ATE148165T1 - Stabilisierung von hochgereinigten proteinen - Google Patents

Stabilisierung von hochgereinigten proteinen

Info

Publication number
ATE148165T1
ATE148165T1 AT90113210T AT90113210T ATE148165T1 AT E148165 T1 ATE148165 T1 AT E148165T1 AT 90113210 T AT90113210 T AT 90113210T AT 90113210 T AT90113210 T AT 90113210T AT E148165 T1 ATE148165 T1 AT E148165T1
Authority
AT
Austria
Prior art keywords
protein
stabilization
highly purified
purified proteins
carbohydrate
Prior art date
Application number
AT90113210T
Other languages
English (en)
Inventor
Michael H Coan
Vivian W Lee
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23517903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE148165(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE148165T1 publication Critical patent/ATE148165T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90113210T 1989-07-24 1990-07-11 Stabilisierung von hochgereinigten proteinen ATE148165T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38458489A 1989-07-24 1989-07-24

Publications (1)

Publication Number Publication Date
ATE148165T1 true ATE148165T1 (de) 1997-02-15

Family

ID=23517903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90113210T ATE148165T1 (de) 1989-07-24 1990-07-11 Stabilisierung von hochgereinigten proteinen

Country Status (8)

Country Link
EP (1) EP0410207B1 (de)
JP (1) JPH0358998A (de)
AT (1) ATE148165T1 (de)
CA (1) CA2021452A1 (de)
DE (1) DE69029765T2 (de)
DK (1) DK0410207T3 (de)
ES (1) ES2097120T3 (de)
GR (1) GR3022614T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165467A (en) * 1991-07-20 2000-12-26 Yoshihide Hagiwara Stabilized human monoclonal antibody preparation
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
US6270723B1 (en) * 1998-06-15 2001-08-07 Bbi Bioseq, Inc. Rapid cryobaric sterilization and vaccine preparation
CN100553678C (zh) 1999-02-22 2009-10-28 巴克斯特国际有限公司 新的无白蛋白的因子ⅷ制剂
CA2378742C (en) 1999-07-14 2010-06-01 Spectral Diagnostics, Inc. Preparation of spheres for diagnostic tests
PL209928B1 (pl) 2000-11-07 2011-11-30 Novartis Vaccines & Diagnostic Kompozycja farmaceutyczna zawierająca biologicznie aktywny IFN-β i mannitol, wstępnie napełniona strzykawka zawierająca tę kompozycję oraz sposób wytwarzania preparatu IFN-β
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
ATE344319T1 (de) * 2001-08-07 2006-11-15 Novozymes As Kohlhydrate und polyole zum lösen der proteinkristalle
KR20030060660A (ko) * 2002-01-10 2003-07-16 손정일 앞/뒷면 구별 없는 양면 양말
WO2004007520A2 (en) * 2002-07-12 2004-01-22 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット
EP1749018B1 (de) * 2004-04-23 2014-10-22 Expedeon Limited Verfahren und kits zur stabilisierung, zum schutz und zur solubilisierung von proteinen
EP2124889A2 (de) * 2007-02-16 2009-12-02 Wyeth a Corporation of the State of Delaware Proteinformulierungen mit sorbitol
CN102026621A (zh) 2008-05-15 2011-04-20 巴克斯特国际公司 稳定的药物制剂
ES2706296T3 (es) 2008-11-07 2019-03-28 Univ Connecticut Formulaciones de Factor VIII
CN103269716B (zh) 2010-12-02 2015-05-27 昂科利蒂克斯生物科技公司 冻干病毒制剂
EA201390810A1 (ru) 2010-12-02 2013-09-30 Онколитикс Байотек Инк. Жидкие вирусные составы
ES2822199T3 (es) * 2011-04-29 2021-04-29 Oncolytics Biotech Inc Métodos de purificación de virus usando cromatografía por permeación en gel
WO2016020210A1 (en) 2014-08-04 2016-02-11 Csl Behring Gmbh Csl behring gmbh
JP2022538357A (ja) 2019-07-04 2022-09-01 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第ＶＩＩＩ凝固因子のｉｎ ｖｉｔｒｏでの安定性を向上させるための切断型フォン・ヴィレブランド因子（ＶＷＦ）
WO2022099223A2 (en) 2020-11-09 2022-05-12 Takeda Pharmaceutical Company Limited Purification of fviii from plasma using silicon oxide adsorption

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media

Also Published As

Publication number Publication date
EP0410207A2 (de) 1991-01-30
JPH0358998A (ja) 1991-03-14
GR3022614T3 (en) 1997-05-31
DE69029765T2 (de) 1997-05-15
DK0410207T3 (da) 1997-07-14
CA2021452A1 (en) 1991-01-25
EP0410207A3 (en) 1992-01-15
ES2097120T3 (es) 1997-04-01
EP0410207B1 (de) 1997-01-22
DE69029765D1 (de) 1997-03-06

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Legal Events

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UEP Publication of translation of european patent specification