SI0963980T1 - 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine" - Google Patents

1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine"

Info

Publication number
SI0963980T1
SI0963980T1 SI9930088T SI9930088T SI0963980T1 SI 0963980 T1 SI0963980 T1 SI 0963980T1 SI 9930088 T SI9930088 T SI 9930088T SI 9930088 T SI9930088 T SI 9930088T SI 0963980 T1 SI0963980 T1 SI 0963980T1
Authority
SI
Slovenia
Prior art keywords
lamotrigine
stability
preparation
reference marker
triazine derivative
Prior art date
Application number
SI9930088T
Other languages
English (en)
Slovenian (sl)
Inventor
Lorraine Mary Edmeades
Nigel Arthur Griffith-Skinner
Derek Anthony Hill
Graham Thornton Hill
Terrence William Packham
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10833464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0963980(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of SI0963980T1 publication Critical patent/SI0963980T1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
SI9930088T 1998-06-10 1999-03-10 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine" SI0963980T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9812413.4A GB9812413D0 (en) 1998-06-10 1998-06-10 Compound and its use
EP99200695A EP0963980B1 (fr) 1998-06-10 1999-03-10 Dérivé de 1,2,4-triazine, la preparation et l'utilisation comme marqueur de référence pour verifié la pureté et la stabilité de "lamotrigine"

Publications (1)

Publication Number Publication Date
SI0963980T1 true SI0963980T1 (en) 2002-12-31

Family

ID=10833464

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930088T SI0963980T1 (en) 1998-06-10 1999-03-10 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine"

Country Status (31)

Country Link
US (1) US6333198B1 (fr)
EP (2) EP1170588A1 (fr)
JP (1) JP2989189B1 (fr)
KR (1) KR100322354B1 (fr)
CN (2) CN1238454A (fr)
AP (3) AP9901481A0 (fr)
AR (1) AR014074A1 (fr)
AT (1) ATE218552T1 (fr)
AU (1) AU2031999A (fr)
BR (1) BR9900984A (fr)
CA (1) CA2265194C (fr)
DE (1) DE69901656T2 (fr)
DK (1) DK0963980T3 (fr)
EA (1) EA000666B1 (fr)
ES (1) ES2178342T3 (fr)
GB (1) GB9812413D0 (fr)
HR (1) HRP990074A2 (fr)
HU (1) HUP9900592A3 (fr)
ID (1) ID22957A (fr)
MA (1) MA24777A1 (fr)
NO (2) NO991151L (fr)
NZ (1) NZ334590A (fr)
PE (1) PE20000332A1 (fr)
PL (1) PL331870A1 (fr)
PT (1) PT963980E (fr)
SG (1) SG85628A1 (fr)
SI (1) SI0963980T1 (fr)
TR (1) TR199900520A3 (fr)
UY (1) UY25946A1 (fr)
YU (1) YU12399A (fr)
ZA (1) ZA991951B (fr)

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CN102766104A (zh) * 2012-08-20 2012-11-07 三金集团湖南三金制药有限责任公司 一种治疗双向情感障碍及癫痫病药物拉莫三嗪的合成方法
US10189859B2 (en) 2013-12-21 2019-01-29 Nektar Therapeutics Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
CN110467560A (zh) 2018-05-09 2019-11-19 深圳微芯生物科技股份有限公司 一种苯基氨基丙酸钠衍生物、其制备方法和应用
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN113156009B (zh) * 2021-04-20 2023-12-22 三金集团湖南三金制药有限责任公司 高效液相色谱分析拉莫三嗪的方法

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Publication number Priority date Publication date Assignee Title
HU182086B (en) 1979-06-01 1983-12-28 Wellcome Found Process for preparing new 1,2,4-triazine derivatives
JPS5625170A (en) 1979-06-01 1981-03-10 Wellcome Found Triazine derivative
GB8613183D0 (en) 1986-05-30 1986-07-02 Wellcome Found Triazine salt
PT800520E (pt) * 1994-12-30 2002-11-29 Wellcome Found Processo para a preparacao de lamotrigina
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation

Also Published As

Publication number Publication date
KR20000005611A (ko) 2000-01-25
TR199900520A2 (en) 2000-01-21
PT963980E (pt) 2002-10-31
NO20032753L (no) 1999-12-13
SG85628A1 (en) 2002-01-15
EP0963980A3 (fr) 2000-05-31
HUP9900592A2 (hu) 2000-04-28
AP0102286A0 (en) 2000-09-10
HU9900592D0 (en) 1999-04-28
AP2001002286A0 (en) 2001-12-31
AP9901481A0 (en) 1999-03-31
TR199900520A3 (tr) 2000-01-21
NO991151D0 (no) 1999-03-10
JP2989189B1 (ja) 1999-12-13
HUP9900592A3 (en) 2002-04-29
DK0963980T3 (da) 2002-09-16
US6333198B1 (en) 2001-12-25
NO20032753D0 (no) 2003-06-17
CA2265194C (fr) 2000-10-10
YU12399A (sh) 2002-08-12
PE20000332A1 (es) 2000-04-10
CN1306210A (zh) 2001-08-01
MA24777A1 (fr) 1999-10-01
AU2031999A (en) 2000-01-06
NZ334590A (en) 2000-07-28
AR014074A1 (es) 2001-01-31
DE69901656T2 (de) 2003-01-30
EP0963980A2 (fr) 1999-12-15
UY25946A1 (es) 2000-12-29
ES2178342T3 (es) 2002-12-16
ZA991951B (en) 1999-08-16
ATE218552T1 (de) 2002-06-15
GB9812413D0 (en) 1998-08-05
PL331870A1 (en) 1999-12-20
DE69901656D1 (de) 2002-07-11
BR9900984A (pt) 2000-05-02
HRP990074A2 (en) 2000-10-31
CN1238454A (zh) 1999-12-15
EP1170588A1 (fr) 2002-01-09
ID22957A (id) 1999-12-23
EA199900159A1 (ru) 1999-12-29
JP2000009714A (ja) 2000-01-14
EA000666B1 (ru) 2000-02-28
KR100322354B1 (ko) 2002-02-07
NO991151L (no) 1999-12-13
EP0963980B1 (fr) 2002-06-05

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