BR112013022544A2 - método de fabricação e de purificação de composto, e, composto - Google Patents

método de fabricação e de purificação de composto, e, composto

Info

Publication number
BR112013022544A2
BR112013022544A2 BR112013022544A BR112013022544A BR112013022544A2 BR 112013022544 A2 BR112013022544 A2 BR 112013022544A2 BR 112013022544 A BR112013022544 A BR 112013022544A BR 112013022544 A BR112013022544 A BR 112013022544A BR 112013022544 A2 BR112013022544 A2 BR 112013022544A2
Authority
BR
Brazil
Prior art keywords
purification method
compound manufacturing
compound
manufacturing
purification
Prior art date
Application number
BR112013022544A
Other languages
English (en)
Inventor
Stanislav Radl
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of BR112013022544A2 publication Critical patent/BR112013022544A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112013022544A 2011-03-04 2012-03-05 método de fabricação e de purificação de composto, e, composto BR112013022544A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2011-118A CZ306650B6 (cs) 2011-03-04 2011-03-04 Způsob výroby 2-ethoxy-1-((2´-((hydroxyamino)iminomethyl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylové kyseliny a jejích esterů, klíčových intermediátů syntézy azilsartanu
PCT/CZ2012/000023 WO2012119573A1 (en) 2011-03-04 2012-03-05 A method of manufacturing 2-ethoxy-1-((2'-((hydroxyamino) iminomethyl)biphenyl-4- yl)methyl)-1h-benzo [d] imidazole-7-carboxylic acid and its esters

Publications (1)

Publication Number Publication Date
BR112013022544A2 true BR112013022544A2 (pt) 2016-07-19

Family

ID=45932060

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013022544A BR112013022544A2 (pt) 2011-03-04 2012-03-05 método de fabricação e de purificação de composto, e, composto

Country Status (15)

Country Link
EP (1) EP2681201B1 (pt)
JP (1) JP6126019B2 (pt)
KR (1) KR20140008371A (pt)
CN (1) CN103476758B (pt)
BR (1) BR112013022544A2 (pt)
CY (1) CY1119452T1 (pt)
CZ (1) CZ306650B6 (pt)
EA (1) EA023029B1 (pt)
ES (1) ES2604938T3 (pt)
HU (1) HUE031893T2 (pt)
IL (1) IL228153A (pt)
MX (1) MX340549B (pt)
UA (1) UA113057C2 (pt)
WO (1) WO2012119573A1 (pt)
ZA (1) ZA201306522B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664920B (zh) * 2012-09-24 2016-03-09 上海医药工业研究院 阿奇沙坦中间体及其与阿奇沙坦的制备方法
CN103664792B (zh) * 2012-09-24 2016-03-30 上海医药工业研究院 阿奇沙坦中间体及其制备方法
CN104119326B (zh) * 2013-04-25 2017-04-26 正大天晴药业集团股份有限公司 一种阿齐沙坦的制备方法
CN103408500B (zh) * 2013-07-25 2016-03-16 上海博志研新药物技术有限公司 一种血管紧张素ⅱ受体拮抗剂及其关键中间体的制备方法
CN104418807A (zh) * 2013-09-09 2015-03-18 天津药物研究院 一种2-乙氧基-1-[[2`-(羟基脒基)-联苯基]-4-基]甲基-1h-苯并咪唑-7-羧酸及其酯衍生物的制备方法
CN103554031B (zh) * 2013-11-01 2015-04-15 深圳科兴生物工程有限公司 阿齐沙坦中间体的制备方法
CN103880756B (zh) * 2014-03-26 2016-06-01 四川奥邦药业有限公司 一种阿齐沙坦中间体的制备方法
WO2016022626A1 (en) * 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
WO2016147120A1 (en) * 2015-03-18 2016-09-22 Smilax Laboratories Limited An improved process for the preparation of substantially pure azilsartan
CN107840827A (zh) * 2017-11-06 2018-03-27 江苏中邦制药有限公司 一种阿齐沙坦中间体的合成方法
CN108640911B (zh) * 2018-04-03 2020-03-27 科兴生物制药股份有限公司 一种阿齐沙坦的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1064044C (zh) * 1991-06-27 2001-04-04 武田药品工业株式会社 杂环化合物，其制备及应用
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
TW251288B (pt) * 1991-06-27 1995-07-11 Takeda Dharm Industry Co Ltd
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
JP4549461B2 (ja) * 1998-08-31 2010-09-22 富山化学工業株式会社 ７−ブロモ−キノロンカルボン酸誘導体の製造法
US6166254A (en) * 1998-11-24 2000-12-26 Silicon Valley Chemlabs, Inc. Method of manufacturing high purity amidoximes from hydroxylamine and nitriles
MXPA04001353A (es) * 2001-08-15 2004-10-27 Icos Corp 2h-ftalazin-1-onas y metodos para su uso.
JP5024851B2 (ja) * 2004-10-28 2012-09-12 第一三共株式会社 光学活性４，４−二置換オキサゾリジン誘導体とその製造方法
UA92485C2 (ru) * 2005-03-30 2010-11-10 Такеда Фармасьютикал Компани Лимитед Производная бензамида и ее применение как антагониста ангиотензина ии
EP2151440A4 (en) * 2007-05-21 2010-10-20 Takeda Pharmaceutical Heterocyclic compound and its use
CN102344415B (zh) * 2010-07-29 2016-04-13 上海医药工业研究院 阿奇沙坦中间体的制备方法

Also Published As

Publication number Publication date
CZ2011118A3 (cs) 2012-10-10
MX340549B (es) 2016-07-14
WO2012119573A1 (en) 2012-09-13
EA201391268A1 (ru) 2014-02-28
IL228153A0 (en) 2013-11-25
CZ306650B6 (cs) 2017-04-19
CY1119452T1 (el) 2018-03-07
CN103476758A (zh) 2013-12-25
MX2013010058A (es) 2013-10-01
IL228153A (en) 2015-04-30
HUE031893T2 (en) 2017-08-28
CN103476758B (zh) 2016-06-08
EP2681201A1 (en) 2014-01-08
EP2681201B1 (en) 2016-08-24
KR20140008371A (ko) 2014-01-21
ES2604938T3 (es) 2017-03-10
JP6126019B2 (ja) 2017-05-10
JP2014506898A (ja) 2014-03-20
ZA201306522B (en) 2014-05-28
EA023029B1 (ru) 2016-04-29
UA113057C2 (xx) 2016-12-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]