SI1051398T1 - Thermodynamically stable form of (r)-3-(((4-fluorophenyl) sulphonyl)amino) -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban) - Google Patents

Thermodynamically stable form of (r)-3-(((4-fluorophenyl) sulphonyl)amino) -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Info

Publication number
SI1051398T1
SI1051398T1 SI9830656T SI9830656T SI1051398T1 SI 1051398 T1 SI1051398 T1 SI 1051398T1 SI 9830656 T SI9830656 T SI 9830656T SI 9830656 T SI9830656 T SI 9830656T SI 1051398 T1 SI1051398 T1 SI 1051398T1
Authority
SI
Slovenia
Prior art keywords
ramatroban
sulphonyl
carbazole
fluorophenyl
tetrahydro
Prior art date
Application number
SI9830656T
Other languages
English (en)
Slovenian (sl)
Inventor
Alfons Grunenberg
Karl-Heinz Wahl
Klaus-Peter Voges
Original Assignee
Bayer Yakuhin Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd. filed Critical Bayer Yakuhin Ltd.
Publication of SI1051398T1 publication Critical patent/SI1051398T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SI9830656T 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-(((4-fluorophenyl) sulphonyl)amino) -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban) SI1051398T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (de) 1997-12-24 1997-12-24 Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
PCT/JP1998/005844 WO1999033803A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)
EP98961506A EP1051398B1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3- (4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Publications (1)

Publication Number Publication Date
SI1051398T1 true SI1051398T1 (en) 2004-08-31

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830656T SI1051398T1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-(((4-fluorophenyl) sulphonyl)amino) -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Country Status (37)

Country Link
US (1) US6362214B1 (ru)
EP (1) EP1051398B1 (ru)
JP (2) JP3817668B2 (ru)
KR (1) KR100586350B1 (ru)
CN (1) CN1140510C (ru)
AR (1) AR013803A1 (ru)
AT (1) ATE263152T1 (ru)
AU (1) AU744242B2 (ru)
BG (1) BG65024B1 (ru)
BR (1) BR9814496A (ru)
CA (1) CA2313230A1 (ru)
CO (1) CO4970800A1 (ru)
DE (2) DE19757983A1 (ru)
DK (1) DK1051398T3 (ru)
ES (1) ES2218874T3 (ru)
GT (1) GT199800198A (ru)
HK (1) HK1034517A1 (ru)
HN (1) HN1998000186A (ru)
HU (1) HUP0004432A3 (ru)
ID (1) ID25446A (ru)
IL (1) IL136278A (ru)
IN (1) IN192932B (ru)
MY (1) MY116312A (ru)
NO (1) NO316618B1 (ru)
NZ (1) NZ504741A (ru)
PE (1) PE20000115A1 (ru)
PL (1) PL341359A1 (ru)
PT (1) PT1051398E (ru)
RU (1) RU2220137C2 (ru)
SI (1) SI1051398T1 (ru)
SK (1) SK285109B6 (ru)
TR (1) TR200001936T2 (ru)
TW (1) TW552258B (ru)
UA (1) UA66832C2 (ru)
UY (2) UY25324A1 (ru)
WO (1) WO1999033803A1 (ru)
ZA (1) ZA9811817B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007336077A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2008087371A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CN103054857A (zh) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 一种以雷马曲班为活性成分的固体制剂
EP4420734A2 (en) 2015-02-13 2024-08-28 Institut National de la Santé et de la Recherche Médicale Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631824A1 (de) 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
CN1015711B (zh) 1986-02-21 1992-03-04 拜尔公司 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法
DE19506739A1 (de) * 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester

Also Published As

Publication number Publication date
KR20010033529A (ko) 2001-04-25
US6362214B1 (en) 2002-03-26
JP2001527067A (ja) 2001-12-25
BG65024B1 (bg) 2006-12-29
GT199800198A (es) 1998-12-15
SK9752000A3 (en) 2001-02-12
AU1687499A (en) 1999-07-19
KR100586350B1 (ko) 2006-06-07
SK285109B6 (sk) 2006-06-01
BR9814496A (pt) 2000-10-10
PL341359A1 (en) 2001-04-09
CA2313230A1 (en) 1999-07-08
IL136278A (en) 2005-03-20
UY25324A1 (es) 2000-12-29
AR013803A1 (es) 2001-01-10
NO20003217D0 (no) 2000-06-21
UA66832C2 (ru) 2004-06-15
ZA9811817B (en) 1999-06-29
BG104554A (en) 2001-05-31
HUP0004432A3 (en) 2002-10-28
WO1999033803A1 (en) 1999-07-08
ID25446A (id) 2000-10-05
DE69822882D1 (en) 2004-05-06
EP1051398A1 (en) 2000-11-15
DE69822882T2 (de) 2005-02-03
HK1034517A1 (en) 2001-10-26
EP1051398B1 (en) 2004-03-31
TR200001936T2 (tr) 2001-01-22
NO20003217L (no) 2000-06-21
CN1140510C (zh) 2004-03-03
AU744242B2 (en) 2002-02-21
IL136278A0 (en) 2001-05-20
JP3817668B2 (ja) 2006-09-06
RU2220137C2 (ru) 2003-12-27
PE20000115A1 (es) 2000-03-26
DK1051398T3 (da) 2004-07-19
DE19757983A1 (de) 1999-07-01
HN1998000186A (es) 1999-11-03
MY116312A (en) 2003-12-31
TW552258B (en) 2003-09-11
JP4411269B2 (ja) 2010-02-10
NZ504741A (en) 2002-10-25
CO4970800A1 (es) 2000-11-07
PT1051398E (pt) 2004-07-30
JP2006151977A (ja) 2006-06-15
UY25575A1 (es) 1999-11-17
CN1282320A (zh) 2001-01-31
HUP0004432A2 (hu) 2001-06-28
ES2218874T3 (es) 2004-11-16
NO316618B1 (no) 2004-03-08
IN192932B (ru) 2004-06-12
ATE263152T1 (de) 2004-04-15

Similar Documents

Publication Publication Date Title
ZA976326B (en) Analogs of cationic proteins.
EP1028709A4 (en) NEW "ONCE A DAY" SULFONYL URINE FORMULATION WITH CONTROLLED RELEASE
PT946100E (pt) Composicoes herbicidas contendo n-¬(4,6-dimetoxipirimidin-2-il)aminocarbonil|-5-metilsulfonamidometil-2-alcoxicarbonilbenzenossulfonamidas
IT1283232B1 (it) Procedimento per la sintesi di 2-buten-1, 4-diesteri
HK1074201A1 (en) Substituted aryl sulphonyl (thio) ureas used as herbicides
ITBO970640A0 (it) Apparecchio per l'elettroemanazione di principi attivi.
DE69823394D1 (de) Verfahren zur Herstellung von 1-(9'H-Carbazol-4'-yloxy)-3-(2''-(2'''-methoxy-phenoxy)-ethylamino)-propan-2-ol ( Carvediol)
HK1032785A1 (en) Novel 3,6-hemiketals from the class of 9a-azalides
SI1051398T1 (en) Thermodynamically stable form of (r)-3-(((4-fluorophenyl) sulphonyl)amino) -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)
AU2092897A (en) Substituted aryl sulphonyl amino(thio)carbonyl-triazolin(thi)ones as herbicides
IT1274571B (it) Procedimento per la preparazione di ¬r-(r*,r*)|-5-(3-clorofenil)-3- ¬2-(3,4-dimetossifenil)-1-metil-etil|-ossazolidin-2-one
EG24052A (en) Novel processes for the preparation of (r)-a (2,3-demethoxyphenyl-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethapnol
IL132623A0 (en) Process for making 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates
AU8985298A (en) Novel sulphonamide derived from substituted anilines useful as medicines
EP1146040A3 (en) Method of crystallizing 2-azabicyclo(2.2.1)hept-5-en-3-one
DE69828906D1 (de) Herstellung von 1,3 propandiolestern
AU5627790A (en) Preparation of N-(3(((2,6-dihalophenyl)amino)sulfonyl)-1H-1, 2,4--triazol-5-yl)amines
HUP9800277A3 (en) N-(1,2,3,4-tetrahydro-naphthyl- and -quinolyl)sulfonamide derivatives, their use for preparation of pharmaceutical compositions and pharmaceutical compositions containing them
AU1505999A (en) Immunosuppressant agonists
HUP9801761A2 (hu) (R)-5-(metil-amino-szulfonil-metil)-3-(N-metil-pirrolidin-2-il-metil)-1H-indol fumarátsója, előállítása, alkalmazása, valamint a vegyületet tartalmazó gyógyászati készítmény
PL330141A1 (en) Novel derivatives of 10,11-dihydro-10-oxo-5h-dibezyl(b,f)-azepin-5-carboxagmide
EP1052982A4 (en) AMINOTETRALINS AS AGONISTS OF 5-HT 1D $ g (a)?
AU6958898A (en) Preparation of heterocycles using 1,3-dihalopropenes
ITMI950540A0 (it) Procedimento per la preparazione di 4 (nitrofenil) diidropiridine
ITRC970004A0 (it) "impasto per manufatti termoelastici impermeabili" denominato "elastoterm base"