SK281938B6 - Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov - Google Patents

Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov Download PDF

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Publication number
SK281938B6
SK281938B6 SK1052-94A SK105294A SK281938B6 SK 281938 B6 SK281938 B6 SK 281938B6 SK 105294 A SK105294 A SK 105294A SK 281938 B6 SK281938 B6 SK 281938B6
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SK
Slovakia
Prior art keywords
group
compound
formula
alkyl
carbon atoms
Prior art date
Application number
SK1052-94A
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English (en)
Slovak (sk)
Other versions
SK105294A3 (en
Inventor
John E. Macor
Jolanta T. Nowakowski
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SK105294A3 publication Critical patent/SK105294A3/sk
Publication of SK281938B6 publication Critical patent/SK281938B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK1052-94A 1992-03-05 1993-03-03 Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov SK281938B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84664092A 1992-03-05 1992-03-05
PCT/US1993/001667 WO1993018032A1 (en) 1992-03-05 1993-03-03 Indole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
SK105294A3 SK105294A3 (en) 1995-05-10
SK281938B6 true SK281938B6 (sk) 2001-09-11

Family

ID=25298499

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1052-94A SK281938B6 (sk) 1992-03-05 1993-03-03 Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov

Country Status (30)

Country Link
US (2) US5594014A (ru)
EP (1) EP0629199B1 (ru)
JP (1) JPH07121943B2 (ru)
KR (1) KR0179073B1 (ru)
CN (4) CN1032309C (ru)
AT (1) ATE218566T1 (ru)
AU (1) AU666716B2 (ru)
BR (1) BR9306012A (ru)
CA (1) CA2117643C (ru)
CZ (1) CZ282652B6 (ru)
DE (1) DE69331988T2 (ru)
DK (1) DK0629199T3 (ru)
EG (1) EG20416A (ru)
ES (1) ES2176199T3 (ru)
FI (1) FI930968A (ru)
HU (1) HU219489B (ru)
IL (1) IL104941A (ru)
MX (1) MX9301197A (ru)
MY (1) MY109298A (ru)
NO (1) NO302617B1 (ru)
NZ (1) NZ249755A (ru)
PL (1) PL172388B1 (ru)
PT (1) PT629199E (ru)
RU (1) RU2124012C1 (ru)
SK (1) SK281938B6 (ru)
TW (1) TW288010B (ru)
UA (1) UA39866C2 (ru)
WO (1) WO1993018032A1 (ru)
YU (1) YU14893A (ru)
ZA (1) ZA931539B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
PL172405B1 (en) 1992-04-07 1997-09-30 Pfizer Derivatives of indole
KR100191973B1 (ko) * 1993-08-31 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 5-아릴인돌 유도체
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
DK0871619T3 (da) * 1995-12-29 2003-03-03 Boehringer Ingelheim Pharma Phenylthiazolderivater med antiherpesvirusegenskaber
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
DE60130675T2 (de) 2000-11-27 2008-01-24 Pfizer Products Inc., Groton Selektive agonisten des ep4 rezeptors für die behandlung von osteoporose
MXPA03009490A (es) * 2001-04-20 2004-02-12 Wyeth Corp Derivados de heterociclilalcoxi-,-alquiltio-y- alquilaminobenzazol como ligando de 5-hidroxitriptamina-6.
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) * 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
MX2022009528A (es) * 2020-02-04 2022-11-14 Mindset Pharma Inc Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
IL98392A (en) * 1990-06-07 1996-01-19 Wellcome Found History of indole, their preparation and the pharmaceutical preparations containing them
RU2095360C1 (ru) * 1990-10-15 1997-11-10 Пфайзер Инк. Производные индола, их оптические изомеры и фармацевтически приемлемые соли
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (ru) * 1991-02-12 1995-11-21 Pfizer

Also Published As

Publication number Publication date
FI930968A (fi) 1993-09-06
NO943261L (no) 1994-09-02
CN1032309C (zh) 1996-07-17
JPH07121943B2 (ja) 1995-12-25
NO302617B1 (no) 1998-03-30
NZ249755A (en) 1996-08-27
CN1136566A (zh) 1996-11-27
IL104941A (en) 1998-06-15
CZ282652B6 (cs) 1997-08-13
HU9300593D0 (en) 1993-05-28
CN1136565A (zh) 1996-11-27
AU3733093A (en) 1993-10-05
ES2176199T3 (es) 2002-12-01
DK0629199T3 (da) 2002-07-15
TW288010B (ru) 1996-10-11
DE69331988T2 (de) 2002-09-19
CN1044910C (zh) 1999-09-01
CN1082815C (zh) 2002-04-17
MX9301197A (es) 1993-09-01
PL172388B1 (pl) 1997-09-30
HU219489B (hu) 2001-04-28
SK105294A3 (en) 1995-05-10
KR0179073B1 (ko) 1999-03-20
CA2117643C (en) 2000-03-14
US5717102A (en) 1998-02-10
KR950700291A (ko) 1995-01-16
CN1136432A (zh) 1996-11-27
JPH07500353A (ja) 1995-01-12
HUT64061A (en) 1993-11-29
CZ212594A3 (en) 1995-06-14
CN1044909C (zh) 1999-09-01
ZA931539B (en) 1994-09-05
AU666716B2 (en) 1996-02-22
BR9306012A (pt) 1997-11-18
IL104941A0 (en) 1993-07-08
EP0629199B1 (en) 2002-06-05
UA39866C2 (uk) 2001-07-16
FI930968A0 (fi) 1993-03-04
RU2124012C1 (ru) 1998-12-27
EG20416A (en) 1999-02-28
ATE218566T1 (de) 2002-06-15
DE69331988D1 (de) 2002-07-11
PT629199E (pt) 2002-09-30
WO1993018032A1 (en) 1993-09-16
RU94040914A (ru) 1996-08-10
MY109298A (en) 1996-12-31
NO943261D0 (no) 1994-09-02
CA2117643A1 (en) 1993-09-16
CN1082044A (zh) 1994-02-16
EP0629199A1 (en) 1994-12-21
US5594014A (en) 1997-01-14
YU14893A (sh) 1996-05-20

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