SG170013A1 - Processes for the convergent synthesis of calicheamicin derivatives - Google Patents

Processes for the convergent synthesis of calicheamicin derivatives

Info

Publication number
SG170013A1
SG170013A1 SG201101229-1A SG2011012291A SG170013A1 SG 170013 A1 SG170013 A1 SG 170013A1 SG 2011012291 A SG2011012291 A SG 2011012291A SG 170013 A1 SG170013 A1 SG 170013A1
Authority
SG
Singapore
Prior art keywords
processes
convergent synthesis
calicheamicin derivatives
calicheamicin
derivatives
Prior art date
Application number
SG201101229-1A
Other languages
English (en)
Inventor
Justin Keith Moran
Gu Jianxin
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38437933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG170013(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of SG170013A1 publication Critical patent/SG170013A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG201101229-1A 2006-02-21 2007-02-16 Processes for the convergent synthesis of calicheamicin derivatives SG170013A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77537006P 2006-02-21 2006-02-21

Publications (1)

Publication Number Publication Date
SG170013A1 true SG170013A1 (en) 2011-04-29

Family

ID=38437933

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201101229-1A SG170013A1 (en) 2006-02-21 2007-02-16 Processes for the convergent synthesis of calicheamicin derivatives

Country Status (32)

Country Link
US (6) US20070197455A1 (tr)
EP (2) EP2799441B1 (tr)
JP (4) JP5179383B2 (tr)
KR (1) KR101454489B1 (tr)
CN (1) CN101389639B (tr)
AR (1) AR059592A1 (tr)
AU (1) AU2007217795B2 (tr)
BR (1) BRPI0708149B1 (tr)
CA (1) CA2642194C (tr)
CL (1) CL2009001487A1 (tr)
CR (1) CR10230A (tr)
CY (1) CY1120206T1 (tr)
DK (2) DK1987048T3 (tr)
EC (1) ECSP088691A (tr)
ES (2) ES2527107T3 (tr)
GT (1) GT200800161A (tr)
HK (1) HK1203515A1 (tr)
HU (1) HUE037880T2 (tr)
IL (1) IL193343A (tr)
MX (1) MX2008010768A (tr)
NO (1) NO20083698L (tr)
PE (1) PE20071229A1 (tr)
PL (2) PL1987048T3 (tr)
PT (2) PT2799441T (tr)
RU (1) RU2436790C2 (tr)
SG (1) SG170013A1 (tr)
SI (2) SI2799441T1 (tr)
SV (1) SV2009003002A (tr)
TR (1) TR201808220T4 (tr)
TW (1) TW200806685A (tr)
WO (1) WO2007098124A2 (tr)
ZA (1) ZA200807196B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives
US20120316106A1 (en) 2009-12-29 2012-12-13 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives
HUE041381T2 (hu) 2012-08-16 2019-05-28 Pfizer Glikokonjugációs eljárások és kompozíciók
KR101932824B1 (ko) * 2013-11-04 2018-12-27 화이자 인코포레이티드 칼리케아미신 유도체를 합성하기 위한, 중간체 및 방법
AU2014342610A1 (en) 2013-11-04 2016-06-02 Abbvie Stemcentrx Llc Anti-EFNA4 antibody-drug conjugates
CN106659801B (zh) 2014-04-30 2019-12-10 辉瑞大药厂 抗-ptk7抗体-药物缀合物
US10464442B2 (en) * 2016-10-11 2019-11-05 Honda Motor Co., Ltd. Non-contact power supply system and power transmission apparatus, and designing method and installing method of power transmission apparatus
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
EP3720842A4 (en) * 2017-12-06 2021-11-03 Ontario Institute For Cancer Research ACYLHYDRAZONE LINKERS, METHODS, AND USES THEREOF
US11850287B2 (en) 2017-12-22 2023-12-26 Ontario Institute For Cancer Search (Oicr) Heterocyclic acyl hydrazone linkers, methods and uses thereof
CN111647865B (zh) * 2020-08-06 2020-11-24 北京卓立汉光仪器有限公司 溅射镀膜方法、装置及系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5108912A (en) * 1987-01-30 1992-04-28 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5770701A (en) 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5773001A (en) * 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives

Also Published As

Publication number Publication date
PE20071229A1 (es) 2007-11-30
GT200800161A (es) 2009-01-15
PL1987048T3 (pl) 2015-03-31
US20180016228A1 (en) 2018-01-18
EP1987048A2 (en) 2008-11-05
WO2007098124A3 (en) 2007-12-27
CN101389639A (zh) 2009-03-18
JP2016011316A (ja) 2016-01-21
AU2007217795B2 (en) 2012-09-13
US10343989B2 (en) 2019-07-09
CR10230A (es) 2008-10-03
BRPI0708149B1 (pt) 2022-01-25
KR101454489B1 (ko) 2014-10-27
PT1987048E (pt) 2015-01-14
US20140081010A1 (en) 2014-03-20
KR20080094925A (ko) 2008-10-27
AU2007217795A1 (en) 2007-08-30
JP5179383B2 (ja) 2013-04-10
ES2527107T3 (es) 2015-01-20
CY1120206T1 (el) 2018-12-12
IL193343A (en) 2017-03-30
HUE037880T2 (hu) 2018-09-28
ECSP088691A (es) 2008-09-29
EP2799441B1 (en) 2018-04-18
EP2799441A1 (en) 2014-11-05
JP2009527557A (ja) 2009-07-30
US20090312530A1 (en) 2009-12-17
US20130018179A1 (en) 2013-01-17
RU2436790C2 (ru) 2011-12-20
US20070197455A1 (en) 2007-08-23
RU2008132777A (ru) 2010-03-27
NO20083698L (no) 2008-11-12
CN101389639B (zh) 2012-07-18
JP2013040213A (ja) 2013-02-28
CA2642194A1 (en) 2007-08-30
US8273862B2 (en) 2012-09-25
SI2799441T1 (en) 2018-07-31
CL2009001487A1 (es) 2009-10-16
EP1987048B1 (en) 2014-11-19
TW200806685A (en) 2008-02-01
BRPI0708149A2 (pt) 2011-05-17
CA2642194C (en) 2015-12-08
ES2670709T3 (es) 2018-05-31
DK1987048T3 (en) 2014-12-15
IL193343A0 (en) 2009-08-03
SI1987048T1 (sl) 2015-01-30
TR201808220T4 (tr) 2018-07-23
PL2799441T3 (pl) 2018-08-31
ZA200807196B (en) 2009-05-27
JP2014196352A (ja) 2014-10-16
PT2799441T (pt) 2018-05-29
AR059592A1 (es) 2008-04-16
US8546549B2 (en) 2013-10-01
DK2799441T3 (en) 2018-05-28
WO2007098124A2 (en) 2007-08-30
MX2008010768A (es) 2008-11-28
US9802890B2 (en) 2017-10-31
US20150315138A1 (en) 2015-11-05
SV2009003002A (es) 2009-01-28
HK1203515A1 (en) 2015-10-30

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