RU2720934C2 - Последовательности 3'-utr для стабилизации рнк - Google Patents

Последовательности 3'-utr для стабилизации рнк Download PDF

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RU2720934C2
RU2720934C2 RU2018112325A RU2018112325A RU2720934C2 RU 2720934 C2 RU2720934 C2 RU 2720934C2 RU 2018112325 A RU2018112325 A RU 2018112325A RU 2018112325 A RU2018112325 A RU 2018112325A RU 2720934 C2 RU2720934 C2 RU 2720934C2
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Russia
Prior art keywords
nucleic acid
acid sequence
fragment
sequence
rna
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RU2018112325A
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English (en)
Russian (ru)
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RU2018112325A (ru
RU2018112325A3 (de
Inventor
ФОН НИССЕН Александра ОРЛАНДИНИ
Штефани ФЕССЕР
Бритта ВАЛЛАЦЦА
Тим БАЙССЕРТ
Андреас КУН
Угур ЗАХИН
Марко Александр ПОЛЕГАНОВ
Original Assignee
Бионтэк Рна Фармасьютикалз Гмбх
Трон - Транслационале Онкологи Ан Дер Униферзитетсмедицин Дер Иоганн Гутенберг-Униферзитет Майнц Ггмбх
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • A—HUMAN NECESSITIES
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    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B3/00—Folding or stowable tables
    • A47B3/002—Folding or stowable tables with foldable underframe
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    • A47B43/00—Cabinets, racks or shelf units, characterised by features enabling folding of the cabinet or the like
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    • A47B77/08—Provision for particular uses of compartments or other parts ; Compartments moving up and down, revolving parts for incorporating apparatus operated by power, including water power; for incorporating apparatus for cooking, cooling, or laundry purposes
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    • A47B77/16—Provision for particular uses of compartments or other parts ; Compartments moving up and down, revolving parts by adaptation of compartments or drawers for receiving or holding foodstuffs; by provision of rotatable or extensible containers for foodstuffs
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    • A47B77/18—Provision for particular uses of compartments or other parts ; Compartments moving up and down, revolving parts by special arrangements for accommodating removable containers
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    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K3/00—Baths; Douches; Appurtenances therefor
    • A47K3/28—Showers or bathing douches
    • A47K3/283—Fixed showers
    • A47K3/284—Pre-fabricated shower cabinets
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B60B33/00—Castors in general; Anti-clogging castors
    • C—CHEMISTRY; METALLURGY
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
    • E04H1/00—Buildings or groups of buildings for dwelling or office purposes; General layout, e.g. modular co-ordination or staggered storeys
    • E04H1/12—Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
    • E04H1/125—Small buildings, arranged in other buildings
    • E04H1/1266—Cubicles for dressing; Toilets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
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    • A47B2200/00—General construction of tables or desks
    • A47B2200/0011—Underframes
    • A47B2200/0017—Nodal leg assembly for table
    • A47B2200/0018—Nodal leg assembly for table in two parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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RU2018112325A 2015-10-07 2016-10-05 Последовательности 3'-utr для стабилизации рнк RU2720934C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2015/073180 2015-10-07
PCT/EP2015/073180 WO2017059902A1 (en) 2015-10-07 2015-10-07 3' utr sequences for stabilization of rna
PCT/EP2016/073814 WO2017060314A2 (en) 2015-10-07 2016-10-05 3' utr sequences for stabilization of rna

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2020114989A Division RU2783165C1 (ru) 2015-10-07 2016-10-05 Последовательности 3'-utr для стабилизации рнк

Publications (3)

Publication Number Publication Date
RU2018112325A RU2018112325A (ru) 2019-11-07
RU2018112325A3 RU2018112325A3 (de) 2019-11-07
RU2720934C2 true RU2720934C2 (ru) 2020-05-14

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RU2018112325A RU2720934C2 (ru) 2015-10-07 2016-10-05 Последовательности 3'-utr для стабилизации рнк

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US (2) US11492628B2 (de)
EP (3) EP3337902B1 (de)
JP (6) JP7084302B2 (de)
KR (3) KR20240118189A (de)
CN (1) CN108291230B (de)
AU (3) AU2016335029B2 (de)
BR (2) BR112018003486B1 (de)
CA (2) CA2998554C (de)
CY (2) CY1122347T1 (de)
DK (2) DK3337902T3 (de)
ES (2) ES2753201T3 (de)
HK (2) HK1256701A1 (de)
HR (2) HRP20191907T1 (de)
HU (2) HUE055152T2 (de)
IL (3) IL293020A (de)
LT (2) LT3636764T (de)
MX (2) MX2018004160A (de)
NZ (1) NZ740946A (de)
PL (2) PL3337902T3 (de)
PT (2) PT3636764T (de)
RS (2) RS59538B1 (de)
RU (1) RU2720934C2 (de)
SG (1) SG10201912558YA (de)
SI (2) SI3636764T1 (de)
WO (2) WO2017059902A1 (de)
ZA (1) ZA201800835B (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
AU2017296195A1 (en) 2016-07-11 2019-01-24 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
EP3668980A1 (de) * 2017-08-15 2020-06-24 Intellia Therapeutics, Inc. Stabilisierte nukleinsäuren, die boten-ribonukleinsäuren (mrna) codieren
AU2019219200A1 (en) 2018-02-12 2020-08-06 BioNTech SE Treatment using cytokine encoding RNA
US20210047375A1 (en) * 2018-05-01 2021-02-18 Wake Forest University Health Sciences Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
JP7550745B2 (ja) 2018-07-24 2024-09-13 バイオエヌテック エスエー Ｉｌ２アゴニスト
AU2020208193A1 (en) 2019-01-14 2021-07-29 BioNTech SE Methods of treating cancer with a PD-1 axis binding antagonist and an RNA vaccine
CA3129100A1 (en) 2019-02-08 2020-08-13 Biontech Cell & Gene Therapies Gmbh Treatment involving car-engineered t cells and cytokines
BR112021016962A2 (pt) 2019-03-18 2021-11-23 Biontech Cell & Gene Therapies Gmbh Variantes do receptor de interleucina-2 (il2r) e da interleucina-2 (il2) para ativação específica de células efetoras imunes
WO2020200481A1 (en) 2019-04-05 2020-10-08 Biontech Rna Pharmaceuticals Gmbh Treatment involving interleukin-2 (il2) and interferon (ifn)
TW202115105A (zh) 2019-06-24 2021-04-16 德商拜恩迪克Ｒｎａ製藥有限公司 Ｉｌ２激動劑
EP4022068A1 (de) * 2019-08-29 2022-07-06 Universität Zürich Minimale messenger-rnas und deren verwendungen
WO2021081261A1 (en) * 2019-10-22 2021-04-29 The Regents Of The University Of California Modulation of engineered immune cell receptor translation using noncoding sequence elements
JP2023512654A (ja) 2020-01-31 2023-03-28 ジェネンテック， インコーポレイテッド Ｐｄ－１軸結合アンタゴニストおよびｒｎａワクチンを用いてネオエピトープ特異的ｔ細胞を誘導する方法
WO2021160346A1 (en) 2020-02-13 2021-08-19 Institut Pasteur Nucleic acid vaccine against the sars-cov-2 coronavirus
CA3171370A1 (en) 2020-03-16 2021-09-23 Ugur Sahin Antigen-specific t cell receptors and t cell epitopes
KR102462990B1 (ko) * 2020-03-17 2022-11-07 에이비온 주식회사 인비트로 트랜스크립트 mRNA 및 이를 함유하는 약학조성물
KR20220161316A (ko) 2020-03-30 2022-12-06 비온테크 에스이 Claudin-18.2를 표적화하는 rna 조성물
WO2021197589A1 (en) 2020-03-31 2021-10-07 BioNTech SE Treatment involving non-immunogenic rna for antigen vaccination
GB202307565D0 (en) 2020-04-22 2023-07-05 BioNTech SE Coronavirus vaccine
EP4139616A1 (de) 2020-04-22 2023-03-01 Pfizer Inc. Coronavirus-impfstoff
WO2022008519A1 (en) 2020-07-07 2022-01-13 BioNTech SE Therapeutic rna for hpv-positive cancer
AU2021308081A1 (en) 2020-07-17 2022-11-17 Genentech, Inc. Attention-based neural network to predict peptide binding, presentation, and immunogenicity
CN116194477A (zh) 2020-08-06 2023-05-30 生物技术欧洲股份公司 冠状病毒s蛋白的结合剂
CN116648303A (zh) 2020-09-08 2023-08-25 基因泰克公司 用于使用蠕动泵和阻尼器来生产药物组合物的系统和方法
TW202227478A (zh) 2020-09-15 2022-07-16 德商拜恩迪克公司 對細胞靶向遞送的藥劑及方法
EP4203997A1 (de) 2020-10-26 2023-07-05 Pécsi Tudományegyetem Impfstoffplattform
MX2023005386A (es) 2020-11-11 2023-05-23 BioNTech SE Anticuerpos monoclonales dirigidos contra la proteina de muerte programada-1 y su uso en medicina.
WO2022106860A1 (en) 2020-11-20 2022-05-27 Pécsi Tudományegyetem Recombinant peptides for use in therapy
KR20230129432A (ko) 2020-12-09 2023-09-08 비온테크 에스이 Rna 제조
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (zh) * 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
CN114717230B (zh) * 2021-01-05 2024-09-03 麦塞拿治疗(香港)有限公司 成纤维细胞生长因子mRNA的无细胞和无载体体外RNA转录方法和核酸分子
EP4326317A1 (de) 2021-04-20 2024-02-28 BioNTech SE Virusimpfstoff
JP2024518335A (ja) 2021-04-26 2024-05-01 アンスティチュ パスツール ＳＡＲＳ－ＣｏＶ－２に対するヒト中和モノクローナル抗体、及びそれらの使用
AU2022270658A1 (en) 2021-05-04 2023-11-16 BioNTech SE Technologies for early detection of variants of interest
EP4351633A1 (de) 2021-06-08 2024-04-17 Biontech Cell & Gene Therapies Gmbh Mittel und verfahren zur aktivierung und zum targeting von immuneffektorzellen
EP4361270A1 (de) * 2021-06-24 2024-05-01 Hanmi Pharm. Co., Ltd. Nichtnatürliche 5'-untranslierte region und 3'-untranslierte region und verwendung davon
MX2024000678A (es) 2021-07-15 2024-02-07 BioNTech SE Agentes que codifican elementos de union a cldn6 y cd3 para el tratamiento de canceres positivos para cldn6.
JP2024526870A (ja) * 2021-07-27 2024-07-19 エスケー バイオサイエンス カンパニー リミテッド タンパク質発現のためのｍＲＮＡ、及びそのためのテンプレート
TW202320842A (zh) 2021-07-29 2023-06-01 德商拜恩技術股份公司 用於治療黑色素瘤之組合物及方法
WO2023025404A1 (en) 2021-08-24 2023-03-02 BioNTech SE In vitro transcription technologies
WO2023030635A1 (en) 2021-09-02 2023-03-09 BioNTech SE Potency assay for therapeutic potential of coding nucleic acid
WO2023051926A1 (en) 2021-09-30 2023-04-06 BioNTech SE Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
KR20240073046A (ko) * 2021-10-07 2024-05-24 프레시젼 나노시스템스 유엘씨 Rna 백신 지질 나노입자
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023061550A1 (en) 2021-10-11 2023-04-20 BioNTech SE Therapeutic rna for lung cancer
TW202333803A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性ｒｎａ（一）
EP4416274A2 (de) 2021-10-15 2024-08-21 BioNTech SE Pharmazeutische zusammensetzungen zur abgabe von viralen antigenen und zugehörige verfahren
CA3235180A1 (en) 2021-10-21 2023-04-27 BioNTech SE Coronavirus vaccine
EP4285933A1 (de) 2022-05-30 2023-12-06 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4286003A1 (de) 2022-05-30 2023-12-06 BioNTech SE Oligosaccharidverbindungen und -komplexe
EP4286394A1 (de) 2022-05-30 2023-12-06 BioNTech SE Oligosaccharidverbindungen und -komplexe
EP4402150A1 (de) 2021-10-22 2024-07-24 BioNTech SE Oligosaccharidverbindungen und komplexe
EP4186528A1 (de) 2021-11-30 2023-05-31 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4286004A1 (de) 2022-05-30 2023-12-06 BioNTech SE Disulfid-oligosaccharid-verbindungen und -komplexe
EP4169580A1 (de) 2021-10-22 2023-04-26 BioNTech SE Oligosaccharidverbindungen und -komplexe
EP4285932A1 (de) 2022-05-30 2023-12-06 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4169578A1 (de) 2021-10-22 2023-04-26 BioNTech SE Oligosaccharidverbindungen und -komplexe
WO2023067121A1 (en) 2021-10-22 2023-04-27 BioNTech SE Oligosaccharide compounds and complexes
EP4169579A1 (de) 2021-10-22 2023-04-26 BioNTech SE Disulfid-oligosaccharid-verbindungen und -komplexe
WO2023067124A1 (en) 2021-10-22 2023-04-27 BioNTech SE Disulfide oligosaccharide compounds and complexes
WO2023067193A2 (en) 2021-10-22 2023-04-27 BioNTech SE Compositions for administration of different doses of rna
EP4169534A1 (de) 2021-10-22 2023-04-26 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4401789A1 (de) 2021-10-22 2024-07-24 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4401788A1 (de) 2021-10-22 2024-07-24 BioNTech SE Oligosaccharidkomplexe und verwendungen
EP4409006A1 (de) 2021-10-28 2024-08-07 BioNTech SE Rna-konstrukte und verwendungen davon
WO2023083434A1 (en) 2021-11-09 2023-05-19 BioNTech SE Rna encoding peptidoglycan hydrolase and use thereof for treating bacterial infection
GB2615177A (en) 2021-11-29 2023-08-02 BioNTech SE Coronavirus vaccine
KR20240133791A (ko) 2021-12-09 2024-09-04 비온테크 에스이 Cldn6를 발현하는 암을 치료하기 위한 키메라 항원 수용체 변형 세포
WO2024046572A1 (en) 2022-09-01 2024-03-07 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
WO2023126053A1 (en) 2021-12-28 2023-07-06 BioNTech SE Lipid-based formulations for administration of rna
AU2023212857A1 (en) 2022-01-27 2024-07-04 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
WO2023147091A1 (en) 2022-01-28 2023-08-03 BioNTech SE Coronavirus vaccine
WO2023214801A1 (ko) * 2022-05-03 2023-11-09 단국대학교 산학협력단 단백질의 발현 수준 및 발현 위치 조절을 위한 utr 서열 및 이를 포함하는 mrna 서열
US11932693B2 (en) 2022-05-12 2024-03-19 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
WO2023218431A1 (en) 2022-05-13 2023-11-16 BioNTech SE Rna compositions targeting hiv
WO2023230295A1 (en) 2022-05-25 2023-11-30 BioNTech SE Rna compositions for delivery of monkeypox antigens and related methods
WO2023232747A1 (en) 2022-05-30 2023-12-07 BioNTech SE Complexes for delivery of nucleic acids
WO2023237726A1 (en) 2022-06-10 2023-12-14 Pantarhei Oncology B.V. An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine
WO2024017479A1 (en) 2022-07-21 2024-01-25 BioNTech SE Multifunctional cells transiently expressing an immune receptor and one or more cytokines, their use and methods for their production
WO2024028445A1 (en) 2022-08-03 2024-02-08 BioNTech SE Rna for preventing or treating tuberculosis
WO2024027910A1 (en) 2022-08-03 2024-02-08 BioNTech SE Rna for preventing or treating tuberculosis
CN117660494A (zh) * 2022-09-07 2024-03-08 远大赛威信生命科学(南京)有限公司 用于表达水痘-带状疱疹病毒抗原蛋白的mRNA及其用途
WO2024056856A1 (en) 2022-09-15 2024-03-21 BioNTech SE Systems and compositions comprising trans-amplifying rna vectors with mirna
WO2024063788A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
WO2024064934A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of plasmodium csp antigens and related methods
WO2024064931A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of liver stage antigens and related methods
WO2024063789A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
WO2024068674A1 (en) 2022-09-26 2024-04-04 BioNTech SE Nucleic acid complexes and uses thereof
WO2024074634A1 (en) * 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
WO2024074211A1 (en) * 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
WO2024086575A1 (en) 2022-10-17 2024-04-25 BioNTech SE Combination vaccines against coronavirus infection, influenza infection, and/or rsv infection
WO2024083345A1 (en) 2022-10-21 2024-04-25 BioNTech SE Methods and uses associated with liquid compositions
WO2024084462A1 (en) 2022-10-21 2024-04-25 BioNTech SE Nucleic acid complexes and uses thereof
WO2024107754A1 (en) 2022-11-15 2024-05-23 Genentech, Inc. Selection of diverse candidate peptides for peptide therapeutics
WO2024137589A2 (en) 2022-12-20 2024-06-27 Genentech, Inc. Methods of treating pancreatic cancer with a pd-1 axis binding antagonist and an rna vaccine
WO2024141955A1 (en) 2022-12-28 2024-07-04 BioNTech SE Rna compositions targeting hiv
WO2024153324A1 (en) 2023-01-18 2024-07-25 BioNTech SE Rna formulations for pharmaceutical use
WO2024157221A1 (en) 2023-01-27 2024-08-02 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein c, glycoprotein d, and glycoprotein e antigens and related methods
WO2024176192A1 (en) 2023-02-24 2024-08-29 BioNTech SE Immunogenic compositions
WO2024180054A1 (en) 2023-02-28 2024-09-06 BioNTech SE Linker sequence potency assays for multiple coding nucleic acids
WO2024180363A1 (en) 2023-02-28 2024-09-06 BioNTech SE Linker sequence potency assays for multiple coding nucleic acids
WO2024184533A1 (en) 2023-03-09 2024-09-12 BioNTech SE Peptidoglycan hydrolases with bactericidal activity
EP4442276A1 (de) 2023-04-07 2024-10-09 Institut Pasteur Kombinierte antikörper gegen sarbecoviren und verwendungen davon
CN117535295B (zh) * 2024-01-09 2024-04-26 艾斯拓康医药科技(北京)有限公司 一种优化的3`utr序列及其应用

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2126047C1 (ru) * 1987-05-29 1999-02-10 Новартис Аг Способ получения растений zea mays l., устойчивых к повреждениям, вызываемым насекомыми
RU2148081C1 (ru) * 1990-06-18 2000-04-27 Монсанто Компани Способ получения генетически трансформированных растений с повышенным содержанием крахмала и рекомбинантная двухцепочечная днк-молекула
RU2152997C2 (ru) * 1992-12-28 2000-07-20 Стихтинг Схейкундиг Ондерзук ин Недерланд Днк-конструкция (варианты), способ получения трансгенных растений и фруктаны
WO2003018760A2 (en) * 2001-08-24 2003-03-06 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
US20050054011A1 (en) * 2002-09-06 2005-03-10 Yiwen Jan Methods of modulating cell death based on the Bit1/AES regulatory pathway
EA006761B1 (ru) * 2000-03-27 2006-04-28 Зингента Партисипейшнс Аг Промоторные последовательности вируса желтого скручивания листьев цестровых и способы их применения
RU2307872C2 (ru) * 2002-10-09 2007-10-10 СиАйДи КО., ЛТД НОВАЯ ПОЛНОРАЗМЕРНАЯ ГЕНОМНАЯ PHK ВИРУСА ЯПОНСКОГО ЭНЦЕФАЛИТА, ПОЛУЧЕННАЯ ИЗ НЕЕ ИНФЕКЦИОННАЯ кДНК JEV И ИХ ПРИМЕНЕНИЕ
WO2007122369A2 (en) * 2006-04-13 2007-11-01 Oncomethylome Sciences Sa Novel tumour suppressor
EA011557B1 (ru) * 2005-02-01 2009-04-28 Паудерджект Вэксинс, Инк. Конструкции нуклеиновых кислот
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
WO2011075838A1 (en) * 2009-12-21 2011-06-30 Audigen Inc. Method of treating or preventing hearing loss
RU2491343C1 (ru) * 2011-12-23 2013-08-27 Общество с ограниченной ответственностью "Биотехнологический центр трансгенеза в фарминдустрии "Трансгенфарм" Генетические конструкции ltf3, ltf5, ltf7, ltf10, ltf11 для получения рекомбинантного лактоферрина человека (варианты)
US20130244243A1 (en) * 2012-03-15 2013-09-19 Takashi Matsuyama Method for producing expression product of exogenous gene in yeast, regulator of expression in yeast, and use thereof
WO2014184684A2 (en) * 2013-05-16 2014-11-20 Oslo Universitetssykehus Hf Methods and biomarkers for detection of hematological cancers
RU2535871C1 (ru) * 2013-07-10 2014-12-20 Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") Плазмида для экспрессии в клетке китайского хомячка, клетка китайского хомячка - продуцент белка с Gla-доменом и способ получения белка с Gla-доменом
WO2015138348A1 (en) * 2014-03-09 2015-09-17 The Trustees Of The University Of Pennsylvania Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0846771A1 (de) 1987-05-20 1998-06-10 Novartis AG Zea mays-Pflanzen und transgene Zea mays-Pflanzen, die aus Protoplasten oder aus von Protoplasten erhaltenen Zellen regeneriert wurden
US5804381A (en) 1996-10-03 1998-09-08 Cornell Research Foundation Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US6235525B1 (en) 1991-05-23 2001-05-22 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof
EP0677112B1 (de) 1992-12-28 2003-03-26 Stichting Scheikundig Onderzoek In Nederland (Son) Verfahren zur herstellung transgener pflanzen mit modifiziertem fructanmuster
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
AU738649B2 (en) 1996-04-26 2001-09-20 Rijksuniversiteit Te Leiden Methods for selecting and producing T cell peptide epitopes and vaccines incorporating said selected epitopes
CA2271388C (en) 1996-09-13 2007-11-06 The School Of Pharmacy, University Of London Liposomes encapsulating polynucleotides operatively coding for immunogenic polypeptides
EP0839912A1 (de) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren
US6074645A (en) 1996-11-12 2000-06-13 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
JP2001522603A (ja) 1997-11-06 2001-11-20 ロシュ ダイアグノスティックス ゲーエムベーハー 腫瘍特異的抗原、その製造方法、ならびに免疫および診断のためのその使用
US6432925B1 (en) 1998-04-16 2002-08-13 John Wayne Cancer Institute RNA cancer vaccine and methods for its use
CA2345440A1 (en) 1998-10-05 2000-04-13 Charles A. Nicolette Genes differentially expressed in cancer cells to design cancer vaccines
WO2000050592A1 (en) 1999-02-24 2000-08-31 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
KR100922809B1 (ko) 1999-05-06 2009-10-21 웨이크 포리스트 유니버시티 면역 반응을 유발하는 항원을 동정하기 위한 조성물과 방법
AU4903101A (en) 1999-11-30 2001-07-09 Cornell Research Foundation Inc. Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
BR0017052B1 (pt) 1999-12-28 2013-12-24 Epimmune Inc Método para a projeção de um constructo poliepitópico e constructo poliepitópico preparado pelo referido método
US7462354B2 (en) 1999-12-28 2008-12-09 Pharmexa Inc. Method and system for optimizing minigenes and peptides encoded thereby
WO2001093902A2 (en) 2000-06-07 2001-12-13 Biosynexus Incorporated Immunostimulatory rna/dna hybrid molecules
US6472176B2 (en) 2000-12-14 2002-10-29 Genvec, Inc. Polynucleotide encoding chimeric protein and related vector, cell, and method of expression thereof
EP2305699B1 (de) * 2001-06-05 2014-08-13 CureVac GmbH Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose
DE10162480A1 (de) 2001-12-19 2003-08-07 Ingmar Hoerr Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
AUPS054702A0 (en) 2002-02-14 2002-03-07 Immunaid Pty Ltd Cancer therapy
KR20050016410A (ko) * 2002-05-17 2005-02-21 베일러 칼리지 오브 메디신 도세탁셀 약제민감성 및 약제내성을 예측하는 특징적인유전자 발현 패턴
CA2489296A1 (en) 2002-06-13 2003-12-24 Merck Patent Gesellschaft Mit Beschraenkter Haftung Methods for the identification of allo-antigens and their use for cancer therapy and transplantation
DE10229872A1 (de) 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
DE10344799A1 (de) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
EP2286794B8 (de) 2003-10-15 2016-06-01 SynCore Biotechnology CO., LTD Verwendung von kationischen liposomen mit paclitacel
EP2270511A3 (de) 2003-10-24 2011-08-24 Immunaid Pty Ltd Therapieverfahren
US7303881B2 (en) 2004-04-30 2007-12-04 Pds Biotechnology Corporation Antigen delivery compositions and methods of use
DE102004023187A1 (de) 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
DE102004057303A1 (de) 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
JP2008526764A (ja) 2004-12-29 2008-07-24 マンカインド コーポレイション 免疫応答の誘導におけるｃｄ４＋細胞の回避方法
CN117534755A (zh) 2005-05-09 2024-02-09 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
SI3611266T1 (sl) 2005-08-23 2023-02-28 The Trustees Of The University Of Pennsylvania Modificirani nukleozidi, ki vsebujejo RNA, in postopki za njihovo uporabo
DE102005041616B4 (de) 2005-09-01 2011-03-17 Johannes-Gutenberg-Universität Mainz Melanom-assoziierte MHC Klasse I assoziierte Oligopeptide und für diese kodierende Polynukleotide und deren Verwendungen
EP1762575A1 (de) 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identifizierung Tumor-assoziierter Antigene für Diagnoseund Therapie
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
US9017965B2 (en) * 2005-12-12 2015-04-28 King Faisal Specialist Hospital & Research Centre Hybrid 3′ untranslated regions suitable for efficient protein expression in mammalian cells
US20090186042A1 (en) 2006-02-27 2009-07-23 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
CA2663521A1 (en) 2006-09-20 2008-07-17 The Johns Hopkins University Combinatorial therapy of cancer and infectious diseases with anti-b7-h1 antibodies
DE102006060824B4 (de) 2006-12-21 2011-06-01 Johannes-Gutenberg-Universität Mainz Nachweis von individuellen T-Zell-Reaktionsmustern gegen Tumor-assoziierte Antigene (TAA) in Tumorpatienten als Basis für die individuelle therapeutische Vakzinierung von Patienten
HUE030139T2 (en) 2006-12-27 2017-04-28 Univ Emory Preparations and procedures for treating inflammations
EP2135080A4 (de) * 2007-03-08 2010-12-01 Switchgear Genomics Funktionelle arrays zur charakterisierung mit hohem durchsatz von regulatorischen elementen in nichttranslatierten bereichen von genen
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
US8140270B2 (en) 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
HUE031422T2 (en) 2007-09-26 2017-07-28 Intrexon Corp Artificial 5'UTRs, expression vectors, and methods for increasing transgene expression
EP2060583A1 (de) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identifikation Tumor-assoziierter Marker für Diagnose und Therapie
RS53059B (en) 2008-03-24 2014-04-30 4Sc Discovery Gmbh NEW SUBSTITUTED IMIDAZOCHINOLINES
JP5971945B2 (ja) 2008-04-17 2016-08-17 ピーディーエス バイオテクノロジー コーポレイションＰｄｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ カチオン性脂質の鏡像異性体による免疫応答の刺激
DE102008061522A1 (de) 2008-12-10 2010-06-17 Biontech Ag Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung
EP3581197A1 (de) 2009-07-31 2019-12-18 ethris GmbH Rna mit einer kombination aus unmodifizierten und modifizierten nucleotiden zur proteinexpression
WO2013040142A2 (en) 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
CN103180730B (zh) 2010-05-14 2016-03-02 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法
CA2821992A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
DE102011102734A1 (de) 2011-05-20 2012-11-22 WMF Württembergische Metallwarenfabrik Aktiengesellschaft Vorrichtung zum Aufschäumen von Milch, Getränkebereiter mit dieser Vorrichtung und Verfahren zum Aufschäumen von Milch
EP3492109B1 (de) 2011-10-03 2020-03-04 ModernaTX, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US20150030576A1 (en) 2012-01-10 2015-01-29 Moderna Therapeutics, Inc. Methods and compositions for targeting agents into and across the blood-brain barrier
WO2013120497A1 (en) * 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
EP2817322B1 (de) 2012-02-20 2016-04-20 Universita' degli Studi di Milano Homo- und heterodimere mimetische smac-verbindungen als apoptoseinduktoren
CN104220599A (zh) * 2012-03-27 2014-12-17 库瑞瓦格有限责任公司 人工核酸分子
CA2859452C (en) * 2012-03-27 2021-12-21 Curevac Gmbh Artificial nucleic acid molecules for improved protein or peptide expression
JP6301906B2 (ja) * 2012-03-27 2018-03-28 キュアバック アーゲー ５’ｔｏｐｕｔｒを含む人工核酸分子
US20130255281A1 (en) 2012-03-29 2013-10-03 General Electric Company System and method for cooling electrical components
EP2833923A4 (de) 2012-04-02 2016-02-24 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von proteinen
WO2014012051A1 (en) 2012-07-12 2014-01-16 Persimmune, Inc. Personalized cancer vaccines and adoptive immune cell therapies
AU2013302947B2 (en) 2012-08-17 2017-06-01 Diaa ALABED Use of a maize untranslated region for transgene expression in plants
US20150307542A1 (en) 2012-10-03 2015-10-29 Moderna Therapeutics, Inc. Modified nucleic acid molecules and uses thereof
WO2014071219A1 (en) 2012-11-01 2014-05-08 Factor Bioscience Inc. Methods and products for expressing proteins in cells
LT2922554T (lt) 2012-11-26 2022-06-27 Modernatx, Inc. Terminaliai modifikuota rnr
EP2964234A4 (de) 2013-03-09 2016-12-07 Moderna Therapeutics Inc Heterologe untranslatierte regionen für mrna
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20160032316A1 (en) 2013-03-14 2016-02-04 The Trustees Of The University Of Pennsylvania Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
EP2971010B1 (de) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulierung und abgabe von modifizierten nukleosid-, nukleotid- und nukleinsäurezusammensetzungen
WO2014144711A1 (en) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Analysis of mrna heterogeneity and stability
EP2971033B8 (de) 2013-03-15 2019-07-10 ModernaTX, Inc. Herstellungsverfahren zur herstellung von rna-transkripten
US10077439B2 (en) 2013-03-15 2018-09-18 Modernatx, Inc. Removal of DNA fragments in mRNA production process
US20160032273A1 (en) 2013-03-15 2016-02-04 Moderna Therapeutics, Inc. Characterization of mrna molecules
EP4279610A3 (de) 2013-03-15 2024-01-03 ModernaTX, Inc. Ribonukleinsäurereinigung
EP2983804A4 (de) 2013-03-15 2017-03-01 Moderna Therapeutics, Inc. Ionenaustauschreinigung von mrna
CA2908434C (en) 2013-04-07 2021-12-28 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
WO2015014375A1 (en) 2013-07-30 2015-02-05 Biontech Ag Tumor antigens for determining cancer therapy
EP3041934A1 (de) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimäre polynukleotide
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
EP3043826A4 (de) 2013-09-13 2017-05-24 Moderna Therapeutics, Inc. Polynukleotidzusammensetzungen mit aminosäuren
JP6363179B2 (ja) 2013-09-26 2018-07-25 バイオンテック アーゲー Ｒｎａによるシェルを含む粒子
EP3052511A4 (de) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynukleotidmoleküle und verwendungen davon
US20160264614A1 (en) 2013-10-02 2016-09-15 Moderna Therapeutics, Inc. Polynucleotide molecules and uses thereof
WO2015058780A1 (en) 2013-10-25 2015-04-30 Biontech Ag Method and kit for determining whether a subject shows an immune response
US20170173128A1 (en) 2013-12-06 2017-06-22 Moderna TX, Inc. Targeted adaptive vaccines
US20150167017A1 (en) 2013-12-13 2015-06-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
CA2927254C (en) * 2013-12-30 2023-10-24 Curevac Ag Artificial nucleic acid molecules
CN111304231A (zh) * 2013-12-30 2020-06-19 库瑞瓦格股份公司 人工核酸分子
JP2017507703A (ja) 2014-02-05 2017-03-23 バイオエヌテック アーゲーＢｉｏＮＴｅｃｈ ＡＧ カニューレ、注射または注入装置、およびカニューレまたは注射もしくは注入装置を使用する方法
SG10201912038TA (en) 2014-04-23 2020-02-27 Modernatx Inc Nucleic acid vaccines
WO2015172843A1 (en) 2014-05-16 2015-11-19 Biontech Diagnostics Gmbh Methods and kits for the diagnosis of cancer
WO2016005004A1 (en) * 2014-07-11 2016-01-14 Biontech Rna Pharmaceuticals Gmbh Stabilization of poly(a) sequence encoding dna sequences
WO2016062323A1 (en) 2014-10-20 2016-04-28 Biontech Ag Methods and compositions for diagnosis and treatment of cancer
PL3708668T3 (pl) * 2014-12-12 2022-12-05 Curevac Ag Sztuczne cząsteczki kwasu nukleinowego dla poprawy ekspresji białka
SG11201704681QA (en) 2014-12-30 2017-07-28 Curevac Ag Artificial nucleic acid molecules
WO2016155809A1 (en) 2015-03-31 2016-10-06 Biontech Rna Pharmaceuticals Gmbh Lipid particle formulations for delivery of rna and water-soluble therapeutically effective compounds to a target cell
WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2126047C1 (ru) * 1987-05-29 1999-02-10 Новартис Аг Способ получения растений zea mays l., устойчивых к повреждениям, вызываемым насекомыми
RU2148081C1 (ru) * 1990-06-18 2000-04-27 Монсанто Компани Способ получения генетически трансформированных растений с повышенным содержанием крахмала и рекомбинантная двухцепочечная днк-молекула
RU2152997C2 (ru) * 1992-12-28 2000-07-20 Стихтинг Схейкундиг Ондерзук ин Недерланд Днк-конструкция (варианты), способ получения трансгенных растений и фруктаны
EA006761B1 (ru) * 2000-03-27 2006-04-28 Зингента Партисипейшнс Аг Промоторные последовательности вируса желтого скручивания листьев цестровых и способы их применения
WO2003018760A2 (en) * 2001-08-24 2003-03-06 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
US20050054011A1 (en) * 2002-09-06 2005-03-10 Yiwen Jan Methods of modulating cell death based on the Bit1/AES regulatory pathway
US8017326B2 (en) * 2002-09-06 2011-09-13 Sanford-Burnham Medical Research Institute Methods of modulating cell death based on the Bit-1/AES regulatory pathway
RU2307872C2 (ru) * 2002-10-09 2007-10-10 СиАйДи КО., ЛТД НОВАЯ ПОЛНОРАЗМЕРНАЯ ГЕНОМНАЯ PHK ВИРУСА ЯПОНСКОГО ЭНЦЕФАЛИТА, ПОЛУЧЕННАЯ ИЗ НЕЕ ИНФЕКЦИОННАЯ кДНК JEV И ИХ ПРИМЕНЕНИЕ
EA011557B1 (ru) * 2005-02-01 2009-04-28 Паудерджект Вэксинс, Инк. Конструкции нуклеиновых кислот
WO2007122369A2 (en) * 2006-04-13 2007-11-01 Oncomethylome Sciences Sa Novel tumour suppressor
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
WO2011075838A1 (en) * 2009-12-21 2011-06-30 Audigen Inc. Method of treating or preventing hearing loss
RU2491343C1 (ru) * 2011-12-23 2013-08-27 Общество с ограниченной ответственностью "Биотехнологический центр трансгенеза в фарминдустрии "Трансгенфарм" Генетические конструкции ltf3, ltf5, ltf7, ltf10, ltf11 для получения рекомбинантного лактоферрина человека (варианты)
US20130244243A1 (en) * 2012-03-15 2013-09-19 Takashi Matsuyama Method for producing expression product of exogenous gene in yeast, regulator of expression in yeast, and use thereof
WO2014184684A2 (en) * 2013-05-16 2014-11-20 Oslo Universitetssykehus Hf Methods and biomarkers for detection of hematological cancers
RU2535871C1 (ru) * 2013-07-10 2014-12-20 Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") Плазмида для экспрессии в клетке китайского хомячка, клетка китайского хомячка - продуцент белка с Gla-доменом и способ получения белка с Gla-доменом
WO2015138348A1 (en) * 2014-03-09 2015-09-17 The Trustees Of The University Of Pennsylvania Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MIKULSKA J.E. et al, Cloning and analysis of the gene encoding the human neonatal Fc receptor, European Journal of Immunogenetics, 27, 2000, 231-240, особенно стр.238, 239. *
RICHARD T. PON, Tandem oligonucleotide synthesis using linker phosphoramidites, Nucleic Acids Res, 2005; 33(6), 1940-1948. RICHARD J. ROBERTS, REBASE - enzymes and genes for DNA restriction and modification, Nucleic Acids Res, 2007; 35(Database issue):D269-70. *

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