ES2097120T3 - Estabilizacion de proteinas altamente purificadas. - Google Patents
Estabilizacion de proteinas altamente purificadas.Info
- Publication number
- ES2097120T3 ES2097120T3 ES90113210T ES90113210T ES2097120T3 ES 2097120 T3 ES2097120 T3 ES 2097120T3 ES 90113210 T ES90113210 T ES 90113210T ES 90113210 T ES90113210 T ES 90113210T ES 2097120 T3 ES2097120 T3 ES 2097120T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- stabilization
- highly purified
- purified proteins
- carbohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN CARBOHIDRATO, TAL COMO MANITOL O DEXTRAN-70 SE AÑADE DURANTE LA PURIFICACION DE UNA PROTEINA, TAL COMO EL FACTOR VIII:C. EL CARBOHIDRATO ESTABILIZA LA PROTEINA, INCLUSO CUANDO LA PROTEINA SE ENCUENTRA ENTRE EL 60 Y 99% DE PUEREZA. EL CARBOHIDRATO SE AÑADE A TRAVES DE VARIOS PASOS DE PURIFICACION Y ESTA PRESENTE EN EL ENVASE FINAL PARA, DE ESTA FORMA, ESTABILIZAR LA PROTEINA DURANTE SU CONGELACION EN SECO Y SU RECONSTITUCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38458489A | 1989-07-24 | 1989-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097120T3 true ES2097120T3 (es) | 1997-04-01 |
Family
ID=23517903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90113210T Expired - Lifetime ES2097120T3 (es) | 1989-07-24 | 1990-07-11 | Estabilizacion de proteinas altamente purificadas. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0410207B1 (es) |
JP (1) | JPH0358998A (es) |
AT (1) | ATE148165T1 (es) |
CA (1) | CA2021452A1 (es) |
DE (1) | DE69029765T2 (es) |
DK (1) | DK0410207T3 (es) |
ES (1) | ES2097120T3 (es) |
GR (1) | GR3022614T3 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6165467A (en) * | 1991-07-20 | 2000-12-26 | Yoshihide Hagiwara | Stabilized human monoclonal antibody preparation |
JP2966592B2 (ja) * | 1991-07-20 | 1999-10-25 | 萩原 義秀 | 安定化されたヒトモノクローナル抗体製剤 |
US6270723B1 (en) * | 1998-06-15 | 2001-08-07 | Bbi Bioseq, Inc. | Rapid cryobaric sterilization and vaccine preparation |
CZ307715B6 (cs) | 1999-02-22 | 2019-03-06 | University Of Connecticut | Způsob lyofilizace vodné farmaceutické formulace faktoru VIII prosté albuminu |
DE60041363D1 (de) | 1999-07-14 | 2009-02-26 | Spectral Diagnostics Inc | Präparierung von sphären für diagnostische tests |
AU3070702A (en) | 2000-11-07 | 2002-05-21 | Chiron Corp | Stabilized inteferon compositions |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
EP1417301B1 (en) * | 2001-08-07 | 2006-11-02 | Novozymes A/S | Carbohydrates and polyols for dissolving protein crystals |
KR20030060660A (ko) * | 2002-01-10 | 2003-07-16 | 손정일 | 앞/뒷면 구별 없는 양면 양말 |
CA2492143A1 (en) * | 2002-07-12 | 2004-01-22 | Medarex, Inc. | Methods and compositions for preventing oxidative degradation of proteins |
WO2005103067A1 (en) * | 2004-04-23 | 2005-11-03 | Novexin Limited | Methods and kits for stabilising, protecting and solubilising proteins |
JP2008501639A (ja) * | 2004-04-23 | 2008-01-24 | ノベシン リミテッド | タンパク質を安定化、保護及び可溶化させるための方法及びキット |
CA2675602A1 (en) * | 2007-02-16 | 2008-08-21 | Wyeth | Protein formulations containing sorbitol |
JP2011520889A (ja) | 2008-05-15 | 2011-07-21 | バクスター・インターナショナル・インコーポレイテッド | 安定な医薬製剤 |
TR201900207T4 (tr) | 2008-11-07 | 2019-02-21 | Baxalta GmbH | Faktör VIII Formülasyonları |
KR102023207B1 (ko) | 2010-12-02 | 2019-11-25 | 온콜리틱스 바이오테크 인코포레이티드 | 동결건조 바이러스 제형 |
EA201390810A1 (ru) | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
KR102151890B1 (ko) * | 2011-04-29 | 2020-09-03 | 온콜리틱스 바이오테크 인코포레이티드 | 겔 침투 크로마토그래피를 이용한 바이러스의 정제방법 |
ES2788870T3 (es) | 2014-08-04 | 2020-10-23 | Csl Ltd | Formulación de factor VIII |
KR20220029733A (ko) | 2019-07-04 | 2022-03-08 | 체에스엘 베링 렝나우 아게 | 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf) |
US20220380439A1 (en) | 2020-11-09 | 2022-12-01 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743680A (en) * | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
-
1990
- 1990-07-11 AT AT90113210T patent/ATE148165T1/de active
- 1990-07-11 DE DE69029765T patent/DE69029765T2/de not_active Revoked
- 1990-07-11 DK DK90113210.0T patent/DK0410207T3/da active
- 1990-07-11 ES ES90113210T patent/ES2097120T3/es not_active Expired - Lifetime
- 1990-07-11 EP EP90113210A patent/EP0410207B1/en not_active Revoked
- 1990-07-18 CA CA002021452A patent/CA2021452A1/en not_active Abandoned
- 1990-07-20 JP JP2190898A patent/JPH0358998A/ja active Pending
-
1997
- 1997-02-19 GR GR970400303T patent/GR3022614T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3022614T3 (en) | 1997-05-31 |
EP0410207A3 (en) | 1992-01-15 |
ATE148165T1 (de) | 1997-02-15 |
EP0410207B1 (en) | 1997-01-22 |
JPH0358998A (ja) | 1991-03-14 |
CA2021452A1 (en) | 1991-01-25 |
DE69029765D1 (de) | 1997-03-06 |
DE69029765T2 (de) | 1997-05-15 |
EP0410207A2 (en) | 1991-01-30 |
DK0410207T3 (da) | 1997-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2097120T3 (es) | Estabilizacion de proteinas altamente purificadas. | |
DE3874798D1 (de) | Therapeutisches proteinagens in form von aerosol. | |
DE68928956T2 (de) | Verfahren zur Herstellung von optisch aktivem 1,3-Butanediol | |
DE69118535T2 (de) | Osteo-induktive pharmazeutische formulierungen | |
CA2117193A1 (en) | Vaccine comprising part of constant region of ige for treatment of ige-medicated allergic reactions | |
DE59308628D1 (de) | Verfahren zur Herstellung von Faktor VIII | |
ATE95564T1 (de) | Aeusseres membranprotein f von pseudomonas aeruginosa. | |
DE69219622T2 (de) | Herstellung von optisch aktiven aliphatischen carbonsäuren | |
MC1884A1 (fr) | Variants de l'hirudine,leur utilisation et leur preparation | |
ES2058479T3 (es) | Compuestos peptidicos. | |
CA2105282A1 (en) | Preparation of factor ix | |
DE69313099D1 (de) | Herstellung von optisch aktiven aliphatischen carbonsäuren | |
NO942323D0 (no) | Soyaprotein eller hydrolysater i farmasöytiske preparater for beskyttelse av bioaktive peptider mot enzymatisk inaktivering | |
DK0422846T3 (da) | Aroylurinstoffer | |
DE69534738D1 (de) | Leukocyten-aktivierender Faktor | |
DE59305709D1 (de) | Verfahren zur Herstellung von 1,4-Diaminoanthrachinon-2,3-disulfonsäure und 1,4-Diaminoanthrachinon-2,3-dinitril | |
DE68915694T2 (de) | Verfahren zur Herstellung von verzweigten 1,3-Glykolen und ihren Monoestern. | |
DE59307374D1 (de) | Verfahren zur Herstellung von 5-Halogen-2-(1-anthrachinonylamino)benzoesäuren und 4'-Halogen-2,1(N)-anthrachinonyl-1',2'(N)-benzacridonen | |
TH31446EX (th) | ขวด | |
TH23850EX (th) | ขวด | |
TH40331EX (th) | ลัง |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 410207 Country of ref document: ES |