SG115508A1 - Steroid sulphatase inhibitors - Google Patents

Steroid sulphatase inhibitors

Info

Publication number
SG115508A1
SG115508A1 SG200207238A SG200207238A SG115508A1 SG 115508 A1 SG115508 A1 SG 115508A1 SG 200207238 A SG200207238 A SG 200207238A SG 200207238 A SG200207238 A SG 200207238A SG 115508 A1 SG115508 A1 SG 115508A1
Authority
SG
Singapore
Prior art keywords
sub
compound
steroid sulphatase
enzyme
sulphate
Prior art date
Application number
SG200207238A
Other languages
English (en)
Inventor
John Reed Michael
Victor Lloyd Potter Barry
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of SG115508A1 publication Critical patent/SG115508A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG200207238A 1991-08-29 1992-08-28 Steroid sulphatase inhibitors SG115508A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
SG115508A1 true SG115508A1 (en) 2005-10-28

Family

ID=10700604

Family Applications (7)

Application Number Title Priority Date Filing Date
SG200003815A SG88782A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207232A SG106116A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003816A SG103820A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003817A SG88783A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG1996005394A SG73391A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207238A SG115508A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207242A SG103374A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Family Applications Before (5)

Application Number Title Priority Date Filing Date
SG200003815A SG88782A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200207232A SG106116A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003816A SG103820A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG200003817A SG88783A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors
SG1996005394A SG73391A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG200207242A SG103374A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Country Status (26)

Country Link
US (3) US5616574A (sk)
EP (6) EP1099706B1 (sk)
JP (6) JP3219408B2 (sk)
KR (4) KR100258396B1 (sk)
AT (5) ATE278704T1 (sk)
AU (2) AU689043B2 (sk)
BR (1) BR9206434A (sk)
CA (4) CA2305767A1 (sk)
CY (4) CY2253B1 (sk)
CZ (1) CZ295939B6 (sk)
DE (5) DE69233020T2 (sk)
DK (4) DK0982032T3 (sk)
ES (4) ES2148178T3 (sk)
FI (5) FI940903A (sk)
GB (1) GB9118478D0 (sk)
GE (6) GEP20022637B (sk)
GR (1) GR3034579T3 (sk)
HK (3) HK1019753A1 (sk)
HU (1) HUT66097A (sk)
LV (1) LV12618B (sk)
NO (6) NO307301B1 (sk)
RU (4) RU2001125673A (sk)
SG (7) SG88782A1 (sk)
SK (4) SK282188B6 (sk)
UA (4) UA41875C2 (sk)
WO (1) WO1993005064A1 (sk)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
EP0758230B1 (en) * 1994-04-05 2003-06-11 Celltech Therapeutics Limited Use of steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4429398C2 (de) * 1994-08-09 1997-09-11 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
EP0885211B1 (en) * 1996-03-05 2004-12-29 Sterix Limited Compounds with a sulfamate group
CA2266051A1 (en) * 1996-09-12 1998-03-19 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331988B (en) * 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
CA2334119C (en) 1998-06-10 2011-09-13 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
WO2000066095A2 (en) * 1999-04-30 2000-11-09 Sterix Limited Use of estrone derivatives as antitumour agents
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
DE60023740T2 (de) * 1999-12-13 2006-07-27 Sterix Ltd. Halogenierte sulphamat-, phoshonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
US7335650B2 (en) * 2000-01-14 2008-02-26 Sterix Limited Composition
EP1284272A4 (en) * 2000-04-24 2003-09-10 Kyowa Hakko Kogyo Kk Estra-1,3,5 (10) -triene
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
JP2004521951A (ja) * 2001-07-13 2004-07-22 シエーリング アクチエンゲゼルシャフト Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
ES2258174T3 (es) 2001-10-18 2006-08-16 Sterix Limited Compuestos esteroideos para la inhibicion de la sulfatasa esteroidea.
ATE319734T1 (de) * 2001-10-18 2006-03-15 Sterix Ltd Steroidale verbindungen zur inhibierung von steroidsulfatasen
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
AU2003272964A1 (en) * 2002-10-09 2004-05-04 Kyowa Hakko Kogyo Co., Ltd. Remedy for hormone-dependent cancer
DE10307104A1 (de) 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
ES2329241T3 (es) * 2003-05-16 2009-11-24 Laboratoire Theramex Derivados de sufamato de benzotiofeno como inhibidores de sulfatasa esteroidea.
DE602004026571D1 (en) 2003-05-21 2010-05-27 Aska Pharm Co Ltd Cyclisches aminophenylsulfamatderivativ
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
JP5543920B2 (ja) 2007-09-17 2014-07-09 プレグレム エスアー 閉経前の女性におけるエストロゲン依存症状の治療
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE114806C (sk) *
DE1593846A1 (de) * 1967-01-28 1971-02-25 Hoechst Ag Verfahren zur Herstellung von Sulfamidsaeure-arylestern
US3647738A (en) * 1970-11-03 1972-03-07 Union Carbide Corp Alpha-olefin polymer compositions
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE2418217A1 (de) * 1974-04-13 1975-11-06 Hoechst Ag Sulfamidsaeureester und verfahren zu ihrer herstellung
DD114806A1 (sk) * 1974-10-11 1975-08-20
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
PT94305B (pt) * 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
EP0885211B1 (en) * 1996-03-05 2004-12-29 Sterix Limited Compounds with a sulfamate group
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
AU1007799A (en) 1999-03-04
SK24694A3 (en) 1994-11-09
UA70957C2 (uk) 2004-11-15
DE69233149T2 (de) 2004-06-24
GR3034579T3 (en) 2001-01-31
US5616574A (en) 1997-04-01
AU717116B2 (en) 2000-03-16
EP0982032A2 (en) 2000-03-01
CA2305749A1 (en) 1993-03-18
NO20025725D0 (no) 2002-11-28
ES2193475T3 (es) 2003-11-01
JP3581820B2 (ja) 2004-10-27
ES2196483T3 (es) 2003-12-16
RU2182152C2 (ru) 2002-05-10
NO940635D0 (no) 1994-02-24
NO995075D0 (no) 1999-10-18
ATE246706T1 (de) 2003-08-15
NO20044458L (no) 1994-04-29
GB9118478D0 (en) 1991-10-16
HK1020672A1 (en) 2000-05-19
EP0982032B1 (en) 2003-08-06
GEP20022803B (en) 2002-09-25
US5830886A (en) 1998-11-03
SK282189B6 (sk) 2001-12-03
JP2000355598A (ja) 2000-12-26
KR100321019B1 (ko) 2002-03-20
EP0921130A2 (en) 1999-06-09
EP0982032A3 (en) 2002-03-20
EP0928609A2 (en) 1999-07-14
NO20025725L (no) 1994-04-29
SK282186B6 (sk) 2001-12-03
NO995075L (no) 1994-04-29
FI20050991A (fi) 2005-10-03
EP1099706B1 (en) 2004-10-06
SG88783A1 (en) 2002-05-21
NO20002595D0 (no) 2000-05-19
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
RU2001125673A (ru) 2003-06-27
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
CA2114630A1 (en) 1993-03-18
FI20002259A (fi) 2000-10-13
JP2002255993A (ja) 2002-09-11
NO308903B1 (no) 2000-11-13
JPH07501515A (ja) 1995-02-16
GEP20022637B (en) 2002-02-25
NO995076D0 (no) 1999-10-18
SK282188B6 (sk) 2001-12-03
CZ295939B6 (cs) 2005-12-14
CA2305767A1 (en) 1993-03-18
DE69233020D1 (de) 2003-05-22
NO995076L (no) 1994-04-29
DE69231280T2 (de) 2000-11-30
SG103820A1 (en) 2004-05-26
HK1025051A1 (en) 2000-11-03
EP0641355B1 (en) 2000-07-19
JP3581802B2 (ja) 2004-10-27
KR100258396B1 (ko) 2000-08-01
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
NO314287B1 (no) 2003-03-03
ES2204059T3 (es) 2004-04-16
CA2305758A1 (en) 1993-03-18
LV12618A (en) 2001-02-20
DK0921130T3 (da) 2003-07-21
UA70956C2 (uk) 2004-11-15
HUT66097A (en) 1994-09-28
GEP20033094B (en) 2003-10-27
EP0921130A3 (en) 2001-09-05
DE69233020T2 (de) 2003-11-06
GEP20022802B (en) 2002-09-25
ATE194843T1 (de) 2000-08-15
BR9206434A (pt) 1994-09-27
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
JP2003176297A (ja) 2003-06-24
EP1099706A2 (en) 2001-05-16
KR100322650B1 (ko) 2002-03-20
NO308774B1 (no) 2000-10-30
ATE237333T1 (de) 2003-05-15
SK282187B6 (sk) 2001-12-03
NO2595A (no) 1994-04-29
DK0928609T3 (da) 2003-07-21
EP1522543A1 (en) 2005-04-13
SG88782A1 (en) 2002-05-21
CZ44094A3 (en) 1995-01-18
JP3581821B2 (ja) 2004-10-27
CY2397B1 (en) 2004-09-10
AU689043B2 (en) 1998-03-19
DE69233053D1 (de) 2003-06-12
JP3219408B2 (ja) 2001-10-15
EP0928609A3 (en) 2001-11-07
NO940635L (sk) 1994-04-29
UA41875C2 (uk) 2001-10-15
RU2207134C2 (ru) 2003-06-27
FI940903A (fi) 1994-04-20
RU2210574C2 (ru) 2003-08-20
CY2398B1 (en) 2004-09-10
LV12618B (en) 2001-07-20
DK0982032T3 (da) 2003-11-03
NO307301B1 (no) 2000-03-13
CY2253B1 (en) 2003-07-04
ATE239753T1 (de) 2003-05-15
SG73391A1 (en) 2006-08-30
DE69233431T2 (de) 2006-02-23
SG106116A1 (en) 2004-09-30
EP1099706A3 (en) 2002-09-04
HK1019753A1 (en) 2000-02-25
EP0641355A1 (en) 1995-03-08
SG103374A1 (en) 2004-04-29
ATE278704T1 (de) 2004-10-15
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