AU5618501A - Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis - Google Patents

Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis

Info

Publication number
AU5618501A
AU5618501A AU56185/01A AU5618501A AU5618501A AU 5618501 A AU5618501 A AU 5618501A AU 56185/01 A AU56185/01 A AU 56185/01A AU 5618501 A AU5618501 A AU 5618501A AU 5618501 A AU5618501 A AU 5618501A
Authority
AU
Australia
Prior art keywords
dihydropyrimidines
medicaments
hepatitis
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU56185/01A
Inventor
Karl Deres
Siegfried Goldmann
Erwin Graef
Thomas Kramer
Ulrich Niewohner
Arnold Paessens
Karl-Heinz Schlemmer
Jurgen Stoltefuss
Olaf Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU5618501A publication Critical patent/AU5618501A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AU56185/01A 2000-03-16 2001-03-05 Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis Abandoned AU5618501A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10012824 2000-03-16
DE10012824A DE10012824A1 (en) 2000-03-16 2000-03-16 New 6-hydroxyhydrocarbyl or 6-thiohydrocarbyl-dihydropyrimidine-5-carboxylic acid derivatives, useful for the treatment of viral infections, especially hepatitis B infections
PCT/EP2001/002444 WO2001068642A1 (en) 2000-03-16 2001-03-05 Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b

Publications (1)

Publication Number Publication Date
AU5618501A true AU5618501A (en) 2001-09-24

Family

ID=7634954

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56185/01A Abandoned AU5618501A (en) 2000-03-16 2001-03-05 Dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis

Country Status (3)

Country Link
AU (1) AU5618501A (en)
DE (1) DE10012824A1 (en)
WO (1) WO2001068642A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101225084A (en) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 Dihydropyrimidine compound and use thereof in preparation of medicine treating and preventing virus diseases
CN101225083A (en) 2007-01-16 2008-07-23 北京摩力克科技有限公司 Tetrahydro quinazoline ketone compound and use thereof in preparation of medicine treating and preventing virus diseases
WO2008154818A1 (en) * 2007-06-18 2008-12-24 Zhang, Zhongneng Fluorophenyl-substituted thiazolyl dihydropyrimidines
WO2008154819A1 (en) * 2007-06-18 2008-12-24 Zhang, Zhongneng Carbethoxy-substituted thiazolyl dihydropyrimidines
PL2514750T3 (en) 2007-06-18 2014-05-30 Ruyuan Wei Xiang Tech Co Ltd Bromo-phenyl substituted thiazolyl dihydropyrimidines
WO2008154820A1 (en) * 2007-06-18 2008-12-24 Zhang, Zhongneng Carbethoxy-substituted thiazolyl dihydropyrimidines
EA026977B1 (en) 2012-01-06 2017-06-30 Янссен Сайенсиз Айрлэнд Юси 4,4-disubstituted 1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b
KR20140143160A (en) * 2012-03-31 2014-12-15 에프. 호프만-라 로슈 아게 Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
MX2015002511A (en) 2012-08-24 2016-03-08 Sunshine Lake Pharma Co Ltd Dihydropyrimidine compounds and their application in pharmaceuticals.
CN103664897B (en) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 Dihydropyrimidines and its application in medicine
WO2014037480A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
MX2016006564A (en) 2013-11-19 2017-09-12 Sunshine Lake Pharma Co Ltd Dihydropyrimidine compounds and their application in pharmaceuticals.
KR102284938B1 (en) 2013-11-27 2021-08-02 선샤인 레이크 파르마 컴퍼니 리미티드 Processes for preparing dihydropyrimidine derivatives and intermediates thereof
PE20161338A1 (en) 2014-03-07 2016-12-12 Hoffmann La Roche NEW 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
CN104945395B (en) 2014-03-28 2018-01-23 广东东阳光药业有限公司 Dihydropyrimidines and its application in medicine
CA2970838A1 (en) 2015-02-07 2016-08-11 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
SI3270915T1 (en) 2015-03-16 2020-07-31 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
CN109715214B (en) 2016-09-13 2022-03-04 豪夫迈·罗氏有限公司 Combination therapy of a TLR7 agonist and an HBV capsid assembly inhibitor
CA3070004A1 (en) 2017-07-27 2019-01-31 Jiangsu Hengrui Medicine Co., Ltd. Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine
AU2020249331A1 (en) 2019-03-25 2021-09-23 F. Hoffmann-La Roche Ag Solid forms of a compound of HBV core protein allosteric modifier

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702564D0 (en) * 1997-07-02 1997-07-02 Astra Ab New compounds
DE19817262A1 (en) * 1998-04-18 1999-10-21 Bayer Ag New dihydropyrimidine derivatives and their corresponding mesomers useful in treatment of hepatitis
DE19817265A1 (en) * 1998-04-18 1999-10-21 Bayer Ag Treating hepatitis B using new or known dihydropyrimidine derivative antiviral agents

Also Published As

Publication number Publication date
WO2001068642A1 (en) 2001-09-20
DE10012824A1 (en) 2001-09-20

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase