SG10201607768YA - Humanized il-15 animals - Google Patents

Humanized il-15 animals

Info

Publication number
SG10201607768YA
SG10201607768YA SG10201607768YA SG10201607768YA SG10201607768YA SG 10201607768Y A SG10201607768Y A SG 10201607768YA SG 10201607768Y A SG10201607768Y A SG 10201607768YA SG 10201607768Y A SG10201607768Y A SG 10201607768YA SG 10201607768Y A SG10201607768Y A SG 10201607768YA
Authority
SG
Singapore
Prior art keywords
humanized
animals
Prior art date
Application number
SG10201607768YA
Other languages
English (en)
Inventor
Jose F Rojas
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201607768YA publication Critical patent/SG10201607768YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG10201607768YA 2013-10-15 2014-10-15 Humanized il-15 animals SG10201607768YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15

Publications (1)

Publication Number Publication Date
SG10201607768YA true SG10201607768YA (en) 2016-11-29

Family

ID=51830649

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201607768YA SG10201607768YA (en) 2013-10-15 2014-10-15 Humanized il-15 animals
SG11201601828XA SG11201601828XA (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201601828XA SG11201601828XA (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Country Status (28)

Country Link
US (5) US9155290B2 (es)
EP (3) EP3461331A1 (es)
JP (3) JP6492095B2 (es)
KR (1) KR102376041B1 (es)
CN (2) CN105744829B (es)
AU (2) AU2014337526B2 (es)
BR (1) BR112016008175A2 (es)
CA (1) CA2926090C (es)
CY (2) CY1118675T1 (es)
DK (2) DK2908626T3 (es)
ES (2) ES2715949T3 (es)
HK (1) HK1210659A1 (es)
HR (2) HRP20170380T1 (es)
HU (2) HUE033272T2 (es)
IL (2) IL244525B (es)
LT (2) LT2908626T (es)
MX (1) MX2016004781A (es)
NZ (1) NZ718655A (es)
PL (2) PL2908626T3 (es)
PT (2) PT2908626T (es)
RS (2) RS55472B1 (es)
RU (1) RU2674910C2 (es)
SG (2) SG10201607768YA (es)
SI (2) SI3138397T1 (es)
SM (1) SMT201700024B (es)
TR (1) TR201904342T4 (es)
WO (1) WO2015057758A1 (es)
ZA (1) ZA201601676B (es)

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DK3375284T3 (da) 2011-02-15 2023-06-12 Univ Yale Humaniserede M-CSF-mus og anvendelser deraf
EP4193834A1 (en) 2012-09-07 2023-06-14 Yale University Genetically modified non-human animals and methods of use thereof
EP3556206B1 (en) 2012-11-05 2021-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
SI3138397T1 (sl) 2013-10-15 2019-04-30 Regeneron Pharmaceuticals, Inc. Humanizirane živali IL-15
RU2020103811A (ru) 2014-05-05 2020-02-18 Регенерон Фармасьютикалз, Инк. Гуманизированные животные по с5 и с3
NO2785538T3 (es) 2014-05-07 2018-08-04
DK3841877T3 (da) 2014-05-19 2023-11-27 Regeneron Pharma Genetisk modificeret mus, der eksprimerer human EPO
US20160345549A1 (en) 2014-12-05 2016-12-01 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
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KR102493894B1 (ko) 2016-02-29 2023-01-31 리제너론 파마슈티칼스 인코포레이티드 인간화 tmprss 유전자를 갖는 설치류
US10912287B2 (en) 2016-06-28 2021-02-09 Biocytogen Pharmaceuticals (Beijing) Co., Ltd Genetically modified mice expressing humanized PD-1
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WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
WO2018086594A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tim-3
CN108070613B (zh) 2016-11-11 2020-03-13 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108239659B (zh) 2016-12-23 2020-03-03 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN108467873B (zh) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
CN108588126B (zh) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN109136274B (zh) 2017-06-19 2021-04-23 百奥赛图江苏基因生物技术有限公司 人源化cd40基因改造动物模型的制备方法及应用
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WO2020074005A1 (en) 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
CN111304247B (zh) 2018-12-20 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化lag-3基因改造动物模型的制备方法及应用
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WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
IL286905B1 (en) 2019-04-04 2024-02-01 Regeneron Pharma Non-human animals containing the human coagulation factor 12 locus
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KR20220017939A (ko) 2019-06-07 2022-02-14 리제너론 파마슈티칼스 인코포레이티드 인간화 알부민 좌위를 포함하는 비-인간 동물
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
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Also Published As

Publication number Publication date
HUE043969T2 (hu) 2019-09-30
DK3138397T3 (en) 2019-04-15
MX2016004781A (es) 2016-07-26
AU2014337526A1 (en) 2016-04-28
JP2019216750A (ja) 2019-12-26
ES2613379T3 (es) 2017-05-24
KR20160068774A (ko) 2016-06-15
RU2016116847A (ru) 2017-11-21
US11503813B2 (en) 2022-11-22
JP2019022518A (ja) 2019-02-14
IL244525A0 (en) 2016-04-21
WO2015057758A1 (en) 2015-04-23
AU2014337526B2 (en) 2020-09-10
CA2926090A1 (en) 2015-04-23
PL2908626T3 (pl) 2017-05-31
RS58465B1 (sr) 2019-04-30
EP3138397B1 (en) 2018-12-26
PT2908626T (pt) 2017-01-09
RU2016116847A3 (es) 2018-06-07
US20230189772A1 (en) 2023-06-22
CN105744829A (zh) 2016-07-06
CN109090037B (zh) 2021-05-28
US10561125B2 (en) 2020-02-18
NZ718655A (en) 2022-08-26
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
EP2908626A1 (en) 2015-08-26
US9155290B2 (en) 2015-10-13
US20150366175A1 (en) 2015-12-24
CY1121405T1 (el) 2020-05-29
ZA201601676B (en) 2019-12-18
SI3138397T1 (sl) 2019-04-30
CA2926090C (en) 2022-07-05
HUE033272T2 (en) 2017-11-28
HRP20190542T1 (hr) 2019-07-26
EP3138397A1 (en) 2017-03-08
IL244525B (en) 2019-10-31
LT2908626T (lt) 2017-01-25
EP2908626B1 (en) 2016-12-07
SI2908626T1 (sl) 2017-02-28
PT3138397T (pt) 2019-03-26
HRP20170380T1 (hr) 2017-05-19
RS55472B1 (sr) 2017-04-28
DK2908626T3 (en) 2017-03-20
CY1118675T1 (el) 2018-03-07
SG11201601828XA (en) 2016-04-28
ES2715949T3 (es) 2019-06-07
PL3138397T3 (pl) 2019-06-28
JP6600061B2 (ja) 2019-10-30
KR102376041B1 (ko) 2022-03-18
AU2020286186B2 (en) 2024-05-23
US20150106961A1 (en) 2015-04-16
AU2020286186A1 (en) 2021-01-07
CN109090037A (zh) 2018-12-28
US20200178508A1 (en) 2020-06-11
LT3138397T (lt) 2019-04-10
BR112016008175A2 (pt) 2017-10-03
CN105744829B (zh) 2018-08-07
EP3461331A1 (en) 2019-04-03
JP6492095B2 (ja) 2019-03-27
US20180116192A1 (en) 2018-05-03
RU2674910C2 (ru) 2018-12-13
JP2016533192A (ja) 2016-10-27
TR201904342T4 (tr) 2019-05-21
SMT201700024B (it) 2017-03-08

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