NO20071327L - Fibroblast vekstfaktor-21 muteiner - Google Patents

Fibroblast vekstfaktor-21 muteiner

Info

Publication number
NO20071327L
NO20071327L NO20071327A NO20071327A NO20071327L NO 20071327 L NO20071327 L NO 20071327L NO 20071327 A NO20071327 A NO 20071327A NO 20071327 A NO20071327 A NO 20071327A NO 20071327 L NO20071327 L NO 20071327L
Authority
NO
Norway
Prior art keywords
muteins
growth factor
fibroblast growth
nucleic acid
indicated
Prior art date
Application number
NO20071327A
Other languages
English (en)
Inventor
Radmila Micanovic
Christopher Carl Frye
Lihua Huang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20071327L publication Critical patent/NO20071327L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Den foreliggende oppfinnelsen er relatert til nye muteiner av human fibroblast vekstfaktor 21 med redusert kapasitet for O-glykosylering når uttrykt i gjær sammenliknet med villtype human FGF-21. Både protein og de respektive kodende nukleinsyreartene er angitt. Oppfinnelsen omslutter også vektorer og vertsceller for propageringen av nevnte nukleinsyresekvenser og produksjonen av nevnte muteiner. Også angitt er fremgangsmåter for å behandle type 2 diabetes, fedme eller metabolsk syndrom.
NO20071327A 2004-09-02 2007-03-12 Fibroblast vekstfaktor-21 muteiner NO20071327L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60680504P 2004-09-02 2004-09-02
PCT/US2005/026398 WO2006028595A2 (en) 2004-09-02 2005-07-26 Muteins of fibroblast growth factor 21

Publications (1)

Publication Number Publication Date
NO20071327L true NO20071327L (no) 2007-05-29

Family

ID=36036790

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071327A NO20071327L (no) 2004-09-02 2007-03-12 Fibroblast vekstfaktor-21 muteiner

Country Status (21)

Country Link
US (1) US7582607B2 (no)
EP (2) EP2161281A1 (no)
JP (1) JP4809352B2 (no)
KR (1) KR100854198B1 (no)
CN (1) CN101010338B (no)
AT (1) ATE444307T1 (no)
AU (1) AU2005283025B2 (no)
BR (1) BRPI0514790A (no)
CA (1) CA2575753A1 (no)
DE (1) DE602005016946D1 (no)
DK (1) DK1789442T3 (no)
EA (1) EA011390B1 (no)
ES (1) ES2332057T3 (no)
HR (1) HRP20090597T1 (no)
IL (1) IL181573A0 (no)
MX (1) MX2007002616A (no)
NO (1) NO20071327L (no)
PL (1) PL1789442T3 (no)
PT (1) PT1789442E (no)
SI (1) SI1789442T1 (no)
WO (1) WO2006028595A2 (no)

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Also Published As

Publication number Publication date
WO2006028595A2 (en) 2006-03-16
EA200700533A1 (ru) 2007-08-31
EP1789442A2 (en) 2007-05-30
WO2006028595A3 (en) 2007-01-18
JP2008511323A (ja) 2008-04-17
DE602005016946D1 (de) 2009-11-12
CA2575753A1 (en) 2006-03-16
CN101010338A (zh) 2007-08-01
EP1789442B1 (en) 2009-09-30
BRPI0514790A (pt) 2008-06-24
IL181573A0 (en) 2007-07-04
CN101010338B (zh) 2011-06-15
ATE444307T1 (de) 2009-10-15
US7582607B2 (en) 2009-09-01
AU2005283025A1 (en) 2006-03-16
SI1789442T1 (sl) 2010-01-29
HRP20090597T1 (hr) 2009-12-31
MX2007002616A (es) 2007-05-16
PT1789442E (pt) 2009-11-11
DK1789442T3 (da) 2009-11-16
AU2005283025B2 (en) 2011-06-30
ES2332057T3 (es) 2010-01-25
EA011390B1 (ru) 2009-02-27
KR20070050454A (ko) 2007-05-15
KR100854198B1 (ko) 2008-08-26
EP2161281A1 (en) 2010-03-10
US20080103096A1 (en) 2008-05-01
JP4809352B2 (ja) 2011-11-09
PL1789442T3 (pl) 2010-02-26

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