SG88782A1 - Steroid sulphatase inhibitors - Google Patents

Steroid sulphatase inhibitors

Info

Publication number
SG88782A1
SG88782A1 SG200003815A SG381592A SG88782A1 SG 88782 A1 SG88782 A1 SG 88782A1 SG 200003815 A SG200003815 A SG 200003815A SG 381592 A SG381592 A SG 381592A SG 88782 A1 SG88782 A1 SG 88782A1
Authority
SG
Singapore
Prior art keywords
sub
compound
steroid sulphatase
enzyme
sulphate
Prior art date
Application number
SG200003815A
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of SG88782A1 publication Critical patent/SG88782A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG200003815A 1991-08-29 1992-08-28 Steroid sulphatase inhibitors SG88782A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
SG88782A1 true SG88782A1 (en) 2002-05-21

Family

ID=10700604

Family Applications (7)

Application Number Title Priority Date Filing Date
SG200207238A SG115508A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003817A SG88783A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003816A SG103820A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003815A SG88782A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207232A SG106116A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207242A SG103374A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG1996005394A SG73391A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SG200207238A SG115508A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003817A SG88783A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003816A SG103820A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Family Applications After (3)

Application Number Title Priority Date Filing Date
SG200207232A SG106116A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207242A SG103374A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG1996005394A SG73391A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Country Status (26)

Country Link
US (3) US5616574A (sk)
EP (6) EP0982032B1 (sk)
JP (6) JP3219408B2 (sk)
KR (4) KR100258396B1 (sk)
AT (5) ATE278704T1 (sk)
AU (2) AU689043B2 (sk)
BR (1) BR9206434A (sk)
CA (4) CA2305758A1 (sk)
CY (4) CY2253B1 (sk)
CZ (1) CZ295939B6 (sk)
DE (5) DE69233149T2 (sk)
DK (4) DK0921130T3 (sk)
ES (4) ES2193475T3 (sk)
FI (5) FI940903A (sk)
GB (1) GB9118478D0 (sk)
GE (6) GEP20022637B (sk)
GR (1) GR3034579T3 (sk)
HK (3) HK1019753A1 (sk)
HU (1) HUT66097A (sk)
LV (1) LV12618B (sk)
NO (6) NO307301B1 (sk)
RU (4) RU2001125673A (sk)
SG (7) SG115508A1 (sk)
SK (4) SK282189B6 (sk)
UA (4) UA41875C2 (sk)
WO (1) WO1993005064A1 (sk)

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US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6083978A (en) * 1996-03-05 2000-07-04 Sterix Limited Compounds with a sulfamate group
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
WO1995026717A1 (en) * 1994-04-05 1995-10-12 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
DE4447715C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
EP0934949A1 (en) * 1996-09-12 1999-08-11 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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GB2331988B (en) * 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
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WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
AU765386B2 (en) * 1998-06-10 2003-09-18 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
AU783910B2 (en) * 1999-04-30 2005-12-22 Sterix Limited Use of estrone derivatives as antitumour agents
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
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US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
ES2250224T3 (es) * 1999-12-13 2006-04-16 Sterix Limited Compuestos halogenos de sulfamato, fosfonato, tiofosfonato, sulfonato y sulfonamida como inhibidores de sulfatasa esteoride.
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
US6953785B2 (en) * 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
PT1448592E (pt) * 2001-10-18 2006-07-31 Sterix Ltd Compostos esteroides para inibicao da esteroide sulfatase
CA2463227C (en) 2001-10-18 2010-08-10 Sterix Limited Steroidal compounds for inhibiting steroid sulphotase
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CA2525684C (en) * 2003-05-16 2015-01-06 Laboratoire Theramex Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors
ATE464293T1 (de) 2003-05-21 2010-04-15 Aska Pharm Co Ltd Cyclisches aminophenylsulfamatderivativ
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ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
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Citations (1)

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AU5700090A (en) * 1989-06-12 1990-12-13 A.H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals

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GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6083978A (en) * 1996-03-05 2000-07-04 Sterix Limited Compounds with a sulfamate group
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Patent Citations (1)

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AU5700090A (en) * 1989-06-12 1990-12-13 A.H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals

Also Published As

Publication number Publication date
AU668882B2 (en) 1996-05-23
FI20002259A (fi) 2000-10-13
GEP20033094B (en) 2003-10-27
DE69233020T2 (de) 2003-11-06
DK0921130T3 (da) 2003-07-21
SG106116A1 (en) 2004-09-30
EP0641355A1 (en) 1995-03-08
RU2001125673A (ru) 2003-06-27
BR9206434A (pt) 1994-09-27
CY2397B1 (en) 2004-09-10
CZ295939B6 (cs) 2005-12-14
ATE246706T1 (de) 2003-08-15
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
GEP20063773B (en) 2006-03-27
SK282187B6 (sk) 2001-12-03
CA2114630C (en) 2003-09-30
GEP20022803B (en) 2002-09-25
JP2003176297A (ja) 2003-06-24
EP1099706B1 (en) 2004-10-06
GEP20022802B (en) 2002-09-25
EP0982032B1 (en) 2003-08-06
CY2253B1 (en) 2003-07-04
JP2000038341A (ja) 2000-02-08
AU2490592A (en) 1993-04-05
ES2204059T3 (es) 2004-04-16
EP0641355B1 (en) 2000-07-19
FI20002260A (fi) 2000-10-13
KR100322650B1 (ko) 2002-03-20
GB9118478D0 (en) 1991-10-16
NO308774B1 (no) 2000-10-30
LV12618B (en) 2001-07-20
CA2305758A1 (en) 1993-03-18
JPH07501515A (ja) 1995-02-16
CA2305767A1 (en) 1993-03-18
DE69233020D1 (de) 2003-05-22
EP0921130A3 (en) 2001-09-05
UA41875C2 (uk) 2001-10-15
AU717116B2 (en) 2000-03-16
DE69231280D1 (de) 2000-08-24
NO20025725D0 (no) 2002-11-28
WO1993005064A1 (en) 1993-03-18
FI940903A0 (fi) 1994-02-25
JP2000355542A (ja) 2000-12-26
EP1099706A2 (en) 2001-05-16
SG88783A1 (en) 2002-05-21
CY2398B1 (en) 2004-09-10
FI20050991A (fi) 2005-10-03
ES2196483T3 (es) 2003-12-16
NO20025725L (no) 1994-04-29
US5616574A (en) 1997-04-01
FI20002261A (fi) 2000-10-13
SG103374A1 (en) 2004-04-29
JP3581821B2 (ja) 2004-10-27
LV12618A (en) 2001-02-20
FI940903A (fi) 1994-04-20
SK282186B6 (sk) 2001-12-03
CA2305749A1 (en) 1993-03-18
CZ44094A3 (en) 1995-01-18
NO995076L (no) 1994-04-29
US5830886A (en) 1998-11-03
EP1522543A1 (en) 2005-04-13
DE69231280T2 (de) 2000-11-30
ATE237333T1 (de) 2003-05-15
EP0928609A3 (en) 2001-11-07
RU2207134C2 (ru) 2003-06-27
DK0928609T3 (da) 2003-07-21
RU2210574C2 (ru) 2003-08-20
CA2114630A1 (en) 1993-03-18
DK0982032T3 (da) 2003-11-03
UA70957C2 (uk) 2004-11-15
JP3581820B2 (ja) 2004-10-27
NO995076D0 (no) 1999-10-18
KR100321018B1 (ko) 2002-03-20
HU9400583D0 (en) 1994-05-30
SK24694A3 (en) 1994-11-09
NO940635D0 (no) 1994-02-24
EP0921130A2 (en) 1999-06-09
JP3581802B2 (ja) 2004-10-27
JP2000355598A (ja) 2000-12-26
ES2193475T3 (es) 2003-11-01
JP3219408B2 (ja) 2001-10-15
DE69233053T2 (de) 2003-11-20
ATE194843T1 (de) 2000-08-15
HK1020672A1 (en) 2000-05-19
EP0921130B1 (en) 2003-05-07
EP0982032A2 (en) 2000-03-01
DE69233053D1 (de) 2003-06-12
SG73391A1 (en) 2006-08-30
ES2148178T3 (es) 2000-10-16
KR100258396B1 (ko) 2000-08-01
UA70956C2 (uk) 2004-11-15
RU2182152C2 (ru) 2002-05-10
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
NO20044458L (no) 1994-04-29
SG103820A1 (en) 2004-05-26
AU5837396A (en) 1996-09-05
JP2002255993A (ja) 2002-09-11
US6159960A (en) 2000-12-12
GR3034579T3 (en) 2001-01-31
DE69233431T2 (de) 2006-02-23
NO308903B1 (no) 2000-11-13
ATE278704T1 (de) 2004-10-15
CY2394B1 (en) 2004-09-10
GEP20022637B (en) 2002-02-25
NO940635L (sk) 1994-04-29
ATE239753T1 (de) 2003-05-15
HK1019753A1 (en) 2000-02-25
NO318009B1 (no) 2005-01-17
NO995075L (no) 1994-04-29
NO307301B1 (no) 2000-03-13
HUT66097A (en) 1994-09-28
KR100321019B1 (ko) 2002-03-20
EP0982032A3 (en) 2002-03-20
NO995075D0 (no) 1999-10-18
SK282188B6 (sk) 2001-12-03
AU689043B2 (en) 1998-03-19
NO2595A (no) 1994-04-29
EP0928609A2 (en) 1999-07-14
NO314287B1 (no) 2003-03-03
AU1007799A (en) 1999-03-04
HK1025051A1 (en) 2000-11-03
SG115508A1 (en) 2005-10-28
GEP20022766B (en) 2002-08-26
EP1099706A3 (en) 2002-09-04
NO20002595D0 (no) 2000-05-19
SK282189B6 (sk) 2001-12-03
DE69233149T2 (de) 2004-06-24

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