SE9303657D0 - Short-acting dihydropyridines - Google Patents

Short-acting dihydropyridines

Info

Publication number
SE9303657D0
SE9303657D0 SE9303657A SE9303657A SE9303657D0 SE 9303657 D0 SE9303657 D0 SE 9303657D0 SE 9303657 A SE9303657 A SE 9303657A SE 9303657 A SE9303657 A SE 9303657A SE 9303657 D0 SE9303657 D0 SE 9303657D0
Authority
SE
Sweden
Prior art keywords
hydrogen
pct
chloro
methyl
nitro
Prior art date
Application number
SE9303657A
Other languages
English (en)
Swedish (sv)
Inventor
Kjell Hjalmar Andersson
Margareta Nordlander
Rolf Christer Westerlund
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9303657A priority Critical patent/SE9303657D0/xx
Publication of SE9303657D0 publication Critical patent/SE9303657D0/xx
Priority to ZA947570A priority patent/ZA947570B/xx
Priority to TW083108995A priority patent/TW279859B/zh
Priority to IS4218A priority patent/IS1674B/is
Priority to IL11112794A priority patent/IL111127A/xx
Priority to SA94150250A priority patent/SA94150250B1/ar
Priority to EG68994A priority patent/EG20539A/xx
Priority to DE69425152T priority patent/DE69425152T2/de
Priority to PL94314128A priority patent/PL185099B1/pl
Priority to CZ961273A priority patent/CZ285691B6/cs
Priority to CN94194500A priority patent/CN1049428C/zh
Priority to HU9601187A priority patent/HU215591B/hu
Priority to PT95900347T priority patent/PT726894E/pt
Priority to ES95900347T priority patent/ES2150544T3/es
Priority to EE9600051A priority patent/EE03230B1/xx
Priority to AU81196/94A priority patent/AU685532B2/en
Priority to AT95900347T priority patent/ATE194330T1/de
Priority to DK95900347T priority patent/DK0726894T3/da
Priority to NZ275915A priority patent/NZ275915A/en
Priority to JP51317095A priority patent/JP3712209B2/ja
Priority to CA002174969A priority patent/CA2174969C/en
Priority to SK559-96A priority patent/SK281467B6/sk
Priority to BR9407946A priority patent/BR9407946A/pt
Priority to KR1019960702346A priority patent/KR100331663B1/ko
Priority to US08/356,224 priority patent/US5856346A/en
Priority to PCT/SE1994/001031 priority patent/WO1995012578A1/en
Priority to RU96112152A priority patent/RU2139278C1/ru
Priority to EP95900347A priority patent/EP0726894B1/en
Priority to UA96041753A priority patent/UA45959C2/uk
Priority to MYPI94002934A priority patent/MY111770A/en
Priority to NO961776A priority patent/NO305656B1/no
Priority to FI961914A priority patent/FI110429B/fi
Priority to HK98114638A priority patent/HK1013292A1/xx
Priority to GR20000402158T priority patent/GR3034469T3/el
Priority to FR12C0053C priority patent/FR12C0053I2/fr
Priority to LU92209C priority patent/LU92209I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
SE9303657A 1993-11-05 1993-11-05 Short-acting dihydropyridines SE9303657D0 (sv)

Priority Applications (36)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
ZA947570A ZA947570B (en) 1993-11-05 1994-09-28 Short-acting dihydropyridines
TW083108995A TW279859B (ar) 1993-11-05 1994-09-29
IS4218A IS1674B (is) 1993-11-05 1994-09-30 Hliðstæð aðferð við að framleiða skammvirk tvíhýdrópýridín
IL11112794A IL111127A (en) 1993-11-05 1994-10-03 Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them
SA94150250A SA94150250B1 (ar) 1993-11-05 1994-10-19 دايهيدرو بيريدين dihydropyridine قصير المفعول
EG68994A EG20539A (en) 1993-11-05 1994-11-02 Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure
UA96041753A UA45959C2 (uk) 1993-11-05 1994-11-03 Дигідропіридини, спосіб їх одержання, фармацевтична композиція для зниження кров'яного тиску та спосіб зниження кров'яного тиску у ссавців
AT95900347T ATE194330T1 (de) 1993-11-05 1994-11-03 Dihydropyridine mit kurzer wirkung
BR9407946A BR9407946A (pt) 1993-11-05 1994-11-03 Composto processo para sua preparaçao preparaçao farmacêutica contendo o mesmo uso do mesmo e processo e preparaçao farmacêutica para abaixamento da press o sanguínea em mamíferos
CZ961273A CZ285691B6 (cs) 1993-11-05 1994-11-03 Krátce působící dihydropyridiny
CN94194500A CN1049428C (zh) 1993-11-05 1994-11-03 短效的二氢吡啶类化合物及其制备方法和用途
HU9601187A HU215591B (hu) 1993-11-05 1994-11-03 Rövid hatástartamú dihidropiridinszármazékok, eljárás előállításukra, és a vegyületeket tartalmazó gyógyászati készítmények
PT95900347T PT726894E (pt) 1993-11-05 1994-11-03 Di-hidropiridinas de curta actividade
ES95900347T ES2150544T3 (es) 1993-11-05 1994-11-03 Dihidropiridinas de accion breve.
EE9600051A EE03230B1 (et) 1993-11-05 1994-11-03 Kiiretoimelised dihüdropüridiinid, nende valmistamise protsessid ja neid sisaldavad ravimvormid
AU81196/94A AU685532B2 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
DE69425152T DE69425152T2 (de) 1993-11-05 1994-11-03 Dihydropyridine mit kurzer wirkung
DK95900347T DK0726894T3 (da) 1993-11-05 1994-11-03 Kortvarigt virkende dihydropyridiner
NZ275915A NZ275915A (en) 1993-11-05 1994-11-03 4-phenyl substituted dihydropyridine 3,5-dicarboxylic acid ester derivatives and medicaments
JP51317095A JP3712209B2 (ja) 1993-11-05 1994-11-03 短時間作用型ジヒドロピリジン類
CA002174969A CA2174969C (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
SK559-96A SK281467B6 (sk) 1993-11-05 1994-11-03 Krátko pôsobiace dihydropyridíny, spôsoby ich prípravy, farmaceutické prípravky s ich obsahom a ich použitie
PL94314128A PL185099B1 (pl) 1993-11-05 1994-11-03 Dihydropirydyny o krótkim działaniu oraz sposób ich wytwarzania
KR1019960702346A KR100331663B1 (ko) 1993-11-05 1994-11-03 단시간작용형디히드로피리딘
US08/356,224 US5856346A (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
PCT/SE1994/001031 WO1995012578A1 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
RU96112152A RU2139278C1 (ru) 1993-11-05 1994-11-03 Дигидропиридины, способ их получения, фармацевтическая композиция на их основе и способ снижения кровяного давления
EP95900347A EP0726894B1 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
MYPI94002934A MY111770A (en) 1993-11-05 1994-11-04 Short-acting dihydropyridines
NO961776A NO305656B1 (no) 1993-11-05 1996-05-02 Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene
FI961914A FI110429B (fi) 1993-11-05 1996-05-06 Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi
HK98114638A HK1013292A1 (en) 1993-11-05 1998-12-22 Short-acting dihydropyridines
GR20000402158T GR3034469T3 (en) 1993-11-05 2000-09-21 Short-acting dihydropyridines
FR12C0053C FR12C0053I2 (fr) 1993-11-05 2012-09-18 Dihydropyridines a activite courte
LU92209C LU92209I2 (fr) 1993-11-05 2013-06-10 Clevidipine sous toutes les formes procurant une protection à partir du brevet de base

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines

Publications (1)

Publication Number Publication Date
SE9303657D0 true SE9303657D0 (sv) 1993-11-05

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines

Country Status (36)

Country Link
US (1) US5856346A (ar)
EP (1) EP0726894B1 (ar)
JP (1) JP3712209B2 (ar)
KR (1) KR100331663B1 (ar)
CN (1) CN1049428C (ar)
AT (1) ATE194330T1 (ar)
AU (1) AU685532B2 (ar)
BR (1) BR9407946A (ar)
CA (1) CA2174969C (ar)
CZ (1) CZ285691B6 (ar)
DE (1) DE69425152T2 (ar)
DK (1) DK0726894T3 (ar)
EE (1) EE03230B1 (ar)
EG (1) EG20539A (ar)
ES (1) ES2150544T3 (ar)
FI (1) FI110429B (ar)
FR (1) FR12C0053I2 (ar)
GR (1) GR3034469T3 (ar)
HK (1) HK1013292A1 (ar)
HU (1) HU215591B (ar)
IL (1) IL111127A (ar)
IS (1) IS1674B (ar)
LU (1) LU92209I2 (ar)
MY (1) MY111770A (ar)
NO (1) NO305656B1 (ar)
NZ (1) NZ275915A (ar)
PL (1) PL185099B1 (ar)
PT (1) PT726894E (ar)
RU (1) RU2139278C1 (ar)
SA (1) SA94150250B1 (ar)
SE (1) SE9303657D0 (ar)
SK (1) SK281467B6 (ar)
TW (1) TW279859B (ar)
UA (1) UA45959C2 (ar)
WO (1) WO1995012578A1 (ar)
ZA (1) ZA947570B (ar)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
JP4580649B2 (ja) * 2001-12-21 2010-11-17 アルコン、インコーポレイテッド ナノ粒子を殺生物剤の担体として眼科用組成物に使用する方法
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
JP5674660B2 (ja) * 2008-08-01 2015-02-25 ザ メディシンズ カンパニー 医薬組成物および不純物の濃度が低い医薬組成物の製造方法
KR20120100945A (ko) * 2009-09-30 2012-09-12 마이크로도스 테라퓨특스, 인코포레이티드 레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2386544B1 (en) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
EA022849B1 (ru) 2010-10-12 2016-03-31 Дзе Медсинз Компани Эмульсионные композиции клевидипина, содержащие противомикробные агенты
RU2623039C2 (ru) * 2011-04-01 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
EP2747757A1 (en) 2011-08-26 2014-07-02 Wockhardt Limited Methods for treating cardiovascular disorders
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
PL2925128T3 (pl) 2012-10-26 2018-10-31 Chiesi Farmaceutici S.P.A. Sposoby kontrolowania ciśnienia krwi i zmniejszania duszności w niewydolności serca
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
CA2947486C (en) 2014-05-19 2023-09-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
RU2707298C2 (ru) 2015-05-20 2019-11-26 Мериал, Инк. Противогельминтные депсипептидные соединения
RU2715556C2 (ru) 2015-12-28 2020-03-02 Мериал, Инк. Противогельминтные депсипептидные соединения
JP2020504710A (ja) 2016-11-16 2020-02-13 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

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DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
JP3712209B2 (ja) 2005-11-02
WO1995012578A1 (en) 1995-05-11
SA94150250B1 (ar) 2006-03-01
MY111770A (en) 2000-12-30
PL185099B1 (pl) 2003-02-28
RU2139278C1 (ru) 1999-10-10
SK55996A3 (en) 1996-12-04
PT726894E (pt) 2000-10-31
NZ275915A (en) 1997-04-24
ATE194330T1 (de) 2000-07-15
DE69425152T2 (de) 2001-03-22
IL111127A0 (en) 1994-12-29
CZ127396A3 (en) 1996-09-11
IS4218A (is) 1995-05-06
CN1049428C (zh) 2000-02-16
CA2174969A1 (en) 1995-05-11
FI110429B (fi) 2003-01-31
CN1137269A (zh) 1996-12-04
GR3034469T3 (en) 2000-12-29
FR12C0053I1 (ar) 2012-02-11
HUT75316A (en) 1997-05-28
CA2174969C (en) 2005-05-17
EP0726894B1 (en) 2000-07-05
NO961776L (no) 1996-05-02
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
HK1013292A1 (en) 1999-08-20
ES2150544T3 (es) 2000-12-01
BR9407946A (pt) 1996-11-26
NO305656B1 (no) 1999-07-05
EP0726894A1 (en) 1996-08-21
KR100331663B1 (ko) 2002-09-26
CZ285691B6 (cs) 1999-10-13
UA45959C2 (uk) 2002-05-15
FR12C0053I2 (fr) 2013-08-16
HU215591B (hu) 1999-01-28
LU92209I2 (fr) 2013-08-23
TW279859B (ar) 1996-07-01
IL111127A (en) 2000-11-21
NO961776D0 (no) 1996-05-02
EG20539A (en) 1999-07-31
ZA947570B (en) 1995-05-29
FI961914A0 (fi) 1996-05-06
HU9601187D0 (en) 1996-07-29
DE69425152D1 (de) 2000-08-10
US5856346A (en) 1999-01-05
DK0726894T3 (da) 2000-10-23
EE03230B1 (et) 1999-10-15
PL314128A1 (en) 1996-08-19
AU685532B2 (en) 1998-01-22
IS1674B (is) 1997-12-31
FI961914A (fi) 1996-05-06
AU8119694A (en) 1995-05-23

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