CY1119926T1 - Νεοι μεταλλακτες prongf και χρησεις αυτων στην παραγωγη bhta-ngf - Google Patents

Νεοι μεταλλακτες prongf και χρησεις αυτων στην παραγωγη bhta-ngf

Info

Publication number
CY1119926T1
CY1119926T1 CY20181100195T CY181100195T CY1119926T1 CY 1119926 T1 CY1119926 T1 CY 1119926T1 CY 20181100195 T CY20181100195 T CY 20181100195T CY 181100195 T CY181100195 T CY 181100195T CY 1119926 T1 CY1119926 T1 CY 1119926T1
Authority
CY
Cyprus
Prior art keywords
prongf
bhta
connectors
new
ngf
Prior art date
Application number
CY20181100195T
Other languages
English (en)
Inventor
Susan Lorey
Bernhard Janowski
Heiko PULTKE
Daniela KATHMANN
Antje PARTHIER
Andreas Anton
Original Assignee
Wacker Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47428641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119926(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wacker Chemie Ag filed Critical Wacker Chemie Ag
Publication of CY1119926T1 publication Critical patent/CY1119926T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Η παρούσα εφεύρεση αναφέρεται σε έναν μεταλλάκτη proNGF και σε χρήσεις αυτού, ειδικότερα στη χρήση ενός μεταλλάκτη proNGF για την παραγωγή ανθρώπινου βήτα-NGF. Η παρούσα εφεύρεση αποκαλύπτει μια μέθοδο παρασκευής ενός βιολογικώς δραστικού ανθρώπινου βήτα-NGF από έναν αδρανή αδιάλυτο μεταλλάκτη proNGF. Ένας μεταλλάκτης proNGF της εφεύρεσης υποκαθίσταται από οποιοδήποτε αμινοξύ αλλά όχι Arg ή Lys στην φυσική τοποθεσία διάσπασης πρωτεάσης R1SK3R4 τουλάχιστον στις θέσεις R1 και Κ3 που αντιστοιχούν στις θέσεις 101 και 103 της ανθρώπινης άγριου τύπου αλληλουχίας proNGF.
CY20181100195T 2011-12-19 2018-02-21 Νεοι μεταλλακτες prongf και χρησεις αυτων στην παραγωγη bhta-ngf CY1119926T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194208 2011-12-19
EP12805695.9A EP2672984B1 (en) 2011-12-19 2012-12-19 Novel prongf mutants and uses thereof in the production of beta-ngf
EP15157320.1A EP2907521B1 (en) 2011-12-19 2012-12-19 Novel prongf mutants and uses thereof in the production of beta-ngf

Publications (1)

Publication Number Publication Date
CY1119926T1 true CY1119926T1 (el) 2018-12-12

Family

ID=47428641

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151100747T CY1117016T1 (el) 2011-12-19 2015-08-26 Νεα μεταλλαγματα prongf και χρησεις αυτων στην παραγωγη toy bhta-ngf
CY20181100195T CY1119926T1 (el) 2011-12-19 2018-02-21 Νεοι μεταλλακτες prongf και χρησεις αυτων στην παραγωγη bhta-ngf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20151100747T CY1117016T1 (el) 2011-12-19 2015-08-26 Νεα μεταλλαγματα prongf και χρησεις αυτων στην παραγωγη toy bhta-ngf

Country Status (28)

Country Link
US (3) US9617322B2 (el)
EP (2) EP2672984B1 (el)
JP (4) JP6039146B2 (el)
KR (2) KR20160120788A (el)
CN (2) CN104203264B (el)
AU (1) AU2012357052B2 (el)
BR (1) BR112014014913B1 (el)
CA (1) CA2859262C (el)
CY (2) CY1117016T1 (el)
DK (2) DK2672984T3 (el)
EA (1) EA031333B1 (el)
ES (2) ES2657344T3 (el)
HK (1) HK1202055A1 (el)
HR (2) HRP20150900T1 (el)
HU (2) HUE036265T2 (el)
IL (1) IL233137A0 (el)
LT (1) LT2907521T (el)
MX (2) MX353074B (el)
NO (1) NO2907521T3 (el)
PL (2) PL2672984T3 (el)
PT (2) PT2672984E (el)
RS (2) RS56893B1 (el)
SG (2) SG11201402585PA (el)
SI (2) SI2672984T1 (el)
SM (1) SMT201500201B (el)
TR (1) TR201802360T4 (el)
WO (1) WO2013092776A1 (el)
ZA (1) ZA201403753B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2672984E (pt) 2011-12-19 2015-10-01 Wacker Chemie Ag Novos mutantes de prongf e suas utilizações na produção de beta-ngf
US20160220639A1 (en) * 2013-09-11 2016-08-04 New York University Methods and compositions for treating bone diseases
EP3406259A1 (en) 2017-05-24 2018-11-28 Dompé farmaceutici S.p.A. Neurotrophins for use in the treatment of hearing loss
CN108456681B (zh) * 2018-03-26 2019-10-11 江苏中新医药有限公司 高效表达重组人神经生长因子的基因组合
WO2019207106A1 (en) 2018-04-27 2019-10-31 Chiesi Farmaceutici Spa Production of nerve growth factor (ngf) and of muteins thereof
AU2019293579A1 (en) * 2018-06-29 2021-01-07 The Doshisha Formulation containing emricasan
EP3852785A1 (en) 2018-09-17 2021-07-28 Chiesi Farmaceutici S.p.A. Agent for treatment of dermatological disorders
IT201900014646A1 (it) * 2019-08-12 2021-02-12 Consiglio Nazionale Ricerche Peptide neurotrofico resistente alle proteasi per il trattamento terapeutico di patologie neurodegenerative e/o cutanee
MX2022002833A (es) * 2019-09-17 2022-04-06 Chiesi Farm Spa Agente para usarse en el tratamiento o prevencion de trastornos oftalmicos.
IL302317A (en) 2020-10-28 2023-06-01 Dompe Farm Spa Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them
EP4039269A1 (en) 2021-02-05 2022-08-10 Dompe' Farmaceutici S.P.A. Ngf isoform for use in the treatment of ocular pathologies
WO2022221351A1 (en) 2021-04-13 2022-10-20 Dompé Farmaceutici S.P.A. Treatment of neuropathic corneal pain with ngf
EP4311554A1 (en) 2022-07-29 2024-01-31 Dompé farmaceutici S.p.a. Combination for use in ophthalmology
EP4316505A1 (en) 2022-08-05 2024-02-07 Dompé farmaceutici S.p.a. Intranasal administration of ngf for the treatment of sensorineural hearing loss
EP4342485A1 (en) 2022-09-23 2024-03-27 Dompe' Farmaceutici S.P.A. Ngf for the treatment of spasticity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4139000A1 (de) * 1991-11-27 1993-06-03 Boehringer Mannheim Gmbh Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf
ATE257514T1 (de) 1998-10-09 2004-01-15 Scil Proteins Gmbh Verfahren zur gewinnung von aktivem beta-ngf
US20030040082A1 (en) 2001-02-16 2003-02-27 Mark Tuszynski Mutant pro-neurotrophin with improved activity
EP1575477B1 (en) 2001-05-25 2012-04-25 Cornell Research Foundation, Inc. HIGH AFFINITY LIGAND FOR p75 NEUROTROPHIN RECEPTOR
DE10360483B4 (de) 2003-12-22 2007-11-15 Scil Proteins Gmbh Expressionsvektor und dessen Verwendung
WO2005068498A2 (en) 2004-01-19 2005-07-28 Nsgene A/S Human therapeutic cells secreting nerve growth factor
US20080050776A1 (en) 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
CN101260398B (zh) 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
PT2672984E (pt) 2011-12-19 2015-10-01 Wacker Chemie Ag Novos mutantes de prongf e suas utilizações na produção de beta-ngf

Also Published As

Publication number Publication date
KR20160120788A (ko) 2016-10-18
SG10201605028VA (en) 2016-07-28
MX353074B (es) 2017-12-19
DK2907521T3 (en) 2018-03-05
PT2672984E (pt) 2015-10-01
EP2907521B1 (en) 2017-11-22
CA2859262C (en) 2021-04-06
JP2019006781A (ja) 2019-01-17
NO2907521T3 (el) 2018-04-21
HRP20180307T1 (hr) 2018-03-23
CN104203264A (zh) 2014-12-10
HUE027245T2 (en) 2016-10-28
MX370861B (es) 2020-01-08
PT2907521T (pt) 2018-02-22
US20200031893A1 (en) 2020-01-30
HUE036265T2 (hu) 2018-06-28
ZA201403753B (en) 2015-11-25
EA031333B1 (ru) 2018-12-28
JP2019011330A (ja) 2019-01-24
BR112014014913B1 (pt) 2020-12-01
SI2672984T1 (sl) 2015-11-30
HK1202055A1 (en) 2015-09-18
JP6039146B2 (ja) 2016-12-07
CN109400693A (zh) 2019-03-01
LT2907521T (lt) 2018-05-10
WO2013092776A1 (en) 2013-06-27
JP6622683B2 (ja) 2019-12-18
US9617322B2 (en) 2017-04-11
NZ627054A (en) 2015-06-26
ES2657344T3 (es) 2018-03-02
BR112014014913A2 (pt) 2017-06-13
PL2907521T3 (pl) 2018-04-30
AU2012357052A1 (en) 2014-07-24
HRP20150900T1 (hr) 2015-10-09
RS54220B1 (en) 2015-12-31
EA201491155A1 (ru) 2015-01-30
CA2859262A1 (en) 2013-06-27
SG11201402585PA (en) 2014-10-30
AU2012357052B2 (en) 2015-06-25
MX2014007317A (es) 2014-11-25
US10308694B2 (en) 2019-06-04
EP2907521A1 (en) 2015-08-19
ES2545701T3 (es) 2015-09-15
SMT201500201B (it) 2015-10-30
US20160244496A1 (en) 2016-08-25
RS56893B1 (sr) 2018-04-30
US20150087020A1 (en) 2015-03-26
DK2672984T3 (en) 2015-08-24
SI2907521T1 (en) 2018-03-30
KR20140103318A (ko) 2014-08-26
PL2672984T3 (pl) 2015-10-30
CY1117016T1 (el) 2017-04-05
TR201802360T4 (tr) 2018-03-21
KR101837802B1 (ko) 2018-03-12
EP2672984A1 (en) 2013-12-18
JP2015501828A (ja) 2015-01-19
IL233137A0 (en) 2014-07-31
CN104203264B (zh) 2018-08-28
EP2672984B1 (en) 2015-05-27
JP2017071611A (ja) 2017-04-13

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