SG11202003668YA - Betulin-containing birch bark extracts and their formulation - Google Patents

Betulin-containing birch bark extracts and their formulation

Info

Publication number
SG11202003668YA
SG11202003668YA SG11202003668YA SG11202003668YA SG11202003668YA SG 11202003668Y A SG11202003668Y A SG 11202003668YA SG 11202003668Y A SG11202003668Y A SG 11202003668YA SG 11202003668Y A SG11202003668Y A SG 11202003668YA SG 11202003668Y A SG11202003668Y A SG 11202003668YA
Authority
SG
Singapore
Prior art keywords
betulin
formulation
birch bark
bark extracts
containing birch
Prior art date
Application number
SG11202003668YA
Other languages
English (en)
Inventor
John Ashleigh Watson
SEBASTIAN JäGER
Tobias Zahn
Original Assignee
Amryt Res Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amryt Res Limited filed Critical Amryt Res Limited
Publication of SG11202003668YA publication Critical patent/SG11202003668YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202003668YA 2018-01-04 2019-01-04 Betulin-containing birch bark extracts and their formulation SG11202003668YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862613646P 2018-01-04 2018-01-04
PCT/EP2019/050186 WO2019134982A1 (en) 2018-01-04 2019-01-04 Betulin-containing birch bark extracts and their formulation

Publications (1)

Publication Number Publication Date
SG11202003668YA true SG11202003668YA (en) 2020-05-28

Family

ID=65031027

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003668YA SG11202003668YA (en) 2018-01-04 2019-01-04 Betulin-containing birch bark extracts and their formulation

Country Status (13)

Country Link
US (6) US20200330481A1 (enExample)
EP (2) EP3735274A1 (enExample)
JP (3) JP7358353B2 (enExample)
KR (1) KR20200106487A (enExample)
CN (1) CN111356479A (enExample)
AU (1) AU2019205091B2 (enExample)
BR (1) BR112020009867A2 (enExample)
CA (1) CA3081624A1 (enExample)
CO (1) CO2020006242A2 (enExample)
IL (1) IL275631B2 (enExample)
MX (2) MX2020006995A (enExample)
SG (1) SG11202003668YA (enExample)
WO (1) WO2019134982A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019134982A1 (en) 2018-01-04 2019-07-11 Amryt Research Limited Betulin-containing birch bark extracts and their formulation
DE102020006675A1 (de) * 2020-10-30 2022-05-05 Prof4Skin Gmbh Verfahren zur Herstellung von Wundauflagen aus phopholipidhaltigen Nanodipersionen
CN115998671B (zh) * 2021-10-23 2024-12-20 北京嘉桦生物技术有限公司 一种桦树汁温敏型原位凝胶在烧烫伤皮肤修复中的应用

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2764620A (en) 1951-12-04 1956-09-25 Phillips Petroleum Co Adsorption process with heating in downstream end of adsorption column to selectively remove occluded liquids
LU47604A1 (enExample) 1964-12-17 1966-06-17
US4044031A (en) 1976-07-02 1977-08-23 Ake Allan Johansson Process for the separation of sterols
FI57956C (fi) 1978-12-12 1980-11-10 Farmos Oy Foerfarande foer isolering av beta-sitosterol med laog alfa-sitosterolhalt
FR2487356A1 (fr) 1980-07-25 1982-01-29 Oreal Emulsions stables obtenues a partir d'un agent emulsionnant naturel stabilise par du suc d'aloes
LU83173A1 (fr) 1981-02-27 1981-06-05 Oreal Nouvelles compositions cosmetiques pour le traitement des cheveux et de la peau contenant une poudre resultant de la pulverisation d'au moins une plante et un agent de cohesion
JPS597106A (ja) 1982-07-06 1984-01-14 Shiseido Co Ltd 乳化組成物
JPS5967212A (ja) 1982-10-12 1984-04-16 Kazuo Suga 化粧品組成物
JPS59206496A (ja) 1983-05-11 1984-11-22 ライオン株式会社 シヤンプ−組成物
FI77441C (fi) 1985-03-04 1989-03-10 Kemira Oy Foerfarande foer omvandling av vaextmaterial till kemikalier.
JPS61205204A (ja) 1985-03-08 1986-09-11 Shiseido Co Ltd 皮膚外用剤
US5166176A (en) 1986-12-29 1992-11-24 Obagi Zein E Composition for healing damaged skin
US5567419A (en) 1988-12-22 1996-10-22 Kanebo Ltd. Stabilized cosmetic compositions containing monoacyl phosphatide and a saponin
JP2652228B2 (ja) 1988-12-22 1997-09-10 鐘紡株式会社 化粧料
DK0526642T3 (da) 1991-01-29 1998-10-19 Shionogi & Co Triterpenderivat
GB9104286D0 (en) 1991-02-28 1991-04-17 Phytopharm Ltd Pharmaceutical compositions for the treatment of skin disorders
JP3363161B2 (ja) 1991-06-27 2003-01-08 ポーラ化成工業株式会社 非水ゲル化粧料
JPH0597106A (ja) 1991-10-07 1993-04-20 Youka Tekko Kk 球状物包装装置
DE4318280A1 (de) 1993-06-02 1993-12-16 Ivo Stane Hautpflegemittel auf natürlicher Basis
US5660727A (en) 1994-06-14 1997-08-26 Dionex Corporation Automated analyte supercritical fluid extraction apparatus
US5843311A (en) 1994-06-14 1998-12-01 Dionex Corporation Accelerated solvent extraction method
US5647976A (en) 1995-03-03 1997-07-15 Dionex Corporation High pressure and temperature cell for solvent extraction
KR100423458B1 (ko) 1995-07-12 2004-05-17 가부시키가이샤 시세이도 피부외용제
DE19544905A1 (de) 1995-12-01 1997-06-05 Robugen Gmbh Verfahren zur Herstellung von Pflanzenextrakten
JPH09179354A (ja) 1995-12-27 1997-07-11 Minolta Co Ltd 液体現像剤用トナー、液体現像剤、およびその製造方法
US5882916A (en) 1996-02-15 1999-03-16 Nouveau Technolgies, Inc. Decontamination process
JPH09235293A (ja) 1996-02-29 1997-09-09 Kanebo Ltd 新規トリテルペン
US6342208B1 (en) 1996-08-02 2002-01-29 Plum Kerni Produktion A/S Oil-in-water emulsion containing C10-C24 fatty acid derivatives for treating skin of mammals
JPH10152444A (ja) 1996-11-22 1998-06-09 Nippon Flour Mills Co Ltd メイラード反応抑制剤及び化粧料
EP0902685A1 (de) 1997-01-24 1999-03-24 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten enthaltend antitumoral, antiviral und antiparasitär wirksame ester von pentacyclischen triterpenen
CA2280093A1 (en) 1997-02-04 1998-08-06 John V. Kosbab Compositions and methods for prevention and treatment of vascular degenerative diseases
US5750578A (en) 1997-02-11 1998-05-12 Regents Of The University Of Minnesota Use of betulin and analogs thereof to treat herpesvirus infection
DE19713768B4 (de) 1997-04-03 2006-07-13 Martin-Luther-Universität Halle-Wittenberg Herstellung von Betulinsäure
US6403816B1 (en) 1997-09-30 2002-06-11 Dabur Research Foundation Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
US6022890A (en) 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
FR2779438B1 (fr) 1998-06-03 2004-12-24 Jean Marc Aiache Gel stable, son procede de preparation, et compositions pharmaceutiques le comprenant
US6124362A (en) 1998-07-17 2000-09-26 The Procter & Gamble Company Method for regulating hair growth
US6746695B1 (en) 1998-10-02 2004-06-08 Armadillo Pharmaceuticals, Inc. Pharmaceutical preparations of bioactive substances extracted from natural sources
CA2250481A1 (fr) 1998-11-02 2000-05-02 Andre Pichette Procede de preparation de derives du betulinol directement a partir de l'ecorce du bouleau blanc
GB9908593D0 (en) 1999-04-16 1999-06-09 Quest Int Dental compositions containing boswellia extracts
WO2001003712A1 (en) 1999-07-09 2001-01-18 Astion Development Aps Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement
US6392070B1 (en) 1999-08-10 2002-05-21 Regents Of The University Of Minnesota Birch bark processing and the isolation of natural products from birch bark
WO2001019365A1 (en) 1999-09-15 2001-03-22 Roche Consumer Health Ag Pharmaceutical and/or cosmetical compositions
AU768306B2 (en) 1999-10-14 2003-12-04 Nisshin Oil Mills, Ltd., The Skin-care agents, skin antiaging agents, whitening agents and external skin preparations
DE60102402T2 (de) 2000-02-10 2005-03-10 Loders Croklaan B.V. Fettmischungen mit Kristallmodifikatoren
US6264998B1 (en) 2000-03-01 2001-07-24 Dabur Research Foundation Extracting betulinic acid from Ziziphus jujuba
DE50102055D1 (de) 2000-03-28 2004-05-27 Birken Gmbh Emulsion enthaltend einen triterpen-haltigen pflanzenextrakt, verfahren zur herstellung der emulsion sowie zur gewinnung des pflanzenextraktes
DE10056902A1 (de) 2000-11-16 2002-05-23 Birken Gmbh Verfahren zur Gewinnung von Triterpenen aus Pflanzen sowie deren Verwendung
CA2404012A1 (en) 2000-03-31 2001-10-04 The Nisshin Oil Mills, Ltd. External agent for the skin and whitening agent
JP2004509972A (ja) 2000-09-29 2004-04-02 リージェンツ　オブ　ザ　ユニバーシティ　オブ　ミネソタ 酵母に対する殺真菌活性を有するトリテルペン
AU2001294959A1 (en) 2000-09-29 2002-04-08 Robert M. Carlson Triterpenes having antibacterial activity
JP2002138014A (ja) 2000-10-31 2002-05-14 Noevir Co Ltd 微細エマルション組成物
DE10108387A1 (de) 2001-02-21 2002-08-29 Basf Ag Kosmetisches oder pharmazeutisches Mittel
DE10143964A1 (de) 2001-09-07 2003-03-27 Basf Ag Emulgatorarme oder emulgatorfreie Systeme vom Typ Öl-in-Wasser mit einem Gehalt an Stabilisatoren und einem aminosubstituierten Hydroxybenzophenon
DE10156297A1 (de) 2001-11-19 2003-05-28 Henkel Kgaa Mittel zum Schutz der Haut
JP2003335627A (ja) 2002-03-14 2003-11-25 Lion Corp 化粧料含浸シート
DE10237281A1 (de) 2002-08-14 2004-03-04 Birken Gmbh Vorrichtung zur kontinuierlichen Extraktion von Extraktstoffen aus Pflanzen
JP3779661B2 (ja) 2002-09-13 2006-05-31 花王株式会社 皮膚化粧料
KR100489701B1 (ko) 2002-10-09 2005-05-16 주식회사 태평양 고농도의 트리터페노이드를 함유하는 미소화 리포좀 및 그제조방법
DE10317400B4 (de) 2003-04-15 2006-04-13 Universitätsklinikum Hamburg-Eppendorf EX-VIVO-Hautorganmodell aus Schweinehaut
DE10329955A1 (de) 2003-07-03 2005-02-03 Merck Patent Gmbh Verwendung eines hydroalkoholischen Extrakts aus Bauhinia zur Herstellung einer Zubereitung
DE102004030044A1 (de) 2004-06-22 2006-01-12 Birken Gmbh Triterpenhaltiger Oleogelbildner, triterpenhaltiges Oleogel und Verfahren zur Herstellung eines triterpenhaltigen Oleogels
US8293710B2 (en) 2005-01-03 2012-10-23 Blue Blood Biotech Corp. Method for treating wounds using an EGF-like domain of thrombomodulin
ES2415362T3 (es) 2005-04-08 2013-07-25 Mie University Agente externo para tratar heridas
US20090131714A1 (en) 2005-06-08 2009-05-21 Krasutsky Pavel A Synthesis of betulonic and betulinic aldehydes
WO2006133395A2 (en) 2005-06-08 2006-12-14 Regents Of The University Of Minnesota Stereoselective reduction of triterpenones
BRPI0613227A2 (pt) 2005-06-09 2011-01-04 Chiang Chuan Chi uma composição para cicatrização de ferida e uso desta
EP1889608B1 (en) * 2006-08-09 2012-11-28 Korea Atomic Energy Research Institute Therapeutic hydrogel for atopic dermatitis and preparation method thereof
DE102006049929B4 (de) 2006-10-19 2012-03-08 Beiersdorf Ag Filmbildende Gelkomposition zur Wund- bzw. Hautpflege
US8580192B2 (en) 2006-10-31 2013-11-12 Ethicon, Inc. Sterilization of polymeric materials
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
GB2455585B (en) 2008-01-16 2010-07-28 Ali Reza Rezai-Fard Capsicum seeds for the treatment of eczema and dermatitis
CN101664562A (zh) 2009-09-30 2010-03-10 都本立 创伤修复水凝胶材料及制备方法
DE102009047092A1 (de) 2009-11-24 2011-05-26 Birken Gmbh Verwendung eines triterpenhaltigen Oleogels zur Wundheilung
EP2363108B1 (de) * 2010-03-02 2017-08-30 Neubourg Skin Care GmbH & Co. KG Schaumformulierungen enthaltend mindestens ein Triterpenoid
CN103439446A (zh) 2013-08-13 2013-12-11 张家港威胜生物医药有限公司 使用rp-hplc法测定桦树皮中桦木醇含量的方法
GB201400292D0 (en) 2014-01-08 2014-02-26 Haemostatix Ltd Peptide dendrimers and agents
EP3419676B1 (en) * 2016-02-22 2022-08-31 Board of Regents, The University of Texas System Antimicrobial compositions and uses thereof
CN110035735A (zh) * 2016-07-18 2019-07-19 安瑞特研究有限公司 包含白桦脂醇的油包水泡沫及其组合物
RU2635533C1 (ru) 2016-09-08 2017-11-13 Общество с ограниченной ответственностью Управляющая компания "МЕРЕЯ ГРУПП" Повязка для закрытия и лечения ран
CN107158156A (zh) 2016-12-16 2017-09-15 江苏苏轩堂药业有限公司 沉香粉中药泡服饮片
WO2019134982A1 (en) * 2018-01-04 2019-07-11 Amryt Research Limited Betulin-containing birch bark extracts and their formulation

Also Published As

Publication number Publication date
BR112020009867A2 (pt) 2020-11-03
WO2019134982A1 (en) 2019-07-11
US11826374B2 (en) 2023-11-28
CN111356479A (zh) 2020-06-30
CO2020006242A2 (es) 2020-05-29
US11266660B2 (en) 2022-03-08
IL275631B1 (en) 2024-06-01
US20250195538A1 (en) 2025-06-19
US12268695B2 (en) 2025-04-08
US11083733B2 (en) 2021-08-10
AU2019205091B2 (en) 2024-07-25
JP2021509891A (ja) 2021-04-08
US20240050445A1 (en) 2024-02-15
US20210093647A1 (en) 2021-04-01
JP7358353B2 (ja) 2023-10-10
EP4249057A3 (en) 2023-11-29
KR20200106487A (ko) 2020-09-14
US20210369733A1 (en) 2021-12-02
EP3735274A1 (en) 2020-11-11
US20220184097A1 (en) 2022-06-16
IL275631A (en) 2020-08-31
IL275631B2 (en) 2024-10-01
JP7747702B2 (ja) 2025-10-01
MX2020006995A (es) 2020-09-09
MX2023009676A (es) 2023-08-25
JP2025172175A (ja) 2025-11-20
RU2020125679A (ru) 2022-02-04
CA3081624A1 (en) 2019-07-11
EP4249057A2 (en) 2023-09-27
AU2019205091A1 (en) 2020-04-30
US20200330481A1 (en) 2020-10-22
JP2023168437A (ja) 2023-11-24

Similar Documents

Publication Publication Date Title
IL278224A (en) Preparations of cannabidiol and their uses
IL275208A (en) Hsp90-targeting conjugates and formulations thereof
EP3713406A4 (en) SEXAGE AND ENDONUCLEASIC STERILIZATION IN INSECTS
PT3638251T (pt) Formulações de gel de bifosfocina e suas utilizações
PL3906016T3 (pl) Ciekły ekstrakt z propolisu, jego preparat i zastosowania
EP3687501A4 (en) INIPARIB FORMULATIONS AND THEIR USES
SG11201803025VA (en) Compositions comprising vitamins and their use
PL3253231T3 (pl) Kompozycje przeciwdrobnoustrojowe zawierające ekstrakty z Punica i Lamiaceae
IL268583A (en) Preparations and methods for use on the skin
IL279059A (en) Methods and preparations for killing spores
IL275631A (en) Birch bark extracts containing betulin and their formulation
EP3489225A4 (en) ANALOG OF VORTIOXETINE, ITS USE AND ITS PREPARATION
SG11202009242RA (en) Short conjugated oligoelectrolytes and uses thereof
IL282527A (en) 5-Azaindazole history and their use
EP3582792A4 (en) FABRIC COLORING AND USES THEREOF
IL282526A (en) 5-Azaindazole history and their use
EP3554944B8 (en) Insect elimination system and use thereof
EP3497080A4 (en) PHARMACEUTICAL FORMULATIONS AND THEIR USE
GB201801986D0 (en) Anthocyanins and used thereof
GB201811143D0 (en) Mangiferin-containing skin-care compositions and methods
EP3664895A4 (en) COMBINATIONS AS WELL AS USES AND TREATMENTS THEREOF
HK40038485A (en) Hsp90-targeting conjugates and formulations thereof
PT3612601T (pt) Revestimento e formulação de revestimento
GB201816605D0 (en) New formulations and uses thereof
HK40036554A (en) Sstr-targeted conjugates and formulations thereof