SI1789442T1 - Proteinske mutante fibroblastnega rastnega faktorja 21 - Google Patents
Proteinske mutante fibroblastnega rastnega faktorja 21Info
- Publication number
- SI1789442T1 SI1789442T1 SI200530852T SI200530852T SI1789442T1 SI 1789442 T1 SI1789442 T1 SI 1789442T1 SI 200530852 T SI200530852 T SI 200530852T SI 200530852 T SI200530852 T SI 200530852T SI 1789442 T1 SI1789442 T1 SI 1789442T1
- Authority
- SI
- Slovenia
- Prior art keywords
- muteins
- growth factor
- fibroblast growth
- nucleic acid
- disclosed
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title 1
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 230000004989 O-glycosylation Effects 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000056713 human FGF21 Human genes 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Child & Adolescent Psychology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60680504P | 2004-09-02 | 2004-09-02 | |
EP05775749A EP1789442B1 (en) | 2004-09-02 | 2005-07-26 | Muteins of fibroblast growth factor 21 |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1789442T1 true SI1789442T1 (sl) | 2010-01-29 |
Family
ID=36036790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200530852T SI1789442T1 (sl) | 2004-09-02 | 2005-07-26 | Proteinske mutante fibroblastnega rastnega faktorja 21 |
Country Status (21)
Country | Link |
---|---|
US (1) | US7582607B2 (sl) |
EP (2) | EP1789442B1 (sl) |
JP (1) | JP4809352B2 (sl) |
KR (1) | KR100854198B1 (sl) |
CN (1) | CN101010338B (sl) |
AT (1) | ATE444307T1 (sl) |
AU (1) | AU2005283025B2 (sl) |
BR (1) | BRPI0514790A (sl) |
CA (1) | CA2575753A1 (sl) |
DE (1) | DE602005016946D1 (sl) |
DK (1) | DK1789442T3 (sl) |
EA (1) | EA011390B1 (sl) |
ES (1) | ES2332057T3 (sl) |
HR (1) | HRP20090597T1 (sl) |
IL (1) | IL181573A0 (sl) |
MX (1) | MX2007002616A (sl) |
NO (1) | NO20071327L (sl) |
PL (1) | PL1789442T3 (sl) |
PT (1) | PT1789442E (sl) |
SI (1) | SI1789442T1 (sl) |
WO (1) | WO2006028595A2 (sl) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
JP2010523084A (ja) | 2007-03-30 | 2010-07-15 | アンブルックス,インコーポレイテッド | 修飾fgf−21ポリペプチド |
EP2142651B1 (en) | 2007-04-27 | 2013-05-22 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
EP3260129A1 (en) * | 2007-08-03 | 2017-12-27 | Eli Lilly and Company | An fgf-21 compound and a glp-1 compound for use in the treatment of obesity |
JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
CN102625811B (zh) | 2008-10-10 | 2016-09-21 | 安姆根有限公司 | Fgf21突变体及其用途 |
MX2011007544A (es) | 2009-01-23 | 2011-08-12 | Novo Nordisk As | Derivados de factor de crecimiento de fibroblastos 21 (fgf21) con ligante de albumina a-b-c-d-e- y su uso. |
US9120871B2 (en) | 2009-01-23 | 2015-09-01 | Novo Nordisk A/S | Process for preparing FGF21 with low degree of O-glycosylation |
UY32607A (es) * | 2009-05-05 | 2010-12-31 | Amgen Inc | Mutantes de fgf21 y usos del mismo |
US20120052069A1 (en) * | 2009-05-05 | 2012-03-01 | Amgen Inc | Fgf21 mutants and uses thereof |
CA2764835A1 (en) * | 2009-06-17 | 2010-12-23 | Amgen Inc. | Chimeric fgf19 polypeptides and uses thereof |
CN101993485B (zh) | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
EP2506861A1 (en) * | 2009-12-02 | 2012-10-10 | Amgen Inc. | Binding proteins that bind to human fgfr1c, human b-klotho and both human fgfr1c and human b-klotho |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
EP2359843A1 (en) | 2010-01-21 | 2011-08-24 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
CN102791730A (zh) * | 2010-01-22 | 2012-11-21 | 诺沃—诺迪斯克有限公司 | 低度o-糖基化的fgf21的制备方法 |
EP2558497A2 (en) | 2010-04-15 | 2013-02-20 | Amgen Inc. | Human fgf receptor and beta-klotho binding proteins |
CA2796459C (en) | 2010-04-16 | 2016-05-24 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf-1 |
JP2013533227A (ja) | 2010-06-08 | 2013-08-22 | ノヴォ ノルディスク アー/エス | Fgf21類似体および誘導体 |
WO2012010553A1 (en) | 2010-07-20 | 2012-01-26 | Novo Nordisk A/S | N-terminal modified fgf21 compounds |
AU2011324886A1 (en) | 2010-11-05 | 2013-05-23 | Covx Technologies Ireland Limited | Anti-diabetic compounds |
US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
PL2726511T3 (pl) | 2011-07-01 | 2019-12-31 | Ngm Biopharmaceuticals, Inc. | Kompozycje, zastosowania i sposoby leczenia zaburzeń oraz chorób metabolicznych |
EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
TWI593708B (zh) * | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
AR087973A1 (es) | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
JP6165168B2 (ja) | 2011-12-22 | 2017-07-19 | ファイザー・インク | 抗糖尿病化合物 |
PL2814842T3 (pl) | 2012-02-15 | 2018-12-31 | Novo Nordisk A/S | Przeciwciała wiążące białko 1 rozpoznające peptydoglikan |
EP3196214B1 (en) | 2012-02-15 | 2019-07-31 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1) |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9475856B2 (en) | 2012-03-02 | 2016-10-25 | New York University | Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders |
US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
KR20150006059A (ko) | 2012-06-11 | 2015-01-15 | 일라이 릴리 앤드 캄파니 | 섬유모세포 성장 인자 21 변이체 |
NZ630484A (en) | 2012-11-28 | 2017-04-28 | Ngm Biopharmaceuticals Inc | Compositions and methods for treatment of metabolic disorders and diseases |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
EP2938740B1 (en) | 2012-12-27 | 2022-04-20 | NGM Biopharmaceuticals, Inc. | Chimeric fgf19 peptides for use in treating bile acid disorders |
US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
MX2016005101A (es) | 2013-10-21 | 2017-01-09 | Salk Inst For Biological Studi | Factor de crecimiento de fibroblastos (fgf) 1 mutado y procedimientos de uso. |
MX2016004822A (es) | 2013-10-28 | 2016-08-17 | Ngm Biopharmaceuticals Inc | Modelos de cancer y metodos asociados. |
HUE050279T2 (hu) | 2014-01-24 | 2020-11-30 | Ngm Biopharmaceuticals Inc | Béta-klotho 2-es doménjéhez kötõdõ antitestek és azok alkalmazási módszerei |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
RS65136B1 (sr) | 2014-07-17 | 2024-02-29 | Novo Nordisk As | Mutageza usmerena na lokaciju trem-1 antitela za smanjenje viskoziteta |
IL251834B2 (en) | 2014-10-23 | 2023-09-01 | Ngm Biopharmaceuticals Inc | Pharmaceutical compositions containing peptide variants and methods of using them |
TWI705071B (zh) | 2014-10-24 | 2020-09-21 | 美商必治妥美雅史谷比公司 | 經修飾之fgf-21多肽及其用途 |
US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
AR103246A1 (es) | 2014-12-23 | 2017-04-26 | Novo Nordiks As | Derivados de fgf21 y sus usos |
WO2016187558A2 (en) | 2015-05-20 | 2016-11-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method to improve neurologic outcomes in temperature managed patients |
WO2017019957A2 (en) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
WO2017075260A1 (en) | 2015-10-30 | 2017-05-04 | Salk Institute For Biological Studies | Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs |
ES2871036T3 (es) | 2015-11-09 | 2021-10-28 | Ngm Biopharmaceuticals Inc | Método para el tratamiento de trastornos relacionados con ácidos biliares |
TW201731867A (zh) * | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
CN107759696A (zh) | 2016-08-19 | 2018-03-06 | 安源医药科技(上海)有限公司 | 人白介素7融合蛋白及其制备方法 |
WO2018039557A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
SG11202001379WA (en) | 2017-09-08 | 2020-03-30 | Bristol Myers Squibb Co | Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash) |
CN109929806B (zh) | 2017-12-19 | 2020-05-08 | 北京吉源生物科技有限公司 | 一种表达glp1和fgf21的干细胞及其用途 |
EP3749683A4 (en) * | 2018-02-08 | 2022-03-16 | Sunshine Lake Pharma Co., Ltd. | FGF21 VARIANT, FUSION PROTEIN AND USE THEREOF |
AU2019248547A1 (en) | 2018-04-02 | 2020-09-10 | Bristol-Myers Squibb Company | Anti-TREM-1 antibodies and uses thereof |
BR112020026512A2 (pt) | 2018-07-03 | 2021-04-06 | Bristol-Myers Squibb Company | Formulações de fgf-21 |
US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
CN115038717A (zh) * | 2019-11-12 | 2022-09-09 | 慕尼黑工业大学 | 人IL-27α-亚基的同质突变蛋白 |
MX2022008336A (es) | 2020-01-08 | 2022-08-08 | Bristol Myers Squibb Co | Formulaciones de conjugados del factor de crecimiento de fibroblastos 21 (fgf-21). |
WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
JP2023538533A (ja) | 2020-08-07 | 2023-09-08 | ブリストル-マイヤーズ スクイブ カンパニー | 線維症の処置のための、ccr2/5拮抗剤と組み合わせたfgf21 |
US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
CN113633756A (zh) * | 2021-06-17 | 2021-11-12 | 温州医科大学 | Fgf21温敏缓释载体和基因修饰方法以及其制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301583D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Yeast strain and methods for expressing heterologous proteins in yeast |
JP4334615B2 (ja) * | 1994-08-12 | 2009-09-30 | ワシントン・ユニバーシティ | 糖タンパク質ホルモンカルテットの一本鎖形態 |
PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
AU7368100A (en) | 1999-09-10 | 2001-04-10 | Curagen Corporation | Fibroblast growth factor polypeptide and nucleic acids encoding same |
US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
DE60043197D1 (sl) * | 1999-11-18 | 2009-12-03 | Univ Kyoto | |
WO2001038357A2 (en) | 1999-11-22 | 2001-05-31 | Millennium Pharmaceuticals, Inc. | Jaffa, a novel fibroblast growth factor family member and uses therefor |
AU2002322394A1 (en) * | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
JP2005519891A (ja) | 2002-01-15 | 2005-07-07 | イーライ・リリー・アンド・カンパニー | 危篤状態の患者における罹病率および死亡率を低下させる方法 |
BRPI0416683A (pt) * | 2003-12-10 | 2007-01-30 | Lilly Co Eli | muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21 |
ATE444306T1 (de) * | 2004-05-13 | 2009-10-15 | Lilly Co Eli | Fgf-21-fusionsproteine |
-
2005
- 2005-07-26 JP JP2007529870A patent/JP4809352B2/ja not_active Expired - Fee Related
- 2005-07-26 DE DE602005016946T patent/DE602005016946D1/de active Active
- 2005-07-26 PT PT05775749T patent/PT1789442E/pt unknown
- 2005-07-26 US US11/574,332 patent/US7582607B2/en not_active Expired - Fee Related
- 2005-07-26 ES ES05775749T patent/ES2332057T3/es active Active
- 2005-07-26 CN CN2005800294803A patent/CN101010338B/zh not_active Expired - Fee Related
- 2005-07-26 KR KR1020077004881A patent/KR100854198B1/ko not_active IP Right Cessation
- 2005-07-26 MX MX2007002616A patent/MX2007002616A/es active IP Right Grant
- 2005-07-26 DK DK05775749T patent/DK1789442T3/da active
- 2005-07-26 EP EP05775749A patent/EP1789442B1/en active Active
- 2005-07-26 EA EA200700533A patent/EA011390B1/ru not_active IP Right Cessation
- 2005-07-26 PL PL05775749T patent/PL1789442T3/pl unknown
- 2005-07-26 EP EP08162741A patent/EP2161281A1/en not_active Withdrawn
- 2005-07-26 AT AT05775749T patent/ATE444307T1/de active
- 2005-07-26 SI SI200530852T patent/SI1789442T1/sl unknown
- 2005-07-26 WO PCT/US2005/026398 patent/WO2006028595A2/en active Application Filing
- 2005-07-26 AU AU2005283025A patent/AU2005283025B2/en not_active Ceased
- 2005-07-26 CA CA002575753A patent/CA2575753A1/en not_active Abandoned
- 2005-07-26 BR BRPI0514790-5A patent/BRPI0514790A/pt not_active IP Right Cessation
-
2007
- 2007-02-26 IL IL181573A patent/IL181573A0/en unknown
- 2007-03-12 NO NO20071327A patent/NO20071327L/no not_active Application Discontinuation
-
2009
- 2009-11-06 HR HR20090597T patent/HRP20090597T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007002616A (es) | 2007-05-16 |
PT1789442E (pt) | 2009-11-11 |
KR100854198B1 (ko) | 2008-08-26 |
AU2005283025A1 (en) | 2006-03-16 |
AU2005283025B2 (en) | 2011-06-30 |
EA011390B1 (ru) | 2009-02-27 |
EP1789442A2 (en) | 2007-05-30 |
ATE444307T1 (de) | 2009-10-15 |
NO20071327L (no) | 2007-05-29 |
BRPI0514790A (pt) | 2008-06-24 |
JP4809352B2 (ja) | 2011-11-09 |
EP1789442B1 (en) | 2009-09-30 |
DE602005016946D1 (de) | 2009-11-12 |
WO2006028595A2 (en) | 2006-03-16 |
KR20070050454A (ko) | 2007-05-15 |
CN101010338B (zh) | 2011-06-15 |
EA200700533A1 (ru) | 2007-08-31 |
WO2006028595A3 (en) | 2007-01-18 |
DK1789442T3 (da) | 2009-11-16 |
PL1789442T3 (pl) | 2010-02-26 |
JP2008511323A (ja) | 2008-04-17 |
EP2161281A1 (en) | 2010-03-10 |
IL181573A0 (en) | 2007-07-04 |
ES2332057T3 (es) | 2010-01-25 |
HRP20090597T1 (hr) | 2009-12-31 |
US20080103096A1 (en) | 2008-05-01 |
CN101010338A (zh) | 2007-08-01 |
CA2575753A1 (en) | 2006-03-16 |
US7582607B2 (en) | 2009-09-01 |
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