RU2717824C2 - СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH Download PDF

Info

Publication number
RU2717824C2
RU2717824C2 RU2017141919A RU2017141919A RU2717824C2 RU 2717824 C2 RU2717824 C2 RU 2717824C2 RU 2017141919 A RU2017141919 A RU 2017141919A RU 2017141919 A RU2017141919 A RU 2017141919A RU 2717824 C2 RU2717824 C2 RU 2717824C2
Authority
RU
Russia
Prior art keywords
vesicles
mosm
buffer
preceding paragraphs
aqueous medium
Prior art date
Application number
RU2017141919A
Other languages
English (en)
Russian (ru)
Other versions
RU2017141919A (ru
RU2017141919A3 (https=
Inventor
Жан-Кристоф ЛЕРУ
Винсент Форстер
Валентина АГОСТОНИ
Original Assignee
Ферзантис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ферзантис Аг filed Critical Ферзантис Аг
Publication of RU2017141919A publication Critical patent/RU2017141919A/ru
Publication of RU2017141919A3 publication Critical patent/RU2017141919A3/ru
Application granted granted Critical
Publication of RU2717824C2 publication Critical patent/RU2717824C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2017141919A 2015-05-04 2016-05-03 СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH RU2717824C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247 2015-05-04
EP15166247.5 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

Publications (3)

Publication Number Publication Date
RU2017141919A RU2017141919A (ru) 2019-06-04
RU2017141919A3 RU2017141919A3 (https=) 2019-09-20
RU2717824C2 true RU2717824C2 (ru) 2020-03-26

Family

ID=53052718

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017141919A RU2717824C2 (ru) 2015-05-04 2016-05-03 СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH

Country Status (11)

Country Link
US (2) US11376218B2 (https=)
EP (1) EP3291797B1 (https=)
JP (1) JP6715265B2 (https=)
CN (1) CN107750156B (https=)
AU (1) AU2016256979B2 (https=)
DK (1) DK3291797T3 (https=)
ES (1) ES2826896T3 (https=)
MX (1) MX381655B (https=)
PT (1) PT3291797T (https=)
RU (1) RU2717824C2 (https=)
WO (1) WO2016177741A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016256979B2 (en) * 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
CA3196479A1 (en) 2020-11-17 2022-05-27 Philippe Delataille Methods of treatment of liver failure
EP4618954A1 (en) 2022-11-16 2025-09-24 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism
WO2026078188A1 (en) 2024-10-11 2026-04-16 Genfit Reducing a pathological blood level of bile acids with a liposome suspension
WO2026078189A1 (en) 2024-10-11 2026-04-16 Genfit Treating endotoxemia with a liposomal suspension

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118249A1 (en) * 2001-11-13 2005-06-02 Murray Webb Lipid carrier compositions and methods for improved drug retention
US20090269396A1 (en) * 2006-10-24 2009-10-29 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
WO2014023421A1 (en) * 2012-08-09 2014-02-13 Eth Zurich Liposome composition for use in peritoneal dialysis
RU2516893C1 (ru) * 2012-12-14 2014-05-20 Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" Липосомальная композиция и способ ее получения

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5297024A (en) 1976-02-09 1977-08-15 Nissan Motor Co Ltd Air fuel ratio controller
FR2521565B1 (fr) 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2553002B1 (fr) 1983-10-06 1992-03-27 Centre Nat Rech Scient Procede perfectionne d'obtention de liposomes unilamellaires de diametres eleves, leur application pharmacologique pour l'encapsulage d'un principe actif en vue de son administration extemporanee et dispositif correspondant
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US5077056A (en) 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5230899A (en) * 1985-08-07 1993-07-27 Smithkline Beecham Corporation Methods and compositions for making liposomes
US5622713A (en) 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
DE3765711D1 (de) 1986-07-15 1990-11-29 Fin Omet S R L Methode zum herstellen von handtuechern fuer spender sowie auf diese weise hergestellte handtuecher und dazugehoeriger behaelter.
WO1988001864A1 (en) 1986-09-18 1988-03-24 Liposome Technology, Inc. High-concentration liposome processing method
JPS63211222A (ja) 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
EP0393145A4 (en) 1987-12-22 1991-09-11 The Liposome Company, Inc. Spontaneous vesiculation of multilamellar liposomes
US5807572A (en) 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
DE68901733T2 (de) 1988-03-04 1993-03-25 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
WO1990003808A1 (en) 1988-10-07 1990-04-19 The Liposome Company, Inc. Heat treating liposomes
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
US5185154A (en) 1989-02-02 1993-02-09 Liposome Technology, Inc. Method for instant preparation of a drug containing large unilamellar vesicles
DE3913875C1 (https=) 1989-04-27 1990-08-09 Heraeus Quarzschmelze Gmbh, 6450 Hanau, De
WO1990014105A1 (en) 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
ATE114967T1 (de) 1989-06-22 1994-12-15 Vestar Inc Einkapselverfahren.
US5039305A (en) 1989-12-18 1991-08-13 Ford Motor Company Multiple ratio compact transaxle assembly for automotive vehicles
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
JP3228957B2 (ja) 1990-06-14 2001-11-12 キヤノン株式会社 巨大リポソームの製造方法及び巨大リポソーム形成用キット
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5327038A (en) 1991-05-09 1994-07-05 Rockwell International Corporation Walking expansion actuator
CA2093381A1 (en) 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
JPH06710A (ja) 1992-06-17 1994-01-11 Toshimasu Eguchi 工作機械及びその加工方法
JPH069710A (ja) 1992-06-25 1994-01-18 Canon Inc 巨大リポソームの調製方法、ｌｂ膜製造装置及び該装置を用いたｌｂ膜の製造方法
US5766627A (en) 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
EP0825852B1 (en) 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US5686309A (en) * 1996-01-19 1997-11-11 Coulter International Corp. Method and apparatus for determination of hemoglobin content of individual red blood cells
GB9605915D0 (en) 1996-03-21 1996-05-22 Univ Bruxelles Liposome encapsulated amphiphilic drug compositions
US20020136762A1 (en) 1998-01-14 2002-09-26 See Jackie R. Method for inducing a systemic immune response to an antigen
US6106858A (en) 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
EP2198854B1 (en) 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
IN190388B (https=) 1997-10-01 2003-07-26 Biomira Usa Inc
US7419683B2 (en) * 1997-10-31 2008-09-02 United States Of America As Represented By The Secretary Of The Army Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
EP1030652B1 (en) 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20050031679A1 (en) 1998-03-27 2005-02-10 Clemens Unger Method for producing liposomal formulations of active ingredients
CA2340118C (en) 1998-08-12 2009-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
DE60014093T2 (de) 1999-07-16 2005-02-03 Alza Corp., Mountain View Liposomzusammensetzung mit Schutz vor Gefrier-/Aufbau-Schaden
AU2001264079A1 (en) 2000-06-14 2001-12-24 William Leslie Porter Lipids for modulating immune response
AR031744A1 (es) 2001-11-08 2003-10-01 Paoli Tomas De Proliposomas en polvo, un procedimiento para la elaboracion de dichas proliposomas en polvo, procedimiento para la preparacion de una composicion farmaceutica empleando proliposomas en polvo y aparato para ser empleado en el procedimiento de elaboracion de dichas proliposomas en polvo
WO2003075889A1 (en) 2002-03-05 2003-09-18 Transave, Inc. An inhalation system for prevention and treatment of intracellular infections
GB0312309D0 (en) * 2003-05-29 2003-07-02 Gaslini Children S Hospital G Targeted liposome
BRPI0416650A (pt) * 2003-11-20 2007-01-16 Delex Therapeutics Inc composição de lipossoma estável para a aplicação de um agente farmacêutico, composição de lipossoma estéril e estável para a aplicação de um agente farmacêutico método para a produção de uma composição de lipossoma estável para a aplicação de um agente farmacêutico, composição farmacêutica, uso de uma composição de lipossoma, dispositivo para conter uma composição de lipossoma estável, kit para a aplicação de um agente farmacêutico a um paciente, método para aumentar a estabilidade de composições de lipossomas, método para a identificação de uma composição de lipossoma estável na fase, composição de lipossoma e composição de lipossoma estável na fase
EP1547580A1 (en) 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
WO2005102359A1 (en) 2004-04-22 2005-11-03 Celator Pharmaceuticals, Inc. Liposomal formulations of anthracycline agents and cytidine analogs
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
TW200618820A (en) * 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
US20060239925A1 (en) * 2005-04-21 2006-10-26 Konica Minolta Medical & Graphic, Inc. Method of manufacturing pharmaceutical preparation containing liposomes
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
CN102940878A (zh) 2006-10-06 2013-02-27 Scil技术股份有限公司 脊柱髓核植入物
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
JP2008136967A (ja) 2006-12-04 2008-06-19 Shinshu Univ リポソームおよびその製造方法
WO2009009115A2 (en) 2007-07-11 2009-01-15 Nevsky Pharmaceutical Development Liposome compositions for treatment of hepatitis c
CA2697044A1 (en) * 2007-08-21 2009-02-26 Alza Corporation Liposome formulations of boronic acid compounds
US20110105995A1 (en) 2008-01-16 2011-05-05 Zhu Ting F Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20100305500A1 (en) 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
CA2781529C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
CN104959087B (zh) 2010-04-09 2017-08-15 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
EP2433619A1 (en) 2010-09-24 2012-03-28 Intsel Chimos Novel antitumoral agent and its therapeutic uses
KR20140092226A (ko) 2010-12-14 2014-07-23 테크니칼 유니버시티 오브 덴마크 나노입자 조성물에서 방사성 핵종의 포집
EP2661308B1 (de) * 2011-01-05 2019-05-08 Prenatal International GmbH Hypotone wässrige zusammensetzung mit verringertem chloridgehalt mit oder ohne phospholipide
JP2012158576A (ja) 2011-02-03 2012-08-23 Yuki Goto 高圧力を利用したリポソームの粒子径制御方法
US8871811B2 (en) 2011-02-07 2014-10-28 Professional Compounding Centers of America, Ltd Permeation enhancers for topical formulations
JP2014101273A (ja) 2011-02-28 2014-06-05 Tokyo Medical And Dental Univ 脂質構造体の製造方法
JP2015507019A (ja) * 2012-02-17 2015-03-05 セルシオン コーポレイション 感熱性ナノ粒子製剤およびその製造方法
CN102626390B (zh) 2012-04-19 2013-05-29 海南灵康制药有限公司 一种天麻素多相脂质体注射液
CN102716089B (zh) 2012-06-29 2013-12-11 海南灵康制药有限公司 一种盐酸吉西他滨脂质体注射剂
GB201212896D0 (en) 2012-07-20 2012-09-05 European Molecular Biology Lab Embl Giant array liposome for high-throughput lipid-protein interaction screening
EP2948132B1 (en) 2013-01-24 2020-08-19 Memorial Sloan Kettering Cancer Center Method for diagnosing or treating tumors using sphingomyelin containing liposomes
CN103182333B (zh) 2013-03-01 2015-07-29 重庆大学 一种脂质体制备和收集装置及方法
AU2016256979B2 (en) * 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118249A1 (en) * 2001-11-13 2005-06-02 Murray Webb Lipid carrier compositions and methods for improved drug retention
US20090269396A1 (en) * 2006-10-24 2009-10-29 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
WO2014023421A1 (en) * 2012-08-09 2014-02-13 Eth Zurich Liposome composition for use in peritoneal dialysis
RU2516893C1 (ru) * 2012-12-14 2014-05-20 Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" Липосомальная композиция и способ ее получения

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nicolas Bertrand et al. Transmembrane pH-Gradient Liposomes To Treat Cardiovascular Drug Intoxication., ACSNANO, 2010, Vol. 4, N 12, pages 7552 - 7558. *

Also Published As

Publication number Publication date
US20220287971A1 (en) 2022-09-15
ES2826896T3 (es) 2021-05-19
AU2016256979A1 (en) 2017-12-07
MX381655B (es) 2025-03-13
CN107750156A (zh) 2018-03-02
JP2018519370A (ja) 2018-07-19
DK3291797T3 (da) 2020-09-21
CN107750156B (zh) 2020-08-21
PT3291797T (pt) 2020-10-19
RU2017141919A (ru) 2019-06-04
AU2016256979B2 (en) 2021-01-28
EP3291797A1 (en) 2018-03-14
MX2017014130A (es) 2018-07-06
JP6715265B2 (ja) 2020-07-01
CA2987844A1 (en) 2016-11-10
BR112017023578A2 (pt) 2018-09-04
US11376218B2 (en) 2022-07-05
EP3291797B1 (en) 2020-09-02
US12427112B2 (en) 2025-09-30
HK1250663A1 (en) 2019-01-11
RU2017141919A3 (https=) 2019-09-20
US20180104189A1 (en) 2018-04-19
WO2016177741A1 (en) 2016-11-10

Similar Documents

Publication Publication Date Title
US12427112B2 (en) Method for preparing transmembrane pH-gradient vesicles
Nishimura et al. Biotransporting biocatalytic reactors toward therapeutic nanofactories
JP5767580B2 (ja) 薬剤送達のためのリポソームおよびその調製方法
JP6276847B2 (ja) リポソーム組成物及びその製造方法
JP2018502870A (ja) トラネキサム酸の多小胞リポソーム処方物
Meyenburg et al. Fibrin encapsulated liposomes as protein delivery system: studies on the in vitro release behavior
Farmer et al. Liposome-encapsulated hemoglobin: a synthetic red cell
RS61273B1 (sr) Lipozomska kompozicija i postupak za njeno dobijanje
Khayrani et al. Effect of freeze-thaw cycles method to transfersome characteristics for growth protein encapsulation
Sankar et al. Nanocochleate—A new approach in lipid drug delivery
US20230338288A1 (en) Asymmetric charged vesicles and methods of preparing and use thereof
JP5916743B2 (ja) ヘモグロビン含有リポソーム及びその製法
Yeole et al. A review on nanocochleate–A novel lipid based drug delivery system
CA2987844C (en) Method for preparing transmembrane ph-gradient vesicles
KR20080046672A (ko) 나노입자 제제를 보관하는 방법
CN105943502A (zh) 一种脂质体载药方法
HK1250663B (en) Method for preparing transmembrane ph-gradient vesicles
BR112017023578B1 (pt) Método para a preparação de vesículas de gradiente de ph transmembranar
Afkhami et al. Encapsulation of magnetotactic bacteria for targeted and controlled delivery of anticancer agents for tumor therapy
Pashirova et al. Enzyme-containing double layer polymersomes coated by erythrocytes as a biomimetic nanoscavengers for in vivo protection from toxicants
Vyas et al. Nanocochleate: novel bypass of conventional drug delivery system
CN1895223A (zh) 一种新的脂质体制备方法
KR20160093322A (ko) 부분 개방 리포좀의 제조 방법
JP3572428B2 (ja) 重合リポソームの製造方法
JP2728890B2 (ja) 巨大プロテオリポソームの調整方法