SA03230569B1 - ببتيدات ضخمة الحلقة فعالة ضد فيروس c - Google Patents
ببتيدات ضخمة الحلقة فعالة ضد فيروس c Download PDFInfo
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- SA03230569B1 SA03230569B1 SA03230569A SA03230569A SA03230569B1 SA 03230569 B1 SA03230569 B1 SA 03230569B1 SA 03230569 A SA03230569 A SA 03230569A SA 03230569 A SA03230569 A SA 03230569A SA 03230569 B1 SA03230569 B1 SA 03230569B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- alkyl
- compound
- acid
- hcv
- cycloalkyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002369711A CA2369711A1 (en) | 2002-01-30 | 2002-01-30 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
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|---|---|
| SA03230569B1 true SA03230569B1 (ar) | 2007-03-05 |
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Family Applications (1)
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| SA03230569A SA03230569B1 (ar) | 2002-01-30 | 2003-03-02 | ببتيدات ضخمة الحلقة فعالة ضد فيروس c |
Country Status (26)
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| EP (1) | EP1472278B1 (enExample) |
| JP (1) | JP4040578B2 (enExample) |
| KR (1) | KR20040077899A (enExample) |
| CN (1) | CN1639187A (enExample) |
| AR (1) | AR038330A1 (enExample) |
| AT (1) | ATE414098T1 (enExample) |
| BR (1) | BR0307297A (enExample) |
| CA (1) | CA2369711A1 (enExample) |
| DE (1) | DE60324660D1 (enExample) |
| EA (1) | EA007738B1 (enExample) |
| EC (1) | ECSP045243A (enExample) |
| ES (1) | ES2316718T3 (enExample) |
| HR (1) | HRP20040689A2 (enExample) |
| MX (1) | MXPA04007462A (enExample) |
| NO (1) | NO20043591L (enExample) |
| NZ (1) | NZ534929A (enExample) |
| PE (1) | PE20030818A1 (enExample) |
| PL (1) | PL371007A1 (enExample) |
| RS (1) | RS67004A (enExample) |
| SA (1) | SA03230569B1 (enExample) |
| TW (1) | TW200307692A (enExample) |
| UA (1) | UA78014C2 (enExample) |
| UY (1) | UY27630A1 (enExample) |
| WO (1) | WO2003064455A2 (enExample) |
| ZA (1) | ZA200405639B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1133649C (zh) | 1996-10-18 | 2004-01-07 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂 |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| WO2002060926A2 (en) | 2000-11-20 | 2002-08-08 | Bristol-Myers Squibb Company | Hepatitis c tripeptide inhibitors |
| US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| DE60324552D1 (en) | 2002-05-20 | 2008-12-18 | Bristol Myers Squibb Co | Substituierte cycloalkyl p1' hepatitis c virus inhibitoren |
| AU2003299519A1 (en) | 2002-05-20 | 2004-05-04 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| DE60334205D1 (en) | 2002-05-20 | 2010-10-28 | Bristol Myers Squibb Co | Heterocyclische sulfonamid-hepatitis-c-virus-hemmer |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US20050159345A1 (en) * | 2002-10-29 | 2005-07-21 | Boehringer Ingelheim International Gmbh | Composition for the treatment of infection by Flaviviridae viruses |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| ES2297424T3 (es) | 2003-05-21 | 2008-05-01 | Boehringer Ingelheim International Gmbh | Compuestos inhibidores de la hepatitis c. |
| DE602004025569D1 (de) | 2003-06-18 | 2010-04-01 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
| MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| ES2361997T3 (es) * | 2003-09-22 | 2011-06-27 | Boehringer Ingelheim International Gmbh | Péptidos macrocíclicos activos contra el virus de la hepatitis c. |
| OA13315A (en) | 2003-10-14 | 2007-04-13 | Intermune Inc | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication. |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2539575C (en) | 2003-11-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Method of removing transition metals, especially from metathesis reaction products |
| DE602004019973D1 (de) * | 2003-12-08 | 2009-04-23 | Boehringer Ingelheim Int | Abtrennung von ruthenium-nebenprodukten durch behandlung mit überkritischen flüssigkeiten |
| WO2005070955A1 (en) * | 2004-01-21 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
| DK1713823T3 (da) | 2004-01-30 | 2010-03-08 | Medivir Ab | HCV NS-3 serinproteaseinhibitorer |
| SG184700A1 (en) | 2004-02-20 | 2012-10-30 | Boehringer Ingelheim Int | Viral polymerase inhibitors |
| EA012389B1 (ru) * | 2004-03-30 | 2009-10-30 | Интермун, Инк. | Макроциклические соединения в качестве ингибиторов вирусной репликации |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| HRP20070043A2 (hr) * | 2004-07-16 | 2007-07-31 | Gilead Sciences | Antivirusna sredstva |
| CA2573346C (en) | 2004-07-20 | 2011-09-20 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
| UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
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| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
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2002
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- 2003-01-24 EP EP03700743A patent/EP1472278B1/en not_active Expired - Lifetime
- 2003-01-24 MX MXPA04007462A patent/MXPA04007462A/es unknown
- 2003-01-24 WO PCT/CA2003/000089 patent/WO2003064455A2/en not_active Ceased
- 2003-01-24 KR KR10-2004-7011682A patent/KR20040077899A/ko not_active Ceased
- 2003-01-24 CN CNA038054841A patent/CN1639187A/zh active Pending
- 2003-01-24 JP JP2003564075A patent/JP4040578B2/ja not_active Expired - Fee Related
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- 2003-01-24 PL PL03371007A patent/PL371007A1/xx not_active Application Discontinuation
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- 2003-01-24 EA EA200400886A patent/EA007738B1/ru not_active IP Right Cessation
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| PE20030818A1 (es) | 2003-10-30 |
| WO2003064455A3 (en) | 2004-02-05 |
| ATE414098T1 (de) | 2008-11-15 |
| JP4040578B2 (ja) | 2008-01-30 |
| UA78014C2 (en) | 2007-02-15 |
| NO20043591L (no) | 2004-08-27 |
| MXPA04007462A (es) | 2005-07-13 |
| BR0307297A (pt) | 2004-12-21 |
| EA200400886A1 (ru) | 2005-02-24 |
| AR038330A1 (es) | 2005-01-12 |
| US20030181363A1 (en) | 2003-09-25 |
| TW200307692A (en) | 2003-12-16 |
| RS67004A (sr) | 2006-10-27 |
| ECSP045243A (es) | 2004-09-28 |
| CA2369711A1 (en) | 2003-07-30 |
| EA007738B1 (ru) | 2006-12-29 |
| HRP20040689A2 (en) | 2005-06-30 |
| KR20040077899A (ko) | 2004-09-07 |
| UY27630A1 (es) | 2003-08-29 |
| ES2316718T3 (es) | 2009-04-16 |
| WO2003064455A2 (en) | 2003-08-07 |
| ZA200405639B (en) | 2005-07-01 |
| JP2005524632A (ja) | 2005-08-18 |
| NZ534929A (en) | 2006-08-31 |
| PL371007A1 (en) | 2005-06-13 |
| EP1472278B1 (en) | 2008-11-12 |
| CN1639187A (zh) | 2005-07-13 |
| EP1472278A2 (en) | 2004-11-03 |
| DE60324660D1 (de) | 2008-12-24 |
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