WO2005092921A3 - Placental growth factor splice variants and their uses - Google Patents

Placental growth factor splice variants and their uses Download PDF

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Publication number
WO2005092921A3
WO2005092921A3 PCT/US2005/008450 US2005008450W WO2005092921A3 WO 2005092921 A3 WO2005092921 A3 WO 2005092921A3 US 2005008450 W US2005008450 W US 2005008450W WO 2005092921 A3 WO2005092921 A3 WO 2005092921A3
Authority
WO
WIPO (PCT)
Prior art keywords
splice variants
growth factor
placental growth
factor splice
relates
Prior art date
Application number
PCT/US2005/008450
Other languages
French (fr)
Other versions
WO2005092921A2 (en
Inventor
Jeffrey Keith Cecil
Jai Pal Singh
Original Assignee
Lilly Co Eli
Jeffrey Keith Cecil
Jai Pal Singh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Jeffrey Keith Cecil, Jai Pal Singh filed Critical Lilly Co Eli
Publication of WO2005092921A2 publication Critical patent/WO2005092921A2/en
Publication of WO2005092921A3 publication Critical patent/WO2005092921A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to nucleic acid and amino acid sequences of human PlGF splice variants and to the use of these sequences in the diagnosis, prevention and treatment of PlGF receptor-mediated disorders. The present invention also relates to vectors, host cells, and antibodies directed to these polypeptides.
PCT/US2005/008450 2004-03-22 2005-03-15 Placental growth factor splice variants and their uses WO2005092921A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55527204P 2004-03-22 2004-03-22
US60/555,272 2004-03-22

Publications (2)

Publication Number Publication Date
WO2005092921A2 WO2005092921A2 (en) 2005-10-06
WO2005092921A3 true WO2005092921A3 (en) 2005-12-08

Family

ID=34964654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/008450 WO2005092921A2 (en) 2004-03-22 2005-03-15 Placental growth factor splice variants and their uses

Country Status (1)

Country Link
WO (1) WO2005092921A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741287B2 (en) * 2008-06-18 2014-06-03 Abbott Laboratories PlGF-1 assay and kits and components thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018212A2 (en) * 1998-09-30 2000-04-06 Ludwig Institute For Cancer Research Platelet-derived growth factor c, dna coding therefor, and uses thereof
WO2003062788A2 (en) * 2002-01-17 2003-07-31 Genetix Pharamaceuticals, Inc. Method for inhibiting angiogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018212A2 (en) * 1998-09-30 2000-04-06 Ludwig Institute For Cancer Research Platelet-derived growth factor c, dna coding therefor, and uses thereof
WO2003062788A2 (en) * 2002-01-17 2003-07-31 Genetix Pharamaceuticals, Inc. Method for inhibiting angiogenesis

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CAO Y ET AL: "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 27 JUN 1997, vol. 235, no. 3, 27 June 1997 (1997-06-27), pages 493 - 498, XP002340930, ISSN: 0006-291X *
DATABASE EMBL-SVA [online] 10 October 2003 (2003-10-10), XP002340965, retrieved from EBI Database accession no. BC007255.1 *
DATABASE UniProt 1 October 1996 (1996-10-01), XP002340966, retrieved from EBI Database accession no. P49763 *
HAUSER S ET AL: "A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta.", GROWTH FACTORS (CHUR, SWITZERLAND) 1993, vol. 9, no. 4, 1993, pages 259 - 268, XP009052438, ISSN: 0897-7194 *
MAGLIONE D ET AL: "Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, October 1991 (1991-10-01), pages 9267 - 9271, XP002080555, ISSN: 0027-8424 *
MAGLIONE D ET AL: "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 8, no. 4, April 1993 (1993-04-01), pages 925 - 931, XP002080556, ISSN: 0950-9232 *
SAWANO A ET AL: "FLT-1 BUT NOT KDR/FLK-1 TYROSINE KINASE IS A RECEPTOR FOR PLACENTA GROWTH FACTOR, WHICH IS RELATED TO VASCULAR ENDOTHELIAL GROWTH FACTOR", CELL GROWTH AND DIFFERENTIATION, THE ASSOCIATION, PHILADELPHIA, PA, US, vol. 7, no. 2, February 1996 (1996-02-01), pages 213 - 221, XP001012716, ISSN: 1044-9523 *

Also Published As

Publication number Publication date
WO2005092921A2 (en) 2005-10-06

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