SE464059C - Användning av inositoltrifosfat för framställning av läkemedel - Google Patents
Användning av inositoltrifosfat för framställning av läkemedelInfo
- Publication number
- SE464059C SE464059C SE8803248A SE8803248A SE464059C SE 464059 C SE464059 C SE 464059C SE 8803248 A SE8803248 A SE 8803248A SE 8803248 A SE8803248 A SE 8803248A SE 464059 C SE464059 C SE 464059C
- Authority
- SE
- Sweden
- Prior art keywords
- inositol
- phosphate
- hydrogen
- triphosphate
- hydroxyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 title claims description 22
- 229940079593 drug Drugs 0.000 title description 14
- 238000002360 preparation method Methods 0.000 title description 5
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 20
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 11
- 229960000367 inositol Drugs 0.000 claims description 11
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 10
- GKDKOMAJZATYAY-GCVPSNMTSA-N [(1r,2s,4r,5r)-2,3,4-trihydroxy-5,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1O GKDKOMAJZATYAY-GCVPSNMTSA-N 0.000 claims description 8
- 150000003839 salts Chemical group 0.000 claims description 8
- 230000000740 bleeding effect Effects 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000001226 triphosphate Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims 1
- MMWCIQZXVOZEGG-XJTPDSDZSA-N D-myo-Inositol 1,4,5-trisphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O MMWCIQZXVOZEGG-XJTPDSDZSA-N 0.000 abstract description 32
- MMWCIQZXVOZEGG-UHFFFAOYSA-N 1,4,5-IP3 Natural products OC1C(O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(O)C1OP(O)(O)=O MMWCIQZXVOZEGG-UHFFFAOYSA-N 0.000 abstract 2
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 description 50
- 235000021317 phosphate Nutrition 0.000 description 50
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 47
- 239000010452 phosphate Substances 0.000 description 47
- 229910052739 hydrogen Inorganic materials 0.000 description 45
- 239000001257 hydrogen Substances 0.000 description 45
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 44
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 31
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 11
- 229910052698 phosphorus Inorganic materials 0.000 description 11
- 239000011574 phosphorus Substances 0.000 description 11
- -1 R 1 Chemical compound 0.000 description 10
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 10
- 230000007062 hydrolysis Effects 0.000 description 9
- 238000006460 hydrolysis reaction Methods 0.000 description 9
- 239000007858 starting material Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 108010011619 6-Phytase Proteins 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 5
- CDAISMWEOUEBRE-NIPYSYMMSA-N epi-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)[C@H]1O CDAISMWEOUEBRE-NIPYSYMMSA-N 0.000 description 5
- 238000005342 ion exchange Methods 0.000 description 5
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229930014626 natural product Natural products 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 3
- 229960001948 caffeine Drugs 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 229940126601 medicinal product Drugs 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229940085127 phytase Drugs 0.000 description 3
- 229940068041 phytic acid Drugs 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000007974 sodium acetate buffer Substances 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003729 cation exchange resin Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 229920000137 polyphosphoric acid Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 229940083982 sodium phytate Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 235000011178 triphosphate Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
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- 239000013566 allergen Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002050 anti-rickettsial effect Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
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- 150000001768 cations Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- CDAISMWEOUEBRE-JMVOWJSSSA-N cis-inositol Chemical compound O[C@@H]1[C@H](O)[C@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-JMVOWJSSSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
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- 230000030609 dephosphorylation Effects 0.000 description 1
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- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
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- 238000011534 incubation Methods 0.000 description 1
- 230000037041 intracellular level Effects 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229910052747 lanthanoid Inorganic materials 0.000 description 1
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- 159000000003 magnesium salts Chemical class 0.000 description 1
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- 230000002906 microbiologic effect Effects 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- CDAISMWEOUEBRE-GNIYUCBRSA-N muco-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H]1O CDAISMWEOUEBRE-GNIYUCBRSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (36)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8803248A SE464059C (sv) | 1988-09-15 | 1988-09-15 | Användning av inositoltrifosfat för framställning av läkemedel |
| AT89117028T ATE84719T1 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat bei der behandlung der beschaedigung von gewebe. |
| DE8989117028T DE68904507T2 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat bei der behandlung der beschaedigung von gewebe. |
| AT89117029T ATE120958T1 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat zur herstellung eines arzneimittels gegen diabetes. |
| AT89117032T ATE88347T1 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat zur herstellung eines arzneimittels gegen abnorme konzentrationen von lipoproteinen. |
| DE68914922T DE68914922T2 (de) | 1988-09-15 | 1989-09-14 | Verwendung von Inositoltrisphosphat zur Herstellung eines Arzneimittels gegen Knochenerkrakungen. |
| EP89117030A EP0359258B1 (en) | 1988-09-15 | 1989-09-14 | The use of inositoltrisphosphate for the preparing of a medicament against bone disorders |
| JP1237429A JP2859318B2 (ja) | 1988-09-15 | 1989-09-14 | イノシトールトリホスフェートを含有する骨疾患に対する医薬 |
| ES89117029T ES2073419T3 (es) | 1988-09-15 | 1989-09-14 | Uso de inositatrifosfato en la preparacion de un medicamento contra la diabetes. |
| EP89117028A EP0359256B1 (en) | 1988-09-15 | 1989-09-14 | The use of inositoltrisphosphate in the treatment of tissue damage |
| ES89117031T ES2043998T3 (es) | 1988-09-15 | 1989-09-14 | El uso de inositoltrisfosfato para la preparacion de un medicamento contra los trastornos relacionados con trasplantes. |
| AT8989117030T ATE104855T1 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltrisphosphat zur herstellung eines arzneimittels gegen knochenerkrakungen. |
| JP1237428A JPH02191218A (ja) | 1988-09-15 | 1989-09-14 | イノシトールトリホスフェートを含有する糖尿病の合併症に対する医薬 |
| EP89117029A EP0359257B1 (en) | 1988-09-15 | 1989-09-14 | Use of inositol triphosphate in the preparation of a medicament against diabetes |
| DE89117032T DE68906106T2 (de) | 1988-09-15 | 1989-09-14 | Verwendung von Inositoltriphosphat zur Herstellung eines Arzneimittels gegen abnorme Konzentrationen von Lipoproteinen. |
| EP89117031A EP0359259B1 (en) | 1988-09-15 | 1989-09-14 | The use of inositoltrisphosphate for the preparing of a medicament against transplantation disorders |
| GB8920806A GB2223169B (en) | 1988-09-15 | 1989-09-14 | Inositol trisphosphate for the treatment of bone disorders |
| JP1237427A JP2547257B2 (ja) | 1988-09-15 | 1989-09-14 | イノシトールトリホスフェートを含有する組織の損傷に対する医薬 |
| AT89117031T ATE79542T1 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat zur herstellung eines arzneimittels gegen stoerungen bei transplantationen. |
| GB8920805A GB2223168B (en) | 1988-09-15 | 1989-09-14 | Pharmaceutical composition comprising inositoltrisphosphate for the treatment of complications of diabetes |
| DE8989117031T DE68902526T2 (de) | 1988-09-15 | 1989-09-14 | Verwendung von inositoltriphosphat zur herstellung eines arzneimittels gegen stoerungen bei transplantationen. |
| JP1237430A JP2859319B2 (ja) | 1988-09-15 | 1989-09-14 | イノシトールトリホスフェートを含有する移植に関する障害に対する医薬 |
| GB8920804A GB2223167B (en) | 1988-09-15 | 1989-09-14 | Inositoltrisphosphate for the treatment of tissue damage |
| ES89117030T ES2055772T3 (es) | 1988-09-15 | 1989-09-14 | Uso del inositoltrisfosfato para la preparacion de un medicamento frente a alteraciones oseas. |
| ES89117032T ES2054965T3 (es) | 1988-09-15 | 1989-09-14 | El uso de un isomero de trifosfato de inositol para la preparacion de un medicamento contra niveles anormales de lipoproteinas en mamiferos. |
| DE68922165T DE68922165T2 (de) | 1988-09-15 | 1989-09-14 | Verwendung von Inositoltriphosphat zur Herstellung eines Arzneimittels gegen Diabetes. |
| EP89117032A EP0359260B1 (en) | 1988-09-15 | 1989-09-14 | The use of inositoltrisphosphate for the preparing of a medicament against abnormal levels of lipoproteins |
| ES89117028T ES2045319T3 (es) | 1988-09-15 | 1989-09-14 | El uso del trifosfato de inosita en el tratamiento de da\os de tejido. |
| JP1237431A JP3058334B2 (ja) | 1988-09-15 | 1989-09-14 | イノシトールトリホスフェートを含有するリポ蛋白質の異常レベルに対する医薬 |
| GB8920807A GB2223403B (en) | 1988-09-15 | 1989-09-14 | Inositoltrisphosphate for the treatment of disorders related to transplantation |
| GB8920811A GB2223404B (en) | 1988-09-15 | 1989-09-14 | Inositoltrisphosphate for the treatment of abnormal levels of lipoproteins |
| SE9003395A SE9003395L (sv) | 1988-09-15 | 1990-10-24 | Anvaendning av inositoltrifosfat foer framstaellning av laekemedel |
| GR920400982T GR3005448T3 (el) | 1988-09-15 | 1992-08-20 | |
| GR920402459T GR3006825T3 (el) | 1988-09-15 | 1993-01-21 | |
| GR930400188T GR3007686T3 (el) | 1988-09-15 | 1993-04-22 | |
| GR940403975T GR3015764T3 (en) | 1988-09-15 | 1995-04-13 | Use of inositol triphosphate in the preparation of a medicament against diabetes. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8803248A SE464059C (sv) | 1988-09-15 | 1988-09-15 | Användning av inositoltrifosfat för framställning av läkemedel |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| SE8803248D0 SE8803248D0 (sv) | 1988-09-15 |
| SE8803248L SE8803248L (sv) | 1990-03-16 |
| SE464059B SE464059B (sv) | 1991-03-04 |
| SE464059C true SE464059C (sv) | 1997-06-02 |
Family
ID=20373330
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8803248A SE464059C (sv) | 1988-09-15 | 1988-09-15 | Användning av inositoltrifosfat för framställning av läkemedel |
| SE9003395A SE9003395L (sv) | 1988-09-15 | 1990-10-24 | Anvaendning av inositoltrifosfat foer framstaellning av laekemedel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9003395A SE9003395L (sv) | 1988-09-15 | 1990-10-24 | Anvaendning av inositoltrifosfat foer framstaellning av laekemedel |
Country Status (8)
| Country | Link |
|---|---|
| EP (5) | EP0359256B1 (el) |
| JP (5) | JP2547257B2 (el) |
| AT (5) | ATE120958T1 (el) |
| DE (5) | DE68914922T2 (el) |
| ES (5) | ES2073419T3 (el) |
| GB (5) | GB2223167B (el) |
| GR (4) | GR3005448T3 (el) |
| SE (2) | SE464059C (el) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5330979A (en) * | 1984-10-23 | 1994-07-19 | Perstorp Ab | Method of treating renal disorders with inositoltriphosphate |
| US5428066A (en) * | 1989-03-08 | 1995-06-27 | Larner; Joseph | Method of reducing elevated blood sugar in humans |
| US5750348A (en) * | 1989-03-08 | 1998-05-12 | The University Of Virginia Patents Foundation | Method for detecting insulin resistance |
| US5427956A (en) * | 1989-03-08 | 1995-06-27 | The University Of Virginia Patent Foundation | Quantitative analysis for diabetic condition predictor |
| WO1990010439A1 (en) * | 1989-03-08 | 1990-09-20 | The University Of Virginia Alumni Patents Foundation | Dietary supplement for insulin-resistant diabetics |
| SE9002278L (sv) * | 1990-06-28 | 1991-12-29 | Perstorp Ab | Anvaendning av inositoltrisfosfat foer framstaellning av ett laekemedel |
| SE467340B (sv) * | 1990-07-04 | 1992-07-06 | Perstorp Ab | Anvaendning av inositolmonofosfat foer framstaellning av ett laekemedel effektivt som en neuropeptid y-(npy-)antagonist |
| JP2750239B2 (ja) * | 1991-08-14 | 1998-05-13 | 三共株式会社 | アデノホスチンａまたはｂならびにその製法 |
| SE503122C2 (sv) * | 1993-11-22 | 1996-03-25 | Perstorp Ab | Användning av en inositoltrisfosfatester för behandling av inflammatoriska tillstånd |
| SE9600194D0 (sv) * | 1996-01-19 | 1996-01-19 | Perstorp Ab | A new chemical compound |
| US5880098A (en) * | 1996-04-12 | 1999-03-09 | Pharmacia & Upjohn Aktiebolag | Therapeutic treatment |
| SE9601396D0 (sv) * | 1996-04-12 | 1996-04-12 | Dieter Haeussinger | New therapeutic treatment 2 |
| SE9602463D0 (sv) * | 1996-06-24 | 1996-06-24 | Perstorp Ab | The use of growth factor modulating compounds |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US5906979A (en) * | 1998-01-27 | 1999-05-25 | Insmed Pharmaceuticals, Inc. | Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility |
| US6486127B1 (en) | 2001-05-23 | 2002-11-26 | Insmed, Incorporated | Compositions comprising D-chiro inositol and lipid lowering compounds and methods of treatment thereof |
| KR100653557B1 (ko) * | 2001-10-06 | 2006-12-05 | 아미코젠주식회사 | 카이로 이노시톨 또는 피니톨의 백내장 예방치료제로서의용도와 그 조성물 |
| WO2019082335A1 (ja) * | 2017-10-26 | 2019-05-02 | 大塚製薬株式会社 | イノシトールリン酸含有組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735902A (en) * | 1984-10-23 | 1988-04-05 | Matti Siren | Stabilized composition containing inositoltriphosphate |
| SE465305B (sv) * | 1986-04-16 | 1991-08-26 | Perstorp Ab | Anvaendning av inositolfosfat foer framstaellning av ett laekemedel |
| SE465951B (sv) * | 1984-10-23 | 1991-11-25 | Perstorp Ab | Isomer av inositoltrifosfat foeretraedesvis i saltform foer anvaendning som terapeutiskt eller profylaktiskt medel samt kompositioner daerav |
-
1988
- 1988-09-15 SE SE8803248A patent/SE464059C/sv not_active IP Right Cessation
-
1989
- 1989-09-14 EP EP89117028A patent/EP0359256B1/en not_active Expired - Lifetime
- 1989-09-14 GB GB8920804A patent/GB2223167B/en not_active Expired - Lifetime
- 1989-09-14 AT AT89117029T patent/ATE120958T1/de not_active IP Right Cessation
- 1989-09-14 AT AT89117031T patent/ATE79542T1/de not_active IP Right Cessation
- 1989-09-14 DE DE68914922T patent/DE68914922T2/de not_active Expired - Fee Related
- 1989-09-14 JP JP1237427A patent/JP2547257B2/ja not_active Expired - Fee Related
- 1989-09-14 DE DE8989117028T patent/DE68904507T2/de not_active Expired - Fee Related
- 1989-09-14 ES ES89117029T patent/ES2073419T3/es not_active Expired - Lifetime
- 1989-09-14 AT AT8989117030T patent/ATE104855T1/de not_active IP Right Cessation
- 1989-09-14 GB GB8920811A patent/GB2223404B/en not_active Expired - Lifetime
- 1989-09-14 GB GB8920805A patent/GB2223168B/en not_active Expired - Lifetime
- 1989-09-14 ES ES89117031T patent/ES2043998T3/es not_active Expired - Lifetime
- 1989-09-14 ES ES89117030T patent/ES2055772T3/es not_active Expired - Lifetime
- 1989-09-14 ES ES89117028T patent/ES2045319T3/es not_active Expired - Lifetime
- 1989-09-14 JP JP1237430A patent/JP2859319B2/ja not_active Expired - Fee Related
- 1989-09-14 EP EP89117031A patent/EP0359259B1/en not_active Expired - Lifetime
- 1989-09-14 EP EP89117032A patent/EP0359260B1/en not_active Expired - Lifetime
- 1989-09-14 JP JP1237428A patent/JPH02191218A/ja active Pending
- 1989-09-14 AT AT89117032T patent/ATE88347T1/de not_active IP Right Cessation
- 1989-09-14 EP EP89117029A patent/EP0359257B1/en not_active Expired - Lifetime
- 1989-09-14 ES ES89117032T patent/ES2054965T3/es not_active Expired - Lifetime
- 1989-09-14 GB GB8920807A patent/GB2223403B/en not_active Expired - Lifetime
- 1989-09-14 DE DE89117032T patent/DE68906106T2/de not_active Expired - Fee Related
- 1989-09-14 DE DE68922165T patent/DE68922165T2/de not_active Expired - Fee Related
- 1989-09-14 DE DE8989117031T patent/DE68902526T2/de not_active Expired - Fee Related
- 1989-09-14 JP JP1237431A patent/JP3058334B2/ja not_active Expired - Lifetime
- 1989-09-14 JP JP1237429A patent/JP2859318B2/ja not_active Expired - Fee Related
- 1989-09-14 EP EP89117030A patent/EP0359258B1/en not_active Expired - Lifetime
- 1989-09-14 GB GB8920806A patent/GB2223169B/en not_active Expired - Lifetime
- 1989-09-14 AT AT89117028T patent/ATE84719T1/de not_active IP Right Cessation
-
1990
- 1990-10-24 SE SE9003395A patent/SE9003395L/ not_active Application Discontinuation
-
1992
- 1992-08-20 GR GR920400982T patent/GR3005448T3/el unknown
-
1993
- 1993-01-21 GR GR920402459T patent/GR3006825T3/el unknown
- 1993-04-22 GR GR930400188T patent/GR3007686T3/el unknown
-
1995
- 1995-04-13 GR GR940403975T patent/GR3015764T3/el unknown
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