MA51290A - Nouvelles pyridopyrimidinones à substitution benzylamino et dérivés à utiliser en tant qu'inhibiteurs de sos1 - Google Patents
Nouvelles pyridopyrimidinones à substitution benzylamino et dérivés à utiliser en tant qu'inhibiteurs de sos1Info
- Publication number
- MA51290A MA51290A MA051290A MA51290A MA51290A MA 51290 A MA51290 A MA 51290A MA 051290 A MA051290 A MA 051290A MA 51290 A MA51290 A MA 51290A MA 51290 A MA51290 A MA 51290A
- Authority
- MA
- Morocco
- Prior art keywords
- pyridopyrimidinones
- benzylamino
- derivative
- new
- sos1 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17209865 | 2017-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51290A true MA51290A (fr) | 2021-03-31 |
Family
ID=60781991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051290A MA51290A (fr) | 2017-12-21 | 2018-12-20 | Nouvelles pyridopyrimidinones à substitution benzylamino et dérivés à utiliser en tant qu'inhibiteurs de sos1 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US10829487B2 (fr) |
| EP (2) | EP3728254B1 (fr) |
| JP (1) | JP7189956B2 (fr) |
| KR (1) | KR20200111163A (fr) |
| CN (1) | CN111372932B (fr) |
| AR (1) | AR114164A1 (fr) |
| AU (1) | AU2018390927B2 (fr) |
| BR (1) | BR112020010123A2 (fr) |
| CA (1) | CA3085835A1 (fr) |
| CL (2) | CL2020001501A1 (fr) |
| CO (1) | CO2020007218A2 (fr) |
| CR (2) | CR20210307A (fr) |
| DK (1) | DK3728254T3 (fr) |
| EA (1) | EA202091491A1 (fr) |
| EC (1) | ECSP20040257A (fr) |
| ES (1) | ES2944306T3 (fr) |
| FI (1) | FI3728254T3 (fr) |
| HR (1) | HRP20230400T1 (fr) |
| HU (1) | HUE062076T2 (fr) |
| IL (1) | IL275379B2 (fr) |
| JO (1) | JOP20200154A1 (fr) |
| LT (1) | LT3728254T (fr) |
| MA (1) | MA51290A (fr) |
| MX (1) | MX2020006438A (fr) |
| PE (1) | PE20210163A1 (fr) |
| PL (1) | PL3728254T3 (fr) |
| PT (1) | PT3728254T (fr) |
| RS (1) | RS64167B1 (fr) |
| SA (1) | SA520412278B1 (fr) |
| SG (1) | SG11202005881YA (fr) |
| SI (1) | SI3728254T1 (fr) |
| TW (1) | TWI810230B (fr) |
| UA (1) | UA126173C2 (fr) |
| WO (1) | WO2019122129A1 (fr) |
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| AU2018350980B2 (en) | 2017-10-18 | 2023-02-23 | Incyte Corporation | Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-y gamma inhibitors |
| CR20210307A (es) * | 2017-12-21 | 2021-07-27 | Boehringer Ingelheim Int | NUEVAS PIRIDOPIRIMIDINONAS SUSTITUIDAS CON BENCILAMINO Y DERIVADOS COMO INHIBIDORES DE SOS1 (Divisional 2020-312) |
| KR20220024191A (ko) | 2019-06-19 | 2022-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 항암제 조합 요법 |
| EP4045505A1 (fr) * | 2019-10-15 | 2022-08-24 | Bayer Aktiengesellschaft | 2-méthyl-aza-quinazolines |
| KR20220100903A (ko) * | 2019-11-08 | 2022-07-18 | 레볼루션 메디슨즈, 인크. | 이환식 헤테로아릴 화합물 및 이의 용도 |
| LT4065575T (lt) * | 2019-11-29 | 2024-05-27 | Lupin Limited | Pakeisti tricikliniai junginiai |
| BR112022012106A2 (pt) * | 2019-12-20 | 2022-09-20 | Mirati Therapeutics Inc | Inibidores de sos1 |
| CN113045565A (zh) * | 2019-12-27 | 2021-06-29 | 微境生物医药科技(上海)有限公司 | 新型K-Ras G12C抑制剂 |
| EP4081521A1 (fr) * | 2019-12-27 | 2022-11-02 | Lupin Limited | Composés tricycliques substitués |
| US20230101312A1 (en) * | 2020-02-24 | 2023-03-30 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
| TW202144338A (zh) * | 2020-04-08 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 嘧啶并二環類衍生物、其製備方法及其在醫藥上的應用 |
| US11945812B2 (en) | 2020-06-02 | 2024-04-02 | Boehringer Ingelheim International Gmbh | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| CN113801114B (zh) * | 2020-06-11 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用 |
| US20230219951A1 (en) | 2020-06-11 | 2023-07-13 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pyridine-pyrimidine derivative, preparation method therefor and pharmaceutical use thereof |
| WO2021259972A1 (fr) * | 2020-06-24 | 2021-12-30 | Boehringer Ingelheim International Gmbh | Polythérapie anticancéreuse comprenant un inhibiteur de sos1 et un inhibiteur de kras g12c |
| CN113912608B (zh) * | 2020-07-10 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用 |
| EP4186903A1 (fr) * | 2020-07-24 | 2023-05-31 | Medshine Discovery Inc. | Composé quinazoline |
| CN116194446A (zh) * | 2020-08-06 | 2023-05-30 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| MX2023002248A (es) | 2020-09-03 | 2023-05-16 | Revolution Medicines Inc | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. |
| PE20231207A1 (es) | 2020-09-15 | 2023-08-17 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer |
| US20240025863A1 (en) | 2020-09-16 | 2024-01-25 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| EP4214204A1 (fr) | 2020-09-18 | 2023-07-26 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines en tant qu'inhibiteurs de sos1 |
| CN116323590A (zh) | 2020-10-20 | 2023-06-23 | 苏州泽璟生物制药股份有限公司 | 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用 |
| WO2022105921A1 (fr) * | 2020-11-21 | 2022-05-27 | 上海凌达生物医药有限公司 | Composé pyrimido-hétérocyclique, son procédé de préparation et son utilisation |
| CN117396472A (zh) | 2020-12-22 | 2024-01-12 | 上海齐鲁锐格医药研发有限公司 | Sos1抑制剂及其用途 |
| CN114685487B (zh) * | 2020-12-27 | 2024-04-19 | 上海凌达生物医药有限公司 | 一类嘧啶并杂环类化合物、制备方法和用途 |
| CA3203205A1 (fr) * | 2021-01-19 | 2022-07-28 | Mandar Ramesh Bhonde | Combinaisons pharmaceutiques d'inhibiteurs de sos1 pour le traitement et/ou la prevention du cancer |
| CN116546985A (zh) * | 2021-01-28 | 2023-08-04 | 浙江海正药业股份有限公司 | 吡啶并嘧啶类衍生物及其制备方法和用途 |
| CN117279914A (zh) * | 2021-01-29 | 2023-12-22 | 南京再明医药有限公司 | Sos1抑制剂及其制备方法和应用 |
| CN114436976B (zh) * | 2021-01-29 | 2023-07-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一种新型喹唑啉类衍生物及其制备和应用 |
| CN114835719A (zh) * | 2021-02-01 | 2022-08-02 | 苏州泽璟生物制药股份有限公司 | 取代双环并芳杂环胺类抑制剂及其制备方法和应用 |
| CN114835703A (zh) * | 2021-02-02 | 2022-08-02 | 苏州泽璟生物制药股份有限公司 | 取代嘧啶并吡啶酮类抑制剂及其制备方法和应用 |
| JP2024505732A (ja) | 2021-02-08 | 2024-02-07 | 武漢人福創新薬物研発中心有限公司 | ピリドピリミジノン系誘導体及びその製造方法と使用 |
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| CN113200981A (zh) * | 2021-02-10 | 2021-08-03 | 杭州英创医药科技有限公司 | 作为sos1抑制剂的杂环化合物 |
| WO2022171118A1 (fr) * | 2021-02-10 | 2022-08-18 | 石药集团中奇制药技术（石家庄）有限公司 | Composé ayant une activité antitumorale et son utilisation |
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| JP5634995B2 (ja) | 2008-08-12 | 2014-12-03 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 化学化合物 |
| EP2572709A1 (fr) | 2008-11-28 | 2013-03-27 | Novartis AG | Inhibiteurs de HSP90 utiles dans un traitement thérapeutique |
| UA105198C2 (ru) | 2008-12-12 | 2014-04-25 | Берингер Ингельхайм Интернациональ Гмбх | Антитело против инсулиноподобных факторов роста |
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| CN105107228B (zh) | 2010-12-06 | 2017-03-29 | 颇尔公司 | 生物制品的连续加工方法 |
| US8846656B2 (en) | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
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| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
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| JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| WO2016077793A1 (fr) | 2014-11-14 | 2016-05-19 | Children's Hospital Medical Center | Inhibiteurs de sos1 pour le traitement du cancer |
| CN107286180B (zh) * | 2016-04-11 | 2019-07-02 | 上海勋和医药科技有限公司 | 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用 |
| EP3878850A1 (fr) | 2016-12-22 | 2021-09-15 | Boehringer Ingelheim International GmbH | Nouvelles quinazolines substituées benzylamino et dérivés en tant qu'inhibiteurs de sos1 |
| EP3601267A1 (fr) | 2017-03-21 | 2020-02-05 | Bayer Pharma Aktiengesellschaft | 2-méthyl-quinazolines |
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| KR20220024191A (ko) | 2019-06-19 | 2022-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 항암제 조합 요법 |
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