RU94040914A - Производные индола как вещества, обладающие сродством к рецептору 5-нтi, фармкомпозиция и способ лечения - Google Patents

Производные индола как вещества, обладающие сродством к рецептору 5-нтi, фармкомпозиция и способ лечения

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Publication number
RU94040914A
RU94040914A RU94040914/04A RU94040914A RU94040914A RU 94040914 A RU94040914 A RU 94040914A RU 94040914/04 A RU94040914/04 A RU 94040914/04A RU 94040914 A RU94040914 A RU 94040914A RU 94040914 A RU94040914 A RU 94040914A
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RU
Russia
Prior art keywords
alkyl
aryl
rand
alkylaryl
ring
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RU94040914/04A
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English (en)
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RU2124012C1 (ru
Inventor
Е. Мейкор Джон
Us]
Т. Новаковски Еланта
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Пфайзер Инк. (US)
Пфайзер Инк.
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Publication of RU94040914A publication Critical patent/RU94040914A/ru
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Publication of RU2124012C1 publication Critical patent/RU2124012C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данные соединения могут применяться в качестве психотерапевтических средств, обладают потенциальным сродством к серотонину и могут быть использованы для лечения депрессии, тревожности, нарушений в пищевом поведении, ожирения, токсикомании, "гистаминовой" головной боли, мигрени, боли и хронической пароксизмальной гемикрании и головной боли, вызванных сосудистыми нарушениями, а также иных заболеваний, обусловленных недостаточной серотонергической нейротрансмиссией. Соединения также могут применяться в качестве антигипертензивных и сосудорасширяющих средств центрального действия.

Claims (1)

  1. Данные соединения могут применяться в качестве психотерапевтических средств, обладают потенциальным сродством к серотонину и могут быть использованы для лечения депрессии, тревожности, нарушений в пищевом поведении, ожирения, токсикомании, "гистаминовой" головной боли, мигрени, боли и хронической пароксизмальной гемикрании и головной боли, вызванных сосудистыми нарушениями, а также иных заболеваний, обусловленных недостаточной серотонергической нейротрансмиссией. Соединения также могут применяться в качестве антигипертензивных и сосудорасширяющих средств центрального действия.
RU94040914/04A 1992-03-05 1993-03-03 Производные индола и содержащие их фармацевтические композиции RU2124012C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84664092A 1992-03-05 1992-03-05
US07/846,640 1992-03-05
US07/846.640 1992-03-05

Publications (2)

Publication Number Publication Date
RU94040914A true RU94040914A (ru) 1996-08-10
RU2124012C1 RU2124012C1 (ru) 1998-12-27

Family

ID=25298499

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94040914/04A RU2124012C1 (ru) 1992-03-05 1993-03-03 Производные индола и содержащие их фармацевтические композиции

Country Status (30)

Country Link
US (2) US5594014A (ru)
EP (1) EP0629199B1 (ru)
JP (1) JPH07121943B2 (ru)
KR (1) KR0179073B1 (ru)
CN (4) CN1032309C (ru)
AT (1) ATE218566T1 (ru)
AU (1) AU666716B2 (ru)
BR (1) BR9306012A (ru)
CA (1) CA2117643C (ru)
CZ (1) CZ282652B6 (ru)
DE (1) DE69331988T2 (ru)
DK (1) DK0629199T3 (ru)
EG (1) EG20416A (ru)
ES (1) ES2176199T3 (ru)
FI (1) FI930968A (ru)
HU (1) HU219489B (ru)
IL (1) IL104941A (ru)
MX (1) MX9301197A (ru)
MY (1) MY109298A (ru)
NO (1) NO302617B1 (ru)
NZ (1) NZ249755A (ru)
PL (1) PL172388B1 (ru)
PT (1) PT629199E (ru)
RU (1) RU2124012C1 (ru)
SK (1) SK281938B6 (ru)
TW (1) TW288010B (ru)
UA (1) UA39866C2 (ru)
WO (1) WO1993018032A1 (ru)
YU (1) YU14893A (ru)
ZA (1) ZA931539B (ru)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
CZ281763B6 (cs) 1992-04-07 1997-01-15 Pfizer Inc. Indolové deriváty představující 5-HT1 agonisty, způsob jejich přípravy, farmaceutické prostředky obsahující tyto látky, jejich použití a meziprodukty postupu přípravy
HUT75646A (en) * 1993-08-31 1997-05-28 Pfizer 5-arylindole derivatives and pharmaceutical compositions containing them
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
NZ331104A (en) * 1995-12-29 2000-03-27 Boehringer Ingelheim Ca Ltd Phenyl thiazole derivatives that inhibit herpes replication by inhibiting the herpes helicase primase enzyme complex
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
CN1476429A (zh) 2000-11-27 2004-02-18 �Ʒ� 治疗骨质疏松的ep4受体选择性激动剂
MXPA03009490A (es) * 2001-04-20 2004-02-12 Wyeth Corp Derivados de heterociclilalcoxi-,-alquiltio-y- alquilaminobenzazol como ligando de 5-hidroxitriptamina-6.
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) * 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
AU2021215709A1 (en) * 2020-02-04 2022-09-01 Mindset Pharma Inc. 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
CA2064815C (en) * 1990-06-07 1999-11-16 Alan Duncan Robertson Therapeutic heterocyclic compounds
AU651637B2 (en) * 1990-10-15 1994-07-28 Pfizer Inc. Indole derivatives
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (ru) * 1991-02-12 1995-11-21 Pfizer

Also Published As

Publication number Publication date
KR0179073B1 (ko) 1999-03-20
CN1136432A (zh) 1996-11-27
CA2117643A1 (en) 1993-09-16
MX9301197A (es) 1993-09-01
UA39866C2 (uk) 2001-07-16
US5594014A (en) 1997-01-14
EG20416A (en) 1999-02-28
PT629199E (pt) 2002-09-30
HU219489B (hu) 2001-04-28
DE69331988T2 (de) 2002-09-19
CN1044910C (zh) 1999-09-01
WO1993018032A1 (en) 1993-09-16
NO302617B1 (no) 1998-03-30
NZ249755A (en) 1996-08-27
ZA931539B (en) 1994-09-05
CN1044909C (zh) 1999-09-01
CN1082815C (zh) 2002-04-17
US5717102A (en) 1998-02-10
CN1136565A (zh) 1996-11-27
YU14893A (sh) 1996-05-20
CA2117643C (en) 2000-03-14
CN1032309C (zh) 1996-07-17
AU3733093A (en) 1993-10-05
SK105294A3 (en) 1995-05-10
IL104941A (en) 1998-06-15
PL172388B1 (pl) 1997-09-30
HU9300593D0 (en) 1993-05-28
NO943261D0 (no) 1994-09-02
ES2176199T3 (es) 2002-12-01
NO943261L (no) 1994-09-02
ATE218566T1 (de) 2002-06-15
DE69331988D1 (de) 2002-07-11
EP0629199B1 (en) 2002-06-05
IL104941A0 (en) 1993-07-08
CN1136566A (zh) 1996-11-27
CZ212594A3 (en) 1995-06-14
BR9306012A (pt) 1997-11-18
DK0629199T3 (da) 2002-07-15
AU666716B2 (en) 1996-02-22
TW288010B (ru) 1996-10-11
MY109298A (en) 1996-12-31
JPH07500353A (ja) 1995-01-12
HUT64061A (en) 1993-11-29
SK281938B6 (sk) 2001-09-11
RU2124012C1 (ru) 1998-12-27
KR950700291A (ko) 1995-01-16
FI930968A0 (fi) 1993-03-04
FI930968A (fi) 1993-09-06
EP0629199A1 (en) 1994-12-21
CZ282652B6 (cs) 1997-08-13
JPH07121943B2 (ja) 1995-12-25
CN1082044A (zh) 1994-02-16

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