HK1075832A1 - Use of an alpha helical apolipoprotein of hdl assiociated protein for the manufacture of a medicament adapted to be administered locally to prevent ortreat restenosis - Google Patents

Use of an alpha helical apolipoprotein of hdl assiociated protein for the manufacture of a medicament adapted to be administered locally to prevent ortreat restenosis

Info

Publication number
HK1075832A1
HK1075832A1 HK05107947A HK05107947A HK1075832A1 HK 1075832 A1 HK1075832 A1 HK 1075832A1 HK 05107947 A HK05107947 A HK 05107947A HK 05107947 A HK05107947 A HK 05107947A HK 1075832 A1 HK1075832 A1 HK 1075832A1
Authority
HK
Hong Kong
Prior art keywords
ortreat
assiociated
hdl
restenosis
protein
Prior art date
Application number
HK05107947A
Other languages
English (en)
Inventor
Charles L Bisgaier
Original Assignee
Esperion Therapeutics Inc
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc, Cedars Sinai Medical Center filed Critical Esperion Therapeutics Inc
Publication of HK1075832A1 publication Critical patent/HK1075832A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
HK05107947A 2001-09-28 2005-09-09 Use of an alpha helical apolipoprotein of hdl assiociated protein for the manufacture of a medicament adapted to be administered locally to prevent ortreat restenosis HK1075832A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32637901P 2001-09-28 2001-09-28
PCT/US2002/031068 WO2003026492A2 (en) 2001-09-28 2002-09-27 Prevention and treatment of restenosis by local administration of drug

Publications (1)

Publication Number Publication Date
HK1075832A1 true HK1075832A1 (en) 2005-12-30

Family

ID=23271954

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107947A HK1075832A1 (en) 2001-09-28 2005-09-09 Use of an alpha helical apolipoprotein of hdl assiociated protein for the manufacture of a medicament adapted to be administered locally to prevent ortreat restenosis

Country Status (15)

Country Link
US (1) US8119590B2 (xx)
EP (1) EP1438060B1 (xx)
JP (1) JP2005504085A (xx)
KR (1) KR20040081418A (xx)
CN (2) CN1943790A (xx)
AU (1) AU2002362612B2 (xx)
BR (1) BR0212880A (xx)
CA (1) CA2460787A1 (xx)
HK (1) HK1075832A1 (xx)
IL (1) IL161110A0 (xx)
MX (1) MXPA04002848A (xx)
NZ (1) NZ532217A (xx)
PL (1) PL372925A1 (xx)
WO (1) WO2003026492A2 (xx)
ZA (1) ZA200402548B (xx)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351421B2 (en) * 1996-11-05 2008-04-01 Hsing-Wen Sung Drug-eluting stent having collagen drug carrier chemically treated with genipin
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
JP2005504085A (ja) 2001-09-28 2005-02-10 エスペリオン セラピューティクス，インコーポレイテッド 薬剤の局所投与による再狭窄の予防および治療
AU2003270688A1 (en) * 2002-10-22 2004-05-13 Wenda Carlyle Method and agent for treating vulnerable plaque
US7641643B2 (en) * 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
PE20050438A1 (es) * 2003-10-20 2005-06-14 Esperion Therapeutics Inc Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos
CN1870894B (zh) * 2003-10-20 2011-08-10 埃斯普里昂治疗公司 用于治疗和预防急性冠状动脉综合征的药物制剂、方法和给药方案
CA2544309A1 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
EP1699527A1 (en) 2004-01-02 2006-09-13 Advanced Cardiovascular Systems, Inc. High-density lipoprotein coated medical devices
US20050228473A1 (en) * 2004-04-05 2005-10-13 David Brown Device and method for delivering a treatment to an artery
JP2007531537A (ja) * 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置
KR20060015963A (ko) * 2004-08-16 2006-02-21 주식회사 스텐텍 셀레콕십을 포함하는 동맥 재협착 예방 및 치료를 위한 약학 조성물
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
EP2269623A1 (en) 2005-04-29 2011-01-05 The Regents of The University of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US20070254832A1 (en) * 2006-02-17 2007-11-01 Pressler Milton L Methods for the treatment of macular degeneration and related eye conditions
US8785382B2 (en) 2006-04-03 2014-07-22 Abbott Cardiovascular Systems Inc. Lipid therapy
CN101489577B (zh) * 2006-06-01 2013-10-16 蒙特利尔心脏病学研究所 治疗心瓣膜病的方法和化合物
CA2659655A1 (en) 2006-08-08 2008-02-21 Alan M. Fogelman Salicylanilides enhance oral delivery of therapeutic peptides
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US20090036965A1 (en) * 2007-07-30 2009-02-05 Robert Glenmore Walsh Conjunctive stent therapy
US20090036875A1 (en) * 2007-07-30 2009-02-05 Robert Glenmore Walsh Cardiac tissue therapy
CN101361980B (zh) * 2007-08-07 2011-07-20 山东省生物药物研究院 一种适合非注射途径给药的肝素磷脂复合物及其制备方法
DK2195331T3 (da) 2007-08-28 2014-02-03 Uab Research Foundation Syntetiske polypeptider, der efterligner apolipoprotein e, og anvendelsesmetoder
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
US8044021B2 (en) 2007-09-20 2011-10-25 Abbott Cardiovascular Systems Inc. Sustained release of apo A-I mimetic peptides and methods of treatment
US8101565B2 (en) * 2007-09-20 2012-01-24 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US9173890B2 (en) 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985728B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985727B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Apo A-I mimetic peptides and methods of treatment
WO2009076272A2 (en) * 2007-12-07 2009-06-18 Boston Scientific Scimed, Inc. Drug coated stent with endosome-disrupting conjugate
US20090297577A1 (en) * 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Local Delivery of Apolipoproteins and Their Derivatives
US8722630B2 (en) * 2008-06-13 2014-05-13 The General Hospital Corporation Use of apolipoproteins to decrease inflammation
SI2396017T1 (sl) 2009-02-16 2015-12-31 Cerenis Therapeutics Holding Sa Mimika apolipoproteina A-1
BRPI1012910A2 (pt) * 2009-06-12 2020-06-02 Alphacore Pharma Llc Uso de um agente que leva a atividade de lcat ou eleva o nível de plasma do lcat ou ambos e composição farmacêutica compreendendo tal agente
JP5480272B2 (ja) * 2009-08-27 2014-04-23 テルモ株式会社 薬剤送達用医療器具
CN101716382B (zh) * 2009-12-02 2015-07-15 浙江大学 一种质粒dna/纤维蛋白凝胶/聚合物三元复合支架的制备方法
PL3178481T3 (pl) 2010-06-30 2019-07-31 Csl Limited Odtworzona formulacja lipoproteiny o wysokiej gęstości i sposób jej produkcji
US20130142760A1 (en) 2010-08-18 2013-06-06 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
KR101255337B1 (ko) * 2010-10-04 2013-04-16 한국과학기술연구원 온도 감응성 합성 고분자를 이용한 일산화질소 전달체
CN102240405A (zh) * 2011-05-09 2011-11-16 上海市第十人民医院 ApoA-Ⅰmilano基因药物
WO2012166798A2 (en) * 2011-06-01 2012-12-06 Wake Forest University Health Sciences Systems and apparatus for indicating risk of coronary stenosis
MX2014006589A (es) * 2011-12-21 2014-10-17 Csl Ltd Régimen de dosificación para formulaciones de apolipoproteína.
US9610324B2 (en) 2012-07-11 2017-04-04 Esperion Therapeutics, Inc. Apolipoprotein mixtures
US9125943B2 (en) 2012-11-02 2015-09-08 Csl Limited Reconstituted HDL formulation
CN103880949B (zh) * 2014-03-05 2016-09-14 王家祥 类载脂蛋白c-i及其在制备治疗肾母细胞瘤的药物中的应用
RU2016144908A (ru) 2014-05-02 2018-06-05 Серени Терапеутикс Холдинг Са Маркеры hdl-терапии
EP3189069A4 (en) 2014-07-31 2018-03-07 UAB Research Foundation Apoe mimetic peptides and higher potency to clear plasma cholesterol
US11091529B2 (en) 2014-09-17 2021-08-17 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
MX2019008529A (es) 2017-01-19 2020-02-07 Us Health Peptidos mimeticos de apolipoproteina c-ii (apoc-ii).

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2302698A (en) * 1941-05-12 1942-11-24 Albert M Kessel Multiple tissue carrier
US4009777A (en) * 1975-12-29 1977-03-01 Ryder International Corporation Contact lens holder
US4205747A (en) * 1978-09-05 1980-06-03 Cilco, Inc. Lens storage device
US4277172A (en) * 1979-11-05 1981-07-07 American Optical Corporation Soft contact lens apparatus
US4257521A (en) * 1979-11-16 1981-03-24 Stanley Poler Packaging means for an intraocular lens
US4326306A (en) * 1980-12-16 1982-04-27 Lynell Medical Technology, Inc. Intraocular lens and manipulating tool therefor
US4423809A (en) * 1982-02-05 1984-01-03 Staar Surgical Company, Inc. Packaging system for intraocular lens structures
US4439319A (en) * 1982-07-16 1984-03-27 Rock John G Receptacle for the collection of medical specimens and the like
US4970144A (en) * 1984-12-31 1990-11-13 International Genetic Engineering Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use
US4980286A (en) * 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
JP2703893B2 (ja) * 1985-07-05 1998-01-26 ホワイトヘッド・インスティテュ−ト・フォ−・バイオメディカル・リサ−チ 外来遺伝子物質を発現する上皮細胞
GB2189596B (en) * 1986-04-16 1990-08-01 Pa Consulting Services Methods of and apparatus for preparing tissue specimens
US5019084A (en) * 1986-08-06 1991-05-28 Minnesota Mining And Manufacturing Company Corneal holder
US4697697A (en) * 1986-08-18 1987-10-06 Coopervision, Inc. Method and apparatus for packaging an intraocular lens
GB8625435D0 (en) 1986-10-23 1986-11-26 Erba Farmitalia Human apolipoprotein ai
US4750610A (en) * 1986-12-29 1988-06-14 Ryder International Corporation Lens case with pressure sensitive venting system
US4844242A (en) * 1987-09-02 1989-07-04 The Johns Hopkins University Cornea retainer
WO1989007136A2 (en) 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US5972890A (en) * 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
EP0432216A1 (en) 1988-09-01 1991-06-19 Whitehead Institute For Biomedical Research Recombinant retroviruses with amphotropic and ecotropic host ranges
IT1229996B (it) * 1989-04-20 1991-09-20 Cesare Sirtori Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine.
SE468881B (sv) 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
SE9103701D0 (sv) * 1991-12-13 1991-12-13 Kabi Pharmacia Ab Apolipoprotein
WO1993018067A1 (en) 1992-03-06 1993-09-16 Abbott Laboratories Immunocapture assay for direct quantitation of specific lipoprotein cholesterol levels
WO1994000592A1 (en) 1992-06-26 1994-01-06 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
EP0671926B1 (en) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
US5281227A (en) * 1992-11-09 1994-01-25 Allergan, Inc. Lens case with IOL folding device
US5424040A (en) * 1992-11-09 1995-06-13 Bjornsson; Bjorn L. Tissue specimen collection kit
SE9203753D0 (sv) * 1992-12-11 1992-12-11 Kabi Pharmacia Ab Expression system for producing apolipoprotein ai-m
US5409833A (en) * 1993-07-01 1995-04-25 Baxter International Inc. Microvessel cell isolation apparatus
WO1995023592A1 (en) 1994-03-04 1995-09-08 The University Of British Columbia Liposome compositions and methods for the treatment of atherosclerosis
US6773719B2 (en) * 1994-03-04 2004-08-10 Esperion Luv Development, Inc. Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias
US5643757A (en) * 1994-03-21 1997-07-01 American Cyanamid Company High yield production of human apolipoprotein A1 in E. coli.
US5532168A (en) * 1994-08-18 1996-07-02 Marantz; Calvin Tissue biopsy specimen strainer and method
US5518612A (en) * 1994-08-30 1996-05-21 Becton, Dickinson And Company Cell strainer assembly and method of use
JP3691533B2 (ja) * 1994-12-07 2005-09-07 財団法人化学及血清療法研究所 抗動脈硬化ペプチド
SE9500778D0 (sv) * 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
US5609827A (en) * 1995-05-02 1997-03-11 Beekley Corporation Biopsy specimen container
US6258596B1 (en) * 1995-05-22 2001-07-10 Aventis Pharmaceuticals Products Inc. Variants of apolipoprotein A-I
FR2734568B1 (fr) 1995-05-22 1997-06-20 Rhone Poulenc Rorer Sa Nouveaux variants de l'apolipoproteine
US6074614A (en) * 1995-06-07 2000-06-13 Molecular Devices Corporation Multi-assay plate cover for elimination of meniscus
US5928935A (en) * 1995-09-26 1999-07-27 Reuss, Jr.; William Alexander Biological specimen containment and incubation device
US5843474A (en) * 1995-10-11 1998-12-01 Reverse Transport Licensing & Consulting, Inc. Method of dialysis treatment, and dialysis apparatus related thereto
KR0185334B1 (ko) * 1995-11-02 1999-04-01 김은영 인간 혈장 아포지단백질 비-100에 결합하는 생쥐 항체를 암호하는 씨디엔에이
GB9609702D0 (en) 1996-05-09 1996-07-10 Royal Free Hosp School Med Anticoagulant peptides
US5817032A (en) * 1996-05-14 1998-10-06 Biopath Automation Llc. Means and method for harvesting and handling tissue samples for biopsy analysis
JPH1025248A (ja) * 1996-07-08 1998-01-27 Chemo Sero Therapeut Res Inst 抗血管リモデリング剤
SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603303D0 (sv) * 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) * 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
GB9620153D0 (en) 1996-09-27 1996-11-13 Univ Strathclyde Non-naturally occurring lipoprotein particle
US7351421B2 (en) * 1996-11-05 2008-04-01 Hsing-Wen Sung Drug-eluting stent having collagen drug carrier chemically treated with genipin
GB9705831D0 (en) 1997-03-20 1997-05-07 Univ Leicester Oxidised ldl
US6635623B1 (en) 1997-06-13 2003-10-21 Baylor College Of Medicine Lipoproteins as nucleic acid vectors
US6727102B1 (en) * 1997-06-20 2004-04-27 Leuven Research & Development Vzw Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
US6225070B1 (en) 1997-08-07 2001-05-01 The Regents Of The University Of California Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
US6004925A (en) * 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en) * 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6156315A (en) 1997-10-10 2000-12-05 The Trustees Of Columbia University In The City Of New York Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
EP0911344B1 (en) 1997-10-15 2004-03-03 Fujirebio Inc. Anti-Apo-B-48 monoclonal antibody, hybridoma, and methods of use
US6579682B1 (en) 1998-03-10 2003-06-17 The Regents Of University Of California Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding
AU5200699A (en) 1998-07-13 2000-02-01 University Of Otago Inhibition of lipoprotein formation
US6410802B1 (en) * 1999-04-01 2002-06-25 Esperion Therapeutics, Inc. Methods for synthesizing ether compounds and intermediates therefor
US6364098B2 (en) * 1999-04-09 2002-04-02 Third Millenium Trust Soft contact lens cleaning and storage system
DE60045869D1 (de) 1999-10-26 2011-06-01 Univ California Reagenzien und verfahren für diagnose, 'imaging' und behandlung von atherosklerotischen krankheiten
US20020081590A1 (en) 2000-02-04 2002-06-27 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
JP2003525883A (ja) 2000-03-03 2003-09-02 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
SE0000855D0 (sv) 2000-03-15 2000-03-15 Karolinska Innovations Ab Antigenic composition useful as a vaccine against atherosclerosis
GB0017641D0 (en) 2000-07-18 2000-09-06 Medigene Oy Peptides and their use
EP1186299A1 (en) 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system
AU2002214644A1 (en) 2000-10-13 2002-04-22 University Of Cincinnati Methods for enhancing lysing of coagulated blood with apolipoprotein e2 phenotype
CA2425513A1 (en) 2000-10-25 2002-06-20 Vincent Agnello Method of inhibiting infection by hcv, other flaviviridae viruses, and any other virus that complexes to low density lipoprotein or to very low density lipoprotein in blood preventing viral entry into a cell
EP2343317A1 (en) * 2000-11-10 2011-07-13 F. Hoffmann-La Roche Ltd. Apolipoprotein analogues
AU2002241603A1 (en) 2000-11-10 2002-06-03 University Of Utah Research Foundation Carrier system for specific artery wall gene delivery
SE0103754L (sv) 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
RU2003136090A (ru) 2001-05-15 2005-04-20 Джэпэн Иммьюнорисерч Лэборэтериз Ко., Лтд (Jp) Пептид, взаимодействующий с липопротеином высокой плотности
MXPA04000564A (es) 2001-07-20 2005-02-17 Univ Zuerich Composiciones y metodos para uso de agentes bioactivos derivados de aminoacidos sulfatados y sulfonados.
JP2005504085A (ja) 2001-09-28 2005-02-10 エスペリオン セラピューティクス，インコーポレイテッド 薬剤の局所投与による再狭窄の予防および治療
PE20050438A1 (es) * 2003-10-20 2005-06-14 Esperion Therapeutics Inc Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos
JP2007531537A (ja) 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置

Also Published As

Publication number Publication date
NZ532217A (en) 2006-12-22
KR20040081418A (ko) 2004-09-21
JP2005504085A (ja) 2005-02-10
PL372925A1 (en) 2005-08-08
AU2002362612B2 (en) 2007-11-15
US20030109442A1 (en) 2003-06-12
MXPA04002848A (es) 2005-06-06
EP1438060A4 (en) 2005-09-14
CN1283313C (zh) 2006-11-08
IL161110A0 (en) 2004-08-31
US8119590B2 (en) 2012-02-21
ZA200402548B (en) 2005-05-03
CA2460787A1 (en) 2003-04-03
CN1943790A (zh) 2007-04-11
WO2003026492A2 (en) 2003-04-03
EP1438060A2 (en) 2004-07-21
CN1596121A (zh) 2005-03-16
WO2003026492A3 (en) 2003-10-16
EP1438060B1 (en) 2015-11-11
BR0212880A (pt) 2005-12-13

Similar Documents

Publication Publication Date Title
HK1075832A1 (en) Use of an alpha helical apolipoprotein of hdl assiociated protein for the manufacture of a medicament adapted to be administered locally to prevent ortreat restenosis
AU2003220317A8 (en) Methods and drug delivery systems for the treatment of orofacial diseases
AU2003285091A8 (en) Interferon antagonists useful for the treatment of interferon related diseases
IL171956A0 (en) Combination therapy with glatiramer acetate and mitoxantrone for the treatment of multiple sclerosis
HK1073997A1 (en) Administration of agents for the treatment of inflammation
HK1072558A1 (en) Methods and dosage forms for controlled delivery of oxycodone
HK1068548A1 (en) Use of omega interferon in the manufacture of a medicament for treating hepatitis c
AU2003259381A8 (en) Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
EP1404343A4 (en) THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF HORMONE DEFICIENCIES
EP1487446A4 (en) BICYCLIC HETEROCYCLES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES
AU5618501A (en) Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis
AU2003243708A1 (en) Use of bases for the manufacture of a medicament in the treatment of different forms of inflammatory dermatosis
IL160780A0 (en) USE OF hCG IN THE MANUFACTURE OF A MEDICAMENT
HUP0303988A2 (hu) Azitromicin alkalmzása nem fertőző gyulladásos betegségek kezelésére szolgáló gyógyszerkészítmény előállítására
SI1487828T1 (sl) Morfolinil-sečninski derivati za uporabo pri zdravljenu vnetnih bolezni
AU2002226427A1 (en) Use of flumazenil in developing a drug for the treatment of alcohol dependence
HK1072568A1 (en) Use of new etonogestrel esters
GB0207410D0 (en) Compounds and their therapeutic use
IL160782A0 (en) USE OF hCG IN THE MANUFACTURE OF A MEDICAMENT
HK1076034A1 (en) Novel association of an antithrombotic agent with aspirin and use thereof for the manufacture of a medicament for treating atherothrombotic diseases
PL378197A1 (pl) Pochodne kwasów indenokarboksylowych oraz ich zastosowanie do leczenia i zapobiegania cukrzycy i dyslipidemii
HK1077216A1 (en) Use of thiazole derivatives for the manufacture ofa medicament for the treatment of chronic obstruc tive pulmonary disease
HUP0300876A3 (en) Use of diclofenac for the manufacture of medicament for the topical treatment of burns
GB0212790D0 (en) Medicament for the treatment of diabetes
GB0207409D0 (en) Benzofuran-2H-3-one compounds and their therapeutic use

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100927