CA2369711A1 - Macrocyclic peptides active against the hepatitis c virus - Google Patents

Macrocyclic peptides active against the hepatitis c virus Download PDF

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Publication number
CA2369711A1
CA2369711A1 CA002369711A CA2369711A CA2369711A1 CA 2369711 A1 CA2369711 A1 CA 2369711A1 CA 002369711 A CA002369711 A CA 002369711A CA 2369711 A CA2369711 A CA 2369711A CA 2369711 A1 CA2369711 A1 CA 2369711A1
Authority
CA
Canada
Prior art keywords
mmol
compound
alkyl
mixture
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002369711A
Other languages
English (en)
French (fr)
Inventor
Unknown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Boehringer Ingelheim (Canada) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim (Canada) Ltd filed Critical Boehringer Ingelheim (Canada) Ltd
Priority to CA002369711A priority Critical patent/CA2369711A1/en
Priority to US10/320,978 priority patent/US20030181363A1/en
Priority to CA2474035A priority patent/CA2474035C/en
Priority to NZ534929A priority patent/NZ534929A/en
Priority to PCT/CA2003/000089 priority patent/WO2003064455A2/en
Priority to HR20040689A priority patent/HRP20040689A2/hr
Priority to AT03700743T priority patent/ATE414098T1/de
Priority to CNA038054841A priority patent/CN1639187A/zh
Priority to JP2003564075A priority patent/JP4040578B2/ja
Priority to UA20040807068A priority patent/UA78014C2/uk
Priority to ES03700743T priority patent/ES2316718T3/es
Priority to YU67004A priority patent/RS67004A/sr
Priority to BR0307297-5A priority patent/BR0307297A/pt
Priority to EA200400886A priority patent/EA007738B1/ru
Priority to EP03700743A priority patent/EP1472278B1/en
Priority to MXPA04007462A priority patent/MXPA04007462A/es
Priority to KR10-2004-7011682A priority patent/KR20040077899A/ko
Priority to DE60324660T priority patent/DE60324660D1/de
Priority to PL03371007A priority patent/PL371007A1/xx
Priority to TW092101813A priority patent/TW200307692A/zh
Priority to ARP030100252A priority patent/AR038330A1/es
Priority to US10/353,894 priority patent/US7119072B2/en
Priority to UY27630A priority patent/UY27630A1/es
Priority to PE2003000095A priority patent/PE20030818A1/es
Priority to SA03230569A priority patent/SA03230569B1/ar
Publication of CA2369711A1 publication Critical patent/CA2369711A1/en
Priority to ZA200405639A priority patent/ZA200405639B/en
Priority to EC2004005243A priority patent/ECSP045243A/es
Priority to NO20043591A priority patent/NO20043591L/no
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002369711A 2002-01-30 2002-01-30 Macrocyclic peptides active against the hepatitis c virus Abandoned CA2369711A1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
CA002369711A CA2369711A1 (en) 2002-01-30 2002-01-30 Macrocyclic peptides active against the hepatitis c virus
US10/320,978 US20030181363A1 (en) 2002-01-30 2002-12-17 Macrocyclic peptides active against the hepatitis C virus
EA200400886A EA007738B1 (ru) 2002-01-30 2003-01-24 Макроциклические пептиды, обладающие активностью в отношении вируса гепатита с
MXPA04007462A MXPA04007462A (es) 2002-01-30 2003-01-24 Peptidos macrociclicos activos contra el virus de la hepatitis c.
PCT/CA2003/000089 WO2003064455A2 (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitis c virus
HR20040689A HRP20040689A2 (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitisc virus
AT03700743T ATE414098T1 (de) 2002-01-30 2003-01-24 Makrozyklische peptide mit anti-hepatitis c virus wirkung
CNA038054841A CN1639187A (zh) 2002-01-30 2003-01-24 有效抗c型肝炎病毒的大环肽
JP2003564075A JP4040578B2 (ja) 2002-01-30 2003-01-24 Ｃ型肝炎ウイルスに対して活性な大環状ペプチド
UA20040807068A UA78014C2 (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against hepatitis c virus
ES03700743T ES2316718T3 (es) 2002-01-30 2003-01-24 Peptidos macrociclicos activos contra el virus de la hepaitis c.
YU67004A RS67004A (sr) 2002-01-30 2003-01-24 Makrociklični peptidi aktivni prema virusu hepatitisa c
BR0307297-5A BR0307297A (pt) 2002-01-30 2003-01-24 Peptìdeos macrocìclicos ativos contra o vìrus de hepatite c
CA2474035A CA2474035C (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitis c virus
EP03700743A EP1472278B1 (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitis c virus
NZ534929A NZ534929A (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitis C virus
KR10-2004-7011682A KR20040077899A (ko) 2002-01-30 2003-01-24 Ｃ형 간염 바이러스에 대해 활성인 마크로사이클릭 펩티드
DE60324660T DE60324660D1 (de) 2002-01-30 2003-01-24 Makrozyklische peptide mit anti-hepatitis c virus wirkung
PL03371007A PL371007A1 (en) 2002-01-30 2003-01-24 Macrocyclic peptides active against the hepatitis c virus
TW092101813A TW200307692A (en) 2002-01-30 2003-01-28 Macrocyclic peptides active against the hepatitis C virus
ARP030100252A AR038330A1 (es) 2002-01-30 2003-01-29 Peptidos macrociclicos activos contra el virus de la hepatitis c
US10/353,894 US7119072B2 (en) 2002-01-30 2003-01-29 Macrocyclic peptides active against the hepatitis C virus
UY27630A UY27630A1 (es) 2002-01-30 2003-01-29 Péptidos macrocíclicos activos contrael virus de la hepatitis c.
PE2003000095A PE20030818A1 (es) 2002-01-30 2003-01-29 Peptidos macrociclicos activos contra el virus de la hepatitis c
SA03230569A SA03230569B1 (ar) 2002-01-30 2003-03-02 ببتيدات ضخمة الحلقة فعالة ضد فيروس c
ZA200405639A ZA200405639B (en) 2002-01-30 2004-07-15 Macrocyclic peptides active against the hepatitis C virus.
EC2004005243A ECSP045243A (es) 2002-01-30 2004-08-20 Péptidos macrocíclicos activos contra el virus de la hepatitis C
NO20043591A NO20043591L (no) 2002-01-30 2004-08-27 Makrosykliske peptider aktive mot hepatitt C virus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002369711A CA2369711A1 (en) 2002-01-30 2002-01-30 Macrocyclic peptides active against the hepatitis c virus

Publications (1)

Publication Number Publication Date
CA2369711A1 true CA2369711A1 (en) 2003-07-30

Family

ID=27626541

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002369711A Abandoned CA2369711A1 (en) 2002-01-30 2002-01-30 Macrocyclic peptides active against the hepatitis c virus

Country Status (26)

Country Link
US (1) US20030181363A1 (enExample)
EP (1) EP1472278B1 (enExample)
JP (1) JP4040578B2 (enExample)
KR (1) KR20040077899A (enExample)
CN (1) CN1639187A (enExample)
AR (1) AR038330A1 (enExample)
AT (1) ATE414098T1 (enExample)
BR (1) BR0307297A (enExample)
CA (1) CA2369711A1 (enExample)
DE (1) DE60324660D1 (enExample)
EA (1) EA007738B1 (enExample)
EC (1) ECSP045243A (enExample)
ES (1) ES2316718T3 (enExample)
HR (1) HRP20040689A2 (enExample)
MX (1) MXPA04007462A (enExample)
NO (1) NO20043591L (enExample)
NZ (1) NZ534929A (enExample)
PE (1) PE20030818A1 (enExample)
PL (1) PL371007A1 (enExample)
RS (1) RS67004A (enExample)
SA (1) SA03230569B1 (enExample)
TW (1) TW200307692A (enExample)
UA (1) UA78014C2 (enExample)
UY (1) UY27630A1 (enExample)
WO (1) WO2003064455A2 (enExample)
ZA (1) ZA200405639B (enExample)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
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