SE437520B - Dibensocyklohepteniminer, forfarande for framstellning av dessa och farmaceutisk komposition - Google Patents

Dibensocyklohepteniminer, forfarande for framstellning av dessa och farmaceutisk komposition

Info

Publication number
SE437520B
SE437520B SE7809187A SE7809187A SE437520B SE 437520 B SE437520 B SE 437520B SE 7809187 A SE7809187 A SE 7809187A SE 7809187 A SE7809187 A SE 7809187A SE 437520 B SE437520 B SE 437520B
Authority
SE
Sweden
Prior art keywords
lower alkyl
alkyl
hydrogen
dibenzo
cycloalkyl
Prior art date
Application number
SE7809187A
Other languages
English (en)
Swedish (sv)
Other versions
SE7809187L (sv
Inventor
P S Anderson
M E Christy
B E Evans
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7809187L publication Critical patent/SE7809187L/xx
Publication of SE437520B publication Critical patent/SE437520B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE7809187A 1977-09-19 1978-08-31 Dibensocyklohepteniminer, forfarande for framstellning av dessa och farmaceutisk komposition SE437520B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (2)

Publication Number Publication Date
SE7809187L SE7809187L (sv) 1979-03-20
SE437520B true SE437520B (sv) 1985-03-04

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7809187A SE437520B (sv) 1977-09-19 1978-08-31 Dibensocyklohepteniminer, forfarande for framstellning av dessa och farmaceutisk komposition

Country Status (33)

Country Link
JP (1) JPS5463100A (ru)
AR (1) AR231544A1 (ru)
AT (1) AT370103B (ru)
AU (1) AU520178B2 (ru)
BE (1) BE870562A (ru)
CA (1) CA1129850A (ru)
CH (1) CH637954A5 (ru)
CY (1) CY1283A (ru)
DE (1) DE2840786A1 (ru)
DK (1) DK153843C (ru)
ES (7) ES473492A1 (ru)
FI (1) FI65618C (ru)
FR (1) FR2403334A1 (ru)
GB (2) GB2061947B (ru)
GR (1) GR65703B (ru)
HK (1) HK30885A (ru)
HU (1) HU180868B (ru)
IE (1) IE47355B1 (ru)
IL (1) IL55521A0 (ru)
IT (1) IT1113279B (ru)
KE (1) KE3501A (ru)
LU (1) LU80262A1 (ru)
NL (1) NL191488C (ru)
NO (1) NO151861C (ru)
NZ (1) NZ188361A (ru)
PH (1) PH15920A (ru)
PL (3) PL118478B1 (ru)
PT (1) PT68544A (ru)
SE (1) SE437520B (ru)
SG (1) SG9585G (ru)
SU (2) SU895288A3 (ru)
YU (1) YU41432B (ru)
ZA (1) ZA785291B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en) 2015-11-30 2020-03-10 INSERM (Institut National de la Santé et de la Recherche Médicale) NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
FI782680A (fi) 1979-03-20
IL55521A0 (en) 1978-12-17
GR65703B (en) 1980-10-22
AU3966878A (en) 1980-03-13
YU219678A (en) 1983-02-28
IE781866L (en) 1979-03-19
NZ188361A (en) 1982-06-29
ES483287A1 (es) 1980-04-16
YU41432B (en) 1987-06-30
HK30885A (en) 1985-04-26
PL121605B1 (en) 1982-05-31
NL7808847A (nl) 1979-03-21
SE7809187L (sv) 1979-03-20
NO151861C (no) 1985-06-19
PH15920A (en) 1983-04-22
ES483288A1 (es) 1980-04-16
GB2004872A (en) 1979-04-11
GB2061947B (en) 1982-08-04
SG9585G (en) 1985-08-08
FR2403334A1 (fr) 1979-04-13
DK389978A (da) 1979-03-20
IT1113279B (it) 1986-01-20
JPS5463100A (en) 1979-05-21
CA1129850A (en) 1982-08-17
ES473492A1 (es) 1980-07-16
PL118478B1 (en) 1981-10-31
FI65618C (fi) 1984-06-11
SU915800A3 (en) 1982-03-23
FR2403334B1 (ru) 1982-11-19
CH637954A5 (de) 1983-08-31
ES483283A1 (es) 1980-04-16
SU895288A3 (ru) 1981-12-30
ES483286A1 (es) 1980-04-16
ZA785291B (en) 1980-04-30
IT7851126A0 (it) 1978-09-18
NO783017L (no) 1979-03-20
CY1283A (en) 1985-07-05
ATA669778A (de) 1982-07-15
ES483285A1 (es) 1980-09-01
DE2840786A1 (de) 1979-03-22
LU80262A1 (fr) 1979-06-01
AU520178B2 (en) 1982-01-21
NL191488B (nl) 1995-04-03
KE3501A (en) 1985-02-22
GB2004872B (en) 1982-04-15
FI65618B (fi) 1984-02-29
DE2840786C2 (ru) 1987-05-21
IE47355B1 (en) 1984-02-22
DK153843C (da) 1989-01-23
ES483284A1 (es) 1980-09-01
PL209632A1 (pl) 1979-06-04
BE870562A (fr) 1979-03-19
GB2061947A (en) 1981-05-20
NO151861B (no) 1985-03-11
AR231544A1 (es) 1984-12-28
PL112834B1 (en) 1980-11-29
JPS5639315B2 (ru) 1981-09-11
NL191488C (nl) 1995-08-04
PT68544A (en) 1978-10-01
DK153843B (da) 1988-09-12
AT370103B (de) 1983-03-10
HU180868B (en) 1983-04-29

Similar Documents

Publication Publication Date Title
US3014911A (en) Derivatives of dibenzo[a, e]cycloheptatriene
US5356905A (en) Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs
CS216544B2 (en) Method of preparation of basic ethers
US4399141A (en) 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof
NO170919B (no) Omhylling for baandmetallspole og fremgangsmaate for aa forme den
DK158351B (da) Analogifremgangsmaade til fremstilling af substituerede 4-fenylalkylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf
CA1055945A (en) Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms
EP0375210B1 (en) Pyrazoloisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
SE437520B (sv) Dibensocyklohepteniminer, forfarande for framstellning av dessa och farmaceutisk komposition
GB1586655A (en) Pyrido-indole transquilising agents
US3981877A (en) Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene
Larsen et al. The resolution of methadone and related compounds
EP0077536B1 (en) 2&#39;-substituted-spiro(benzofuran-2(3h),1&#39;-cycloalkanes), a process for preparing same, pharmaceutical compositions containing such compounds and their use as medicaments
US4409229A (en) Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
AU635755B2 (en) Substituted isoxazole and isothiazole derivatives
EP0090275B1 (en) Isoxazole (5,4-b) pyridines
US3992546A (en) 4-Piperidinobutyrophenones as neuroleptics
US4032640A (en) 4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes
EP0011206B1 (en) 9,10-dihydro-4h-benzo(4,5)cyclohepta(1,2-b)thiophen-4,9 imines, process for their preparation and pharmaceutical compositions containing them
US3743735A (en) Pharmaceutical compositions containing tropanol esters of alpha-phenyl-alpha-cyclopentyl-acetic acid and methods of use
EP0002512B1 (en) Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof
US4054570A (en) 4-Piperidinobutyrophenones
KR830001667B1 (ko) 페닐 퀴놀리지딘의 제조방법
US3988342A (en) Piperidylidene derivatives of cyano-5H-dibenzo[a,d]cycloheptene
US4524207A (en) Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7809187-3

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7809187-3

Format of ref document f/p: F