CL2020001501A1 - Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1. - Google Patents

Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1.

Info

Publication number
CL2020001501A1
CL2020001501A1 CL2020001501A CL2020001501A CL2020001501A1 CL 2020001501 A1 CL2020001501 A1 CL 2020001501A1 CL 2020001501 A CL2020001501 A CL 2020001501A CL 2020001501 A CL2020001501 A CL 2020001501A CL 2020001501 A1 CL2020001501 A1 CL 2020001501A1
Authority
CL
Chile
Prior art keywords
benzylamino
derivatives
new
sos1 inhibitors
pyridopyrimidinones
Prior art date
Application number
CL2020001501A
Other languages
English (en)
Inventor
Christiane Kofink
Juergen Ramharter
Annika Gille
Stefan Goepper
Marco Santagostino
Marco Hans Hofmann
Heinz Stadtmueller
Tobias Wunberg
Anke Baum
Michael Gmachl
Dorothea Ingrid RUDOLPH
Fabio Savarese
Markus Ostermeier
Markus Frank
Julian Wippich
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2020001501A1 publication Critical patent/CL2020001501A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención abarca compuestos de fórmula (I), donde los grupos R1 a R4, A y p tienen los significados dados en las reivindicaciones y la memoria descriptiva, su uso como inhibidores de SOS1, composiciones farmacéuticas que contienen compuestos de esta clase y su uso como medicamentos/usos médicos, especialmente como agentes para el tratamiento y/o la prevención de enfermedades oncológicas.
CL2020001501A 2017-12-21 2020-06-05 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1. CL2020001501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17209865 2017-12-21

Publications (1)

Publication Number Publication Date
CL2020001501A1 true CL2020001501A1 (es) 2020-11-13

Family

ID=60781991

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020001501A CL2020001501A1 (es) 2017-12-21 2020-06-05 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1.
CL2021000907A CL2021000907A1 (es) 2017-12-21 2021-04-13 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 (divisional de solicitud n° 01501-2020)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2021000907A CL2021000907A1 (es) 2017-12-21 2021-04-13 Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 (divisional de solicitud n° 01501-2020)

Country Status (34)

Country Link
US (2) US10829487B2 (es)
EP (2) EP4219493A1 (es)
JP (1) JP7189956B2 (es)
KR (1) KR20200111163A (es)
CN (1) CN111372932B (es)
AR (1) AR114164A1 (es)
AU (1) AU2018390927B2 (es)
BR (1) BR112020010123A2 (es)
CA (1) CA3085835A1 (es)
CL (2) CL2020001501A1 (es)
CO (1) CO2020007218A2 (es)
CR (2) CR20210307A (es)
DK (1) DK3728254T3 (es)
EA (1) EA202091491A1 (es)
EC (1) ECSP20040257A (es)
ES (1) ES2944306T3 (es)
FI (1) FI3728254T3 (es)
HR (1) HRP20230400T1 (es)
HU (1) HUE062076T2 (es)
IL (1) IL275379B2 (es)
JO (1) JOP20200154A1 (es)
LT (1) LT3728254T (es)
MA (1) MA51290A (es)
MX (1) MX2020006438A (es)
PE (1) PE20210163A1 (es)
PL (1) PL3728254T3 (es)
PT (1) PT3728254T (es)
RS (1) RS64167B1 (es)
SA (1) SA520412278B1 (es)
SG (1) SG11202005881YA (es)
SI (1) SI3728254T1 (es)
TW (1) TWI810230B (es)
UA (1) UA126173C2 (es)
WO (1) WO2019122129A1 (es)

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