HK1210659A1 - Humanized il-15 animals il-15 - Google Patents

Humanized il-15 animals il-15

Info

Publication number
HK1210659A1
HK1210659A1 HK15111500.3A HK15111500A HK1210659A1 HK 1210659 A1 HK1210659 A1 HK 1210659A1 HK 15111500 A HK15111500 A HK 15111500A HK 1210659 A1 HK1210659 A1 HK 1210659A1
Authority
HK
Hong Kong
Prior art keywords
humanized
animals
Prior art date
Application number
HK15111500.3A
Other languages
English (en)
Chinese (zh)
Inventor
Jose F Rojas
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1210659A1 publication Critical patent/HK1210659A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK15111500.3A 2013-10-15 2015-11-20 Humanized il-15 animals il-15 HK1210659A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Publications (1)

Publication Number Publication Date
HK1210659A1 true HK1210659A1 (en) 2016-05-06

Family

ID=51830649

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111500.3A HK1210659A1 (en) 2013-10-15 2015-11-20 Humanized il-15 animals il-15

Country Status (28)

Country Link
US (5) US9155290B2 (es)
EP (3) EP2908626B1 (es)
JP (3) JP6492095B2 (es)
KR (1) KR102376041B1 (es)
CN (2) CN105744829B (es)
AU (2) AU2014337526B2 (es)
BR (1) BR112016008175A2 (es)
CA (1) CA2926090C (es)
CY (2) CY1118675T1 (es)
DK (2) DK3138397T3 (es)
ES (2) ES2613379T3 (es)
HK (1) HK1210659A1 (es)
HR (2) HRP20170380T1 (es)
HU (2) HUE043969T2 (es)
IL (2) IL244525B (es)
LT (2) LT3138397T (es)
MX (1) MX2016004781A (es)
NZ (1) NZ718655A (es)
PL (2) PL3138397T3 (es)
PT (2) PT3138397T (es)
RS (2) RS55472B1 (es)
RU (1) RU2674910C2 (es)
SG (2) SG10201607768YA (es)
SI (2) SI3138397T1 (es)
SM (1) SMT201700024B (es)
TR (1) TR201904342T4 (es)
WO (1) WO2015057758A1 (es)
ZA (1) ZA201601676B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010303737B2 (en) 2009-10-06 2014-05-29 Institute For Research In Biomedicine (Irb) Genetically modified mice and engraftment
PT2675271T (pt) 2011-02-15 2018-10-11 Univ Yale Ratinhos humanizados para m-csf
RU2768282C2 (ru) 2012-09-07 2022-03-23 Йель Юниверсити Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования
DK3939423T3 (da) 2012-11-05 2024-05-06 Regeneron Pharma Genetisk modificerede ikke-humane dyr og fremgangsmåder til anvendelse deraf
KR102376041B1 (ko) 2013-10-15 2022-03-18 리제너론 파마슈티칼스 인코포레이티드 인간화된 il-15 동물
AU2015256299C1 (en) 2014-05-05 2022-01-06 Regeneron Pharmaceuticals, Inc. Humanized C5 and C3 animals
NO2785538T3 (es) 2014-05-07 2018-08-04
RU2711744C1 (ru) 2014-05-19 2020-01-21 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные животные, отличные от человека, экспрессирующие epo человека
FI3850946T3 (fi) 2014-12-05 2023-12-28 Regeneron Pharma Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
RU2020124128A (ru) 2015-04-13 2020-09-22 Ридженерон Фармасьютикалз, Инк. Гуманизированные мыши с нокином sirpa-il15 и способы их использования
EP3411392B1 (en) 2016-02-04 2021-12-29 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
EP3476865B1 (en) 2016-06-28 2023-09-13 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Method for constructing pd-1 gene-modified humanized animal model and use thereof
WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
US11317611B2 (en) 2016-08-31 2022-05-03 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric PD-L1
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN107815467B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018086594A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tim-3
CN108070613B (zh) 2016-11-11 2020-03-13 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108239659B (zh) 2016-12-23 2020-03-03 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN108467873B (zh) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN108588126B (zh) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
CN109136274B (zh) 2017-06-19 2021-04-23 百奥赛图江苏基因生物技术有限公司 人源化cd40基因改造动物模型的制备方法及应用
CN109136275B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化gitr基因改造动物模型的制备方法及应用
CN109136261B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化cd28基因改造动物模型的制备方法及应用
US20200236916A1 (en) * 2017-08-09 2020-07-30 The Jackson Laboratory Immunodeficient mice expressing human interleukin 15
WO2019072241A1 (en) 2017-10-13 2019-04-18 Beijing Biocytogen Co., Ltd NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
CN109913493B (zh) 2017-12-12 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化cd3基因改造动物模型的制备方法及应用
KR20210031868A (ko) 2018-07-16 2021-03-23 리제너론 파마슈티칼스 인코포레이티드 Ditra 질환의 비인간 동물 모델 및 이의 용도
CN111057721B (zh) 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
WO2020125763A1 (en) 2018-12-20 2020-06-25 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric lag3
CN111304248B (zh) 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
CN114107385A (zh) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
WO2020206139A1 (en) 2019-04-04 2020-10-08 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized coagulation factor 12 locus
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ttr遺伝子座を含む非ヒト動物と使用方法
BR112021022722A2 (pt) 2019-06-07 2022-01-04 Regeneron Pharma Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
AU2021212668A1 (en) * 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术(上海)有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
CN112481303B (zh) * 2021-02-09 2021-05-25 百奥赛图(北京)医药科技股份有限公司 Il15ra基因人源化非人动物及其构建方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001239750A1 (en) 2000-02-08 2001-08-20 Genaissance Pharmaceuticals, Inc. Haplotypes of the interleukin 15 gene
US7759541B2 (en) * 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
PL1899364T3 (pl) * 2005-05-17 2020-08-24 University Of Connecticut Kompozycje i sposoby immunomodulacji w organizmie
EP3456190B1 (en) * 2008-06-27 2021-11-24 Merus N.V. Antibody producing transgenic murine animal
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
AU2010303737B2 (en) 2009-10-06 2014-05-29 Institute For Research In Biomedicine (Irb) Genetically modified mice and engraftment
AU2010339863B2 (en) * 2009-12-21 2014-07-17 Regeneron Pharmaceuticals, Inc. Humanized FcyR mice
PT2675271T (pt) 2011-02-15 2018-10-11 Univ Yale Ratinhos humanizados para m-csf
KR101926442B1 (ko) * 2011-10-28 2018-12-12 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체 (mhc) ii 분자들을 발현하는 유전자 변형된 마우스
EP4311833A3 (en) 2011-10-28 2024-05-01 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
US9043996B2 (en) * 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
EP2818478B1 (en) 2011-10-28 2017-02-01 Regeneron Pharmaceuticals, Inc. Humanized IL-6 and IL-6 receptor
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
RU2768282C2 (ru) 2012-09-07 2022-03-23 Йель Юниверсити Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования
DK3939423T3 (da) 2012-11-05 2024-05-06 Regeneron Pharma Genetisk modificerede ikke-humane dyr og fremgangsmåder til anvendelse deraf
SI2958937T1 (sl) 2013-02-22 2018-12-31 Regeneron Pharmaceuticals, Inc. Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks
IL297607B2 (en) 2013-09-23 2024-01-01 Regeneron Pharma Non-human animals with a humanized gene for SIGNAL-REGULATORY PROTEIN
KR102376041B1 (ko) 2013-10-15 2022-03-18 리제너론 파마슈티칼스 인코포레이티드 인간화된 il-15 동물

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US20150366175A1 (en) 2015-12-24
HRP20190542T1 (hr) 2019-07-26
AU2020286186B2 (en) 2024-05-23
EP3138397B1 (en) 2018-12-26
PL3138397T3 (pl) 2019-06-28
IL244525B (en) 2019-10-31
KR20160068774A (ko) 2016-06-15
RU2016116847A3 (es) 2018-06-07
RS58465B1 (sr) 2019-04-30
CN105744829B (zh) 2018-08-07
IL269907B (en) 2020-09-30
SG10201607768YA (en) 2016-11-29
LT3138397T (lt) 2019-04-10
AU2014337526A1 (en) 2016-04-28
JP2019216750A (ja) 2019-12-26
CN109090037B (zh) 2021-05-28
KR102376041B1 (ko) 2022-03-18
DK3138397T3 (en) 2019-04-15
IL244525A0 (en) 2016-04-21
AU2014337526B2 (en) 2020-09-10
US20150106961A1 (en) 2015-04-16
SI3138397T1 (sl) 2019-04-30
CA2926090C (en) 2022-07-05
US20200178508A1 (en) 2020-06-11
HRP20170380T1 (hr) 2017-05-19
BR112016008175A2 (pt) 2017-10-03
JP2019022518A (ja) 2019-02-14
EP3461331A1 (en) 2019-04-03
US10561125B2 (en) 2020-02-18
TR201904342T4 (tr) 2019-05-21
ZA201601676B (en) 2019-12-18
SI2908626T1 (sl) 2017-02-28
EP2908626B1 (en) 2016-12-07
SG11201601828XA (en) 2016-04-28
LT2908626T (lt) 2017-01-25
HUE033272T2 (en) 2017-11-28
US9155290B2 (en) 2015-10-13
CN105744829A (zh) 2016-07-06
DK2908626T3 (en) 2017-03-20
RS55472B1 (sr) 2017-04-28
EP3138397A1 (en) 2017-03-08
EP2908626A1 (en) 2015-08-26
NZ718655A (en) 2022-08-26
PL2908626T3 (pl) 2017-05-31
CY1118675T1 (el) 2018-03-07
CY1121405T1 (el) 2020-05-29
HUE043969T2 (hu) 2019-09-30
CA2926090A1 (en) 2015-04-23
PT2908626T (pt) 2017-01-09
ES2715949T3 (es) 2019-06-07
RU2674910C2 (ru) 2018-12-13
US11503813B2 (en) 2022-11-22
AU2020286186A1 (en) 2021-01-07
JP6492095B2 (ja) 2019-03-27
WO2015057758A1 (en) 2015-04-23
JP2016533192A (ja) 2016-10-27
CN109090037A (zh) 2018-12-28
US20180116192A1 (en) 2018-05-03
JP6600061B2 (ja) 2019-10-30
PT3138397T (pt) 2019-03-26
SMT201700024B (it) 2017-03-08
MX2016004781A (es) 2016-07-26
US20230189772A1 (en) 2023-06-22
ES2613379T3 (es) 2017-05-24
RU2016116847A (ru) 2017-11-21

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