|
US2488564A
(en)
|
1947-06-03 |
1949-11-22 |
Orthe Pharmaecutlcal Corp |
Preparation of hyaluronidase
|
|
US2488565A
(en)
|
1947-06-04 |
1949-11-22 |
Ortho Pharma Corp |
Preparation of hyaluronidase
|
|
US2676139A
(en)
|
1950-09-01 |
1954-04-20 |
American Home Prod |
Hyaluronidase
|
|
US2808362A
(en)
|
1952-05-02 |
1957-10-01 |
Armour & Co |
Preparation of hyaluronidase
|
|
US2795529A
(en)
|
1954-06-17 |
1957-06-11 |
American Home Prod |
Stabilized hyaluronidase solution containing calcium chloride
|
|
US2806815A
(en)
|
1955-04-12 |
1957-09-17 |
Ortho Pharma Corp |
Stabilized hyaluronidase
|
|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3630200A
(en)
|
1969-06-09 |
1971-12-28 |
Alza Corp |
Ocular insert
|
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
US3847770A
(en)
|
1972-04-10 |
1974-11-12 |
Continental Can Co |
Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
|
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
GB8322007D0
(en)
|
1983-08-16 |
1983-09-21 |
Wellcome Found |
Pharmaceutical delivery system
|
|
US4952496A
(en)
|
1984-03-30 |
1990-08-28 |
Associated Universities, Inc. |
Cloning and expression of the gene for bacteriophage T7 RNA polymerase
|
|
US4769027A
(en)
|
1984-08-15 |
1988-09-06 |
Burroughs Wellcome Co. |
Delivery system
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5716826A
(en)
|
1988-03-21 |
1998-02-10 |
Chiron Viagene, Inc. |
Recombinant retroviruses
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
WO1990009800A1
(en)
|
1989-02-21 |
1990-09-07 |
Washington University |
Modified forms of reproductive hormones
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
|
US5262522A
(en)
|
1991-11-22 |
1993-11-16 |
Immunex Corporation |
Receptor for oncostatin M and leukemia inhibitory factor
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
AU7097094A
(en)
|
1993-06-01 |
1994-12-20 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
US5457035A
(en)
|
1993-07-23 |
1995-10-10 |
Immunex Corporation |
Cytokine which is a ligand for OX40
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5795569A
(en)
|
1994-03-31 |
1998-08-18 |
Amgen Inc. |
Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
|
|
AU691606B2
(en)
|
1994-03-31 |
1998-05-21 |
Amgen, Inc. |
Compositions and methods for stimulating megakaryocyte growth and differentiation
|
|
US20020159979A1
(en)
|
1994-06-06 |
2002-10-31 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5747027A
(en)
|
1995-04-07 |
1998-05-05 |
The Regents Of The University Of California |
BH55 hyaluronidase
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
|
FR2735789B1
(fr)
|
1995-06-23 |
1997-07-25 |
Centre Nat Rech Scient |
Adenovirus recombinants, leur utilisation pour preparer des aav, lignee cellulaire complementaire et compositions pharmaceutiques les contenant
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
JPH11514853A
(ja)
|
1995-09-08 |
1999-12-21 |
ジエンザイム コーポレイション |
遺伝子治療のための改良されたａａｖベクター
|
|
US7001765B2
(en)
|
1996-03-06 |
2006-02-21 |
Medigene Ag |
Adeno-associated virus vector for boosting immunogenicity of cells
|
|
US5747322A
(en)
|
1996-05-09 |
1998-05-05 |
The Regents Of The University Of California |
Recombinant crab collagenase
|
|
EP0918872B1
(en)
|
1996-08-02 |
2008-02-20 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
EP0973888A1
(en)
|
1997-02-06 |
2000-01-26 |
Human Genome Sciences, Inc. |
Dendritic cell-derived growth factor
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
AU751659B2
(en)
|
1997-05-02 |
2002-08-22 |
Genentech Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US6635472B1
(en)
|
1997-08-15 |
2003-10-21 |
Rubicon Laboratory, Inc. |
Retrovirus and viral vectors
|
|
EP1015619A1
(en)
|
1997-09-19 |
2000-07-05 |
The Trustees Of The University Of Pennsylvania |
Methods and cell line useful for production of recombinant adeno-associated viruses
|
|
US20050158273A1
(en)
|
1997-09-25 |
2005-07-21 |
Harris J. M. |
Soluble, degradable polyethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
JP4465109B2
(ja)
|
1997-12-17 |
2010-05-19 |
エンゾン ファーマシューティカルズ，インコーポレーテッド |
アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ
|
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
|
US6624142B2
(en)
|
1997-12-30 |
2003-09-23 |
Enzon, Inc. |
Trimethyl lock based tetrapartate prodrugs
|
|
ATE399809T1
(de)
|
1998-03-12 |
2008-07-15 |
Nektar Therapeutics Al Corp |
Verfahren zur herstellung von polymerkonjugaten
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6824766B2
(en)
|
1998-04-17 |
2004-11-30 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
|
US6251382B1
(en)
|
1998-04-17 |
2001-06-26 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US6436392B1
(en)
|
1998-05-20 |
2002-08-20 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors
|
|
JP2002519686A
(ja)
|
1998-07-03 |
2002-07-02 |
ネレス・フィールド・コントロールズ・オイ |
液体物質測定方法および装置
|
|
EP1105427A2
(en)
|
1998-08-17 |
2001-06-13 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
JP2002538770A
(ja)
|
1998-11-10 |
2002-11-19 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
ウイルスベクターとその製造及び投与の方法
|
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
EP2112166B1
(en)
|
1998-12-23 |
2018-11-21 |
Pfizer Inc. |
Human monoclonal antibodies to ctla-4
|
|
NZ539776A
(en)
|
1999-01-15 |
2006-12-22 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
GB9904582D0
(en)
|
1999-02-26 |
1999-04-21 |
Nycomed Imaging As |
Process
|
|
US6428968B1
(en)
|
1999-03-15 |
2002-08-06 |
The Trustees Of The University Of Pennsylvania |
Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
|
|
CZ299516B6
(cs)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
PE20010288A1
(es)
|
1999-07-02 |
2001-03-07 |
Hoffmann La Roche |
Derivados de eritropoyetina
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
US6461802B1
(en)
|
1999-08-02 |
2002-10-08 |
Agfa-Gevaert |
Adhesive layer for polyester film
|
|
ATE354655T1
(de)
|
1999-08-24 |
2007-03-15 |
Medarex Inc |
Humane antikörper gegen ctla-4 und deren verwendungen
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
US7241447B1
(en)
|
1999-10-07 |
2007-07-10 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
US6723316B2
(en)
|
1999-12-22 |
2004-04-20 |
Onyx Pharmaceuticals, Inc. |
Herpes simplex virus-1 Glycoprotein C mutants for treating unwanted hyperproliferative cell growth
|
|
ATE317868T1
(de)
|
1999-12-22 |
2006-03-15 |
Nektar Therapeutics Al Corp |
Sterisch gehinderte derivate von wasserlöslichen polymeren
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
BRPI0107736B8
(pt)
|
2000-01-21 |
2021-05-25 |
Biovex Ltd |
cepa hsv1 js1, composição farmacêutica, e, uso de uma cepa hsv1 js1
|
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
ES2484966T3
(es)
|
2000-04-12 |
2014-08-12 |
Novozymes Biopharma Dk A/S |
Proteínas de fusión de albúmina
|
|
US7306902B2
(en)
|
2002-06-28 |
2007-12-11 |
Oncolyties Biotech Inc. |
Oncolytic viruses as phenotyping agents for neoplasms
|
|
ES2290142T3
(es)
|
2000-05-16 |
2008-02-16 |
Bolder Biotechnology, Inc. |
Metodos para replegamiento de proteinas que contiene residuos de cisteina libre.
|
|
WO2001087922A2
(en)
|
2000-05-16 |
2001-11-22 |
Lipoxen Technologies Limited |
Derivatisation of proteins in aqueous solution
|
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
EP1345628B1
(en)
|
2000-12-20 |
2011-04-13 |
F. Hoffmann-La Roche AG |
Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
US20020096037A1
(en)
|
2001-01-25 |
2002-07-25 |
Richard Muller |
Color-coded melody text and method of teaching
|
|
US6888319B2
(en)
|
2001-03-01 |
2005-05-03 |
Palomar Medical Technologies, Inc. |
Flashlamp drive circuit
|
|
JP4336771B2
(ja)
|
2001-03-09 |
2009-09-30 |
モルフォシス アーゲー |
血清アルブミン結合部分
|
|
US6653103B2
(en)
|
2001-03-30 |
2003-11-25 |
Wisconsin Alumni Research Foundation |
Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides
|
|
US20040106794A1
(en)
|
2001-04-16 |
2004-06-03 |
Schering Corporation |
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
|
|
HUP0400882A3
(en)
|
2001-05-11 |
2011-01-28 |
Wellstat Biologics Corp |
Oncolytic virus therapy
|
|
IL149701A0
(en)
|
2001-05-23 |
2002-11-10 |
Pfizer Prod Inc |
Use of anti-ctla-4 antibodies
|
|
WO2003005964A2
(en)
|
2001-07-11 |
2003-01-23 |
University Of Miami |
Recombinant vsv for the treatment of tumor cells
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
US7026440B2
(en)
|
2001-11-07 |
2006-04-11 |
Nektar Therapeutics Al, Corporation |
Branched polymers and their conjugates
|
|
KR101271635B1
(ko)
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
|
US20080194481A1
(en)
|
2001-12-21 |
2008-08-14 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
|
WO2003060071A2
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
JP2006502091A
(ja)
|
2002-03-01 |
2006-01-19 |
イミューノメディクス、インコーポレイテッド |
クリアランス速度を高めるための二重特異性抗体点変異
|
|
EP1487992A4
(en)
|
2002-03-15 |
2007-10-31 |
Brigham & Womens Hospital |
ADMINISTRATION THROUGH THE CENTRAL AIRWAYS FOR THE SYSTEMATIC DELIVERY OF THERAPEUTICS
|
|
JP2005521398A
(ja)
|
2002-03-27 |
2005-07-21 |
ベイラー カレッジ オブ メディスン |
癌治療用の強力な腫瘍溶解性単純ヘルペスウイルス
|
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
|
WO2004000209A2
(en)
|
2002-06-21 |
2003-12-31 |
Wellstat Biologics Corporation |
Administration of therapeutic viruses
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
ATE536188T1
(de)
|
2002-08-14 |
2011-12-15 |
Macrogenics Inc |
Fcgammariib-spezifische antikörper und verfahren zur verwendung davon
|
|
EP1537163B1
(en)
|
2002-09-09 |
2008-10-29 |
Nektar Therapeutics Al, Corporation |
Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
|
|
CN1820078A
(zh)
|
2002-09-09 |
2006-08-16 |
田纳西大学研究基金会 |
弹状病毒的重组突变体及其应用方法
|
|
DK2345671T3
(en)
|
2002-09-27 |
2016-02-15 |
Xencor Inc |
Optimized Fc variants and methods for their formation
|
|
NZ521851A
(en)
|
2002-10-08 |
2005-02-25 |
Auckland Uniservices Ltd |
Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy
|
|
CA2502904C
(en)
|
2002-10-15 |
2013-05-28 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
KR20040040782A
(ko)
|
2002-11-08 |
2004-05-13 |
선바이오(주) |
신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법
|
|
GB2395337B
(en)
|
2002-11-14 |
2005-12-28 |
Gary Michael Wilson |
Warning Unit
|
|
AU2004204494B2
(en)
|
2003-01-09 |
2011-09-29 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
CA2517369C
(en)
|
2003-02-26 |
2013-06-04 |
Nektar Therapeutics Al, Corporation |
Polymer-factor viii moiety conjugates
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
WO2004078991A2
(en)
|
2003-03-04 |
2004-09-16 |
Yeda Research And Development Co. Ltd. |
Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
KR101363658B1
(ko)
|
2003-03-05 |
2014-02-14 |
할로자임, 아이엔씨 |
가용성 하이알우로니다제 당단백질 (ｓＨＡＳＥＧＰ), 이를 제조하는 방법, 용도 및 이를 포함하는 약학 조성물
|
|
NZ542902A
(en)
|
2003-03-27 |
2007-06-29 |
Ottawa Health Research Inst |
Mutant vesicular stomatitis viruses and use thereof
|
|
US7731974B2
(en)
|
2003-03-27 |
2010-06-08 |
Ottawa Hospital Research Institute |
Mutant vesicular stomatitis viruses and uses thereof
|
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
KR100512483B1
(ko)
|
2003-05-07 |
2005-09-05 |
선바이오(주) |
신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법
|
|
DK2644206T3
(da)
|
2003-05-23 |
2019-06-11 |
Nektar Therapeutics |
PEG-derivater indeholdende to PEG-kæder
|
|
WO2005000099A2
(en)
*
|
2003-06-09 |
2005-01-06 |
Genzyme Corporation |
BLOOD FACTOR DOMAINS (BFDs)
|
|
EP1654290B1
(en)
|
2003-08-12 |
2019-03-13 |
Lipoxen Technologies Limited |
Sialic acid derivatives for protein derivatisation and conjugation
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
GB0326798D0
(en)
|
2003-11-17 |
2003-12-24 |
Crusade Lab Ltd |
Methods for generating mutant virus
|
|
EP1694852B1
(en)
|
2003-11-17 |
2010-10-13 |
Crusade Laboratories Limited |
Mutant herpes simplex virus and use thereof in the treatment of squamous cell cancer
|
|
US7897146B2
(en)
|
2003-11-17 |
2011-03-01 |
Crusade Laboratories Limited |
Treatment using herpes simplex virus
|
|
EP1697741A4
(en)
|
2003-12-04 |
2008-02-13 |
Xencor Inc |
PROCESS FOR PRODUCING PROTEIN VARIANTS WITH INCREASED HOST STRUCTURE CONTENT AND COMPOSITIONS THEREOF
|
|
ZA200604864B
(en)
|
2003-12-19 |
2007-10-31 |
Genentech Inc |
Monovalent antibody fragments useful as therapeutics
|
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
|
US20080089892A1
(en)
|
2004-01-12 |
2008-04-17 |
Eli Lilly And Co. |
Fc Region Variants
|
|
AU2005216251B2
(en)
|
2004-02-23 |
2011-03-10 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2005118799A1
(en)
|
2004-04-15 |
2005-12-15 |
Ista Pharmaceuticals, Inc. |
Ovine hyaluronidase
|
|
WO2005116224A2
(en)
|
2004-05-18 |
2005-12-08 |
Children's Memorial Hospital |
Tetracycline-regulated adeno-associated viral (aav) vectors for gene delivery to the nervous system
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
WO2006002394A2
(en)
|
2004-06-24 |
2006-01-05 |
New York University |
Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
JP2008505174A
(ja)
|
2004-07-15 |
2008-02-21 |
ゼンコー・インコーポレイテッド |
最適化Ｆｃ変異体
|
|
US20070166281A1
(en)
|
2004-08-21 |
2007-07-19 |
Kosak Kenneth M |
Chloroquine coupled antibodies and other proteins with methods for their synthesis
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
WO2006060314A2
(en)
|
2004-12-01 |
2006-06-08 |
Bayer Schering Pharma Aktiengesellschaft |
Generation of replication competent viruses for therapeutic use
|
|
US20090074787A1
(en)
|
2005-03-23 |
2009-03-19 |
Pfizer, Inc., Pfizer Products, Inc. |
Anti-CTLA4 Antibody and Indolinone Combination Therapy for Treatment of Cancer
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
CA2611056C
(en)
|
2005-06-01 |
2016-06-28 |
California Institute Of Technology |
Method of targeted gene delivery using viral vectors
|
|
JP5284780B2
(ja)
|
2005-06-23 |
2013-09-11 |
ザ ユニバーシティ オブ ヒューストン |
癌の治療のための単純ヘルペスウイルス２型変異体の使用
|
|
SG163554A1
(en)
|
2005-07-01 |
2010-08-30 |
Medarex Inc |
Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
|
|
WO2007021494A2
(en)
|
2005-08-12 |
2007-02-22 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7943374B2
(en)
|
2005-08-21 |
2011-05-17 |
Markus Hildinger |
Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
|
|
US7301003B2
(en)
|
2005-08-26 |
2007-11-27 |
Enzon Pharmaceuticals, Inc. |
Method of preparing polymers having terminal amine groups
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
US7846445B2
(en)
|
2005-09-27 |
2010-12-07 |
Amunix Operating, Inc. |
Methods for production of unstructured recombinant polymers and uses thereof
|
|
US7601798B2
(en)
|
2005-10-04 |
2009-10-13 |
Enzon Pharmaceuticals, Inc. |
Methods of preparing polymers having terminal amine groups using protected amine salts
|
|
US7989554B2
(en)
|
2006-01-10 |
2011-08-02 |
Enzon Pharmaceuticals, Inc. |
Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
|
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
|
CA2643182C
(en)
|
2006-03-13 |
2014-09-02 |
Tir Technology Lp |
Adaptive control apparatus and method for a solid-state lighting system
|
|
CA2653061A1
(en)
|
2006-06-21 |
2007-12-27 |
Enzon Pharmaceuticals, Inc. |
Stabilized proteins
|
|
BRPI0716744A2
(pt)
|
2006-09-14 |
2016-10-04 |
Human Genome Sciences Inc |
proteínas de fusão de albumina
|
|
EP2063912A4
(en)
|
2006-09-15 |
2010-07-28 |
Enzon Pharmaceuticals Inc |
POLYALKYLENE OXIDES HAVING BIODEGRADABLE BOND SEGMENTS BASED ON COARSE ESTER
|
|
WO2008140621A2
(en)
|
2006-12-21 |
2008-11-20 |
Mount Sinai School Of Medicine Of New York University |
Transgenic oncolytic viruses and uses thereof
|
|
US8163292B2
(en)
|
2007-02-16 |
2012-04-24 |
Virttu Biologics Limited |
Herpes simplex viruses and methods of viral replication
|
|
SI2147116T1
(sl)
*
|
2007-04-20 |
2016-06-30 |
Sigma-Tau Rare Disease Ltd. |
Stabilna rekombinantna adenozin-deaminaza
|
|
NZ580980A
(en)
|
2007-04-20 |
2012-04-27 |
Sigma Tau Rare Diseases S A |
Enzymatic anticancer therapy
|
|
EP2170959B1
(en)
|
2007-06-18 |
2013-10-02 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
|
PT2173890E
(pt)
|
2007-06-21 |
2011-05-06 |
Tech Universit T M Nchen |
Prote?nas biologicamente activas com estabilidade in vivo e/ou in vitro aumentada
|
|
EP2185701A4
(en)
|
2007-08-15 |
2011-03-02 |
Amunix Operating Inc |
COMPOSITIONS AND METHODS FOR ENHANCING THE PRODUCTION OF RECOMBINANT POLYPEPTIDES
|
|
EP3960854B1
(en)
|
2008-03-06 |
2024-07-17 |
Halozyme, Inc. |
Large-scale production of soluble hyaluronidase
|
|
US8313896B2
(en)
|
2008-04-04 |
2012-11-20 |
The General Hospital Corporation |
Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer
|
|
US8703120B2
(en)
|
2008-05-29 |
2014-04-22 |
The General Hospital Corporation |
Use of oncolytic herpes viruses for killing cancer stem cells
|
|
US20110159023A1
(en)
|
2008-08-25 |
2011-06-30 |
Solomon Langermann |
Pd-1 antagonists and methods for treating infectious disease
|
|
US9240043B2
(en)
|
2008-09-16 |
2016-01-19 |
Novartis Ag |
Reproducible quantification of biomarker expression
|
|
US8927249B2
(en)
|
2008-12-09 |
2015-01-06 |
Halozyme, Inc. |
Extended soluble PH20 polypeptides and uses thereof
|
|
MY188826A
(en)
|
2008-12-09 |
2022-01-06 |
Genentech Inc |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
WO2010080909A1
(en)
|
2009-01-08 |
2010-07-15 |
Yale University |
Compositions and methods of use of an oncolytic vesicular stomatitis virus
|
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
|
CN102348715B
(zh)
|
2009-02-03 |
2017-12-08 |
阿穆尼克斯运营公司 |
延伸重组多肽和包含该延伸重组多肽的组合物
|
|
ES2385251B1
(es)
|
2009-05-06 |
2013-05-06 |
Fundació Privada Institut D'investigació Biomèdica De Bellvitge |
Adenovirus oncolíticos para el tratamiento del cáncer.
|
|
WO2010140148A1
(en)
|
2009-06-01 |
2010-12-09 |
Yeda Research And Development Co . Ltd |
Prodrugs containing albumin binding probe
|
|
BRPI1010880A2
(pt)
|
2009-06-08 |
2019-10-01 |
Amunix Operating Inc |
polipeptídeos de hormônio de crescimento e métodos de fazer e usar os mesmos.
|
|
CA2764108A1
(en)
|
2009-06-08 |
2010-12-16 |
Amunix Operating Inc. |
Glucose-regulating polypeptides and methods of making and using same
|
|
WO2011028229A1
(en)
|
2009-08-24 |
2011-03-10 |
Amunix Operating Inc. |
Coagulation factor ix compositions and methods of making and using same
|
|
WO2011028344A2
(en)
|
2009-08-25 |
2011-03-10 |
Amunix Operating Inc. |
Interleukin-1 receptor antagonist compositions and methods of making and using same
|
|
JP5934099B2
(ja)
|
2009-10-01 |
2016-06-15 |
アメリカ合衆国 |
抗血管内皮増殖因子受容体−２キメラ抗原受容体及び癌の治療のためのその使用
|
|
RS56469B1
(sr)
|
2009-11-24 |
2018-01-31 |
Medimmune Ltd |
Ciljano vezujući agensi usmereni na b7-h1
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
US9050318B2
(en)
|
2009-12-06 |
2015-06-09 |
Biogen Idec Hemophilia Inc. |
Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
|
|
KR20140002601A
(ko)
|
2010-07-09 |
2014-01-08 |
바이오겐 이데크 헤모필리아 인코포레이티드 |
키메라 응고 인자
|
|
WO2012006623A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Systems for factor viii processing and methods thereof
|
|
US20130017997A1
(en)
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
|
NO3012268T3
(enrdf_load_stackoverflow)
|
2010-09-08 |
2018-04-14 |
|
|
|
JP6121904B2
(ja)
|
2010-09-08 |
2017-04-26 |
ハロザイム インコーポレイテッド |
条件的活性治療用タンパク質を評価および同定する、または発展させる方法
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
EP2672958A1
(en)
|
2011-02-08 |
2013-12-18 |
Halozyme, Inc. |
Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
|
|
ES2567276T3
(es)
|
2011-05-12 |
2016-04-21 |
Genentech, Inc. |
Método de LC-MS/MS de monitoreo de múltiples reacciones para detectar anticuerpos terapéuticos en muestras de animales usando péptidos de cambio de marco
|
|
CA2843595C
(en)
|
2011-08-01 |
2022-10-18 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
|
|
CN103946242A
(zh)
|
2011-10-20 |
2014-07-23 |
美国卫生和人力服务部 |
抗cd22嵌合抗原受体
|
|
JP2015500287A
(ja)
|
2011-12-05 |
2015-01-05 |
アイジェニカ・バイオセラピューティクス・インコーポレイテッドＩｇｅｎｉｃａ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
抗体−薬物のコンジュゲート、ならびに関連する化合物、組成物および方法
|
|
EA030252B9
(ru)
|
2011-12-30 |
2021-09-08 |
Галозим, Инк. |
Варианты полипептидов ph20, композиции на их основе и их применение
|
|
US20140170159A9
(en)
|
2012-03-08 |
2014-06-19 |
Ge Wei |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
|
AU2013289971A1
(en)
|
2012-07-13 |
2015-01-22 |
The Trustees Of The University Of Pennsylvania |
Enhancing activity of CAR T cells by co-introducing a bispecific antibody
|
|
KR102095700B1
(ko)
|
2013-05-14 |
2020-04-01 |
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 |
가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용
|
|
CN105722522B
(zh)
|
2013-08-30 |
2021-10-19 |
得克萨斯大学体系董事会 |
用于肿瘤疗法的犬尿氨酸耗竭酶的施用
|
|
CA3080200A1
(en)
|
2013-09-13 |
2015-03-19 |
Beigene Switzerland Gmbh |
Anti-pd1 antibodies and their use as therapeutics and diagnostics
|
|
ES2963718T3
(es)
|
2014-01-21 |
2024-04-01 |
Novartis Ag |
Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
|
|
SG11201702934TA
(en)
|
2014-10-14 |
2017-05-30 |
Halozyme Inc |
Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
|