BR0212880A - Uso de uma droga moduladora de lipìdeo, kit para tratamento ou redução, stent revestido com um material a ser liberado em um local a ser tratado, e composição farmacêutica - Google Patents

Uso de uma droga moduladora de lipìdeo, kit para tratamento ou redução, stent revestido com um material a ser liberado em um local a ser tratado, e composição farmacêutica

Info

Publication number
BR0212880A
BR0212880A BR0212880-2A BR0212880A BR0212880A BR 0212880 A BR0212880 A BR 0212880A BR 0212880 A BR0212880 A BR 0212880A BR 0212880 A BR0212880 A BR 0212880A
Authority
BR
Brazil
Prior art keywords
apolipoprotein
lipid
treatment
therapy
apolipoproteins
Prior art date
Application number
BR0212880-2A
Other languages
English (en)
Inventor
Charles L Bisgaier
Original Assignee
Esperion Therapeutics Inc
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc, Cedars Sinai Medical Center filed Critical Esperion Therapeutics Inc
Publication of BR0212880A publication Critical patent/BR0212880A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

"USO DE UMA DROGA MODULADORA DE LIPìDEO, KIT PARA TRATAMENTO OU REDUçãO, STENT REVESTIDO COM UM MATERIAL A SER LIBERADO EM UM LOCAL A SER TRATADO, E COMPOSIçãO FARMACêUTICA". A apolipoproteína A-I (ApoA-I), preferivelmente uma forma variante tal como Apolipoproteína A-1 Milano (ApoA-IM), sozinha ou mais preferivelmente em combinação com um veículo lipídico, tal como fosfolipídeos ou outro medicamento, pode ser administrada localmente antes ou durante cirurgia de desvio de artérias coronárias, periféricas e cerebrais adoentadas, cirurgia para implantar enxertos ou órgãos transplantados, ou angioplastia, ou para estabilizar placas instáveis. Em uma modalidade alternativa, a apolipoproteína não é provida diretamente, porém o gene codificando a apolipoproteína o é. O gene é introduzido dentro do vaso sang³íneo de uma maneira similar àquela usada para a proteína, onde a proteína é então expressa. A técnica pode também ser usada para suprimento de genes para tratamento ou prevenção da restenose ou outras doenças cardiovasculares. Em ainda outra modalidade, os 'stents' são revestidos com apenas apolipoproteínas, apolipoproteínas formuladas com lipídeos, células geneticamente construídas expressando as apolipoproteínas, DNA desnudo codificando para uma apolipoproteína, ou outros medicamentos, tais como antiproliferativos para suprimento local em um sítio ferido. Em uma modalidade preferida, o sistema é usado com terapia de combinação, com suprimento local de um agente tal como uma apolipoproteína, em combinação com terapia anti-hipertensão sistêmica, terapia antiinflamatória, terapia de regulação de lipídeos e/ou anti-coagulação. Estes tratamentos podem começar antes de, concomitantemente com ou em seguida a suprimento local.
BR0212880-2A 2001-09-28 2002-09-27 Uso de uma droga moduladora de lipìdeo, kit para tratamento ou redução, stent revestido com um material a ser liberado em um local a ser tratado, e composição farmacêutica BR0212880A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32637901P 2001-09-28 2001-09-28
PCT/US2002/031068 WO2003026492A2 (en) 2001-09-28 2002-09-27 Prevention and treatment of restenosis by local administration of drug

Publications (1)

Publication Number Publication Date
BR0212880A true BR0212880A (pt) 2005-12-13

Family

ID=23271954

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212880-2A BR0212880A (pt) 2001-09-28 2002-09-27 Uso de uma droga moduladora de lipìdeo, kit para tratamento ou redução, stent revestido com um material a ser liberado em um local a ser tratado, e composição farmacêutica

Country Status (15)

Country Link
US (1) US8119590B2 (pt)
EP (1) EP1438060B1 (pt)
JP (1) JP2005504085A (pt)
KR (1) KR20040081418A (pt)
CN (2) CN1943790A (pt)
AU (1) AU2002362612B2 (pt)
BR (1) BR0212880A (pt)
CA (1) CA2460787A1 (pt)
HK (1) HK1075832A1 (pt)
IL (1) IL161110A0 (pt)
MX (1) MXPA04002848A (pt)
NZ (1) NZ532217A (pt)
PL (1) PL372925A1 (pt)
WO (1) WO2003026492A2 (pt)
ZA (1) ZA200402548B (pt)

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JP2005504085A (ja) 2005-02-10
WO2003026492A2 (en) 2003-04-03
PL372925A1 (en) 2005-08-08
US8119590B2 (en) 2012-02-21
US20030109442A1 (en) 2003-06-12
AU2002362612B2 (en) 2007-11-15
EP1438060B1 (en) 2015-11-11
CN1283313C (zh) 2006-11-08
EP1438060A2 (en) 2004-07-21
EP1438060A4 (en) 2005-09-14
IL161110A0 (en) 2004-08-31
CN1943790A (zh) 2007-04-11
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ZA200402548B (en) 2005-05-03
CA2460787A1 (en) 2003-04-03

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