WO2000073430A3 - Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind - Google Patents
Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind Download PDFInfo
- Publication number
- WO2000073430A3 WO2000073430A3 PCT/DE2000/001809 DE0001809W WO0073430A3 WO 2000073430 A3 WO2000073430 A3 WO 2000073430A3 DE 0001809 W DE0001809 W DE 0001809W WO 0073430 A3 WO0073430 A3 WO 0073430A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- antigens
- conformation
- peptides
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002375033A CA2375033A1 (en) | 1999-05-27 | 2000-05-29 | Vaccines against conformation-dependent antigens and against antigens that are not or are not only proteins or peptides |
AU64243/00A AU6424300A (en) | 1999-05-27 | 2000-05-29 | Vaccines against conformation-dependent antigens and against antigens that are not or are not only proteins or peptides |
EP00951201A EP1181058A2 (de) | 1999-05-27 | 2000-05-29 | Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924405.7 | 1999-05-27 | ||
DE19924405 | 1999-05-27 | ||
DE19943016.0 | 1999-09-09 | ||
DE19943016 | 1999-09-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000073430A2 WO2000073430A2 (de) | 2000-12-07 |
WO2000073430A3 true WO2000073430A3 (de) | 2001-03-29 |
Family
ID=26053552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2000/001809 WO2000073430A2 (de) | 1999-05-27 | 2000-05-29 | Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1181058A2 (de) |
AU (1) | AU6424300A (de) |
CA (1) | CA2375033A1 (de) |
DE (1) | DE10027695A1 (de) |
WO (1) | WO2000073430A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
EP0751992B1 (de) | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Vaskularer endothelialer wachstumsfaktor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
AU8473401A (en) | 2000-08-04 | 2002-02-18 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
KR20030093316A (ko) * | 2001-04-13 | 2003-12-06 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 혈관 내피 성장 인자 2 |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
CA2490280A1 (en) | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
AU2003266236A1 (en) | 2002-07-22 | 2004-02-09 | Nemod Immuntherapie Ag | Method for the production of an immunostimulating mucin (muc1) |
JP4485367B2 (ja) * | 2002-12-03 | 2010-06-23 | パソゲン リムーバル アンド ダイアグノスティック テクノロジーズ インコーポレイテッド | プリオンタンパク質リガンドおよび使用方法 |
GB0324265D0 (en) * | 2003-10-16 | 2003-11-19 | Medical Res Council | Peptide |
PL1735347T3 (pl) | 2004-03-29 | 2013-04-30 | The Univ Court Of The Univ Of Aberdeen | Specyficznie wiążące cząsteczki przeciwko synaptofizynie |
BRPI0608468A2 (pt) * | 2005-03-25 | 2010-01-05 | Glycart Biotechnology Ag | moléculas de ligação a antìgeno direcionadas a mcsp e tendo afinidade de ligação a receptor de fc e função efetora aumentadas |
EP1888640B1 (de) | 2005-05-18 | 2012-03-14 | Ablynx N.V. | Verbesserte nanokörper gegen tumornekrosefaktor-alpha |
DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
CN1301267C (zh) * | 2005-06-21 | 2007-02-21 | 中国人民解放军军事医学科学院附属医院 | Muc1粘蛋白的一个模拟表位肽及其编码dna与应用 |
EP2245052B1 (de) | 2008-01-25 | 2017-05-24 | Aarhus Universitet | Selektive exosite-inhibierung der papp-a-aktivität gegenüber igfbp-4 |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
NZ623264A (en) | 2008-12-05 | 2015-09-25 | Abraxis Bioscience Llc | Sparc binding scfvs |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0508282A2 (de) * | 1991-04-01 | 1992-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Anti-idiotypische monoklonale Antikörper |
WO1998000444A1 (de) * | 1996-06-27 | 1998-01-08 | Max-Delbrück-Centrum für Molekulare Medizin | Vakzine gegen kohlenhydrat-antigene |
WO1999040433A1 (en) * | 1998-02-04 | 1999-08-12 | The Trustees Of The University Of Pennsylvania | Peptide mimotopes of carbohydrate antigens |
WO1999054457A1 (en) * | 1998-04-20 | 1999-10-28 | Chiron S.P.A. | Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates |
-
2000
- 2000-05-29 AU AU64243/00A patent/AU6424300A/en not_active Abandoned
- 2000-05-29 WO PCT/DE2000/001809 patent/WO2000073430A2/de active Search and Examination
- 2000-05-29 DE DE10027695A patent/DE10027695A1/de not_active Withdrawn
- 2000-05-29 EP EP00951201A patent/EP1181058A2/de not_active Withdrawn
- 2000-05-29 CA CA002375033A patent/CA2375033A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0508282A2 (de) * | 1991-04-01 | 1992-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Anti-idiotypische monoklonale Antikörper |
WO1998000444A1 (de) * | 1996-06-27 | 1998-01-08 | Max-Delbrück-Centrum für Molekulare Medizin | Vakzine gegen kohlenhydrat-antigene |
WO1999040433A1 (en) * | 1998-02-04 | 1999-08-12 | The Trustees Of The University Of Pennsylvania | Peptide mimotopes of carbohydrate antigens |
WO1999054457A1 (en) * | 1998-04-20 | 1999-10-28 | Chiron S.P.A. | Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates |
Non-Patent Citations (6)
Title |
---|
APOSTOLOPOULOS V ET AL: "Carbohydrate /peptide mimics: effect on MUC1 cancer immunotherapy.", JOURNAL OF MOLECULAR MEDICINE, (1999 MAY) 77 (5) 427-36. REF: 57, XP000960532 * |
GOLLASCH H ET AL: "Identification of immunogenic peptide-mimics for the Thomsen-Friedenreich-glycoantigen.", ANNALS OF HEMATOLOGY, vol. 77, no. SUPPL. 2, 1998, Annual Congress of the German and Austrian Societies of Hematology and Oncology;Frankfurt, Germany; October 25-28, 1998, pages S84, XP000960533, ISSN: 0939-5555 * |
KARSTEN UWE ET AL: "Enhanced binding of antibodies to the DTR motif of MUC1 tandem repeat peptide is mediated by site-specific glycosylation.", CANCER RESEARCH, vol. 58, no. 12, 15 June 1998 (1998-06-15), pages 2541 - 2549, XP002112486, ISSN: 0008-5472 * |
LOSMAN M J ET AL: "MIMICRY OF A CARCINOEMBRYONIC ANTIGEN EPITOPE BY A RAT MONOCLONAL ANTI-IDIOTYPE ANTIBODY", INTERNATIONAL JOURNAL OF CANCER,US,NEW YORK, NY, vol. 56, no. 4, 15 February 1994 (1994-02-15), pages 580 - 584, XP000577759, ISSN: 0020-7136 * |
PINILLA CLEMENCIA ET AL: "All-D peptides recognized by an anti-carbohydrate antibody identified from a positional scanning library.", JOURNAL OF MOLECULAR BIOLOGY, vol. 283, no. 5, 13 November 1998 (1998-11-13), pages 1013 - 1025, XP002152467, ISSN: 0022-2836 * |
POTTER V ET AL: "DNA vaccination with A scFv of the anti-idiotype antibody 105Ad7 induces a TH1 immune response.", BRITISH JOURNAL OF CANCER, vol. 78, no. SUPPL. 2, 1998, Joint Meeting of the British Oncological Association, the Association of Cancer Physicians and the Royal College of Radiologists;Nottingham, England, UK; July 5-7, 1998, pages 18, XP000960534, ISSN: 0007-0920 * |
Also Published As
Publication number | Publication date |
---|---|
AU6424300A (en) | 2000-12-18 |
CA2375033A1 (en) | 2000-12-07 |
EP1181058A2 (de) | 2002-02-27 |
DE10027695A1 (de) | 2001-04-19 |
WO2000073430A2 (de) | 2000-12-07 |
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