RU99120113A - Ферментативное получение полезных соединений в промышленном масштабе с использованием сред с определенным химическим составом - Google Patents
Ферментативное получение полезных соединений в промышленном масштабе с использованием сред с определенным химическим составомInfo
- Publication number
- RU99120113A RU99120113A RU99120113/13A RU99120113A RU99120113A RU 99120113 A RU99120113 A RU 99120113A RU 99120113/13 A RU99120113/13 A RU 99120113/13A RU 99120113 A RU99120113 A RU 99120113A RU 99120113 A RU99120113 A RU 99120113A
- Authority
- RU
- Russia
- Prior art keywords
- strain
- chemical composition
- compound
- fermentation
- certain chemical
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 20
- 239000000126 substance Substances 0.000 title claims 12
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 230000002255 enzymatic effect Effects 0.000 title 1
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- 230000004151 fermentation Effects 0.000 claims abstract 10
- 230000000813 microbial effect Effects 0.000 claims abstract 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract 3
- 231100000219 mutagenic Toxicity 0.000 claims abstract 2
- 230000003505 mutagenic effect Effects 0.000 claims abstract 2
- 238000012216 screening Methods 0.000 claims abstract 2
- 230000009466 transformation Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 35
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 6
- 241000233866 Fungi Species 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 241000235388 Mucorales Species 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- -1 sulfate ammon I Chemical compound 0.000 claims 4
- 241001446247 uncultured actinomycete Species 0.000 claims 4
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
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- 235000021342 arachidonic acid Nutrition 0.000 claims 2
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- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 2
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- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
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- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
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- 229910002651 NO3 Inorganic materials 0.000 claims 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 108700040099 Xylose isomerases Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims 1
- 235000019289 ammonium phosphates Nutrition 0.000 claims 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims 1
- 235000013793 astaxanthin Nutrition 0.000 claims 1
- 239000001168 astaxanthin Substances 0.000 claims 1
- 229940022405 astaxanthin Drugs 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 1
- 229960002747 betacarotene Drugs 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000002962 chemical mutagen Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 1
- 229960003324 clavulanic acid Drugs 0.000 claims 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims 1
- 229960003276 erythromycin Drugs 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 239000003262 industrial enzyme Substances 0.000 claims 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 1
- 229940029339 inulin Drugs 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 229930010796 primary metabolite Natural products 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000012262 fermentative production Methods 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
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- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
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- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- Chemical & Material Sciences (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Analytical Chemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (2)
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| EP97200494 | 1997-02-20 | ||
| EP97200494.9 | 1997-02-20 |
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|---|---|---|---|---|
| US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| KR100576576B1 (ko) * | 1997-02-20 | 2006-05-04 | 디에스엠 아이피 어셋츠 비.브이. | 화학적 합성 배지를 이용하는 가치있는 화합물들의 산업적 규모의 발효적 생산 |
| US6004784A (en) * | 1998-09-14 | 1999-12-21 | General Electric Co. | Fermentation medium and method for producing α, ω -alkanedicarboxylic acids |
| US6440708B1 (en) * | 1998-09-29 | 2002-08-27 | Dsm N.V. | Fermentation of clavulanic acid at a controlled level of ammonia |
| CN101519679B (zh) | 2000-01-28 | 2013-11-13 | Dsmip资产公司 | 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 |
| DE10106493B4 (de) * | 2001-02-13 | 2010-11-04 | Plasmidfactory Gmbh & Co. Kg | Verfahren zur Herstellung von Nukleinsäuren |
| CN100529066C (zh) | 2002-07-01 | 2009-08-19 | 诺维信公司 | 在发酵过程中加入单丙二醇 |
| KR100454508B1 (ko) * | 2002-07-05 | 2004-11-03 | 허명준 | 소취기능과 다제내성균에 대한 멸균력을 갖는 자연기능수및 그의 제조방법 |
| US6955892B2 (en) * | 2002-11-12 | 2005-10-18 | Akzo Nobel N.V. | Feeding processes for fermentation |
| DE10317877A1 (de) * | 2003-04-17 | 2004-11-18 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von Sporidiobolus ruineniae Stämmen mit verbesserter Coenzym Q10-Produktion |
| WO2004106347A1 (en) | 2003-05-28 | 2004-12-09 | Dsm Ip Assets B.V. | Cephem compound |
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| US20100120154A1 (en) | 2007-03-21 | 2010-05-13 | Dsm Ip Assets B.V. | Method for homologous recombination |
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| EP2310487A2 (en) | 2008-08-05 | 2011-04-20 | DSM IP Assets B.V. | Adipoyl-7-adca producing strains |
| EP2213723A1 (en) | 2009-01-30 | 2010-08-04 | Novozymes A/S | Isomaltose for fungus fermentation |
| EP2401371A1 (en) | 2009-02-27 | 2012-01-04 | Novozymes A/S | Mutant cells having reduced expression of metallopeptidase, suitable for recombinant polypeptide production |
| BR112012000078A2 (pt) | 2009-07-03 | 2017-03-01 | Dsm Ip Assets Bv | cepas de talaromyces e composições de enzima. |
| CA2779796A1 (en) | 2009-11-04 | 2011-05-12 | Dsm Ip Assets B.V. | Talaromyces transformants |
| EP2552934B1 (en) | 2010-03-30 | 2015-07-15 | Novozymes A/S | Crystal metabolite recovery |
| KR101013456B1 (ko) * | 2010-11-24 | 2011-02-14 | 주식회사 그린바이오텍 | 심플리실리움 라멜리콜라 ｂｃｐ 균주 배양용 배지 조성물 및 이의 배양방법 |
| WO2012088276A2 (en) * | 2010-12-21 | 2012-06-28 | J3H, Inc | Phospholipid production and composition manipulation through media manipulation |
| CA2823270A1 (en) | 2011-01-31 | 2012-08-09 | Novozymes A/S | Use of browned glucose as a feed substrate |
| EP2683732B1 (en) | 2011-03-11 | 2016-08-24 | DSM IP Assets B.V. | Vector-host system |
| US10160989B2 (en) * | 2011-05-02 | 2018-12-25 | Renewuel Llc | System and method of co-cultivating microalgae with fungus |
| EP2742145A1 (en) | 2011-08-12 | 2014-06-18 | Novozymes A/S | Reduction of culture viscosity by manganese addition |
| US20150197760A1 (en) | 2012-06-19 | 2015-07-16 | Dsm Ip Assets B.V. | Promoters for expressing a gene in a cell |
| BR112014029846A2 (pt) | 2012-07-06 | 2017-06-27 | Novozymes As | método de inativação da célula hospedeira microbiana em um caldo de fermentação |
| EP2889369B1 (en) * | 2012-08-24 | 2020-03-25 | Yamaguchi University | Yeast culture medium |
| CN104797590A (zh) | 2012-11-01 | 2015-07-22 | 诺维信公司 | 用于去除dna的方法 |
| EP3447136B1 (en) | 2013-02-04 | 2020-05-13 | DSM IP Assets B.V. | Carbohydrate degrading polypeptide and uses thereof |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| WO2014202620A2 (en) | 2013-06-19 | 2014-12-24 | Dsm Ip Assets B.V. | Rasamsonia gene and use thereof |
| WO2014202624A2 (en) | 2013-06-19 | 2014-12-24 | Dsm Ip Assets B.V. | Rasamsonia gene and use thereof |
| WO2014202622A2 (en) | 2013-06-19 | 2014-12-24 | Dsm Ip Assets B.V. | Rasamsonia gene and use thereof |
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| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| JP6393898B2 (ja) * | 2014-08-03 | 2018-09-26 | 国立大学法人 奈良先端科学技術大学院大学 | 酵母の培養方法 |
| CA2958439C (en) | 2014-10-02 | 2022-09-20 | Evonik Industries Ag | Feedstuff of high abrasion resistance and good stability in water, containing pufas |
| BR112017005388B1 (pt) | 2014-10-02 | 2022-09-13 | Evonik Operations Gmbh | Alimento para animais contendo biomassa de aurantiochytrium |
| DK3200606T3 (da) | 2014-10-02 | 2021-06-21 | Evonik Operations Gmbh | Fremgangsmåde til fremstilling af et fodermiddel, der indeholder pufa'er, ved ekstrusion af en biomasse, der indeholder pufa'er, af typen labyrinthulomycetes |
| BR112017006838B1 (pt) | 2014-10-02 | 2021-07-06 | Evonik Operations Gmbh | Processo para produzir um alimento para animais compreendendo biomassa contendo pufa, alimento para animais e método para criar animais |
| WO2017097869A1 (en) | 2015-12-09 | 2017-06-15 | Basf Se | Method of purifying a protein from fermentation solids under desorbing conditions |
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| US20190292514A1 (en) | 2016-07-14 | 2019-09-26 | Basf Se | Fermentation medium comprising chelating agent |
| JP2018023356A (ja) * | 2016-08-04 | 2018-02-15 | 三洋化成工業株式会社 | 有用物質の生産方法 |
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- 1998-02-20 KR KR1019997007546A patent/KR100576576B1/ko not_active Expired - Lifetime
- 1998-02-20 PT PT98909483T patent/PT970236E/pt unknown
- 1998-02-20 CN CNB031589936A patent/CN100351386C/zh not_active Expired - Lifetime
- 1998-02-20 AU AU64000/98A patent/AU6400098A/en not_active Abandoned
- 1998-02-20 WO PCT/EP1998/001122 patent/WO1998037179A2/en not_active Ceased
- 1998-02-20 DE DE69834630T patent/DE69834630T2/de not_active Expired - Fee Related
- 1998-02-20 RU RU99120113/13A patent/RU99120113A/ru not_active Application Discontinuation
- 1998-02-20 CN CN98802632A patent/CN1127571C/zh not_active Expired - Lifetime
- 1998-02-20 EP EP98909483A patent/EP0970236B1/en not_active Expired - Lifetime
- 1998-02-20 JP JP53628498A patent/JP4217277B2/ja not_active Expired - Lifetime
- 1998-02-20 ES ES98909483T patent/ES2262228T3/es not_active Expired - Lifetime
- 1998-02-20 EP EP10174944A patent/EP2345734A3/en not_active Ceased
- 1998-02-20 SI SI9830840T patent/SI0970236T1/sl unknown
- 1998-02-20 EP EP10176934A patent/EP2256211A3/en not_active Withdrawn
- 1998-02-20 PL PL98335227A patent/PL335227A1/xx unknown
- 1998-02-20 AT AT98909483T patent/ATE327340T1/de active
- 1998-02-20 EP EP06114041A patent/EP1690945A3/en not_active Withdrawn
- 1998-02-20 CZ CZ0295499A patent/CZ299290B6/cs not_active IP Right Cessation
- 1998-02-20 BR BR9807362-1A patent/BR9807362A/pt not_active IP Right Cessation
- 1998-02-28 ID IDW990726D patent/ID23995A/id unknown
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2001
- 2001-10-17 US US09/982,474 patent/US20020039758A1/en not_active Abandoned
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2006
- 2006-12-14 US US11/638,564 patent/US20070092955A1/en not_active Abandoned
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2008
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2009
- 2009-06-09 JP JP2009138253A patent/JP2009195254A/ja active Pending
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2014
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- 2014-02-17 US US14/182,212 patent/US20140342396A1/en not_active Abandoned
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