AU2001256184A1 - 6-aminoalkyl-dihydropyrimidines and the use thereof as medicaments against viraldiseases - Google Patents
6-aminoalkyl-dihydropyrimidines and the use thereof as medicaments against viraldiseasesInfo
- Publication number
- AU2001256184A1 AU2001256184A1 AU2001256184A AU5618401A AU2001256184A1 AU 2001256184 A1 AU2001256184 A1 AU 2001256184A1 AU 2001256184 A AU2001256184 A AU 2001256184A AU 5618401 A AU5618401 A AU 5618401A AU 2001256184 A1 AU2001256184 A1 AU 2001256184A1
- Authority
- AU
- Australia
- Prior art keywords
- viraldiseases
- dihydropyrimidines
- aminoalkyl
- medicaments against
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10013126A DE10013126A1 (en) | 2000-03-17 | 2000-03-17 | New 6-aminoalkyl-dihydropyrimidine-5-carboxylate ester derivatives, useful as antiviral agents having strong activity against hepatitis B virus and low cytotoxicity |
| DE10013126 | 2000-03-17 | ||
| PCT/EP2001/002443 WO2001068641A1 (en) | 2000-03-17 | 2001-03-05 | 6-aminoalkyl-dihydropyrimidines and the use thereof as medicaments against viral diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001256184A1 true AU2001256184A1 (en) | 2001-09-24 |
Family
ID=7635175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001256184A Abandoned AU2001256184A1 (en) | 2000-03-17 | 2001-03-05 | 6-aminoalkyl-dihydropyrimidines and the use thereof as medicaments against viraldiseases |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2001256184A1 (en) |
| DE (1) | DE10013126A1 (en) |
| WO (1) | WO2001068641A1 (en) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7358262B2 (en) | 2003-01-29 | 2008-04-15 | Whitehead Institute For Biomedical Research | Identification of genotype-selective anti-tumor agents |
| EP1683797A1 (en) * | 2003-11-13 | 2006-07-26 | Ono Pharmaceutical Co., Ltd. | Heterocyclic spiro compound |
| US8518959B2 (en) | 2005-01-25 | 2013-08-27 | Prolexys Pharmaceuticals, Inc. | Quinoxaline derivatives as antitumor agents |
| KR101173892B1 (en) | 2007-06-18 | 2012-08-16 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Bromo-phenyl substituted thiazolyl dihydropyrimidines |
| CN101328170B (en) * | 2007-06-18 | 2011-09-14 | 张中能 | Fluorophenyl-substituted thiazole dihydropyrimidine |
| CN101328169B (en) * | 2007-06-18 | 2011-05-25 | 张中能 | Diethylcarbamyl-substituted thiazole dihydropyrimidine |
| WO2008154820A1 (en) * | 2007-06-18 | 2008-12-24 | Zhang, Zhongneng | Carbethoxy-substituted thiazolyl dihydropyrimidines |
| CN101575318B (en) | 2009-06-25 | 2012-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | Novel dihydropyridine compound and application thereof on preparing drugs for curing and/or preventing virus diseases |
| US9487534B2 (en) * | 2011-08-02 | 2016-11-08 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
| US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| MX2015002511A (en) | 2012-08-24 | 2016-03-08 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine compounds and their application in pharmaceuticals. |
| CN103664897B (en) * | 2012-09-01 | 2018-04-03 | 广东东阳光药业有限公司 | Dihydropyrimidines and its application in medicine |
| JP6113285B2 (en) | 2012-09-10 | 2017-04-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 6-amino acid heteroaryl dihydropyrimidines for the treatment and prevention of hepatitis B virus infection |
| CA2889892A1 (en) * | 2012-11-09 | 2014-05-15 | Indiana University Research And Technology Corporation | Alternative uses for hbv assembly effectors |
| TW201512193A (en) | 2013-05-17 | 2015-04-01 | Hoffmann La Roche | Novel 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection |
| CN106255684B (en) | 2013-11-14 | 2019-08-23 | 诺维拉治疗公司 | The method of azepan derivatives and treatment hepatitis B infection |
| WO2015074546A1 (en) | 2013-11-19 | 2015-05-28 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| CN104650070B (en) * | 2013-11-25 | 2018-09-14 | 广东东阳光药业有限公司 | Dihydropyrimidines and its application in drug |
| KR102284944B1 (en) | 2013-11-27 | 2021-08-03 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
| UA117518C2 (en) | 2014-03-07 | 2018-08-10 | Ф. Хоффманн-Ля Рош Аг | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| EP3122747B1 (en) | 2014-03-28 | 2020-05-20 | North & South Brother Pharmacy Investment Company Limited | Dihydropyrimidine compounds and their application in pharmaceuticals |
| US10098889B2 (en) | 2015-02-07 | 2018-10-16 | Sunshine Lake Pharma Co., Ltd. | Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals |
| EP3695837A1 (en) | 2015-03-16 | 2020-08-19 | F. Hoffmann-La Roche AG | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017064156A1 (en) * | 2015-10-16 | 2017-04-20 | F. Hoffmann-La Roche Ag | Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| JP6523566B2 (en) * | 2015-11-04 | 2019-06-05 | チールー ファーマシューティカル カンパニー、リミテッド | Crystal form of dihydropyrido ring compound, production method and intermediate |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| ES2938341T3 (en) | 2016-03-07 | 2023-04-10 | Enanta Pharm Inc | Antiviral agents against hepatitis B |
| WO2017214395A1 (en) | 2016-06-10 | 2017-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| TWI670266B (en) * | 2016-09-09 | 2019-09-01 | 大陸商浙江海正藥業股份有限公司 | Dihydropyrimidine compounds, processes for their preparation and use thereof |
| CN109715214B (en) | 2016-09-13 | 2022-03-04 | 豪夫迈·罗氏有限公司 | Combination therapy of a TLR7 agonist and an HBV capsid assembly inhibitor |
| CN109790145B (en) * | 2016-11-18 | 2020-09-22 | 四川科伦博泰生物医药股份有限公司 | Dihydropyrimidine compound and preparation method and application thereof |
| US11142527B2 (en) * | 2017-06-26 | 2021-10-12 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and uses thereof in medicine |
| AU2018291688B2 (en) | 2017-06-27 | 2022-02-03 | Janssen Pharmaceutica Nv | Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections |
| WO2019046271A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| KR20200072512A (en) * | 2017-10-18 | 2020-06-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Dihydropyrimidine compounds and their use in pharmaceuticals |
| WO2019113175A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2019113173A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| JP2021523160A (en) * | 2018-05-08 | 2021-09-02 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Dihydropyrimidine derivatives and their use in the treatment of HBV infections or HBV-induced diseases |
| US11053235B2 (en) | 2018-08-09 | 2021-07-06 | Janssen Sciences Ireland Unlimited Company | Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases |
| KR20210065965A (en) | 2018-09-21 | 2021-06-04 | 이난타 파마슈티칼스, 인코포레이티드 | Heterocycles functionalized as antiviral agents |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| MX2021011614A (en) | 2019-03-25 | 2021-10-13 | Hoffmann La Roche | Solid forms of a compound of hbv core protein allosteric modifier. |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US20230083012A1 (en) * | 2019-07-31 | 2023-03-16 | Janssen Sciences Ireland Unlimited Company | Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases |
| WO2021018238A1 (en) * | 2019-07-31 | 2021-02-04 | Janssen Sciences Ireland Unlimited Company | Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases |
| EP4003987A4 (en) * | 2019-07-31 | 2023-07-26 | Janssen Sciences Ireland Unlimited Company | Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN112778299B (en) * | 2019-11-04 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | Piperazine ureido derivatives, preparation method thereof and application thereof in medicines |
| BR112022011212A2 (en) * | 2019-12-20 | 2022-09-20 | Janssen Pharmaceutica Nv | HETEROARYLDI-HYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| UY39616A (en) * | 2021-01-29 | 2022-07-29 | Janssen Sciences Ireland Unlimited Co | DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR HBV-INDUCED DISEASES |
| CN113135921B (en) * | 2021-04-26 | 2022-06-17 | 山东大学 | Dihydropyrimidine-spiro derivative and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702564D0 (en) * | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
| DE19817265A1 (en) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Treating hepatitis B using new or known dihydropyrimidine derivative antiviral agents |
| DE19817264A1 (en) * | 1998-04-18 | 1999-10-21 | Bayer Ag | New dihydropyrimidine derivatives and their corresponding mesomers useful as antiviral agents |
-
2000
- 2000-03-17 DE DE10013126A patent/DE10013126A1/en not_active Withdrawn
-
2001
- 2001-03-05 WO PCT/EP2001/002443 patent/WO2001068641A1/en active Application Filing
- 2001-03-05 AU AU2001256184A patent/AU2001256184A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001068641A1 (en) | 2001-09-20 |
| DE10013126A1 (en) | 2001-09-20 |
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