SE0103754L - Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid - Google Patents
Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptidInfo
- Publication number
- SE0103754L SE0103754L SE0103754A SE0103754A SE0103754L SE 0103754 L SE0103754 L SE 0103754L SE 0103754 A SE0103754 A SE 0103754A SE 0103754 A SE0103754 A SE 0103754A SE 0103754 L SE0103754 L SE 0103754L
- Authority
- SE
- Sweden
- Prior art keywords
- peptides
- cardiovascular diseases
- apolipoprotein
- immunization
- therapeutic treatment
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 3
- 230000000302 ischemic effect Effects 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 101710095342 Apolipoprotein B Proteins 0.000 title abstract 2
- 102100040202 Apolipoprotein B-100 Human genes 0.000 title abstract 2
- 238000002649 immunization Methods 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 238000002965 ELISA Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (101)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0103754A SE0103754L (sv) | 2001-04-05 | 2001-11-09 | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
US10/115,072 US20030105003A1 (en) | 2001-04-05 | 2002-04-04 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
PL385189A PL215401B1 (pl) | 2001-04-05 | 2002-04-05 | Fragment apolipoproteiny B lub jego miejsce aktywne, zawierajaca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu , szczepionka zawierajaca przeciwcialo przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciala |
EP10181173A EP2289926A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
BRPI0216033A BRPI0216033B8 (pt) | 2001-04-05 | 2002-04-05 | "terapia de imunização à base de peptídio para tratamento de arteriosclerose" |
EP10180199A EP2289918A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
RU2003132443/15A RU2296582C2 (ru) | 2001-04-05 | 2002-04-05 | Фрагменты пептидов, фармацевтические композиции и вакцины на их основе и их применение для профилактики и терапии атеросклероза |
EP10181167A EP2289925A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180193A EP2289917A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180109A EP2289913A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP08158141A EP2147928A3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerososis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180099A EP2295458A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180835A EP2289922A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EEP200300487A EE200300487A (et) | 2001-04-05 | 2002-04-05 | Peptiid-põhine immunoteraapia ateroskleroosi raviks ja peptiid-põhise määramise arendamine immuunvastuste määramiseks oksüdeeritud madala tihedusega lipoproteiini vastu |
DE60230029T DE60230029D1 (de) | 2001-04-05 | 2002-04-05 | Immunisierungstherapie zur behandlung von atherosklerose |
EP10181213A EP2289930A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180162.9A EP2295460B1 (en) | 2001-04-05 | 2002-04-05 | Peptide- or antibody-based immunization therapy for treatment of atherosclerosis targeting ApoB100 |
DK02714667T DK1383526T3 (da) | 2001-04-05 | 2002-04-05 | Immuniseringsterapi til behandling af aterosklerose |
EP10180188A EP2289916A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
ES10181267.5T ES2546293T3 (es) | 2001-04-05 | 2002-04-05 | Terapia de inmunización basada en péptidos para el tratamiento de aterosclerosis que fija ApoB como objetivo |
BR0208685-9A BR0208685A (pt) | 2001-04-05 | 2002-04-05 | Terapia de imunização à base de peptìdio para tratamento de arteriosclerose e desenvolvimento de ensaio à base de peptìdio para determinação de respostas imunes contra lipoproteìna oxidada de baixa densidade |
EP10181196A EP2289928A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
CA2443223A CA2443223C (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180106A EP2289912A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180156A EP2295459A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EEP200700052A EE200700052A (et) | 2001-04-05 | 2002-04-05 | Antikeha he v?i mitme apo-lipoproteiin B fragmendi vastu |
PCT/SE2002/000679 WO2002080954A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP08151489A EP2006301B1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis |
EP08167532A EP2147680A3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP07119130A EP1918300A3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis |
CNA2009100095655A CN101486766A (zh) | 2001-04-05 | 2002-04-05 | 以肽为基础的治疗动脉粥样硬化的免疫疗法,和以肽为基础的用于确定针对氧化低密度脂蛋白的免疫反应的检测方法 |
EP10181217A EP2289931A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180115A EP2305707A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180111A EP2289914A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180026A EP2295457A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180168A EP2295461A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
DK10181267.5T DK2295464T3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for the treatment of atherosclerosis targeting ApoB100 |
CA2827167A CA2827167A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
PL400308A PL400308A1 (pl) | 2001-04-05 | 2002-04-05 | Terapia immunizacyjna w oparciu o peptydy do leczenia miazdzycy oraz w oparciu o peptydy do okreslania odpowiedzi odpornosci przeciwko utlenionym lipoproteinom o niskiej gestosci |
EP08167533A EP2147930A3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180838A EP2289923A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP02714667A EP1383526B1 (en) | 2001-04-05 | 2002-04-05 | Immunization therapy for treatment of atherosclerosis |
AT08151489T ATE510851T1 (de) | 2001-04-05 | 2002-04-05 | Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose |
EP10180176A EP2305708A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
PL391615A PL217858B1 (pl) | 2001-04-05 | 2002-04-05 | Fragment apolipoproteiny B lub jego miejsce aktywne, zawierająca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu, szczepionka zawierająca przeciwciało przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciała |
AU2002246484A AU2002246484B8 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10181188A EP2289927A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP08167531A EP2147929A3 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
CN201210322795.9A CN103122031B (zh) | 2001-04-05 | 2002-04-05 | 以肽为基础的治疗动脉粥样硬化的免疫疗法 |
EP10180184A EP2295462A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
DK08151489.5T DK2006301T3 (da) | 2001-04-05 | 2002-04-05 | Peptid-baseret immuniseringsterapi til behandling af atherosklerose |
EP10181267.5A EP2295464B1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis targeting ApoB100 |
EP10181245A EP2289933A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180826A EP2289920A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180823A EP2289919A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180828A EP2289921A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10181227A EP2289932A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
JP2002578993A JP2004529143A (ja) | 2001-04-05 | 2002-04-05 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
CN2007101953989A CN101284874B (zh) | 2001-04-05 | 2002-04-05 | 以肽为基础的治疗动脉粥样硬化的免疫疗法 |
EP10181253.5A EP2289934B1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis |
EP10180172A EP2289915A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
AT02714667T ATE415423T1 (de) | 2001-04-05 | 2002-04-05 | Immunisierungstherapie zur behandlung von atherosklerose |
EP10181273A EP2289935A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
CN028089405A CN1505525B (zh) | 2001-04-05 | 2002-04-05 | 以肽为基础的治疗动脉粥样硬化的免疫疗法,和以肽为基础的用于确定针对氧化低密度脂蛋白的免疫反应的检测方法 |
EP10181203A EP2289929A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180091A EP2305706A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
PT02714667T PT1383526E (pt) | 2001-04-05 | 2002-04-05 | Terapia de imunização para o tratamento de aterosclerose |
BRPI0216049A BRPI0216049B8 (pt) | 2001-04-05 | 2002-04-05 | "terapia de imunização à base de peptídeo para tratamento de arteriosclerose" |
EP10181263A EP2295463A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
EP10180845A EP2289924A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
ES02714667T ES2317999T3 (es) | 2001-04-05 | 2002-04-05 | Terapia de inmunizacion para el tratamiento de la ateroesclerosis. |
PL02367301A PL367301A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
IL15828502A IL158285A0 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-base assay for determination of immune responses against oxidized low density lipoprotein |
CA2606839A CA2606839C (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
IL158285A IL158285A (en) | 2001-04-05 | 2003-10-07 | Peptides for preparing medicament for immuno- therapy of atherosclerosis and development of peptide-base assay for determination of immune responses against oxidized low density lipoprotein |
US11/485,549 US7537758B2 (en) | 2001-04-05 | 2006-07-12 | Antibodies against a peptide epitope of apolipoprotein B |
US11/924,010 US7527795B2 (en) | 2001-04-05 | 2007-10-25 | Peptide epitopes of apolipoprotein B |
US11/930,969 US20090117137A1 (en) | 2001-04-05 | 2007-10-31 | Peptide epitopes of apolipoprotein b |
US11/930,910 US7556811B2 (en) | 2001-04-05 | 2007-10-31 | Peptide epitopes of apolipoprotein B |
US11/930,859 US7544360B2 (en) | 2001-04-05 | 2007-10-31 | Peptide epitopes of apolipoprotein B |
US11/930,625 US7528225B2 (en) | 2001-04-05 | 2007-10-31 | Peptide epitopes of apolipoprotein B |
IL188286A IL188286A0 (en) | 2001-04-05 | 2007-12-20 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
JP2008015545A JP2008169215A (ja) | 2001-04-05 | 2008-01-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
IL195356A IL195356A0 (en) | 2001-04-05 | 2008-11-18 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
CY20091100202T CY1108817T1 (el) | 2001-04-05 | 2009-02-24 | Ανοσολογικη θεραπεια για την αντιμετωπιση της αθηροσκληρωσης |
US12/394,919 US8034336B2 (en) | 2001-04-05 | 2009-02-27 | Antibodies against a peptide epitope of apoliprotein B |
US12/394,886 US8029786B2 (en) | 2001-04-05 | 2009-02-27 | Antibodies against a peptide epitope of apolipoprotein B |
US12/394,744 US20090226475A1 (en) | 2001-04-05 | 2009-02-27 | Peptide-based immunization therapy for treatment of atherosclerosis |
US12/394,827 US8025876B2 (en) | 2001-04-05 | 2009-02-27 | Antibodies against a peptide epitope of apolipoprotein B |
US12/394,787 US7785589B2 (en) | 2001-04-05 | 2009-02-27 | Antibodies against a peptide epitope of apolipoprotein B |
US12/394,857 US7704499B2 (en) | 2001-04-05 | 2009-02-27 | Antibodies against a peptide epitope of apoliporotein B |
JP2009133383A JP5270456B2 (ja) | 2001-04-05 | 2009-06-02 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
US12/644,810 US20100183706A1 (en) | 2001-04-05 | 2009-12-22 | Peptide epitopes of apolipoprotein b |
JP2010239478A JP5300820B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
JP2010239477A JP5300819B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
US13/177,897 USRE43581E1 (en) | 2001-04-05 | 2011-07-07 | Peptide epitopes of apolipoprotein B |
US13/736,645 US8470768B2 (en) | 2001-04-05 | 2013-01-08 | Peptide epitopes of apolipoprotein B |
US13/736,636 US8642043B2 (en) | 2001-04-05 | 2013-01-08 | Peptide epitopes of apolipoprotein B |
US13/736,633 US8647628B2 (en) | 2001-04-05 | 2013-01-08 | Peptide epitopes of apolipoprotein B |
US13/736,644 US8642726B2 (en) | 2001-04-05 | 2013-01-08 | Peptide epitopes of apolipoprotein B |
JP2013034312A JP5613890B2 (ja) | 2001-04-05 | 2013-02-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
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SE0101232A SE0101232D0 (sv) | 2001-04-05 | 2001-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein |
SE0103754A SE0103754L (sv) | 2001-04-05 | 2001-11-09 | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
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SE0103754L true SE0103754L (sv) | 2002-10-06 |
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SE0103754A SE0103754L (sv) | 2001-04-05 | 2001-11-09 | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
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EP (42) | EP2289924A1 (zh) |
JP (6) | JP2004529143A (zh) |
CN (4) | CN1505525B (zh) |
AT (2) | ATE510851T1 (zh) |
AU (1) | AU2002246484B8 (zh) |
BR (1) | BR0208685A (zh) |
CA (3) | CA2827167A1 (zh) |
CY (1) | CY1108817T1 (zh) |
DE (1) | DE60230029D1 (zh) |
DK (3) | DK2006301T3 (zh) |
EE (2) | EE200300487A (zh) |
ES (2) | ES2546293T3 (zh) |
IL (4) | IL158285A0 (zh) |
PL (4) | PL217858B1 (zh) |
PT (1) | PT1383526E (zh) |
RU (1) | RU2296582C2 (zh) |
SE (1) | SE0103754L (zh) |
WO (1) | WO2002080954A1 (zh) |
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SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
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BR0212880A (pt) | 2001-09-28 | 2005-12-13 | Esperion Therapeutics Inc | Uso de uma droga moduladora de lipìdeo, kit para tratamento ou redução, stent revestido com um material a ser liberado em um local a ser tratado, e composição farmacêutica |
CA2500895A1 (en) * | 2002-10-04 | 2004-04-15 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
SE0302312D0 (sv) | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
SE0302422D0 (sv) | 2003-09-11 | 2003-09-11 | Forskarpatent I Syd Ab | Peptide-based immunization therapy for treatment of atherosclerosis |
SE0400683D0 (sv) | 2004-03-19 | 2004-03-19 | Forskarpatent I Syd Ab | Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis |
EP1732383A4 (en) | 2004-04-06 | 2007-05-02 | Cedars Sinai Medical Center | PREVENTION AND TREATMENT OF VASCULAR DISEASES WITH VIRUS VECTORS ASSOCIATED WITH RECOMBINANT ADENOVIRUS CODING APOLIPOPROTEIN A-I AND APOLIPOPROTEIN A-I MILANO |
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EP1676602A1 (en) | 2005-01-04 | 2006-07-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis |
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EP2115466A4 (en) * | 2006-12-22 | 2010-07-28 | Abbott Lab | HEART CIRCUIT AUTOIMMUNE DISEASE TEST GROUP AND METHOD FOR USE THEREOF |
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CN101657430B (zh) | 2007-03-15 | 2013-05-01 | 诺瓦提斯公司 | 有机化合物及其用途 |
US9359633B2 (en) * | 2007-11-05 | 2016-06-07 | Nordic Bioscience A/S | Biochemical markers for CVD risk assessment |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN102099470B (zh) * | 2008-08-15 | 2014-11-12 | 藤仓化成株式会社 | 用于诊断动脉硬化的多肽标记、用该标记等检测动脉硬化的方法以及用于诊断动脉硬化的试剂盒 |
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US8506964B2 (en) | 2010-02-05 | 2013-08-13 | Cardiovax, Llc | Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis |
US20130142760A1 (en) | 2010-08-18 | 2013-06-06 | Cedars-Sinai Medical Center | Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer |
RU2013126888A (ru) | 2010-11-12 | 2014-12-20 | Седарс-Синаи Медикал Сентер | ИММУНОМОДУЛИРУЮЩИЕ КОМПОЗИЦИИ, СПОСОБЫ И СИСТЕМЫ, СОДЕРЖАЩИЕ ИММУНОГЕННЫЕ ФРАГМЕНТЫ АроВ100 |
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AU2011336997A1 (en) | 2010-11-12 | 2013-05-30 | Cedars-Sinai Medical Center | Immunomodulatory methods and systems for treatment and/or prevention of hypertension |
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CA2888657C (en) | 2012-11-06 | 2022-05-03 | Les Hopitaux Universitaires De Geneve | Mimetic peptides |
CN103520713B (zh) * | 2013-10-16 | 2015-10-28 | 西北农林科技大学 | 一种ApoB100酵母重组疫苗及其制备方法和应用 |
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CN108478817B (zh) * | 2018-03-16 | 2020-10-27 | 北京大学 | 一种动脉粥样硬化检测试剂及其制备方法 |
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