SA520412278B1 - مركبات ومشتقات بيريدو بيريمينون بها استبدال ببنزيل أمينو جديدة كمثبطات جين أس أوه أس 1 - Google Patents
مركبات ومشتقات بيريدو بيريمينون بها استبدال ببنزيل أمينو جديدة كمثبطات جين أس أوه أس 1Info
- Publication number
- SA520412278B1 SA520412278B1 SA520412278A SA520412278A SA520412278B1 SA 520412278 B1 SA520412278 B1 SA 520412278B1 SA 520412278 A SA520412278 A SA 520412278A SA 520412278 A SA520412278 A SA 520412278A SA 520412278 B1 SA520412278 B1 SA 520412278B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- inhibitors
- sevenless
- son
- derivatives
- novel
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات بالصيغة (I) ، حيث يكون للمجموعات R1 إلى R4، A وp المعاني المقدمة في عناصر الحماية والمواصفة، استخدامها كمثبطات inhibitors لجين Son of Sevenless 1 (SOS1)، تركيبات صيدلانية pharmaceutical compositions حيث تحتوي على مركبات من هذا النوع واستخدامها كأدوية/ استخدامات طبية، بصفة خاصة كعوامل لمعالجة و/ أو الوقاية من الأمراض الورمية oncological diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17209865 | 2017-12-21 | ||
| PCT/EP2018/086197 WO2019122129A1 (en) | 2017-12-21 | 2018-12-20 | Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520412278B1 true SA520412278B1 (ar) | 2022-08-17 |
Family
ID=60781991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520412278A SA520412278B1 (ar) | 2017-12-21 | 2020-06-19 | مركبات ومشتقات بيريدو بيريمينون بها استبدال ببنزيل أمينو جديدة كمثبطات جين أس أوه أس 1 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US10829487B2 (ar) |
| EP (2) | EP4219493A1 (ar) |
| JP (1) | JP7189956B2 (ar) |
| KR (1) | KR20200111163A (ar) |
| CN (1) | CN111372932B (ar) |
| AR (1) | AR114164A1 (ar) |
| AU (1) | AU2018390927B2 (ar) |
| BR (1) | BR112020010123A2 (ar) |
| CA (1) | CA3085835A1 (ar) |
| CL (2) | CL2020001501A1 (ar) |
| CO (1) | CO2020007218A2 (ar) |
| CR (2) | CR20210307A (ar) |
| DK (1) | DK3728254T3 (ar) |
| EA (1) | EA202091491A1 (ar) |
| EC (1) | ECSP20040257A (ar) |
| ES (1) | ES2944306T3 (ar) |
| FI (1) | FI3728254T3 (ar) |
| HR (1) | HRP20230400T1 (ar) |
| HU (1) | HUE062076T2 (ar) |
| IL (1) | IL275379B2 (ar) |
| JO (1) | JOP20200154A1 (ar) |
| LT (1) | LT3728254T (ar) |
| MA (1) | MA51290A (ar) |
| MX (1) | MX2020006438A (ar) |
| PE (1) | PE20210163A1 (ar) |
| PL (1) | PL3728254T3 (ar) |
| PT (1) | PT3728254T (ar) |
| RS (1) | RS64167B1 (ar) |
| SA (1) | SA520412278B1 (ar) |
| SG (1) | SG11202005881YA (ar) |
| SI (1) | SI3728254T1 (ar) |
| TW (1) | TWI810230B (ar) |
| UA (1) | UA126173C2 (ar) |
| WO (1) | WO2019122129A1 (ar) |
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| HUE056615T2 (hu) | 2017-10-18 | 2022-02-28 | Incyte Corp | Tercier hidroxicsoportokkal szubsztituált kondenzált imidazol-származékok mint PI3K-gamma inhibitorok |
| KR20200111163A (ko) * | 2017-12-21 | 2020-09-28 | 베링거 인겔하임 인터내셔날 게엠베하 | Sos1 억제제로서의 신규 벤질아미노 치환 피리도피리미디논 및 유도체 |
| WO2020254451A1 (en) | 2019-06-19 | 2020-12-24 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| CN115315424A (zh) * | 2019-10-15 | 2022-11-08 | 拜耳公司 | 2-甲基-氮杂-喹唑啉 |
| MX2022005525A (es) * | 2019-11-08 | 2022-06-08 | Revolution Medicines Inc | Compuestos de heteroarilo bicíclicos y usos de estos. |
| KR20220110241A (ko) * | 2019-11-29 | 2022-08-05 | 루핀 리미티드 | 치환된 트리사이클릭 화합물 |
| AU2020405170A1 (en) * | 2019-12-20 | 2022-06-30 | Mirati Therapeutics, Inc. | SOS1 inhibitors |
| CN113045565A (zh) * | 2019-12-27 | 2021-06-29 | 微境生物医药科技(上海)有限公司 | 新型K-Ras G12C抑制剂 |
| EP4081521A1 (en) | 2019-12-27 | 2022-11-02 | Lupin Limited | Substituted tricyclic compounds |
| EP4110333A4 (en) * | 2020-02-24 | 2023-12-06 | Mirati Therapeutics, Inc. | SOS1 INHIBITORS |
| WO2021203768A1 (zh) * | 2020-04-08 | 2021-10-14 | 江苏恒瑞医药股份有限公司 | 嘧啶并二环类衍生物、其制备方法及其在医药上的应用 |
| CN116234806A (zh) | 2020-06-02 | 2023-06-06 | 勃林格殷格翰国际有限公司 | 用于治疗癌症的环状2-氨基-3-氰基噻吩及其衍生物 |
| TW202214639A (zh) | 2020-06-11 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吡啶酮并嘧啶類衍生物、其製備方法及其在醫藥上的應用 |
| CN113801114B (zh) * | 2020-06-11 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用 |
| US20230233568A1 (en) | 2020-06-24 | 2023-07-27 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| CN113912608B (zh) * | 2020-07-10 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN116234807A (zh) * | 2020-07-24 | 2023-06-06 | 南京明德新药研发有限公司 | 喹唑啉类化合物 |
| WO2022028506A1 (zh) * | 2020-08-06 | 2022-02-10 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| IL301062A (en) | 2020-09-03 | 2023-05-01 | Revolution Medicines Inc | Use of SOS1 inhibitors to treat malignancies with SHP2 mutations |
| TW202227460A (zh) | 2020-09-15 | 2022-07-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| US20240025863A1 (en) | 2020-09-16 | 2024-01-25 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| WO2022058344A1 (en) * | 2020-09-18 | 2022-03-24 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors |
| CA3196287A1 (en) | 2020-10-20 | 2022-04-28 | Binhua Lv | Substituted benzo or pyridopyrimidine amine inhibitor, preparation method therefor, and application thereof |
| CN114524810B (zh) * | 2020-11-21 | 2023-12-01 | 上海凌达生物医药有限公司 | 一类嘧啶并杂环类化合物、制备方法和用途 |
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| KR20230144065A (ko) | 2021-02-08 | 2023-10-13 | 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 | 피리도피리미디논계 유도체 및 이의 제조 방법과 용도 |
| CN116669738A (zh) * | 2021-02-09 | 2023-08-29 | 苏州阿尔脉生物科技有限公司 | 一种作为sos1抑制剂的嘧啶并吡啶酮类衍生物、其制备方法及用途 |
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