JP4040578B2 - Ｃ型肝炎ウイルスに対して活性な大環状ペプチド - Google Patents
Ｃ型肝炎ウイルスに対して活性な大環状ペプチド Download PDFInfo
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- JP4040578B2 JP4040578B2 JP2003564075A JP2003564075A JP4040578B2 JP 4040578 B2 JP4040578 B2 JP 4040578B2 JP 2003564075 A JP2003564075 A JP 2003564075A JP 2003564075 A JP2003564075 A JP 2003564075A JP 4040578 B2 JP4040578 B2 JP 4040578B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
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| CN117105928B (zh) * | 2023-08-22 | 2024-03-26 | 上海蓝木化工有限公司 | 一种蛋白酶抑制剂及其制备方法 |
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| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
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- 2003-01-24 NZ NZ534929A patent/NZ534929A/en unknown
- 2003-01-24 ES ES03700743T patent/ES2316718T3/es not_active Expired - Lifetime
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- 2003-01-24 CN CNA038054841A patent/CN1639187A/zh active Pending
- 2003-01-24 KR KR10-2004-7011682A patent/KR20040077899A/ko not_active Ceased
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- 2003-01-29 UY UY27630A patent/UY27630A1/es not_active Application Discontinuation
- 2003-01-29 AR ARP030100252A patent/AR038330A1/es unknown
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| Publication number | Publication date |
|---|---|
| ECSP045243A (es) | 2004-09-28 |
| BR0307297A (pt) | 2004-12-21 |
| SA03230569B1 (ar) | 2007-03-05 |
| ATE414098T1 (de) | 2008-11-15 |
| RS67004A (sr) | 2006-10-27 |
| UY27630A1 (es) | 2003-08-29 |
| NO20043591L (no) | 2004-08-27 |
| US20030181363A1 (en) | 2003-09-25 |
| UA78014C2 (en) | 2007-02-15 |
| CN1639187A (zh) | 2005-07-13 |
| DE60324660D1 (de) | 2008-12-24 |
| NZ534929A (en) | 2006-08-31 |
| PL371007A1 (en) | 2005-06-13 |
| WO2003064455A3 (en) | 2004-02-05 |
| EP1472278A2 (en) | 2004-11-03 |
| JP2005524632A (ja) | 2005-08-18 |
| MXPA04007462A (es) | 2005-07-13 |
| WO2003064455A2 (en) | 2003-08-07 |
| CA2369711A1 (en) | 2003-07-30 |
| HRP20040689A2 (en) | 2005-06-30 |
| ZA200405639B (en) | 2005-07-01 |
| ES2316718T3 (es) | 2009-04-16 |
| EA007738B1 (ru) | 2006-12-29 |
| TW200307692A (en) | 2003-12-16 |
| EA200400886A1 (ru) | 2005-02-24 |
| EP1472278B1 (en) | 2008-11-12 |
| AR038330A1 (es) | 2005-01-12 |
| KR20040077899A (ko) | 2004-09-07 |
| PE20030818A1 (es) | 2003-10-30 |
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