YU23893A - Derivati indola - Google Patents

Derivati indola

Info

Publication number
YU23893A
YU23893A YU23893A YU23893A YU23893A YU 23893 A YU23893 A YU 23893A YU 23893 A YU23893 A YU 23893A YU 23893 A YU23893 A YU 23893A YU 23893 A YU23893 A YU 23893A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
aryl
hydrogen
substituted
membered
Prior art date
Application number
YU23893A
Other languages
English (en)
Other versions
YU48931B (sh
Inventor
J.E. Macor
J.M. Wythes
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU23893A publication Critical patent/YU23893A/sh
Publication of YU48931B publication Critical patent/YU48931B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

DERIVATI INDOLA jedinjenja formule gde W je n je 0, 1, ili 2; m je 0, 1, 2, ili 3; Y i G su svako nezavisno kiseonik ili sumpor; Z je -0-, -S-, -NH, ili -CH2; R1 je vodonik, C1-C8 alkil, supstituisan C1-C8 alkil supstituisan sa jednim hidroksi, C3-C8 alkenil, C3-C8 alkinil, aril, C1-C3 alkilaril, C1-C3 alkilheteroaril, ili -Q-R4; R2 i R3 su svako nezavisno vodonik, C1-C6 alkil, aril, C1-C3 alkilaril, ili c1-C3 alkil­heteroaril; R4 je cijano, trifluormetil, -COR9, -CO2R9, -CONR9R10, -OR9, -SO2NR9R10, ili -S(0)q R9; R9 i R10 su svako nezavisno vodonik, C1-C6 alkil,C1-C3 alkilaril, aril, ili R9 i R1 o mogu se uzeti zajedno radi obrazovanja troclanog do sedmoclanog alkil ovog prstena ili troclanog do sedmoclanog heteroalkilovog prstena sa 1 heteroatomom 0; Q je Ci do C3 alkil; R11 je vodonik, -OR12, ili -nhcor12; R12 je vodonik, C1-C alkil, aril, Ui c1-C3 alkil-aril; q je 0, 1, ili 2; prvi hiralni ugljenik je oznacen zvezdicom; drugi hiralni ugljenik je oznacen sa ; i gornje aril grupe i ostaci arila gorajih alkil-aril grupa su nezavisno odabrani iz fenila i supstituisanog fenila, gde pomenuti supstiruisani fenil moze bid supstituisan sa jed­nom do tri grupe odabrane iz c1-C4 alkil, halogen, hidroksi, cijano, karboksamido, nitro i C1-C4 alkoksi, i njihove farmaceutski prihvadjive soli. Ova jedinjenja su korisna psihoterapeutska sredstva i predstavljaju potentne serotonin (5-HTi) agoniste i mogu se koristili u lecenju depresije, uznemirenosti, smetnji prilikom uzimanja hrane, gojaznosti, zloupotrerje lekova, opste glavobolje, migrene, bola, i hronicne paroksizmalne hemikranije i glavobolje u vezi sa vaskularnim obolenjima, i drugim obolenjima koja nastaju iz nedovoljne serotonergicne neurotransmisije.
YU23893A 1992-04-07 1993-04-06 Derivati indola YU48931B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86473792A 1992-04-07 1992-04-07

Publications (2)

Publication Number Publication Date
YU23893A true YU23893A (sh) 1996-10-09
YU48931B YU48931B (sh) 2002-12-10

Family

ID=25343950

Family Applications (1)

Application Number Title Priority Date Filing Date
YU23893A YU48931B (sh) 1992-04-07 1993-04-06 Derivati indola

Country Status (26)

Country Link
US (7) US5747501A (sh)
EP (1) EP0635017A1 (sh)
JP (1) JP2644088B2 (sh)
KR (1) KR0179072B1 (sh)
CN (2) CN1050841C (sh)
AU (1) AU670579B2 (sh)
BR (1) BR9306201A (sh)
CA (1) CA2133413C (sh)
CZ (1) CZ281763B6 (sh)
EG (1) EG20226A (sh)
FI (1) FI931558A (sh)
HR (1) HRP930752A2 (sh)
HU (1) HUT64062A (sh)
IL (1) IL105206A (sh)
MX (1) MX9302011A (sh)
MY (1) MY108909A (sh)
NO (1) NO303388B1 (sh)
NZ (1) NZ251086A (sh)
PL (1) PL172405B1 (sh)
RU (1) RU2101283C1 (sh)
SK (1) SK280193B6 (sh)
TW (1) TW341565B (sh)
UA (1) UA27467C2 (sh)
WO (1) WO1993020073A1 (sh)
YU (1) YU48931B (sh)
ZA (1) ZA932440B (sh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5747501A (en) * 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
DK0716649T3 (da) * 1993-08-31 1999-02-08 Pfizer 5-Arylindolderivater
EP0759918A1 (en) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
CA2207201A1 (en) * 1994-12-06 1996-06-13 Caroline Henry Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
AU707537B2 (en) * 1995-07-31 1999-07-15 Anthera Pharmaceuticals, Inc. Pyrrolidine derivatives having phospholipase a2 inhibitory activity
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
US6051593A (en) * 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
EP1100501A4 (en) * 1998-06-30 2002-12-04 Lilly Co Eli PYRROLIDINE AND PYRROLIDINE DERIVATIVES INFLUENTING THE SYSTEMS ASSOCIATED WITH SEROTONIN
EP1103552A4 (en) * 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
AU2006335110B2 (en) * 2005-12-30 2011-04-14 Merck Sharp & Dohme Corp. CETP inhibitors
EP2346505B1 (en) * 2008-10-16 2014-04-23 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP6947749B2 (ja) * 2016-04-28 2021-10-13 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． チロシンキナーゼ阻害剤及びその誘導体を製造する方法
IL295374A (en) * 2020-02-04 2022-10-01 Mindset Pharma Inc 3-pyrrolidine indole derivatives as serotonergic psychedelics for the treatment of central nervous system disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
FR2601008B1 (fr) * 1986-07-03 1990-03-30 Sanofi Sa Procede de synthese stereospecifique de derives de l'indole
HU203330B (en) * 1987-06-10 1991-07-29 Pfizer Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
YU48855B (sh) * 1990-06-07 2002-06-19 The Wellcome Foundation Limited Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
WO1992006973A1 (en) * 1990-10-15 1992-04-30 Pfizer Inc. Indole derivatives
US5559246A (en) 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (sh) * 1991-02-12 1995-11-21 Pfizer
BR9206810A (pt) 1991-11-25 1995-10-31 Pfizer Derivados de indol
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
US5409941A (en) 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (sh) 1992-03-05 1996-10-11 Pfizer
US5747501A (en) * 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
AU670270B2 (en) 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists

Also Published As

Publication number Publication date
NO943762D0 (no) 1994-10-06
US6410739B1 (en) 2002-06-25
JP2644088B2 (ja) 1997-08-25
US6465500B1 (en) 2002-10-15
YU48931B (sh) 2002-12-10
WO1993020073A1 (en) 1993-10-14
CA2133413A1 (en) 1993-10-14
US5747501A (en) 1998-05-05
CA2133413C (en) 2001-04-10
CZ246494A3 (en) 1995-06-14
NO943762L (no) 1994-10-06
KR950700906A (ko) 1995-02-20
ZA932440B (en) 1994-10-05
BR9306201A (pt) 1998-06-23
CN1050841C (zh) 2000-03-29
AU670579B2 (en) 1996-07-25
US6387941B1 (en) 2002-05-14
HRP930752A2 (en) 1994-10-31
FI931558A (fi) 1993-10-08
SK120694A3 (en) 1995-05-10
US6436957B1 (en) 2002-08-20
FI931558A0 (fi) 1993-04-06
EG20226A (en) 1997-12-31
CN1225362A (zh) 1999-08-11
RU94045897A (ru) 1996-09-10
TW341565B (en) 1998-10-01
IL105206A (en) 1999-04-11
KR0179072B1 (ko) 1999-03-20
US6387937B1 (en) 2002-05-14
EP0635017A1 (en) 1995-01-25
UA27467C2 (uk) 2000-09-15
NO303388B1 (no) 1998-07-06
PL172405B1 (en) 1997-09-30
MX9302011A (es) 1994-03-31
SK280193B6 (sk) 1999-09-10
HUT64062A (en) 1993-11-29
NZ251086A (en) 1996-09-25
CN1083443C (zh) 2002-04-24
CZ281763B6 (cs) 1997-01-15
JPH07504919A (ja) 1995-06-01
CN1082543A (zh) 1994-02-23
HU9301003D0 (en) 1993-06-28
IL105206A0 (en) 1993-07-08
AU3789893A (en) 1993-11-08
US6150388A (en) 2000-11-21
RU2101283C1 (ru) 1998-01-10
MY108909A (en) 1996-11-30

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