RU94005001A - Лиофилизат на основе пептида - Google Patents
Лиофилизат на основе пептидаInfo
- Publication number
- RU94005001A RU94005001A RU94005001/14A RU94005001A RU94005001A RU 94005001 A RU94005001 A RU 94005001A RU 94005001/14 A RU94005001/14 A RU 94005001/14A RU 94005001 A RU94005001 A RU 94005001A RU 94005001 A RU94005001 A RU 94005001A
- Authority
- RU
- Russia
- Prior art keywords
- lyophilisate
- lyophilisate according
- peptide
- lyophylizate
- peptide based
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 208000007984 Female Infertility Diseases 0.000 claims 2
- 210000002149 Gonads Anatomy 0.000 claims 2
- 206010021928 Infertility female Diseases 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (7)
1. Лиофилизат на основе пептида с 3-15 аминокислотами и, в случае необходимости, с одним или несколькими структурирующими веществами, отличающийся тем, что он получен путем растворения 1 мас. части пептида в 100 - 10000 мас. частях уксусной кислоты и путем перевода полученного раствора в воду с последующей лиофилизацией.
2. Лиофилизат по п.1, отличающийся тем, что в качестве структурирующего вещества используют маннит.
3. Лиофилизат по пп.1 и 2, отличающийся тем, что пептидом является Cetroretix.
4. Применение лиофилизата по пп.1 - 3 для лечения женского бесплодия.
5. Применение лиофилизата по пп.1 - 4 для защиты половых желез.
6. Применение лиофилизата по пп.1 - 5 для приготовления лекарственного средства для лечения женского бесплодия.
7. Применение лиофилизата по пп.1 - 6 для приготовления лекарственного средства для защиты половых желез.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4305225.8 | 1993-02-19 | ||
| DE4305225A DE4305225A1 (de) | 1993-02-19 | 1993-02-19 | Neues Herstellverfahren für Cetrorelix Lyophilisat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94005001A true RU94005001A (ru) | 1997-11-10 |
| RU2145234C1 RU2145234C1 (ru) | 2000-02-10 |
Family
ID=6480924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94005001A RU2145234C1 (ru) | 1993-02-19 | 1994-02-18 | Лиофилизат на основе пептида и способ его получения |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP0611572B1 (ru) |
| JP (1) | JP4033919B2 (ru) |
| KR (2) | KR100355686B1 (ru) |
| CN (1) | CN1109557C (ru) |
| AT (1) | ATE193653T1 (ru) |
| AU (1) | AU671881C (ru) |
| BR (1) | BR9400617A (ru) |
| CA (1) | CA2115943C (ru) |
| CZ (2) | CZ285768B6 (ru) |
| DE (2) | DE4305225A1 (ru) |
| DK (1) | DK0611572T3 (ru) |
| ES (1) | ES2148247T3 (ru) |
| FI (1) | FI110059B (ru) |
| GR (1) | GR3034237T3 (ru) |
| HR (1) | HRP940117B1 (ru) |
| HU (1) | HU218281B (ru) |
| IL (1) | IL108704A (ru) |
| MX (1) | MX9401312A (ru) |
| NO (1) | NO316601B1 (ru) |
| NZ (2) | NZ250906A (ru) |
| PL (1) | PL177177B1 (ru) |
| PT (1) | PT611572E (ru) |
| RU (1) | RU2145234C1 (ru) |
| SG (1) | SG46632A1 (ru) |
| SI (1) | SI9400087B (ru) |
| SK (2) | SK283021B6 (ru) |
| TW (1) | TW387812B (ru) |
| UA (1) | UA43829C2 (ru) |
| ZA (1) | ZA941136B (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| PE63998A1 (es) * | 1996-04-19 | 1998-10-30 | Merck & Co Inc | Composiciones anti-fungosas |
| DE19712718C2 (de) * | 1997-03-26 | 1999-09-23 | Asta Medica Ag | Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung |
| EP1082129B1 (en) | 1998-04-23 | 2003-10-29 | Zentaris AG | Method for the treatment of fertility disorders |
| DE10024451A1 (de) | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
| DE10040700A1 (de) * | 2000-08-17 | 2002-02-28 | Asta Medica Ag | Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung |
| US20030186892A1 (en) * | 2002-03-28 | 2003-10-02 | Rajneesh Taneja | Enhancement of endogenous gonadotropin production |
| MXPA05003318A (es) | 2002-09-27 | 2005-09-12 | Zentaris Gmbh | Forma de administracion para peptidos farmaceuticamente activos con liberacion sostenida y metodo para la produccion de los mismos. |
| EP1987843A3 (en) | 2004-03-12 | 2011-10-26 | Intercell AG | Method for solubilising peptide mixtures |
| EP1674082A1 (de) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| CN101630607B (zh) * | 2008-07-19 | 2012-04-25 | 浙江家泰电器制造有限公司 | 液体加热器皿过热保护控制器组件 |
| CN101629758B (zh) * | 2008-07-19 | 2012-09-26 | 浙江家泰电器制造有限公司 | 液体加热器皿过热保护控制器组件 |
| RU2454221C2 (ru) * | 2010-07-06 | 2012-06-27 | Общество с ограниченной ответственностью "Завод Медсинтез" | Способ получения лиофилизированного противовирусного средства |
| KR20140091652A (ko) | 2010-12-06 | 2014-07-22 | 아스트론 리서치 리미티드 | 안정적이며 바로 사용 가능한 세트로레릭스 주사액 |
| GB201022147D0 (en) * | 2010-12-31 | 2011-02-16 | Immune Targeting Systems Its Ltd | Formulation |
| CN102423484B (zh) * | 2011-11-23 | 2014-01-15 | 深圳翰宇药业股份有限公司 | 一种稳定的西曲瑞克药物组合物及其制备方法 |
| EP3015553A1 (de) | 2014-10-30 | 2016-05-04 | Biotecon Diagnostics GmbH | Stabilisierte Reaktionsmischung |
| RU2667128C2 (ru) * | 2016-12-29 | 2018-09-14 | Герман Петрович Беккер | Композиция для приготовления противоопухолевого средства и способ приготовления противоопухолевого средства на ее основе |
| CA3143663A1 (en) | 2019-06-17 | 2020-12-24 | Intas Pharmaceuticals Ltd. | A stable formulation of cetrorelix |
| CN112717119B (zh) * | 2021-01-27 | 2024-04-30 | 南京羚诺生物医药技术研究院有限公司 | 一种西曲瑞克药物组合物及其制备方法 |
| JP2024522892A (ja) | 2021-06-25 | 2024-06-21 | エクストロヴィス・アーゲー | 薬学的組成物 |
| CN114159544A (zh) * | 2022-01-24 | 2022-03-11 | 福州华为医药技术开发有限公司 | 注射用醋酸西曲瑞克及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816386A (en) * | 1972-06-20 | 1974-06-11 | Abbott Lab | Purification process for gn-rh |
| DD141996A1 (de) * | 1979-02-21 | 1980-06-04 | Ingrid Wolf | Verfahren zur herstellung von lyophilisierten lhrh-praeparationen |
| CS230614B1 (en) * | 1982-08-06 | 1984-08-13 | Martin Cs Flegel | Analogues of realising factor for luteining and folliculstimulated hormon |
| US4565804A (en) * | 1984-09-07 | 1986-01-21 | The Salk Institute For Biological Studies | GnRH Antagonists VI |
| EP0268066A3 (en) * | 1986-10-17 | 1990-07-11 | Syntex (U.S.A.) Inc. | Fertility control and uterine therapy in dogs with luteinizing hormone releasing hormone antagonists |
| DE3735614A1 (de) * | 1986-10-31 | 1988-07-28 | Asta Pharma Ag | Ifosfamid-lyophilisat und verfahren zu dessen herstellung |
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
| US5180711A (en) * | 1990-06-14 | 1993-01-19 | Applied Research Systems Ars Holding N.V. | Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals |
| CN1036343C (zh) * | 1990-11-10 | 1997-11-05 | 天津市计划生育研究所 | 新促黄体生成素释放激素拮抗类似物的制备方法 |
-
1993
- 1993-02-19 DE DE4305225A patent/DE4305225A1/de not_active Ceased
-
1994
- 1994-01-31 TW TW083100769A patent/TW387812B/zh not_active IP Right Cessation
- 1994-02-04 ES ES94101672T patent/ES2148247T3/es not_active Expired - Lifetime
- 1994-02-04 PT PT94101672T patent/PT611572E/pt unknown
- 1994-02-04 SG SG1996006874A patent/SG46632A1/en unknown
- 1994-02-04 DE DE59409389T patent/DE59409389D1/de not_active Expired - Lifetime
- 1994-02-04 EP EP94101672A patent/EP0611572B1/de not_active Expired - Lifetime
- 1994-02-04 DK DK94101672T patent/DK0611572T3/da active
- 1994-02-04 AT AT94101672T patent/ATE193653T1/de active
- 1994-02-04 EP EP99102340.9A patent/EP0947200B1/de not_active Expired - Lifetime
- 1994-02-14 CZ CZ98974A patent/CZ285768B6/cs not_active IP Right Cessation
- 1994-02-14 CZ CZ94312A patent/CZ284314B6/cs not_active IP Right Cessation
- 1994-02-17 JP JP02053294A patent/JP4033919B2/ja not_active Expired - Lifetime
- 1994-02-17 NZ NZ250906A patent/NZ250906A/en not_active IP Right Cessation
- 1994-02-17 PL PL94302266A patent/PL177177B1/pl unknown
- 1994-02-17 KR KR1019940002771A patent/KR100355686B1/ko not_active IP Right Cessation
- 1994-02-17 NZ NZ314707A patent/NZ314707A/xx not_active IP Right Cessation
- 1994-02-17 AU AU55235/94A patent/AU671881C/en not_active Expired
- 1994-02-18 ZA ZA941136A patent/ZA941136B/xx unknown
- 1994-02-18 UA UA94005526A patent/UA43829C2/uk unknown
- 1994-02-18 CN CN94101378A patent/CN1109557C/zh not_active Expired - Lifetime
- 1994-02-18 BR BR9400617A patent/BR9400617A/pt not_active Application Discontinuation
- 1994-02-18 RU RU94005001A patent/RU2145234C1/ru active
- 1994-02-18 FI FI940779A patent/FI110059B/fi not_active IP Right Cessation
- 1994-02-18 SI SI9400087A patent/SI9400087B/sl unknown
- 1994-02-18 HU HU9400481A patent/HU218281B/hu unknown
- 1994-02-18 SK SK195-94A patent/SK283021B6/sk not_active IP Right Cessation
- 1994-02-18 CA CA002115943A patent/CA2115943C/en not_active Expired - Lifetime
- 1994-02-18 HR HRP4305225.8 patent/HRP940117B1/xx not_active IP Right Cessation
- 1994-02-18 SK SK810-2001A patent/SK283022B6/sk not_active IP Right Cessation
- 1994-02-18 NO NO940564A patent/NO316601B1/no not_active IP Right Cessation
- 1994-02-18 IL IL10870494A patent/IL108704A/xx not_active IP Right Cessation
- 1994-02-21 MX MX9401312A patent/MX9401312A/es unknown
-
2000
- 2000-08-23 GR GR20000401924T patent/GR3034237T3/el unknown
-
2001
- 2001-02-27 KR KR1020010009932A patent/KR100372187B1/ko not_active IP Right Cessation
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