SI2672984T1 - Novi proNGF mutanti in njihove uporabe pri izdelavi beta-NGF - Google Patents
Novi proNGF mutanti in njihove uporabe pri izdelavi beta-NGFInfo
- Publication number
- SI2672984T1 SI2672984T1 SI201230289T SI201230289T SI2672984T1 SI 2672984 T1 SI2672984 T1 SI 2672984T1 SI 201230289 T SI201230289 T SI 201230289T SI 201230289 T SI201230289 T SI 201230289T SI 2672984 T1 SI2672984 T1 SI 2672984T1
- Authority
- SI
- Slovenia
- Prior art keywords
- ngf
- beta
- production
- prongf mutants
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11194208 | 2011-12-19 | ||
EP12805695.9A EP2672984B1 (en) | 2011-12-19 | 2012-12-19 | Novel prongf mutants and uses thereof in the production of beta-ngf |
PCT/EP2012/076251 WO2013092776A1 (en) | 2011-12-19 | 2012-12-19 | Novel prongf mutants and uses thereof in the production of beta-ngf |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2672984T1 true SI2672984T1 (sl) | 2015-11-30 |
Family
ID=47428641
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231212T SI2907521T1 (sl) | 2011-12-19 | 2012-12-19 | Novi proNGF mutanti in njihove uporabe v proizvodnji beta-NGF |
SI201230289T SI2672984T1 (sl) | 2011-12-19 | 2012-12-19 | Novi proNGF mutanti in njihove uporabe pri izdelavi beta-NGF |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231212T SI2907521T1 (sl) | 2011-12-19 | 2012-12-19 | Novi proNGF mutanti in njihove uporabe v proizvodnji beta-NGF |
Country Status (28)
Country | Link |
---|---|
US (3) | US9617322B2 (sl) |
EP (2) | EP2672984B1 (sl) |
JP (4) | JP6039146B2 (sl) |
KR (2) | KR101837802B1 (sl) |
CN (2) | CN104203264B (sl) |
AU (1) | AU2012357052B2 (sl) |
BR (1) | BR112014014913B1 (sl) |
CA (1) | CA2859262C (sl) |
CY (2) | CY1117016T1 (sl) |
DK (2) | DK2907521T3 (sl) |
EA (1) | EA031333B1 (sl) |
ES (2) | ES2657344T3 (sl) |
HK (1) | HK1202055A1 (sl) |
HR (2) | HRP20150900T1 (sl) |
HU (2) | HUE027245T2 (sl) |
IL (1) | IL233137A0 (sl) |
LT (1) | LT2907521T (sl) |
MX (2) | MX370861B (sl) |
NO (1) | NO2907521T3 (sl) |
PL (2) | PL2672984T3 (sl) |
PT (2) | PT2672984E (sl) |
RS (2) | RS54220B1 (sl) |
SG (2) | SG11201402585PA (sl) |
SI (2) | SI2907521T1 (sl) |
SM (1) | SMT201500201B (sl) |
TR (1) | TR201802360T4 (sl) |
WO (1) | WO2013092776A1 (sl) |
ZA (1) | ZA201403753B (sl) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2672984B1 (en) * | 2011-12-19 | 2015-05-27 | Wacker Chemie AG | Novel prongf mutants and uses thereof in the production of beta-ngf |
US20160220639A1 (en) * | 2013-09-11 | 2016-08-04 | New York University | Methods and compositions for treating bone diseases |
EP3406259A1 (en) | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophins for use in the treatment of hearing loss |
CN108456681B (zh) * | 2018-03-26 | 2019-10-11 | 江苏中新医药有限公司 | 高效表达重组人神经生长因子的基因组合 |
EP3784691A1 (en) | 2018-04-27 | 2021-03-03 | Chiesi Farmaceutici S.p.A. | Production of nerve growth factor (ngf) and of muteins thereof |
WO2020004652A1 (ja) * | 2018-06-29 | 2020-01-02 | 学校法人同志社 | エムリカサンを含む製剤 |
BR112021003820A2 (pt) | 2018-09-17 | 2021-05-25 | Chiesi Farmaceutici S.P.A. | agente para tratamento de distúrbios dermatológicos |
IT201900014646A1 (it) * | 2019-08-12 | 2021-02-12 | Consiglio Nazionale Ricerche | Peptide neurotrofico resistente alle proteasi per il trattamento terapeutico di patologie neurodegenerative e/o cutanee |
WO2021052926A1 (en) | 2019-09-17 | 2021-03-25 | Chiesi Farmaceutici S.P.A. | Agent for use in treatment or prevention of ophthalmic disorders |
IL302317A (en) | 2020-10-28 | 2023-06-01 | Dompe Farm Spa | Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them |
EP4039269A1 (en) | 2021-02-05 | 2022-08-10 | Dompe' Farmaceutici S.P.A. | Ngf isoform for use in the treatment of ocular pathologies |
AU2022258342A1 (en) | 2021-04-13 | 2023-11-02 | Dompé Farmaceutici S.P.A. | Treatment of neuropathic corneal pain with ngf |
EP4311554A1 (en) | 2022-07-29 | 2024-01-31 | Dompé farmaceutici S.p.a. | Combination for use in ophthalmology |
EP4316505A1 (en) | 2022-08-05 | 2024-02-07 | Dompé farmaceutici S.p.a. | Intranasal administration of ngf for the treatment of sensorineural hearing loss |
EP4342485A1 (en) | 2022-09-23 | 2024-03-27 | Dompe' Farmaceutici S.P.A. | Ngf for the treatment of spasticity |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
EP0994188B1 (de) * | 1998-10-09 | 2004-01-07 | Scil proteins GmbH | Verfahren zur Gewinnung von aktivem Beta-NGF |
US20030040082A1 (en) | 2001-02-16 | 2003-02-27 | Mark Tuszynski | Mutant pro-neurotrophin with improved activity |
ATE554784T1 (de) | 2001-05-25 | 2012-05-15 | Cornell Res Foundation Inc | Hochaffiner ligand für p75 neurotrophin-rezeptor |
DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
EP1709161B1 (en) * | 2004-01-19 | 2008-10-01 | Nsgene A/S | Human therapeutic cells secreting nerve growth factor |
US20080050776A1 (en) * | 2006-05-26 | 2008-02-28 | Kenneth Neet | Stable mutated pro nerve growth factors |
CN101260398B (zh) * | 2007-03-07 | 2013-06-05 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子基因定位改造动物及其制备方法和应用 |
EP2672984B1 (en) | 2011-12-19 | 2015-05-27 | Wacker Chemie AG | Novel prongf mutants and uses thereof in the production of beta-ngf |
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2012
- 2012-12-19 EP EP12805695.9A patent/EP2672984B1/en active Active
- 2012-12-19 CN CN201280062855.6A patent/CN104203264B/zh active Active
- 2012-12-19 CA CA2859262A patent/CA2859262C/en active Active
- 2012-12-19 SG SG11201402585PA patent/SG11201402585PA/en unknown
- 2012-12-19 NO NO15157320A patent/NO2907521T3/no unknown
- 2012-12-19 EP EP15157320.1A patent/EP2907521B1/en active Active
- 2012-12-19 TR TR2018/02360T patent/TR201802360T4/tr unknown
- 2012-12-19 DK DK15157320.1T patent/DK2907521T3/en active
- 2012-12-19 PL PL12805695T patent/PL2672984T3/pl unknown
- 2012-12-19 CN CN201711352074.1A patent/CN109400693A/zh active Pending
- 2012-12-19 RS RS20150561A patent/RS54220B1/en unknown
- 2012-12-19 LT LTEP15157320.1T patent/LT2907521T/lt unknown
- 2012-12-19 MX MX2017012894A patent/MX370861B/es unknown
- 2012-12-19 ES ES15157320.1T patent/ES2657344T3/es active Active
- 2012-12-19 PT PT128056959T patent/PT2672984E/pt unknown
- 2012-12-19 HU HUE12805695A patent/HUE027245T2/en unknown
- 2012-12-19 PT PT151573201T patent/PT2907521T/pt unknown
- 2012-12-19 WO PCT/EP2012/076251 patent/WO2013092776A1/en active Application Filing
- 2012-12-19 JP JP2014546588A patent/JP6039146B2/ja active Active
- 2012-12-19 KR KR1020147019162A patent/KR101837802B1/ko active IP Right Grant
- 2012-12-19 SG SG10201605028VA patent/SG10201605028VA/en unknown
- 2012-12-19 ES ES12805695.9T patent/ES2545701T3/es active Active
- 2012-12-19 PL PL15157320T patent/PL2907521T3/pl unknown
- 2012-12-19 BR BR112014014913-5A patent/BR112014014913B1/pt active IP Right Grant
- 2012-12-19 MX MX2014007317A patent/MX353074B/es active IP Right Grant
- 2012-12-19 AU AU2012357052A patent/AU2012357052B2/en active Active
- 2012-12-19 EA EA201491155A patent/EA031333B1/ru unknown
- 2012-12-19 HU HUE15157320A patent/HUE036265T2/hu unknown
- 2012-12-19 SI SI201231212T patent/SI2907521T1/sl unknown
- 2012-12-19 DK DK12805695.9T patent/DK2672984T3/en active
- 2012-12-19 RS RS20180159A patent/RS56893B1/sr unknown
- 2012-12-19 SI SI201230289T patent/SI2672984T1/sl unknown
- 2012-12-19 KR KR1020167027254A patent/KR20160120788A/ko not_active Application Discontinuation
- 2012-12-19 US US14/366,460 patent/US9617322B2/en active Active
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2014
- 2014-05-22 ZA ZA2014/03753A patent/ZA201403753B/en unknown
- 2014-06-15 IL IL233137A patent/IL233137A0/en active IP Right Grant
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2015
- 2015-03-12 HK HK15102539.7A patent/HK1202055A1/xx unknown
- 2015-08-20 SM SM201500201T patent/SMT201500201B/xx unknown
- 2015-08-26 HR HRP20150900TT patent/HRP20150900T1/hr unknown
- 2015-08-26 CY CY20151100747T patent/CY1117016T1/el unknown
- 2015-12-22 US US14/978,407 patent/US10308694B2/en active Active
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2016
- 2016-11-03 JP JP2016215749A patent/JP6622683B2/ja active Active
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2018
- 2018-02-21 HR HRP20180307TT patent/HRP20180307T1/hr unknown
- 2018-02-21 CY CY20181100195T patent/CY1119926T1/el unknown
- 2018-08-07 JP JP2018148261A patent/JP2019011330A/ja active Pending
- 2018-08-08 JP JP2018148957A patent/JP2019006781A/ja active Pending
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2019
- 2019-04-05 US US16/376,969 patent/US20200031893A1/en active Pending
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