MX2020006438A - Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1. - Google Patents

Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1.

Info

Publication number
MX2020006438A
MX2020006438A MX2020006438A MX2020006438A MX2020006438A MX 2020006438 A MX2020006438 A MX 2020006438A MX 2020006438 A MX2020006438 A MX 2020006438A MX 2020006438 A MX2020006438 A MX 2020006438A MX 2020006438 A MX2020006438 A MX 2020006438A
Authority
MX
Mexico
Prior art keywords
derivatives
sos1
inhibitors
novel
pyridopyrimidinones
Prior art date
Application number
MX2020006438A
Other languages
English (en)
Inventor
Anke Baum
Marco Santagostino
Michael Gmachl
Markus Ostermeier
Heinz Stadtmueller
Stefan Goepper
Tobias Wunberg
Markus Frank
Juergen Ramharter
Annika Gille
Christiane Kofink
Marco Hans Hofmann
Dorothea Ingrid RUDOLPH
Fabio Savarese
Julian Wippich
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2020006438A publication Critical patent/MX2020006438A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención abarca compuestos de fómiula (I) Ver fórmula donde los grupos R1 a R', A y p tienen los significados dados en las reivindicaciones y la memoria descriptiva, su uso como inhibidores de SOS1, composiciones farmacéuticas que contienen compuestos de esta clase y su uso como medicamentos/usos médicos, especialmente corno agentes para el tratamiento y/o la prevención de enfermedades oncológicas.
MX2020006438A 2017-12-21 2018-12-20 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1. MX2020006438A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17209865 2017-12-21
PCT/EP2018/086197 WO2019122129A1 (en) 2017-12-21 2018-12-20 Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors

Publications (1)

Publication Number Publication Date
MX2020006438A true MX2020006438A (es) 2020-09-17

Family

ID=60781991

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006438A MX2020006438A (es) 2017-12-21 2018-12-20 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1.

Country Status (34)

Country Link
US (2) US10829487B2 (es)
EP (2) EP3728254B1 (es)
JP (1) JP7189956B2 (es)
KR (1) KR20200111163A (es)
CN (1) CN111372932B (es)
AR (1) AR114164A1 (es)
AU (1) AU2018390927B2 (es)
BR (1) BR112020010123A2 (es)
CA (1) CA3085835A1 (es)
CL (2) CL2020001501A1 (es)
CO (1) CO2020007218A2 (es)
CR (2) CR20210307A (es)
DK (1) DK3728254T3 (es)
EA (1) EA202091491A1 (es)
EC (1) ECSP20040257A (es)
ES (1) ES2944306T3 (es)
FI (1) FI3728254T3 (es)
HR (1) HRP20230400T1 (es)
HU (1) HUE062076T2 (es)
IL (1) IL275379B2 (es)
JO (1) JOP20200154A1 (es)
LT (1) LT3728254T (es)
MA (1) MA51290A (es)
MX (1) MX2020006438A (es)
PE (1) PE20210163A1 (es)
PL (1) PL3728254T3 (es)
PT (1) PT3728254T (es)
RS (1) RS64167B1 (es)
SA (1) SA520412278B1 (es)
SG (1) SG11202005881YA (es)
SI (1) SI3728254T1 (es)
TW (1) TWI810230B (es)
UA (1) UA126173C2 (es)
WO (1) WO2019122129A1 (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA50398B1 (fr) 2017-10-18 2021-10-29 Incyte Corp Dérivés d'imidazole condensés, substitués par des groupes hydroxy tertiaires, utilisés comme inhibiteurs de pi3k-gamma
CR20210307A (es) * 2017-12-21 2021-07-27 Boehringer Ingelheim Int NUEVAS PIRIDOPIRIMIDINONAS SUSTITUIDAS CON BENCILAMINO Y DERIVADOS COMO INHIBIDORES DE SOS1 (Divisional 2020-312)
JP2022537044A (ja) 2019-06-19 2022-08-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗がん併用療法
WO2021074227A1 (en) * 2019-10-15 2021-04-22 Bayer Aktiengesellschaft 2-methyl-aza-quinazolines
JP2023500328A (ja) 2019-11-08 2023-01-05 レボリューション メディシンズ インコーポレイテッド 二環式ヘテロアリール化合物及びその使用
CN114746411A (zh) * 2019-11-29 2022-07-12 印度鲁宾有限公司 取代的三环化合物
EP4076418A4 (en) * 2019-12-20 2024-01-24 Mirati Therapeutics Inc SOS1 INHIBITORS
EP4081521A1 (en) * 2019-12-27 2022-11-02 Lupin Limited Substituted tricyclic compounds
CN113045565A (zh) * 2019-12-27 2021-06-29 微境生物医药科技(上海)有限公司 新型K-Ras G12C抑制剂
US20230101312A1 (en) * 2020-02-24 2023-03-30 Mirati Therapeutics, Inc. Sos1 inhibitors
TW202144338A (zh) * 2020-04-08 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 嘧啶并二環類衍生物、其製備方法及其在醫藥上的應用
US20230212164A1 (en) 2020-06-02 2023-07-06 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
TW202214639A (zh) 2020-06-11 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 吡啶酮并嘧啶類衍生物、其製備方法及其在醫藥上的應用
CN113801114B (zh) * 2020-06-11 2022-11-18 江苏恒瑞医药股份有限公司 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用
CN115942936A (zh) * 2020-06-24 2023-04-07 勃林格殷格翰国际有限公司 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
CN113912608B (zh) * 2020-07-10 2023-07-14 江苏恒瑞医药股份有限公司 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用
CN116234807A (zh) * 2020-07-24 2023-06-06 南京明德新药研发有限公司 喹唑啉类化合物
TWI793704B (zh) * 2020-08-06 2023-02-21 大陸商北京泰德製藥股份有限公司 Sos1抑制劑、包含其的藥物組合物及其用途
IL301062A (en) 2020-09-03 2023-05-01 Revolution Medicines Inc Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
US11690915B2 (en) 2020-09-15 2023-07-04 Revolution Medicines, Inc. Ras inhibitors
TW202227427A (zh) 2020-09-16 2022-07-16 美商拜歐斯瑞克斯公司 Sos1蛋白降解劑、其醫藥組合物及其治療應用
WO2022058344A1 (en) 2020-09-18 2022-03-24 Bayer Aktiengesellschaft Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors
AU2021367089A1 (en) 2020-10-20 2023-06-22 Shanghai Zelgen Pharma.Tech Co., Ltd. Substituted benzo or pyridopyrimidine amine inhibitor, preparation method therefor, and application thereof
CN114524810B (zh) * 2020-11-21 2023-12-01 上海凌达生物医药有限公司 一类嘧啶并杂环类化合物、制备方法和用途
CN117396472A (zh) 2020-12-22 2024-01-12 上海齐鲁锐格医药研发有限公司 Sos1抑制剂及其用途
CN114685487B (zh) * 2020-12-27 2024-04-19 上海凌达生物医药有限公司 一类嘧啶并杂环类化合物、制备方法和用途
CA3203205A1 (en) * 2021-01-19 2022-07-28 Mandar Ramesh Bhonde Pharmaceutical combinations of sos1 inhibitors for treating and/or preventing cancer
CN116546985A (zh) * 2021-01-28 2023-08-04 浙江海正药业股份有限公司 吡啶并嘧啶类衍生物及其制备方法和用途
CN114436976B (zh) * 2021-01-29 2023-07-11 石药集团中奇制药技术（石家庄）有限公司 一种新型喹唑啉类衍生物及其制备和应用
WO2022161461A1 (zh) * 2021-01-29 2022-08-04 江苏先声药业有限公司 Sos1抑制剂及其制备方法和应用
CN114835719A (zh) * 2021-02-01 2022-08-02 苏州泽璟生物制药股份有限公司 取代双环并芳杂环胺类抑制剂及其制备方法和应用
CN114835703A (zh) * 2021-02-02 2022-08-02 苏州泽璟生物制药股份有限公司 取代嘧啶并吡啶酮类抑制剂及其制备方法和应用
CA3207590A1 (en) * 2021-02-08 2022-08-11 Xuejun Zhang Pyridopyrimidinone derivative, preparation method therefor, and use thereof
WO2022170802A1 (zh) * 2021-02-09 2022-08-18 苏州阿尔脉生物科技有限公司 一种作为sos1抑制剂的嘧啶并吡啶酮类衍生物、其制备方法及用途
CN113200981A (zh) * 2021-02-10 2021-08-03 杭州英创医药科技有限公司 作为sos1抑制剂的杂环化合物
WO2022171118A1 (zh) * 2021-02-10 2022-08-18 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
US11648254B2 (en) 2021-03-02 2023-05-16 Kumquat Biosciences Inc. Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
CN117062818A (zh) * 2021-03-05 2023-11-14 南京再明医药有限公司 新型sos1抑制剂及其制备方法和应用
KR20230159543A (ko) * 2021-03-26 2023-11-21 메드샤인 디스커버리 아이엔씨. 6-카바메이트로 치환된 헤테로방향족 고리 유도체
GB202104609D0 (en) 2021-03-31 2021-05-12 Sevenless Therapeutics Ltd New Treatments for Pain
WO2022212546A1 (en) * 2021-03-31 2022-10-06 Acerand Therapeutics (Usa) Limited Pyridopyrimidinone compounds
WO2022207673A1 (en) 2021-03-31 2022-10-06 Sevenless Therapeutics Limited Sos1 inhibitors and ras inhibitors for use in the treatment of pain
EP4319757A1 (en) 2021-04-09 2024-02-14 Boehringer Ingelheim International GmbH Anticancer therapy
TW202304452A (zh) * 2021-04-09 2023-02-01 美商銳新醫藥公司 Ｓｏｓ１抑制劑與ｒａｓ抑制劑於治療癌症之用途
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
TWI807787B (zh) * 2021-04-19 2023-07-01 大陸商昆藥集團股份有限公司 苯並嘧啶三環衍生物及製備方法和應用
EP4328219A1 (en) * 2021-04-23 2024-02-28 Shanghai Leadingtac Pharmaceutical Co. Ltd. Sos1 degrading agent and preparation method therefor and application thereof
JPWO2023008462A1 (es) 2021-07-27 2023-02-02
WO2023011540A1 (zh) * 2021-08-03 2023-02-09 苏州信诺维医药科技股份有限公司 稠环化合物、药物组合物及其应用
TW202328076A (zh) * 2021-08-17 2023-07-16 南韓商治納輔醫藥科技有限公司 Sos1抑制劑及其用途
CN117730080A (zh) * 2021-08-30 2024-03-19 浙江海正药业股份有限公司 吡啶并嘧啶酮类衍生物及其制备方法和用途
WO2023029833A1 (zh) * 2021-09-02 2023-03-09 上海海和药物研究开发股份有限公司 一种sos1抑制剂、其制备方法及用途
CN115246841B (zh) * 2021-09-14 2024-02-09 北京福元医药股份有限公司 苄氨基取代的嘧啶并吡喃酮衍生物及其组合物、制剂和用途
CN117957226A (zh) 2021-09-17 2024-04-30 南京再明医药有限公司 作为sos1抑制剂的杂环化合物及其用途
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN115724844A (zh) * 2021-11-22 2023-03-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
TW202340208A (zh) 2021-12-01 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
WO2023099624A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099608A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099592A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099620A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes
WO2023114954A1 (en) 2021-12-17 2023-06-22 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
CN116265462A (zh) * 2021-12-17 2023-06-20 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
WO2023125737A1 (en) * 2021-12-29 2023-07-06 Silexon Ai Technology Co., Ltd. Heterocyclic compounds and use thereof
WO2023135260A1 (en) 2022-01-14 2023-07-20 Jazz Pharmaceuticals Ireland Limited Novel amine-substituted phthalazines and derivatives as sos1 inhibitors
WO2023138526A1 (zh) * 2022-01-21 2023-07-27 南京明德新药研发有限公司 含烯丙基的甲基吡啶并嘧啶化合物的晶型
WO2023143147A1 (zh) * 2022-01-28 2023-08-03 上海优理惠生医药有限公司 一种哒嗪并吡啶酮类化合物、其药物组合物及应用
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
GB202203976D0 (en) 2022-03-22 2022-05-04 Jazz Pharmaceuticals Ireland Ltd Tricyclic phthalazines and derivatives as sos1 inhibitors
US11912708B2 (en) 2022-04-20 2024-02-27 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
WO2023215256A1 (en) * 2022-05-03 2023-11-09 Revolution Medicines, Inc. Sos1 inhibitors and uses thereof
WO2023215257A2 (en) * 2022-05-03 2023-11-09 Revolution Medicines, Inc. Sos1 inhibitors and uses thereof
WO2023230205A1 (en) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024002318A1 (zh) * 2022-07-01 2024-01-04 四川汇宇制药股份有限公司 哒嗪并吡啶酮衍生物及其用途
CN117357650A (zh) * 2022-07-07 2024-01-09 武汉人福创新药物研发中心有限公司 包含sos1抑制剂的药物组合物
CN115057847B (zh) * 2022-07-26 2024-01-26 山东百启生物医药有限公司 一种4,6-二氯-5-(1,3-二氧戊环-2-基)-2-甲基嘧啶的制备方法
WO2024027762A1 (zh) * 2022-08-05 2024-02-08 上海艾力斯医药科技股份有限公司 一种稠环化合物、其制备方法及其应用
CN117534667A (zh) * 2022-08-08 2024-02-09 武汉人福创新药物研发中心有限公司 吡啶并嘧啶酮化合物的晶型、其酸式盐、其酸式盐的晶型和用途
WO2024040131A1 (en) 2022-08-17 2024-02-22 Treeline Biosciences, Inc. Pyridopyrimidine kras inhibitors
WO2024056782A1 (en) 2022-09-16 2024-03-21 Bayer Aktiengesellschaft Sulfone-substituted pyrido[3,4-d]pyrimidine derivatives for the treatment of cancer
WO2024074827A1 (en) 2022-10-05 2024-04-11 Sevenless Therapeutics Limited New treatments for pain
WO2024079252A1 (en) 2022-10-13 2024-04-18 Bayer Aktiengesellschaft Sos1 inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6174899B1 (en) 1998-05-14 2001-01-16 Morton Shulman Orally administered analgesic composition comprising myfadol
EP2139895A1 (en) 2007-03-23 2010-01-06 F. Hoffmann-Roche AG Aza-pyridopyrimidinone derivatives
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
WO2010019637A1 (en) * 2008-08-12 2010-02-18 Smithkline Beecham Corporation Chemical compounds
CN102227220A (zh) 2008-11-28 2011-10-26 诺瓦提斯公司 用于治疗性治疗的Hsp90抑制剂
CN103396487A (zh) 2008-12-12 2013-11-20 贝林格尔.英格海姆国际有限公司 抗igf抗体
NZ630860A (en) 2009-10-29 2016-03-31 Genosco Bissubstituted pyrido[4,3-d]-pyrimindin-5-one kinase nhibitors and medical uses
BR112013013884A2 (pt) 2010-12-06 2016-09-13 Pall Corp métodos de processamento contínuo para produtos biológicos
US8846656B2 (en) 2011-07-22 2014-09-30 Novartis Ag Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
ES2741896T3 (es) 2012-03-14 2020-02-12 Lupin Ltd Compuestos de heterociclilo
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
AU2014239542A1 (en) 2013-03-15 2015-10-01 Araxes Pharma Llc Covalent inhibitors of KRas G12C
GB2532627B (en) * 2013-08-19 2019-04-03 Council Scient Ind Res 3-(4-ethynylphenyl) pyridopyrimidinone compounds and process for preparation thereof useful as potential anticancer agents
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016077793A1 (en) 2014-11-14 2016-05-19 Children's Hospital Medical Center Sos1 inhibitors for cancer treatment
CN107286180B (zh) * 2016-04-11 2019-07-02 上海勋和医药科技有限公司 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
JP7219218B2 (ja) 2016-12-22 2023-02-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体
WO2018172250A1 (en) 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
CR20210307A (es) * 2017-12-21 2021-07-27 Boehringer Ingelheim Int NUEVAS PIRIDOPIRIMIDINONAS SUSTITUIDAS CON BENCILAMINO Y DERIVADOS COMO INHIBIDORES DE SOS1 (Divisional 2020-312)
JP2022537044A (ja) * 2019-06-19 2022-08-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗がん併用療法

Also Published As

Publication number Publication date
PT3728254T (pt) 2023-05-02
IL275379A (en) 2020-07-30
US10829487B2 (en) 2020-11-10
PE20210163A1 (es) 2021-01-26
FI3728254T3 (fi) 2023-05-05
AR114164A1 (es) 2020-07-29
EP3728254A1 (en) 2020-10-28
CL2021000907A1 (es) 2021-10-29
CN111372932A (zh) 2020-07-03
MA51290A (fr) 2021-03-31
WO2019122129A1 (en) 2019-06-27
EA202091491A1 (ru) 2020-11-13
CL2020001501A1 (es) 2020-11-13
AU2018390927A1 (en) 2020-05-28
DK3728254T3 (da) 2023-06-06
US20210009588A1 (en) 2021-01-14
UA126173C2 (uk) 2022-08-25
JOP20200154A1 (ar) 2020-06-18
CN111372932B (zh) 2023-11-21
CO2020007218A2 (es) 2020-06-19
JP7189956B2 (ja) 2022-12-14
IL275379B2 (en) 2023-06-01
SA520412278B1 (ar) 2022-08-17
ES2944306T3 (es) 2023-06-20
US11814380B2 (en) 2023-11-14
CA3085835A1 (en) 2019-06-27
CR20210307A (es) 2021-07-27
SI3728254T1 (sl) 2023-06-30
ECSP20040257A (es) 2020-08-31
LT3728254T (lt) 2023-05-10
US20190194192A1 (en) 2019-06-27
EP3728254B1 (en) 2023-02-15
CR20200312A (es) 2020-09-11
JP2021506864A (ja) 2021-02-22
SG11202005881YA (en) 2020-07-29
KR20200111163A (ko) 2020-09-28
BR112020010123A2 (pt) 2020-11-10
PL3728254T3 (pl) 2023-06-12
TW201938557A (zh) 2019-10-01
HRP20230400T1 (hr) 2023-06-23
EP4219493A1 (en) 2023-08-02
HUE062076T2 (hu) 2023-09-28
AU2018390927B2 (en) 2023-01-12
TWI810230B (zh) 2023-08-01
RS64167B1 (sr) 2023-05-31

Similar Documents

Publication Publication Date Title
CR20210307A (es) NUEVAS PIRIDOPIRIMIDINONAS SUSTITUIDAS CON BENCILAMINO Y DERIVADOS COMO INHIBIDORES DE SOS1 (Divisional 2020-312)
PH12018500259A1 (en) Muscarinic agonists
MY196909A (en) Boronic acid derivatives and therapeutic uses thereof
GEP20186887B (en) Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
MD4800C1 (ro) Compuşi de aminopirimidinil ca inhibitori de JAK
PH12015502414A1 (en) Enhancer of zeste homolog 2 inhibitors
MX2015008957A (es) Fluoro-[1,3]oxazinas como inhibidores de beta-secretasa 1 (bace1).
NZ708593A (en) Novel pyrazole derivative
MD20150043A2 (ro) Inhibitori ai histon-demetilazelor
PH12017500453A1 (en) Spirocyclic inhibitors of cathepsin c
MX2017014035A (es) Formas solidas novedosas.
PH12015502365B1 (en) Bace1 inhibitors
GEP20196961B (en) 4-oxo-3,4-dihydro-1,2,3 -benzotriazines modulators of gpr139
MY167898A (en) Co-crystals and salts of ccr3-inhibitors
PH12018500378A1 (en) Novel annelated phenoxyacetamides
NZ702254A (en) 5-amino[1,4]thiazines as bace 1 inhibitors
MX2017009849A (es) Composiciones de profármaco de monometilfumarato.
PH12017501876A1 (en) Pyridopyrimidones and their use as nmda receptor modulators
PH12017501668A1 (en) Bace1 inhibitors
PH12016502480A1 (en) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
MX2019014436A (es) Derivados de piridoquinazolina eficaces como inhibidores de proteina quinasa.
MX2016016061A (es) 2,2,2-trifluoroetil-tiadiazinas.
GB2553685A (en) Novel éthynylxanthines, their preparation and use as inhibitors of matrix metalloproteinases and angiogenesis
TN2013000150A1 (en) Co-crystals and salts of ccr3-inhibitors