RU94045897A - Производные индола в качестве 5-hti-агонистов, фармацевтическая композиция и способ лечения - Google Patents

Производные индола в качестве 5-hti-агонистов, фармацевтическая композиция и способ лечения

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Publication number
RU94045897A
RU94045897A RU94045897/04A RU94045897A RU94045897A RU 94045897 A RU94045897 A RU 94045897A RU 94045897/04 A RU94045897/04 A RU 94045897/04A RU 94045897 A RU94045897 A RU 94045897A RU 94045897 A RU94045897 A RU 94045897A
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alkyl
rmeans
aryl
alkylaryl
compounds
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RU94045897/04A
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English (en)
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RU2101283C1 (ru
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И.Мэйкор Джон
Us]
Дж.Уитс Мартин
Gb]
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Пфайзер Инк. (US)
Пфайзер Инк.
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Publication of RU2101283C1 publication Critical patent/RU2101283C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Раскрываются соединения общей формулы, приведенной в описании, а также фармацевтически приемлемые соли этих соединений. Эти соединения являются новыми и могут быть использованы для лечeния мигрени и других расстройств. Указанные соединения являются ценными психотерапевтическими средствами и сильными агонистами серотонина (5-НТ) и могут быть использованы для лечения депрессии тревожных состояний, нарушений, связанных с приемом пищи, ожирения, злоупотребления наркотиками, "гистаминовой" головной боли, мигрени, болей хронической пароксизмальной гемикрании и головной боли, связанной с сосудистыми заболеваниями, а также для лечения других расстройств, связанных с недостаточной серотонинергической нейротрансмиссией. Кроме того, указанные соединения могут быть использованы в качестве гипотенсивных и сусудисторасширяющих средств центрального действия.

Claims (1)

  1. Раскрываются соединения общей формулы, приведенной в описании, а также фармацевтически приемлемые соли этих соединений. Эти соединения являются новыми и могут быть использованы для лечeния мигрени и других расстройств. Указанные соединения являются ценными психотерапевтическими средствами и сильными агонистами серотонина (5-НТ1) и могут быть использованы для лечения депрессии тревожных состояний, нарушений, связанных с приемом пищи, ожирения, злоупотребления наркотиками, "гистаминовой" головной боли, мигрени, болей хронической пароксизмальной гемикрании и головной боли, связанной с сосудистыми заболеваниями, а также для лечения других расстройств, связанных с недостаточной серотонинергической нейротрансмиссией. Кроме того, указанные соединения могут быть использованы в качестве гипотенсивных и сусудисторасширяющих средств центрального действия.
RU94045897/04A 1992-04-07 1993-03-10 Производные индола или их фармацевтически приемлемые соли RU2101283C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86473792A 1992-04-07 1992-04-07
US864,737 1992-04-07
PCT/US1993/001967 WO1993020073A1 (en) 1992-04-07 1993-03-10 Indole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
RU94045897A true RU94045897A (ru) 1996-09-10
RU2101283C1 RU2101283C1 (ru) 1998-01-10

Family

ID=25343950

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045897/04A RU2101283C1 (ru) 1992-04-07 1993-03-10 Производные индола или их фармацевтически приемлемые соли

Country Status (26)

Country Link
US (7) US5747501A (ru)
EP (1) EP0635017A1 (ru)
JP (1) JP2644088B2 (ru)
KR (1) KR0179072B1 (ru)
CN (2) CN1050841C (ru)
AU (1) AU670579B2 (ru)
BR (1) BR9306201A (ru)
CA (1) CA2133413C (ru)
CZ (1) CZ281763B6 (ru)
EG (1) EG20226A (ru)
FI (1) FI931558A (ru)
HR (1) HRP930752A2 (ru)
HU (1) HUT64062A (ru)
IL (1) IL105206A (ru)
MX (1) MX9302011A (ru)
MY (1) MY108909A (ru)
NO (1) NO303388B1 (ru)
NZ (1) NZ251086A (ru)
PL (1) PL172405B1 (ru)
RU (1) RU2101283C1 (ru)
SK (1) SK280193B6 (ru)
TW (1) TW341565B (ru)
UA (1) UA27467C2 (ru)
WO (1) WO1993020073A1 (ru)
YU (1) YU48931B (ru)
ZA (1) ZA932440B (ru)

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GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
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GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
CA2207201A1 (en) * 1994-12-06 1996-06-13 Caroline Henry Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
AU707537B2 (en) * 1995-07-31 1999-07-15 Anthera Pharmaceuticals, Inc. Pyrrolidine derivatives having phospholipase a2 inhibitory activity
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EP1103552A4 (en) * 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
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US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
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Also Published As

Publication number Publication date
NO943762D0 (no) 1994-10-06
US6410739B1 (en) 2002-06-25
JP2644088B2 (ja) 1997-08-25
US6465500B1 (en) 2002-10-15
YU48931B (sh) 2002-12-10
WO1993020073A1 (en) 1993-10-14
CA2133413A1 (en) 1993-10-14
US5747501A (en) 1998-05-05
CA2133413C (en) 2001-04-10
CZ246494A3 (en) 1995-06-14
NO943762L (no) 1994-10-06
KR950700906A (ko) 1995-02-20
ZA932440B (en) 1994-10-05
YU23893A (sh) 1996-10-09
BR9306201A (pt) 1998-06-23
CN1050841C (zh) 2000-03-29
AU670579B2 (en) 1996-07-25
US6387941B1 (en) 2002-05-14
HRP930752A2 (en) 1994-10-31
FI931558A (fi) 1993-10-08
SK120694A3 (en) 1995-05-10
US6436957B1 (en) 2002-08-20
FI931558A0 (fi) 1993-04-06
EG20226A (en) 1997-12-31
CN1225362A (zh) 1999-08-11
TW341565B (en) 1998-10-01
IL105206A (en) 1999-04-11
KR0179072B1 (ko) 1999-03-20
US6387937B1 (en) 2002-05-14
EP0635017A1 (en) 1995-01-25
UA27467C2 (ru) 2000-09-15
NO303388B1 (no) 1998-07-06
PL172405B1 (en) 1997-09-30
MX9302011A (es) 1994-03-31
SK280193B6 (sk) 1999-09-10
HUT64062A (en) 1993-11-29
NZ251086A (en) 1996-09-25
CN1083443C (zh) 2002-04-24
CZ281763B6 (cs) 1997-01-15
JPH07504919A (ja) 1995-06-01
CN1082543A (zh) 1994-02-23
HU9301003D0 (en) 1993-06-28
IL105206A0 (en) 1993-07-08
AU3789893A (en) 1993-11-08
US6150388A (en) 2000-11-21
RU2101283C1 (ru) 1998-01-10
MY108909A (en) 1996-11-30

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