RU2763795C2 - Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии - Google Patents

Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии Download PDF

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RU2763795C2
RU2763795C2 RU2016145424A RU2016145424A RU2763795C2 RU 2763795 C2 RU2763795 C2 RU 2763795C2 RU 2016145424 A RU2016145424 A RU 2016145424A RU 2016145424 A RU2016145424 A RU 2016145424A RU 2763795 C2 RU2763795 C2 RU 2763795C2
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cells
selection
certain embodiments
cell
enrichment
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RU2016145424A (ru
RU2016145424A3 (OSRAM
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Крис РЭМСБОРГ
Марк Л. БОНИХАДИ
Кэлвин ЧЭН
Паскаль БОШЕН
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Джуно Терапьютикс, Инк.
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RU2016145424A 2014-04-23 2015-04-23 Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии RU2763795C2 (ru)

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Application Number Priority Date Filing Date Title
US201461983415P 2014-04-23 2014-04-23
US61/983,415 2014-04-23
PCT/US2015/027401 WO2015164675A1 (en) 2014-04-23 2015-04-23 Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy

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RU2021136264A Division RU2021136264A (ru) 2014-04-23 2015-04-23 Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии

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RU2016145424A RU2016145424A (ru) 2018-05-23
RU2016145424A3 RU2016145424A3 (OSRAM) 2018-12-12
RU2763795C2 true RU2763795C2 (ru) 2022-01-11

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Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100183558A1 (en) 2008-10-17 2010-07-22 Zhennan Lai Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
RU2746407C1 (ru) 2012-02-23 2021-04-13 Стейдж Селл Терапеутикс Гмбх Хроматографическое выделение клеток и других сложных биологических материалов
IL293587B2 (en) 2014-04-16 2025-02-01 Juno Therapeutics Gmbh Methods, kits and devices for increasing cell populations
CN106459917B (zh) 2014-04-23 2021-03-09 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法
ES2708584T3 (es) * 2014-04-24 2019-04-10 Miltenyi Biotec Gmbh Método para la generación automatizada de células T modificadas genéticamente
US10987412B2 (en) * 2014-09-17 2021-04-27 The John Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells
HUE050264T2 (hu) 2014-11-05 2020-11-30 Juno Therapeutics Inc Eljárások transzdukálásra és sejtfeldolgozásra
CN108473957B (zh) 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
WO2017007994A1 (en) 2015-07-08 2017-01-12 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
AR105433A1 (es) 2015-07-21 2017-10-04 Novartis Ag Métodos para mejorar la eficacia y expansión de las células inmunes
WO2017023803A1 (en) 2015-07-31 2017-02-09 Regents Of The University Of Minnesota Modified cells and methods of therapy
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
MA45426A (fr) 2015-10-22 2019-05-01 Juno Therapeutics Gmbh Procédés, kits, agents et appareils de transduction
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
JP2019500874A (ja) * 2015-12-28 2019-01-17 ノバルティス アーゲー キメラ抗原受容体発現細胞の作製方法
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
CN116064678A (zh) 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
US10888613B2 (en) 2016-02-08 2021-01-12 American Gene Technologies International Inc. Method of producing cells resistant to HIV infection
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
EP3430549A1 (en) 2016-03-16 2019-01-23 Juno Therapeutics, Inc. Methods for adaptive design of a treatment regimen and related treatments
JP7173548B2 (ja) 2016-06-08 2022-11-16 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド 非組み込みウイルス送達系およびその関連方法
IL300730A (en) 2016-07-08 2023-04-01 American Gene Tech Int Inc Pre-HIV vaccine and immunotherapy
US11583562B2 (en) 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
AU2017322752A1 (en) 2016-09-12 2019-03-21 Juno Therapeutics, Inc. Perfusion bioreactor bag assemblies
CA3041068A1 (en) 2016-10-18 2018-04-26 Regents Of The University Of Minnesota Tumor infiltrating lymphocytes and methods of therapy
US20200095547A1 (en) * 2016-12-02 2020-03-26 Darya ALIZADEH Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors
KR20190098747A (ko) * 2016-12-05 2019-08-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 위한 조작된 세포의 제조방법
EP3555267B1 (en) 2016-12-16 2021-08-04 Diagnologix, LLC Buoyancy enabled separation method and system
MX2019010171A (es) 2017-02-27 2019-10-15 Juno Therapeutics Inc Composiciones, articulos de fabricacion y metodos relacionados con la dosificacion en la terapia celular.
KR102771581B1 (ko) 2017-03-14 2025-02-25 주노 쎄러퓨티크스 인코퍼레이티드 극저온 보관 방법
JOP20190224A1 (ar) 2017-03-29 2019-09-26 Iovance Biotherapeutics Inc عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي
WO2018187231A2 (en) 2017-04-03 2018-10-11 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
EP3610261A1 (en) 2017-04-14 2020-02-19 Juno Therapeutics, Inc. Methods for assessing cell surface glycosylation
CN111032850B (zh) * 2017-04-27 2024-08-13 朱诺治疗学有限公司 寡聚粒子试剂及其使用方法
MX2019014268A (es) 2017-06-02 2020-08-03 Juno Therapeutics Inc Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva.
EA201992875A1 (ru) 2017-06-07 2020-03-25 Сиэтл Дженетикс, Инк. T-клетки со сниженным поверхностным фукозилированием и способы их получения и применения
JP2020530307A (ja) 2017-06-30 2020-10-22 インティマ・バイオサイエンス,インコーポレーテッド 遺伝子治療のためのアデノ随伴ウイルスベクター
WO2019011879A1 (en) 2017-07-09 2019-01-17 Rainer Henning THERAPEUTIC AGENT FOR THE TREATMENT OF CAPILLARY LEAK SYNDROME
EP4620977A3 (en) * 2017-07-21 2025-12-17 Bruker Cellular Analysis, Inc. Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereof
MA49979A (fr) 2017-08-09 2020-06-17 Juno Therapeutics Inc Procédés de production de compositions de cellules génétiquement modifiées et compositions associées
ES2992909T3 (en) 2017-08-09 2024-12-19 Juno Therapeutics Inc Methods and compositions for preparing genetically engineered cells
US11447745B2 (en) * 2017-09-01 2022-09-20 Lonza Walkersville, Inc. End-to-end cell therapy automation
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
EP3697809A1 (en) * 2017-10-20 2020-08-26 Institut Curie Dap10/12 based cars adapted for rush
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
EP3704230B1 (en) 2017-11-01 2024-10-23 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
AU2018360801A1 (en) 2017-11-01 2020-05-14 Celgene Corporation Process for producing a T cell composition
MA50571A (fr) 2017-11-10 2020-09-16 Juno Therapeutics Inc Réservoirs cryogéniques à système fermé
JP2021509009A (ja) * 2017-11-30 2021-03-18 ノバルティス アーゲー Bcmaターゲティングキメラ抗原受容体及びその使用
KR102833956B1 (ko) 2017-12-08 2025-07-15 주노 쎄러퓨티크스 인코퍼레이티드 세포를 배양하기 위한 무혈청 배지 제형 및 이의 사용 방법
CN112203680A (zh) 2017-12-08 2021-01-08 朱诺治疗学股份有限公司 用于细胞疗法的表型标记和相关方法
CN112004824B (zh) 2017-12-08 2024-09-13 朱诺治疗学股份有限公司 生产工程化t细胞组合物的过程
KR20200135852A (ko) * 2018-03-27 2020-12-03 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 유전자 변형 림프구의 제조 방법
JP7447011B2 (ja) * 2018-03-28 2024-03-11 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム エフェクターt細胞をリプログラムするためのヒストン修飾因子の使用
US12473532B2 (en) 2018-05-10 2025-11-18 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
AU2019275076B2 (en) 2018-05-23 2024-12-19 National University Of Singapore Blockade of CD2 surface expression and expression of chimeric antigen receptors for immunotherapy of T-cell malignancies
CN110643577A (zh) * 2018-06-26 2020-01-03 深圳市北科生物科技有限公司 基于机械臂的全自动细胞培养方法及其系统
CN113474450A (zh) 2018-08-09 2021-10-01 朱诺治疗学股份有限公司 产生工程化细胞的方法以及所述工程化细胞的组合物
AU2019316647A1 (en) 2018-08-09 2021-02-25 Juno Therapeutics, Inc. Methods for assessing integrated nucleic acids
US12366580B2 (en) 2018-09-11 2025-07-22 Juno Therapeutics, Inc. Methods for mass spectrometry analysis of engineered cell compositions
CN112752847B (zh) 2018-09-28 2025-03-28 奥克泰生物科技股份有限公司 磁性分离
EP3874024A1 (en) * 2018-10-31 2021-09-08 Juno Therapeutics GmbH Methods for selection and stimulation of cells and apparatus for same
AU2019372331A1 (en) 2018-11-01 2021-05-27 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen
WO2020097132A1 (en) 2018-11-06 2020-05-14 Juno Therapeutics, Inc. Process for producing genetically engineered t cells
AU2019381827A1 (en) 2018-11-16 2021-06-10 Juno Therapeutics, Inc. Methods of dosing engineered T cells for the treatment of B cell malignancies
JP7695882B2 (ja) 2018-11-30 2025-06-19 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法を用いた処置のための方法
BR112021010120A2 (pt) 2018-11-30 2021-08-31 Juno Therapeutics, Inc. Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva
KR20210108406A (ko) 2018-12-21 2021-09-02 론자 워커스빌 아이엔씨. 바이러스 벡터의 자동화된 생산
SG11202106384YA (en) 2018-12-21 2021-07-29 Octane Biotech Inc Carousel for modular biologic production units
TWI732357B (zh) * 2018-12-27 2021-07-01 財團法人工業技術研究院 細胞培養裝置及方法
CN113365654A (zh) * 2019-01-29 2021-09-07 Gpb科学有限公司 具有改进的生产和治疗特征的细胞群
KR20210125510A (ko) 2019-02-08 2021-10-18 론자 워커스빌 아이엔씨. 자동화 생물반응기에서 사용하기 위한 세포 농축 방법 및 장치
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
DE102019108125B4 (de) * 2019-03-28 2022-02-03 Immatics US, Inc. Cd28 t-zellkulturen, zusammensetzungen und verfahren zu deren verwendung
US20220170908A1 (en) * 2019-03-26 2022-06-02 Anton Wyss-Coray Compositions and methods for characterizing and treating alzheimers disease
WO2020210508A1 (en) 2019-04-09 2020-10-15 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
TWI777160B (zh) * 2019-05-08 2022-09-11 美商百歐恩泰美國公司 T細胞製備組合物及方法
CN114206855B (zh) 2019-05-17 2024-11-26 紐力克斯治疗公司 用于Cbl-b抑制的氰基环丁基类化合物及其用途
WO2020236850A1 (en) * 2019-05-20 2020-11-26 Immunovalent Therapeutics Inc. Solid phase devices and methods of use for purifying and quantifying tissue-specific leukocytes
AU2020293230A1 (en) 2019-06-12 2022-01-27 Juno Therapeutics, Inc. Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival BCL2 family protein
CN110358734B (zh) * 2019-06-13 2020-08-25 首都医科大学宣武医院 以Tcm为主要效应成分的CAR-T制备方法及其应用
BR112021026241A2 (pt) 2019-06-26 2022-06-07 Nurix Therapeutics Inc Compostos de benzil-triazol substituído para inibição de cbl-b e outros usos dos mesmos
AU2020320195A1 (en) 2019-07-30 2022-03-10 Nurix Therapeutics, Inc. Urea, amide, and substituted heteroaryl compounds for Cbl-b inhibition
EP4017527A1 (en) 2019-08-22 2022-06-29 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
EP4022637A2 (en) 2019-08-30 2022-07-06 Juno Therapeutics, Inc. Machine learning methods for classifying cells
CN114729292A (zh) 2019-10-24 2022-07-08 奥克泰生物科技股份有限公司 具有经改进的细胞接触表面的细胞培养室
WO2021084050A1 (en) 2019-10-30 2021-05-06 Juno Therapeutics Gmbh Cell selection and/or stimulation devices and methods of use
KR20220131892A (ko) 2019-11-05 2022-09-29 주노 쎄러퓨티크스 인코퍼레이티드 치료용 t 세포 조성물의 속성 결정 방법
WO2021096850A1 (en) 2019-11-11 2021-05-20 Lonza Walkersville, Inc. Quality control methods for automated cell processing
MX2022006715A (es) 2019-12-06 2022-09-23 Juno Therapeutics Inc Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b.
EP4069816A1 (en) * 2020-01-10 2022-10-12 Lonza Walkersville, Inc. Filter apparatus and method for purifying biological processes and cell populations
EP4093433A1 (en) 2020-01-24 2022-11-30 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
KR20220152220A (ko) 2020-02-12 2022-11-15 주노 쎄러퓨티크스 인코퍼레이티드 Cd19-지시된 키메라 항원 수용체 t 세포 조성물 및 이의 방법 및 용도
EP4103203A1 (en) 2020-02-12 2022-12-21 Juno Therapeutics, Inc. Bcma-directed chimeric antigen receptor t cell compositions and methods and uses thereof
JP2023522857A (ja) 2020-04-10 2023-06-01 ジュノー セラピューティクス インコーポレイテッド B細胞成熟抗原を標的とするキメラ抗原受容体によって操作された細胞療法に関する方法および使用
EP4142777A4 (en) * 2020-04-27 2024-06-12 Memorial Sloan-Kettering Cancer Center CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD127 AND USE THEREOF
CN115803824A (zh) 2020-05-13 2023-03-14 朱诺治疗学股份有限公司 鉴定与临床反应相关的特征的方法及其用途
US20230181641A1 (en) 2020-05-13 2023-06-15 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
KR20230152783A (ko) 2020-07-07 2023-11-03 칸큐어 엘엘씨 Mic 항체 및 결합제 및 이의 사용 방법
US20240392226A1 (en) * 2020-10-12 2024-11-28 Life Technologies As Magnetic particle processing systems for use with biological cells and related methods
US12415982B2 (en) 2020-10-23 2025-09-16 Applied Materials, Inc. Automated closed system for cell therapy manufacturing
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
WO2022182891A1 (en) 2021-02-25 2022-09-01 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
EP4314814A1 (en) 2021-03-22 2024-02-07 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
WO2022212400A1 (en) 2021-03-29 2022-10-06 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
EP4334341A2 (en) 2021-05-06 2024-03-13 Juno Therapeutics GmbH Methods for stimulating and transducing t cells
CN113388042B (zh) * 2021-06-28 2022-02-01 北京鼎成肽源生物技术有限公司 一种重组蛋白、重组表达载体、重组细胞和nk细胞激活磁珠及其制备方法和应用
US20240368626A1 (en) * 2021-08-06 2024-11-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute T-cell manufacturing methods
WO2023021571A1 (ja) * 2021-08-17 2023-02-23 日揮株式会社 演算装置、制御装置、培養システム、及び培養システムの設計方法
CN114507274B (zh) * 2022-02-14 2023-08-25 西南大学 可逆结合生物素的链霉亲和素突变蛋白及其应用
CN117659145B (zh) * 2022-02-14 2024-08-02 西南大学 链霉亲和素第27位丝氨酸突变的突变蛋白s27v及其应用
WO2023213969A1 (en) 2022-05-05 2023-11-09 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
IL316839A (en) 2022-05-17 2025-01-01 Umoja Biopharma Inc Production of viral particles
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
EP4532695A1 (en) 2022-05-25 2025-04-09 Celgene Corporation Methods of manufacturing t cell therapies
KR20250029137A (ko) 2022-06-22 2025-03-04 주노 쎄러퓨티크스 인코퍼레이티드 Cd19-표적화된 car t 세포의 2차 요법을 위한 치료 방법
WO2024097992A2 (en) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Particles displaying adhesion-molecule fusions
IL320495A (en) 2022-11-04 2025-06-01 Umoja Biopharma Inc Construction of polynucleotide vectors and related viral methods
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells
CN121100267A (zh) 2022-12-09 2025-12-09 朱诺治疗学股份有限公司 使用全息成像预测细胞表型的机器学习方法
CN121002052A (zh) 2023-02-03 2025-11-21 C3S2 有限公司 用于非病毒生产工程化免疫细胞的方法
CN121127253A (zh) 2023-02-28 2025-12-12 朱诺治疗学股份有限公司 治疗系统性自身免疫性疾病的细胞疗法
CN116640192B (zh) * 2023-04-12 2024-08-02 西南大学 链霉亲和素突变体StrepTactin的Y43A突变蛋白及其应用
WO2024220588A1 (en) 2023-04-18 2024-10-24 Juno Therapeutics, Inc. Cytotoxicity assay for assessing potency of therapeutic cell compositions
WO2024226858A1 (en) 2023-04-26 2024-10-31 Juno Therapeutics, Inc. Methods for viral vector manufacturing
WO2024238153A1 (en) 2023-05-15 2024-11-21 Umoja Biopharma, Inc. Lentiviral delivery of anti-cd20 chimeric antigen receptors
WO2024243365A2 (en) 2023-05-23 2024-11-28 Juno Therapeutics, Inc. Activation markers of t cells and method for assessing t cell activation
WO2025072081A1 (en) * 2023-09-25 2025-04-03 The Cleveland Clinic Foundation Enriched t-cell populations
US20250222469A1 (en) * 2023-12-31 2025-07-10 Trenchant BioSystems, Inc. Centrifuge and mixing system for a cell processing apparatus
WO2025231174A1 (en) 2024-04-30 2025-11-06 Umoja Biopharma, Inc. Manufacturing viral particles
WO2025235604A1 (en) 2024-05-08 2025-11-13 Umoja Biopharma, Inc. Fusion protein for use as immune cell engager
US20250345431A1 (en) 2024-05-10 2025-11-13 Juno Therapeutics, Inc. Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003493A2 (en) * 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
WO2009072003A2 (en) * 2007-12-07 2009-06-11 Miltenyi Biotec Gmbh Sample processing system and methods
WO2013011011A2 (en) * 2011-07-18 2013-01-24 Iba Gmbh Method of reversibly staining a target cell
WO2014011996A1 (en) * 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Methods of assessing the suitability of transduced t cells for administration

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4361549A (en) 1979-04-26 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human T cells, and methods of preparing same
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
FR2540122B1 (fr) 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
IN165717B (OSRAM) 1986-08-07 1989-12-23 Battelle Memorial Institute
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
WO1990007380A2 (en) 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
DE69128037T2 (de) 1990-11-13 1998-05-07 Immunex Corp., Seattle, Wash. Bifunktionelle wählbare fusionsgene
DE4237113B4 (de) 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
CA2163427A1 (en) 1993-05-21 1994-12-08 Stephen D. Lupton Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
JPH08511166A (ja) 1993-06-04 1996-11-26 アメリカ合衆国 T細胞の増殖を選択的に刺激する方法
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1997011183A1 (en) 1995-04-11 1997-03-27 Trustees Of Boston University Streptavidin mutants
US5801115A (en) 1995-09-05 1998-09-01 Kataleuna Gmbh Catalyst composition and methods for using and preparing same
US5773224A (en) * 1996-02-12 1998-06-30 Grandics; Peter Immunoselection system for cell elution
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
US6451995B1 (en) 1996-03-20 2002-09-17 Sloan-Kettering Institute For Cancer Research Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods
DE19641876B4 (de) 1996-10-10 2011-09-29 Iba Gmbh Streptavidinmuteine
US5985658A (en) 1997-11-14 1999-11-16 Health Research Incorporated Calmodulin-based cell separation technique
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US6664042B1 (en) 1999-01-26 2003-12-16 Cornell Research Foundation, Inc. Determining viral load in double negative T cells
WO2001094944A2 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
JP5312721B2 (ja) 2000-11-07 2013-10-09 シティ・オブ・ホープ Cd19特異的再指向免疫細胞
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
DE10113776B4 (de) 2001-03-21 2012-08-09 "Iba Gmbh" Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
US7939059B2 (en) 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
JP2005536184A (ja) 2002-03-01 2005-12-02 エルドマン,ヴォルカー,エー. ストレプトアビジン結合ペプチド
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7754155B2 (en) 2002-03-15 2010-07-13 Ross Amelia A Devices and methods for isolating target cells
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
FR2841905B1 (fr) 2002-07-05 2004-09-03 Centre Nat Rech Scient Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications
EP1569510B1 (en) 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
ES2744275T3 (es) 2002-10-17 2020-02-24 Genmab As Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple
WO2004096975A2 (en) 2003-05-02 2004-11-11 Insception Bioscience, Inc. Apparatus and methods for amplification of blood stem cell numbers
US7943393B2 (en) 2003-07-14 2011-05-17 Phynexus, Inc. Method and device for extracting an analyte
US7109304B2 (en) 2003-07-31 2006-09-19 Immunomedics, Inc. Humanized anti-CD19 antibodies
AU2004292131A1 (en) 2003-11-20 2005-06-02 Biosensor Applications Sweden (Publ) Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture
SE0400181D0 (sv) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
WO2005121798A1 (en) 2004-06-03 2005-12-22 Meso Scale Technologies, Llc Methods and apparatuses for conducting assays
US20110098184A1 (en) 2004-10-15 2011-04-28 Day Anthony G Competitve differntial screeing
EP1827604B1 (en) 2004-12-10 2019-11-20 Peter MacCallum Cancer Institute Methods and compositions for adoptive immunotherapy
US20060252087A1 (en) 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
EP1891113A2 (en) 2005-06-02 2008-02-27 AstraZeneca AB Antibodies directed to cd20 and uses thereof
US7855057B2 (en) 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US20090208471A1 (en) * 2006-04-07 2009-08-20 Yun Theodore J Isolation and Use of Human Regulatory T Cells
US20080085532A1 (en) 2006-09-18 2008-04-10 Jorn Gorlach Method for determining the immune status of a subject
US8043822B2 (en) 2006-11-02 2011-10-25 Kyowa Medex Co., Ltd. Method of immunoassaying a component to be measured
CA2671326A1 (en) 2006-11-15 2008-11-20 Invitrogen Dynal As Methods of reversibly binding a biotin compound to a support
US20080131415A1 (en) 2006-11-30 2008-06-05 Riddell Stanley R Adoptive transfer of cd8 + t cell clones derived from central memory cells
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
CN101226118B (zh) 2007-01-19 2010-06-16 中国医学科学院肿瘤研究所 一种兼容免疫荧光分析的细胞化学染色方法及其用途
JP5840837B2 (ja) 2007-03-30 2016-01-06 メモリアル スローン−ケタリング キャンサー センター 養子移入tリンパ球における副刺激リガンドの構成性発現
EP2178916B1 (en) 2007-07-31 2014-12-17 Regeneron Pharmaceuticals, Inc. Human antibodies to human cd20 and method of using thereof
WO2009091826A2 (en) 2008-01-14 2009-07-23 The Board Of Regents Of The University Of Texas System Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
CA2712303C (en) 2008-01-18 2015-03-31 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
CA2713462C (en) 2008-01-29 2020-04-14 Fred Hutchinson Cancer Research Center Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
US20110070581A1 (en) 2009-04-27 2011-03-24 Amit Gupta Separation of Leukocytes
EP2363501A1 (en) 2010-03-02 2011-09-07 Universitätsklinikum Hamburg-Eppendorf Method for isolating target cells
US9678061B2 (en) 2010-08-06 2017-06-13 Ludwig-Maximilians-Universität München Identification of T cell target antigens
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG190731A1 (en) 2010-12-14 2013-07-31 Glaxosmithkline Biolog Sa Mycobacterium antigenic composition
WO2012081650A1 (ja) 2010-12-16 2012-06-21 株式会社明治 遅延型過敏症軽減剤
MX359513B (es) * 2011-03-23 2018-10-01 Hutchinson Fred Cancer Res Metodo y composiciones para inmunoterapia celular.
KR20230114317A (ko) 2011-07-01 2023-08-01 암젠 인크 포유동물 세포 배양
US9353161B2 (en) 2011-09-13 2016-05-31 Uti Limited Partnership Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
WO2013062365A2 (ko) * 2011-10-26 2013-05-02 국립암센터 변이 ctla4 유전자 이입 t 세포 및 이를 포함하는 항암 면역치료용 조성물
EP2814846B1 (en) 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
RU2746407C1 (ru) 2012-02-23 2021-04-13 Стейдж Селл Терапеутикс Гмбх Хроматографическое выделение клеток и других сложных биологических материалов
EP2859093A4 (en) * 2012-06-11 2016-08-17 Wolf Wilson Mfg Corp IMPROVED METHODS FOR CELL CULTURES FOR ADOPTIVE CELL THERAPIES
WO2013192294A1 (en) 2012-06-20 2013-12-27 Boston 3T Biotechnologies, Inc. Cellular therapies for treating and preventing cancers and other immune system disorders
ES2835232T3 (es) 2012-07-13 2021-06-22 Univ Pennsylvania CART19 para la utilización en un método de reducción del número de células B normales para la inducción de tolerancia
IL293944A (en) 2012-08-20 2022-08-01 Hutchinson Fred Cancer Res Method and preparations for cellular immunotherapy
CN111437386A (zh) 2012-09-07 2020-07-24 吉宁特有限公司 II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗
KR102198058B1 (ko) 2012-10-02 2021-01-06 메모리얼 슬로안 케터링 캔서 센터 면역치료용 조성물 및 방법
JP6141989B2 (ja) 2012-10-12 2017-06-07 セイジ サイエンス,インコーポレイティド 側方溶出型分子分画装置
US10065996B2 (en) 2012-11-16 2018-09-04 Iba Gmbh Streptavidin muteins and methods of using them
WO2014097442A1 (ja) 2012-12-20 2014-06-26 三菱電機株式会社 車載装置及びプログラム
KR102332790B1 (ko) 2013-02-15 2021-12-01 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 키메라 항원 수용체 및 이의 이용 방법
KR102363191B1 (ko) 2013-02-26 2022-02-17 메모리얼 슬로안 케터링 캔서 센터 면역치료용 조성물 및 방법
CA3185368A1 (en) 2013-04-03 2014-10-09 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t cells derived from pluripotent stem cells
EP2997134B1 (en) 2013-05-14 2020-06-24 Board of Regents, The University of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
CN103305464B (zh) * 2013-06-05 2015-04-15 南昌大学 直接分离cd4+和cd8+淋巴细胞的方法
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
PT3083671T (pt) 2013-12-20 2020-12-24 Hutchinson Fred Cancer Res Moléculas efetoras quiméricas etiquetadas e recetores destas
SI3888674T1 (sl) 2014-04-07 2024-08-30 Novartis Ag Zdravljenje raka z uporabo antigenskega himernega receptorja proti-CD19
JP6788573B6 (ja) 2014-04-10 2020-12-16 シアトル チルドレンズ ホスピタル, ディービーエー シアトル チルドレンズ リサーチ インスティテュート メトトレキサートによる選択と組み合わせたSleeping Beautyトランスポゾンによる遺伝子改変T細胞の製造
IL293587B2 (en) 2014-04-16 2025-02-01 Juno Therapeutics Gmbh Methods, kits and devices for increasing cell populations
CN106459917B (zh) 2014-04-23 2021-03-09 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法
JP2017514471A (ja) 2014-04-23 2017-06-08 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム キメラ抗原受容体(car)並びにその製造及び使用方法
ES2708584T3 (es) 2014-04-24 2019-04-10 Miltenyi Biotec Gmbh Método para la generación automatizada de células T modificadas genéticamente
RS60544B1 (sr) 2014-04-25 2020-08-31 Bluebird Bio Inc Poboljšani metodi za proizvodnju adoptivnih ćelijskih terapija
CN107074929B (zh) 2014-05-02 2021-09-03 宾夕法尼亚大学董事会 嵌合自身抗体受体t细胞的组合物和方法
WO2016019300A1 (en) 2014-07-31 2016-02-04 Novartis Ag Subset-optimized chimeric antigen receptor-containing t-cells
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
JP6612340B2 (ja) 2014-10-15 2019-11-27 セージ サイエンス, インコーポレイテッド 核酸の自動化された加工処理および電気泳動による試料調製のための装置、方法およびシステム
KR20170075013A (ko) 2014-10-31 2017-06-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Cart 세포에서 유전자 발현의 변경 및 그의 용도
HUE050264T2 (hu) 2014-11-05 2020-11-30 Juno Therapeutics Inc Eljárások transzdukálásra és sejtfeldolgozásra
JP7068820B2 (ja) 2014-12-03 2022-05-17 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法のための方法および組成物
CN114085856A (zh) 2014-12-05 2022-02-25 希望之城公司 Cs1靶向性嵌合抗原受体修饰的t细胞
LT3230321T (lt) 2014-12-12 2019-12-10 Bluebird Bio Inc Bcma chimeriniai antigeno receptoriai
WO2016109410A2 (en) 2014-12-29 2016-07-07 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
DE102015205759A1 (de) 2015-03-31 2016-10-06 Henkel Ag & Co. Kgaa Mittel für keratinhaltige Fasern, enthaltend mindestens ein Copolymer auf Basis von Vinylpyrrolidon und mindestens ein Copolymer aus Basis von Acrylaten
US20180140602A1 (en) 2015-04-07 2018-05-24 Novartis Ag Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
PT3280729T (pt) 2015-04-08 2022-08-01 Novartis Ag Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
AR105433A1 (es) 2015-07-21 2017-10-04 Novartis Ag Métodos para mejorar la eficacia y expansión de las células inmunes
WO2017015490A1 (en) 2015-07-21 2017-01-26 City Of Hope T cells for expression of chimeric antigen receptors and other receptors
WO2017023803A1 (en) 2015-07-31 2017-02-09 Regents Of The University Of Minnesota Modified cells and methods of therapy
CA2994829A1 (en) 2015-08-07 2017-02-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific car t-cells for solid tumor targeting
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
AU2016363025B2 (en) 2015-12-03 2021-04-08 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods
WO2017156479A1 (en) 2016-03-11 2017-09-14 Bluebird Bio, Inc. Ror1 chimeric antigen receptors
CN108779242B (zh) 2016-03-17 2021-06-11 默克专利股份公司 纯化泊洛沙姆的方法
KR102499191B1 (ko) 2016-03-18 2023-02-13 프레드 허친슨 캔서 센터 Cd20 면역요법을 위한 조성물 및 방법
KR20190098747A (ko) 2016-12-05 2019-08-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 위한 조작된 세포의 제조방법
EP3346001A1 (en) 2017-01-06 2018-07-11 TXCell Monospecific regulatory t cell population with cytotoxicity for b cells
EP3610261A1 (en) 2017-04-14 2020-02-19 Juno Therapeutics, Inc. Methods for assessing cell surface glycosylation
CN107723275B (zh) 2017-10-20 2020-09-04 重庆精准生物技术有限公司 通用型car-t细胞及其制备方法和应用
EP3704230B1 (en) 2017-11-01 2024-10-23 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
CN112004824B (zh) 2017-12-08 2024-09-13 朱诺治疗学股份有限公司 生产工程化t细胞组合物的过程
CN113474450A (zh) 2018-08-09 2021-10-01 朱诺治疗学股份有限公司 产生工程化细胞的方法以及所述工程化细胞的组合物
EP4103203A1 (en) 2020-02-12 2022-12-21 Juno Therapeutics, Inc. Bcma-directed chimeric antigen receptor t cell compositions and methods and uses thereof
KR20220152220A (ko) 2020-02-12 2022-11-15 주노 쎄러퓨티크스 인코퍼레이티드 Cd19-지시된 키메라 항원 수용체 t 세포 조성물 및 이의 방법 및 용도

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003493A2 (en) * 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
WO2009072003A2 (en) * 2007-12-07 2009-06-11 Miltenyi Biotec Gmbh Sample processing system and methods
WO2013011011A2 (en) * 2011-07-18 2013-01-24 Iba Gmbh Method of reversibly staining a target cell
WO2014011996A1 (en) * 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Methods of assessing the suitability of transduced t cells for administration

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LI P. et al., "Comparison of inlet geometry in microfluidic cell affinity chromatography." Analytical chemistry, 2011, 83(3): 774-781. *
LI P. et al., "Multiparameter cell affinity chromatography: separation and analysis in a single microfluidic channel." Analytical chemistry, 2012, 84(19): 8140-8148. *
LI P. et al., "Multiparameter cell affinity chromatography: separation and analysis in a single microfluidic channel." Analytical chemistry, 2012, 84(19): 8140-8148. STEMBERGER C. et al. "Novel serial positive enrichment technology enables clinical multiparameter cell sorting." PloS one, 2012, 7(4): e35798. *
LI P. et al., "Negative enrichment of target cells by microfluidic affinity chromatography." Analytical chemistry, 2011, 83(20): 7863-7869. *
LI P. et al., "Negative enrichment of target cells by microfluidic affinity chromatography." Analytical chemistry, 2011, 83(20): 7863-7869. LI P. et al., "Comparison of inlet geometry in microfluidic cell affinity chromatography." Analytical chemistry, 2011, 83(3): 774-781. PULLAGURLA S.R. et al. "Parallel affinity-based isolation of leukocyte subsets using microfluidics: application for stroke diagnosis." Analytical chemistry, 2014 (March, 20), 86(8): 4058-4065. *
PULLAGURLA S.R. et al. "Parallel affinity-based isolation of leukocyte subsets using microfluidics: application for stroke diagnosis." Analytical chemistry, 2014 (March, 20), 86(8): 4058-4065. *
STEMBERGER C. et al. "Novel serial positive enrichment technology enables clinical multiparameter cell sorting." PloS one, 2012, 7(4): e35798. *

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