BRPI1013657A2 - composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina - Google Patents

composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina

Info

Publication number
BRPI1013657A2
BRPI1013657A2 BRPI1013657A BRPI1013657A BRPI1013657A2 BR PI1013657 A2 BRPI1013657 A2 BR PI1013657A2 BR PI1013657 A BRPI1013657 A BR PI1013657A BR PI1013657 A BRPI1013657 A BR PI1013657A BR PI1013657 A2 BRPI1013657 A2 BR PI1013657A2
Authority
BR
Brazil
Prior art keywords
phenyl
ornithine acetate
acetate salt
ornithine
compressing
Prior art date
Application number
BRPI1013657A
Other languages
English (en)
Portuguese (pt)
Inventor
Attilia Figini
Christine Henderson Dougan
Jim Behling
Keith Anderson
Peter Manini
Stephen William Watt
Original Assignee
Ocera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocera Therapeutics Inc filed Critical Ocera Therapeutics Inc
Publication of BRPI1013657A2 publication Critical patent/BRPI1013657A2/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI1013657A 2009-04-03 2010-04-01 composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina BRPI1013657A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16667609P 2009-04-03 2009-04-03
PCT/US2010/029708 WO2010115055A1 (en) 2009-04-03 2010-04-01 L-ornithine phenyl acetate and methods of making thereof

Publications (1)

Publication Number Publication Date
BRPI1013657A2 true BRPI1013657A2 (pt) 2016-04-26

Family

ID=42828717

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013657A BRPI1013657A2 (pt) 2009-04-03 2010-04-01 composições, processos de produção ade sal de acetato de fenil l-ornitina, método de compressão de acetato de fenil l-ornitina e uso de quantidade terapeuticamente efetiva de forma cristalina do sal de acetato de fenil l-ornitina

Country Status (26)

Country Link
US (9) US8173706B2 (enExample)
EP (4) EP3263100B1 (enExample)
JP (6) JP6144488B2 (enExample)
KR (6) KR102399540B1 (enExample)
CN (3) CN106810464B (enExample)
AU (1) AU2010232521B2 (enExample)
BR (1) BRPI1013657A2 (enExample)
CA (5) CA3205755A1 (enExample)
CY (1) CY1119843T1 (enExample)
DK (3) DK3263100T3 (enExample)
EA (2) EA034409B1 (enExample)
ES (3) ES2791524T3 (enExample)
HR (2) HRP20221232T8 (enExample)
HU (2) HUE060371T2 (enExample)
IL (2) IL215449B (enExample)
LT (2) LT2413924T (enExample)
MX (4) MX388894B (enExample)
NO (1) NO2413924T3 (enExample)
NZ (3) NZ595706A (enExample)
PL (2) PL2413924T3 (enExample)
PT (2) PT3686183T (enExample)
SG (3) SG10201406300YA (enExample)
SI (1) SI2413924T1 (enExample)
SM (2) SMT201700601T1 (enExample)
WO (1) WO2010115055A1 (enExample)
ZA (1) ZA201107189B (enExample)

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CA2757373A1 (en) 2010-10-07
JP6010154B2 (ja) 2016-10-19
KR102217081B1 (ko) 2021-02-18
SMT201700601T1 (it) 2018-03-08
JP7086118B2 (ja) 2022-06-17
EP3686183B1 (en) 2022-08-03
PL2413924T3 (pl) 2018-02-28
MX375111B (es) 2025-03-06
US9034925B2 (en) 2015-05-19
KR20200070438A (ko) 2020-06-17
CN106810464A (zh) 2017-06-09
US20180319736A1 (en) 2018-11-08
US20220162155A1 (en) 2022-05-26
MX356608B (es) 2018-06-06
KR20180033313A (ko) 2018-04-02
JP2020100624A (ja) 2020-07-02
JP6144488B2 (ja) 2017-06-07
SG174982A1 (en) 2011-11-28
EA201500650A1 (ru) 2015-10-30
PT3686183T (pt) 2022-10-03
CA2998344C (en) 2020-06-02
CA3077846C (en) 2023-08-22
EP2413924A1 (en) 2012-02-08
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AU2010232521A1 (en) 2011-11-17
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US8785498B2 (en) 2014-07-22
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US20180044281A1 (en) 2018-02-15
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US8492439B2 (en) 2013-07-23
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IL215449B (en) 2019-01-31
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