active Protection Beyond IP Right Term
- 2007-08-09 DK DK14168065.2T patent/DK2784075T3/en active
- 2007-08-09 NZ NZ574805A patent/NZ574805A/en unknown
- 2007-08-09 SI SI200731764A patent/SI2784075T1/sl unknown
- 2007-08-09 LT LTEP16153044.9T patent/LT3042901T/lt unknown
- 2007-08-09 ES ES16153044.9T patent/ES2662590T3/es active Active
- 2007-08-09 EP EP07800058.5A patent/EP2049522B1/en active Active
- 2007-08-09 ES ES14168065.2T patent/ES2573523T3/es active Active
- 2007-08-09 PL PL16153044T patent/PL3042901T3/pl unknown
- 2007-08-09 EP EP17189589.9A patent/EP3321263A3/en not_active Withdrawn
- 2007-08-09 JP JP2009524736A patent/JP5235882B2/ja not_active Expired - Fee Related
- 2007-08-09 HU HUE16153044A patent/HUE037802T2/hu unknown
- 2007-08-09 MX MX2009001426A patent/MX2009001426A/es active IP Right Grant
- 2007-08-09 PL PL07800058T patent/PL2049522T3/pl unknown
- 2007-08-09 TW TW096129384A patent/TWI432426B/zh not_active IP Right Cessation
- 2007-08-09 CL CL200702327A patent/CL2007002327A1/es unknown
- 2007-08-09 SI SI200731498T patent/SI2049522T1/sl unknown
- 2007-08-09 EP EP16153044.9A patent/EP3042901B1/en active Active
- 2007-08-09 AU AU2007286222A patent/AU2007286222B2/en not_active Ceased
- 2007-08-09 EP EP14168065.2A patent/EP2784075B1/en active Active
- 2007-08-09 DK DK07800058.5T patent/DK2049522T3/da active
- 2007-08-09 SI SI200732006T patent/SI3042901T1/sl unknown
- 2007-08-09 BR BRPI0716483A patent/BRPI0716483B8/pt not_active IP Right Cessation
- 2007-08-09 AR ARP070103535A patent/AR063684A1/es active IP Right Grant
- 2007-08-09 DK DK16153044.9T patent/DK3042901T3/en active
- 2007-08-09 CA CA2660520A patent/CA2660520C/en not_active Expired - Fee Related
- 2007-08-09 CN CN201410607190.3A patent/CN104447707B/zh not_active Expired - Fee Related
- 2007-08-09 PL PL14168065.2T patent/PL2784075T3/pl unknown
-
2009
- 2009-01-29 NO NO20090447A patent/NO340543B1/no not_active IP Right Cessation
- 2009-02-01 IL IL196813A patent/IL196813A/en active Protection Beyond IP Right Term
- 2009-02-10 ZA ZA2009/00962A patent/ZA200900962B/en unknown
- 2009-02-11 CO CO09013323A patent/CO6150171A2/es unknown
- 2009-06-08 HK HK09105119.6A patent/HK1126486A1/xx not_active IP Right Cessation
-
2012
- 2012-10-12 US US13/650,374 patent/US8642025B2/en not_active Expired - Fee Related
-
2013
- 2013-03-26 JP JP2013064764A patent/JP5769749B2/ja not_active Expired - Fee Related
- 2013-09-18 US US14/030,199 patent/US8900566B2/en not_active Expired - Fee Related
-
2014
- 2014-07-30 HR HRP20140737TT patent/HRP20140737T1/hr unknown
- 2014-08-12 CY CY20141100644T patent/CY1115594T1/el unknown
- 2014-09-17 US US14/488,990 patent/US9227961B2/en not_active Expired - Fee Related
-
2015
- 2015-01-14 LU LU92635C patent/LU92635I2/xx unknown
- 2015-01-20 NL NL300713C patent/NL300713I2/nl unknown
- 2015-02-03 LT LTPA2015006C patent/LTC2049522I2/lt unknown
- 2015-02-20 CY CY2015004C patent/CY2015004I2/el unknown
- 2015-03-03 HK HK15102137.3A patent/HK1201535A1/zh not_active IP Right Cessation
- 2015-05-25 JP JP2015105694A patent/JP2015172064A/ja active Pending
- 2015-11-06 US US14/934,538 patent/US9421192B2/en not_active Expired - Fee Related
-
2016
- 2016-04-19 HR HRP20160410TT patent/HRP20160410T8/hr unknown
- 2016-06-15 CY CY20161100534T patent/CY1117641T1/el unknown
- 2016-06-28 US US15/194,980 patent/US9758487B2/en not_active Expired - Fee Related
-
2017
- 2017-07-20 US US15/654,905 patent/US10047056B2/en not_active Expired - Fee Related
- 2017-07-28 NO NO2017036C patent/NO2017036I1/no unknown
-
2018
- 2018-02-28 CY CY20181100254T patent/CY1119988T1/el unknown
- 2018-03-26 HR HRP20180496TT patent/HRP20180496T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI3042901T1 (sl) | Inhibitorji virusa hepatitisa c | |
Rosenquist et al. | Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor | |
HRP20120440T1 (hr) | Inhibitori virusa hepatitisa c | |
RU2401658C2 (ru) | Гетероциклические ингибиторы аспартилпротеазы | |
JP2013532725A5 (sl) | ||
US9060971B2 (en) | Combination pharmaceutical agents as inhibitors of HCV replication | |
US8426458B2 (en) | Hepatitis C Virus inhibitors | |
RU2496774C2 (ru) | Гетероциклические ингибиторы аспартильной протеазы | |
RU2355700C9 (ru) | Новые пептиды как ингибиторы ns3-серинпротеазы вируса гепатита с | |
JP2012528161A5 (sl) | ||
ES2683736T3 (es) | Procedimientos para mejorar la farmacocinética | |
JP2010509359A5 (sl) | ||
JP2010510234A5 (sl) | ||
JP2013521279A5 (sl) | ||
JP2012512169A5 (sl) | ||
JP2012523415A5 (sl) | ||
JP2012504132A5 (sl) | ||
JP2010500415A5 (sl) | ||
JP2011523651A5 (sl) | ||
HRP20120866T1 (hr) | Makrocikliäśni spojevi hinoksalina kao inhibitori hcv ns3 proteaze | |
JP2010500414A5 (sl) | ||
JP2012504632A5 (sl) | ||
JP2012504126A5 (sl) | ||
EP2341065A3 (en) | Inhibitors of serine proteases, particularly HCV NS3-NS4a protease | |
NZ600505A (en) | Hepatitis c virus inhibitors |