EG20416A - Process for preparing of indole derivatives and their use in treating migraine - Google Patents

Process for preparing of indole derivatives and their use in treating migraine

Info

Publication number
EG20416A
EG20416A EG12893A EG12893A EG20416A EG 20416 A EG20416 A EG 20416A EG 12893 A EG12893 A EG 12893A EG 12893 A EG12893 A EG 12893A EG 20416 A EG20416 A EG 20416A
Authority
EG
Egypt
Prior art keywords
pct
compounds
sec
nitrogen
disorders
Prior art date
Application number
EG12893A
Other languages
English (en)
Inventor
John E Macor
Jolanta T Nowakowski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG20416A publication Critical patent/EG20416A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
EG12893A 1992-03-05 1993-03-03 Process for preparing of indole derivatives and their use in treating migraine EG20416A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84664092A 1992-03-05 1992-03-05

Publications (1)

Publication Number Publication Date
EG20416A true EG20416A (en) 1999-02-28

Family

ID=25298499

Family Applications (1)

Application Number Title Priority Date Filing Date
EG12893A EG20416A (en) 1992-03-05 1993-03-03 Process for preparing of indole derivatives and their use in treating migraine

Country Status (30)

Country Link
US (2) US5594014A (xx)
EP (1) EP0629199B1 (xx)
JP (1) JPH07121943B2 (xx)
KR (1) KR0179073B1 (xx)
CN (4) CN1032309C (xx)
AT (1) ATE218566T1 (xx)
AU (1) AU666716B2 (xx)
BR (1) BR9306012A (xx)
CA (1) CA2117643C (xx)
CZ (1) CZ282652B6 (xx)
DE (1) DE69331988T2 (xx)
DK (1) DK0629199T3 (xx)
EG (1) EG20416A (xx)
ES (1) ES2176199T3 (xx)
FI (1) FI930968A (xx)
HU (1) HU219489B (xx)
IL (1) IL104941A (xx)
MX (1) MX9301197A (xx)
MY (1) MY109298A (xx)
NO (1) NO302617B1 (xx)
NZ (1) NZ249755A (xx)
PL (1) PL172388B1 (xx)
PT (1) PT629199E (xx)
RU (1) RU2124012C1 (xx)
SK (1) SK281938B6 (xx)
TW (1) TW288010B (xx)
UA (1) UA39866C2 (xx)
WO (1) WO1993018032A1 (xx)
YU (1) YU14893A (xx)
ZA (1) ZA931539B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
BR9407402A (pt) * 1993-08-31 1996-11-05 Pfizer Derivados do 5-arilindol
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
EP0871619B1 (en) 1995-12-29 2002-11-06 Boehringer Ingelheim Pharmaceuticals Inc. Phenyl thiazole derivatives with anti herpes virus properties
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
BR0115687A (pt) 2000-11-27 2003-09-09 Pfizer Prod Inc Agonistas seletivos do receptor ep4 no tratamento de osteoporose
JP2004526781A (ja) * 2001-04-20 2004-09-02 ワイス ５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロシクリルアルコキシ−、−アルキルチオ−および−アルキルアミノベンザゾール誘導体
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) * 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP2023512821A (ja) * 2020-02-04 2023-03-29 マインドセット ファーマ インコーポレイテッド 中枢神経系障害の治療のためのセロトニン作動性幻覚薬としての３－ピロリジンインドール誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
SK281621B6 (sk) * 1990-06-07 2001-05-10 Astrazeneca Ab Indolové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
DE9190141U1 (xx) * 1990-10-15 1993-07-15 Pfizer, Inc., New York, N.Y., Us
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (xx) * 1991-02-12 1995-11-21 Pfizer

Also Published As

Publication number Publication date
TW288010B (xx) 1996-10-11
CN1082044A (zh) 1994-02-16
EP0629199A1 (en) 1994-12-21
NO943261L (no) 1994-09-02
KR0179073B1 (ko) 1999-03-20
YU14893A (sh) 1996-05-20
RU94040914A (ru) 1996-08-10
DE69331988D1 (de) 2002-07-11
HU9300593D0 (en) 1993-05-28
US5594014A (en) 1997-01-14
KR950700291A (ko) 1995-01-16
HUT64061A (en) 1993-11-29
CN1032309C (zh) 1996-07-17
CA2117643C (en) 2000-03-14
ATE218566T1 (de) 2002-06-15
CN1082815C (zh) 2002-04-17
DE69331988T2 (de) 2002-09-19
EP0629199B1 (en) 2002-06-05
PL172388B1 (pl) 1997-09-30
CN1044909C (zh) 1999-09-01
PT629199E (pt) 2002-09-30
ES2176199T3 (es) 2002-12-01
DK0629199T3 (da) 2002-07-15
RU2124012C1 (ru) 1998-12-27
JPH07500353A (ja) 1995-01-12
US5717102A (en) 1998-02-10
CN1044910C (zh) 1999-09-01
CZ282652B6 (cs) 1997-08-13
CA2117643A1 (en) 1993-09-16
NZ249755A (en) 1996-08-27
SK281938B6 (sk) 2001-09-11
WO1993018032A1 (en) 1993-09-16
JPH07121943B2 (ja) 1995-12-25
IL104941A (en) 1998-06-15
ZA931539B (en) 1994-09-05
CN1136432A (zh) 1996-11-27
AU666716B2 (en) 1996-02-22
MY109298A (en) 1996-12-31
FI930968A0 (fi) 1993-03-04
BR9306012A (pt) 1997-11-18
HU219489B (hu) 2001-04-28
CN1136565A (zh) 1996-11-27
CZ212594A3 (en) 1995-06-14
IL104941A0 (en) 1993-07-08
NO943261D0 (no) 1994-09-02
CN1136566A (zh) 1996-11-27
AU3733093A (en) 1993-10-05
UA39866C2 (uk) 2001-07-16
SK105294A3 (en) 1995-05-10
NO302617B1 (no) 1998-03-30
MX9301197A (es) 1993-09-01
FI930968A (fi) 1993-09-06

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