SI2413924T1 - L-ornithine phenyl acetate and methods of making thereof - Google Patents

L-ornithine phenyl acetate and methods of making thereof Download PDF

Info

Publication number
SI2413924T1
SI2413924T1 SI201031596T SI201031596T SI2413924T1 SI 2413924 T1 SI2413924 T1 SI 2413924T1 SI 201031596 T SI201031596 T SI 201031596T SI 201031596 T SI201031596 T SI 201031596T SI 2413924 T1 SI2413924 T1 SI 2413924T1
Authority
SI
Slovenia
Prior art keywords
preparation according
crystalline form
ppm silver
preparation
benzoic acid
Prior art date
Application number
SI201031596T
Other languages
English (en)
Slovenian (sl)
Inventor
Keith Anderson
Jim Behling
Christine Henderson Dougan
Stephen William Watt
Peter Manini
Attilia Figini
Original Assignee
Ocera Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocera Therapeutics, Inc. filed Critical Ocera Therapeutics, Inc.
Publication of SI2413924T1 publication Critical patent/SI2413924T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201031596T 2009-04-03 2010-04-01 L-ornithine phenyl acetate and methods of making thereof SI2413924T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16667609P 2009-04-03 2009-04-03
EP10759442.6A EP2413924B1 (en) 2009-04-03 2010-04-01 L-ornithine phenyl acetate and methods of making thereof
PCT/US2010/029708 WO2010115055A1 (en) 2009-04-03 2010-04-01 L-ornithine phenyl acetate and methods of making thereof

Publications (1)

Publication Number Publication Date
SI2413924T1 true SI2413924T1 (en) 2018-01-31

Family

ID=42828717

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031596T SI2413924T1 (en) 2009-04-03 2010-04-01 L-ornithine phenyl acetate and methods of making thereof

Country Status (26)

Country Link
US (8) US8173706B2 (enExample)
EP (4) EP4101838A1 (enExample)
JP (6) JP6144488B2 (enExample)
KR (6) KR102399540B1 (enExample)
CN (3) CN104230730B (enExample)
AU (1) AU2010232521B2 (enExample)
BR (1) BRPI1013657A2 (enExample)
CA (5) CA2998434C (enExample)
CY (1) CY1119843T1 (enExample)
DK (3) DK2413924T3 (enExample)
EA (2) EA034409B1 (enExample)
ES (3) ES2791524T3 (enExample)
HR (2) HRP20221232T8 (enExample)
HU (2) HUE060371T2 (enExample)
IL (2) IL215449B (enExample)
LT (2) LT3686183T (enExample)
MX (4) MX388894B (enExample)
NO (1) NO2413924T3 (enExample)
NZ (3) NZ708458A (enExample)
PL (2) PL2413924T3 (enExample)
PT (2) PT2413924T (enExample)
SG (3) SG10201406300YA (enExample)
SI (1) SI2413924T1 (enExample)
SM (2) SMT202200395T1 (enExample)
WO (1) WO2010115055A1 (enExample)
ZA (1) ZA201107189B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2153870E (pt) 2004-11-26 2014-03-12 Ucl Business Plc Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática
NZ708458A (en) 2009-04-03 2017-02-24 Ocera Therapeutics Inc L-ornithine phenyl acetate and methods of making thereof
EA025735B1 (ru) 2009-06-08 2017-01-30 ЮСиЭл БИЗНЕС ПиЭлСи Способ лечения портальной гипертензии с использованием l-орнитина в сочетании по меньшей мере с одним из соединений, выбранных из фенилацетата и фенилбутирата
US8068011B1 (en) 2010-08-27 2011-11-29 Q Street, LLC System and method for interactive user-directed interfacing between handheld devices and RFID media
ES2720148T3 (es) * 2010-10-06 2019-07-18 Ocera Therapeutics Inc Métodos de fabricación de fenilacetato de L-ornitina
CN102993037B (zh) * 2012-11-20 2015-03-04 南京工业大学 一种l-鸟氨酸苯乙酸盐的制备方法
CN105481725B (zh) * 2014-09-18 2019-01-22 博瑞生物医药（苏州）股份有限公司 L-精氨酸苯乙酸盐的晶型及其制备方法
NZ732632A (en) 2014-11-24 2021-07-30 Ucl Business Ltd Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
EP3285756B1 (en) * 2015-04-20 2023-02-22 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
US10835506B2 (en) 2015-08-18 2020-11-17 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
JP6989495B2 (ja) * 2015-09-25 2022-01-05 オセラ セラピューティクス， インコーポレイテッド Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防
CA3004331A1 (en) * 2015-11-13 2017-05-18 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
KR20200024145A (ko) * 2017-05-11 2020-03-06 오세라 테라퓨틱스, 아이엔씨. L-오르니틴 페닐아세테이트의 제조방법
CN111295187A (zh) 2017-08-14 2020-06-16 胺细拉健康公司 用于治疗肝脏疾病的氨基酸组合物
AR115585A1 (es) 2018-06-20 2021-02-03 Axcella Health Inc Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo
JP2022533569A (ja) 2019-05-09 2022-07-25 オセラ セラピューティクス， インコーポレイテッド 肝性脳症を評価および処置する方法
CN110707221B (zh) * 2019-09-25 2023-09-01 北京大学深圳研究生院 氨基酸离子液体在制备钙钛矿光电器件中钙钛矿层的应用
US20220362192A1 (en) * 2019-10-16 2022-11-17 Ocera Therapeutics, Inc. Dosages and uses of ornithine phenylacetate for treating hyperammonemia
WO2023240081A1 (en) * 2022-06-06 2023-12-14 Yale University Treatment, amelioration, and/or prevention of inflammatory and autoimmune diseases
WO2024261477A1 (en) 2023-06-20 2024-12-26 Yaqrit Limited Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB965637A (en) 1962-04-23 1964-08-06 Tanabe Seiyaku Co L-ornithine l-aspartate
NL302572A (enExample) 1962-12-27
GB1067742A (en) 1963-09-16 1967-05-03 Kyowa Hakko Kogyo Kk Process for the preparation of l-ornithine l-aspartate
ZA716628B (en) 1970-10-15 1972-06-28 Richardson Merrell Spa Composition and method for treatment of hepatic disease and mental fatigue
FR2113774A1 (en) 1970-11-13 1972-06-30 Roques Ets Prepn of l-ornithine salts with org acids - using silver oxides
US4100161A (en) 1974-04-15 1978-07-11 The Johns Hopkins University Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
US3950529A (en) 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same
US4320146A (en) 1978-03-17 1982-03-16 The Johns Hopkins University Treatment of hepatic and renal disorders with ornithine and arginine salts of branched chain keto acids
US4228099A (en) 1978-03-17 1980-10-14 The Johns Hopkins University Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders
US4352814A (en) 1979-04-18 1982-10-05 The Johns Hopkins University Treatment of hepatic and renal disorders with mixed salts of essential or semi-essential amino acids and nitrogen-free analogs
US4284647A (en) 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US4457942A (en) 1982-08-20 1984-07-03 Brusilow Saul W Process for waste nitrogen removal
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US5139981A (en) 1987-06-24 1992-08-18 Union Carbide Chemicals & Plastics Technology Corporation Process for preparing silver(I)-exchanged resins
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
JPH03273578A (ja) 1990-03-23 1991-12-04 Ricoh Co Ltd 対物レンズクリーニング装置
US5591613A (en) 1990-07-02 1997-01-07 Degussa Aktiengesellschaft Method for the preparation of D-arginine and L-ornithine
DE4020980C1 (enExample) * 1990-07-02 1991-09-26 Degussa Ag, 6000 Frankfurt, De
JP3127484B2 (ja) 1991-02-28 2001-01-22 味の素株式会社 肝炎治療薬
US5767086A (en) 1992-04-03 1998-06-16 Terrapin Technologies, Inc. Bone marrow stimulation by certain glutathione analogs
ATE153299T1 (de) 1992-09-09 1997-06-15 Fisons Plc Pharmazeutisches verpacken
US5571783A (en) 1993-03-09 1996-11-05 Clintec Nutrition Company Composition and method for treating patients with hepatic disease
JP3273578B2 (ja) 1993-09-21 2002-04-08 第一化学薬品株式会社 オルニチンと酸性アミノ酸類又はケト酸類との塩の製造法
US5856481A (en) 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
IL139728A (en) 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
AU2251897A (en) 1996-02-13 1997-09-02 Trustees Of The University Of Pennsylvania, The Method of treating liver disorders
ZA986614B (en) 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
GB9815567D0 (en) 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
US6258849B1 (en) 1998-07-23 2001-07-10 Stanislaw R. Burzynski Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate
EP1179347A4 (en) 1999-05-21 2002-06-26 Takeda Chemical Industries Ltd CONTROL SUBSTANCES FOR LIVER FUNCTION
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
JP3211824B1 (ja) 2000-10-26 2001-09-25 味の素株式会社 分岐鎖アミノ酸含有医薬用顆粒製剤とその製造方法
DE60233558D1 (de) 2001-03-15 2009-10-15 Takashi Abe Aminosäurezusammensetzungen zur linderung einer fehlfunktion der leber
US6503530B1 (en) 2001-11-01 2003-01-07 Chunghee Kimberly Kang Method of preventing development of severe metabolic derangement in inborn errors of metabolism
US20030105104A1 (en) 2001-11-27 2003-06-05 Burzynski Stanislaw R. Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
US20040229948A1 (en) 2002-04-12 2004-11-18 Summar Marshall L. Method for preventing hepatic encephalopathic episodes
US20030195255A1 (en) 2002-04-12 2003-10-16 Summar Marshall L. Method for treating hepatic encephalopathies
CN1383815A (zh) 2002-05-08 2002-12-11 刘万忠 防治肝病、肝性脑病的鸟氨酸和门冬氨酸的复方制剂及其制备方法
US20040152784A1 (en) 2002-07-23 2004-08-05 Special Products Limited Pharmaceutical composition and method for treatment of a urea cycle deficiency or sickle-cell anaemia
AU2003261825A1 (en) 2002-08-30 2004-03-19 Ajinomoto Co., Inc. Therapeutic agent for hepatic disease
US20050059150A1 (en) * 2003-09-17 2005-03-17 Becton, Dickinson And Company Environments that maintain function of primary liver cells
MXPA03009902A (es) 2003-10-29 2005-05-03 Manuel Francisco Lara Och Jose Compuestos para reducir la hiperamonemia en pacientes con cirrosis u otras incapacidad para la eliminacion de amonio.
AU2005216251B2 (en) * 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
KR20110124317A (ko) * 2004-05-06 2011-11-16 오스테올로지스 에이에스 금속 유기 염의 제조를 위한 고 수율 및 고속 합성 방법
WO2006059237A1 (en) 2004-08-30 2006-06-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
PT2153870E (pt) * 2004-11-26 2014-03-12 Ucl Business Plc Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática
PT1948224E (pt) 2005-11-17 2014-06-12 Silverstone Pharma Est Preparação industrial, e a sua utilização na terapêutica da hipertensão
NZ708458A (en) * 2009-04-03 2017-02-24 Ocera Therapeutics Inc L-ornithine phenyl acetate and methods of making thereof
AU2015221466B2 (en) 2009-04-03 2017-02-02 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
CA2763894A1 (en) 2009-06-02 2011-01-13 Salix Pharmaceuticals, Ltd. Use of rifaximin to maintain remission of hepatic encephalopathy
EA025735B1 (ru) 2009-06-08 2017-01-30 ЮСиЭл БИЗНЕС ПиЭлСи Способ лечения портальной гипертензии с использованием l-орнитина в сочетании по меньшей мере с одним из соединений, выбранных из фенилацетата и фенилбутирата
AU2014250643B2 (en) 2009-06-08 2016-07-14 Ocera Therapeutics, Inc. Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate
JP2011236160A (ja) 2010-05-11 2011-11-24 Shinshu Univ 非アルコール性肝疾患治療薬
ES2720148T3 (es) 2010-10-06 2019-07-18 Ocera Therapeutics Inc Métodos de fabricación de fenilacetato de L-ornitina
ES2654774T3 (es) 2012-11-21 2018-02-15 Horizon Therapeutics, Llc Métodos para administrar y evaluar fármacos de recuperación de nitrógeno para el tratamiento de encefalopatía hepática
NZ732632A (en) 2014-11-24 2021-07-30 Ucl Business Ltd Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
EP3285756B1 (en) 2015-04-20 2023-02-22 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
US10835506B2 (en) 2015-08-18 2020-11-17 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate

Also Published As

Publication number Publication date
KR20220067001A (ko) 2022-05-24
ZA201107189B (en) 2012-12-27
EP2413924B1 (en) 2017-09-27
JP7086118B2 (ja) 2022-06-17
KR20180033313A (ko) 2018-04-02
BRPI1013657A2 (pt) 2016-04-26
CA2998434A1 (en) 2010-10-07
HRP20221232T1 (hr) 2022-12-23
ES2928586T3 (es) 2022-11-21
CA3077846C (en) 2023-08-22
CN104230730A (zh) 2014-12-24
JP6144488B2 (ja) 2017-06-07
DK3686183T3 (da) 2022-10-03
CA2757373A1 (en) 2010-10-07
CA3205755A1 (en) 2010-10-07
KR20120006039A (ko) 2012-01-17
US11161802B2 (en) 2021-11-02
EA201171216A1 (ru) 2012-05-30
MX388894B (es) 2025-03-20
CA2998344A1 (en) 2010-10-07
CN102421432B (zh) 2014-09-17
MX375111B (es) 2025-03-06
CA2998344C (en) 2020-06-02
HUE035921T2 (en) 2018-05-28
ES2652187T3 (es) 2018-01-31
ES2791524T3 (es) 2020-11-04
SMT201700601T1 (it) 2018-03-08
EA034409B1 (ru) 2020-02-05
US10550069B2 (en) 2020-02-04
JP2020100624A (ja) 2020-07-02
KR20200070438A (ko) 2020-06-17
JP2015145372A (ja) 2015-08-13
EA023051B1 (ru) 2016-04-29
US9604909B2 (en) 2017-03-28
HRP20171962T1 (hr) 2018-02-09
CA2998434C (en) 2020-05-12
US8173706B2 (en) 2012-05-08
HUE060371T2 (hu) 2023-02-28
KR102217081B1 (ko) 2021-02-18
HRP20221232T8 (hr) 2023-02-03
MX2020009699A (es) 2021-12-17
US8492439B2 (en) 2013-07-23
NO2413924T3 (enExample) 2018-02-24
EP3263100A1 (en) 2018-01-03
EA201500650A1 (ru) 2015-10-30
EP3263100B1 (en) 2020-04-01
EP4101838A1 (en) 2022-12-14
IL215449B (en) 2019-01-31
CN104230730B (zh) 2017-05-24
KR101844605B1 (ko) 2018-04-02
JP2022088504A (ja) 2022-06-14
CA2757373C (en) 2018-05-08
CA3077846A1 (en) 2010-10-07
US20220162155A1 (en) 2022-05-26
NZ595706A (en) 2014-01-31
CN106810464A (zh) 2017-06-09
IL263784A (en) 2019-01-31
US20150251990A1 (en) 2015-09-10
KR101975726B1 (ko) 2019-05-07
AU2010232521B2 (en) 2015-07-16
US8785498B2 (en) 2014-07-22
MX2011010262A (es) 2012-01-25
EP3686183B1 (en) 2022-08-03
CN102421432A (zh) 2012-04-18
JP2017081940A (ja) 2017-05-18
JP6647336B2 (ja) 2020-02-14
SG10201406300YA (en) 2015-01-29
WO2010115055A1 (en) 2010-10-07
PL3686183T3 (pl) 2022-11-28
KR102123243B1 (ko) 2020-06-17
JP2012522803A (ja) 2012-09-27
US20120208885A1 (en) 2012-08-16
JP2018138575A (ja) 2018-09-06
CY1119843T1 (el) 2018-06-27
CN106810464B (zh) 2019-01-22
US9034925B2 (en) 2015-05-19
LT3686183T (lt) 2022-11-10
US20200239406A1 (en) 2020-07-30
PL2413924T3 (pl) 2018-02-28
US20100280119A1 (en) 2010-11-04
US20180044281A1 (en) 2018-02-15
DK3263100T3 (da) 2020-05-11
SMT202200395T1 (it) 2022-11-18
JP6010154B2 (ja) 2016-10-19
SG174982A1 (en) 2011-11-28
US20140288327A1 (en) 2014-09-25
DK2413924T3 (en) 2017-12-11
IL215449A0 (en) 2011-12-29
US20180319736A1 (en) 2018-11-08
HK1248558A1 (en) 2018-10-19
SG10202010988WA (en) 2020-12-30
NZ619235A (en) 2015-06-26
KR102399540B1 (ko) 2022-05-17
PT3686183T (pt) 2022-10-03
AU2010232521A1 (en) 2011-11-17
EP3686183A1 (en) 2020-07-29
LT2413924T (lt) 2018-02-12
JP6328737B2 (ja) 2018-05-23
KR20190068561A (ko) 2019-06-18
PT2413924T (pt) 2018-01-04
US20130296429A1 (en) 2013-11-07
EP2413924A1 (en) 2012-02-08
US10173964B2 (en) 2019-01-08
NZ708458A (en) 2017-02-24
EP2413924A4 (en) 2013-01-02
KR20210019592A (ko) 2021-02-22
MX356608B (es) 2018-06-06

Similar Documents

Publication Publication Date Title
SI2413924T1 (en) L-ornithine phenyl acetate and methods of making thereof
RU2013158649A (ru) Средство для ухода за зубами на основе ионов металлов с низким содержанием воды
MX338382B (es) Composicion de gel.
EA201591390A1 (ru) Пиразол[1,5-a]пиримидины для противовирусного лечения
JP6160621B2 (ja) ピロロキノリンキノンテトラアルカリ塩及びその結晶、これらの製造方法、並びに、組成物
JP2009511412A5 (enExample)
WO2015011119A3 (en) Salts of dasatinib in amorphous form
NZ614434A (en) High-strength, low viscosity herbicidal concentrate of clopyralid dimethylamine
JP2013028589A5 (enExample)
NZ600263A (en) 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods for preparation, and methods for use thereof
MX364735B (es) Concentrado en suspensión acuosa que comprende una sal ácida de dodecilguanidina.
NZ599377A (en) Salts, aqueous liquid compositions containing salts of S-(+)-abscisic acid and methods of their preparation
RU2013101546A (ru) Гербицидная композиция
JP2016204309A (ja) 液状抗菌剤組成物及びその製造方法並びに抗菌処理方法
HRP20131164T1 (hr) Delta kristalni oblik argininske soli perindoprila, postupak za njegovu pripremu i farmaceutske pripravke koji ga sadrže
MX388315B (es) Formulacion activa para usarse en productos alimenticios.
WO2012064159A3 (ko) 항암용 조성물
CN102870811A (zh) 一种畜禽养殖环境消毒剂
RU2016115716A (ru) Атимикробные наночастицы диоксида титана, модифицированные катионами серебра
BR112013032882B8 (pt) composição biocida, uso de uma composição, e, processo para controlar e lutar contra o crescimento de erva daninha em um campo de cultivo
CN101653120B (zh) 一种含有喹螨醚的杀螨组合物
SV2005001762A (es) Composicion agroquimica en suspension acuosa
RU2014153494A (ru) Состав для ухода за полостью рта
US7683008B2 (en) High-strength, low-temperature stable herbicidal formulations of 2,4-dichlorophenoxy acetic acid salts
CA2555915C (en) High-strength, low-temperature stable herbicidal formulations of 2,4-dichlorophenoxy acetic acid salts