EP0472639A4 - Accumulation of drugs into liposomes by a proton gradient - Google Patents

Accumulation of drugs into liposomes by a proton gradient

Info

Publication number
EP0472639A4
EP0472639A4 EP19900908748 EP90908748A EP0472639A4 EP 0472639 A4 EP0472639 A4 EP 0472639A4 EP 19900908748 EP19900908748 EP 19900908748 EP 90908748 A EP90908748 A EP 90908748A EP 0472639 A4 EP0472639 A4 EP 0472639A4
Authority
EP
European Patent Office
Prior art keywords
liposomes
drugs
accumulation
proton gradient
proton
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900908748
Other versions
EP0472639A1 (en
Inventor
Thomas D. Madden
Michael J. Hope
Colin P. S. Tilcock
Pieter R. Cullis
P. Richard Harrigan
Barbara S. Mui
Marcel B. Bally
Linda Tai
Lawrence D. Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of EP0472639A1 publication Critical patent/EP0472639A1/en
Publication of EP0472639A4 publication Critical patent/EP0472639A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19900908748 1989-05-15 1990-05-15 Accumulation of drugs into liposomes by a proton gradient Withdrawn EP0472639A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35249789A 1989-05-15 1989-05-15
US352497 1989-05-15

Publications (2)

Publication Number Publication Date
EP0472639A1 EP0472639A1 (en) 1992-03-04
EP0472639A4 true EP0472639A4 (en) 1992-07-01

Family

ID=23385362

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900908748 Withdrawn EP0472639A4 (en) 1989-05-15 1990-05-15 Accumulation of drugs into liposomes by a proton gradient

Country Status (5)

Country Link
EP (1) EP0472639A4 (en)
JP (1) JPH04505616A (en)
CA (1) CA2056435A1 (en)
MX (1) MX9203793A (en)
WO (1) WO1990014105A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960702297A (en) * 1993-05-21 1996-04-27 카롤 질레스피 REDUCTION OF LIPOSOME-INDUCED ADVERSE PHYSIOLOGICAL REACTIONS
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
BR0114713A (en) * 2000-10-16 2004-01-13 Neopharm Inc Liposomal formulation of mitoxantrone
AU2004290476A1 (en) * 2003-11-20 2005-06-02 Ym Biosciences Inc. Stable liposome compositions comprising lipophilic amine containing pharmaceutical agents
AT500143A1 (en) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag CHOLINESTERASE INHIBITORS IN LIPOSOMES AND THEIR PREPARATION AND USE
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
JP5846711B2 (en) * 2005-06-09 2016-01-20 メダ アーベー Methods and compositions for the treatment of inflammatory diseases
MX2015005992A (en) 2012-11-20 2016-03-07 Spectrum Pharmaceuticals Inc Improved method for the preparation of liposome encapsulated vincristine for therapeutic use.
JP6715265B2 (en) 2015-05-04 2020-07-01 フェルザンティス アーゲーＶｅｒｓａｎｔｉｓ Ａｇ Method for preparing transmembrane pH gradient vesicles
TWI678213B (en) 2015-07-22 2019-12-01 美商史倍壯製藥公司 A ready-to-use formulation for vincristine sulfate liposome injection
CN113041223B (en) * 2019-12-26 2022-08-19 南京绿叶制药有限公司 Preparation method of local anesthetic liposome
CN111729087A (en) * 2020-07-24 2020-10-02 成都大学 Lipid modifier of selective beta 2 receptor agonist and preparation method and application thereof
CA3182955A1 (en) * 2021-07-16 2023-01-16 Celator Pharmaceuticals, Inc. Methods for preparing liposomal formulations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152379A2 (en) * 1984-02-15 1985-08-21 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
WO1987005803A1 (en) * 1986-04-01 1987-10-08 Aktiebolaget Draco COMPOSITIONS OF LIPOSOMES AND beta2-RECEPTOR ACTIVE SUBSTANCES
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152379A2 (en) * 1984-02-15 1985-08-21 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
WO1987005803A1 (en) * 1986-04-01 1987-10-08 Aktiebolaget Draco COMPOSITIONS OF LIPOSOMES AND beta2-RECEPTOR ACTIVE SUBSTANCES
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY vol. 27, no. 6, 22 March 1988, EASTON, PA pages 2053 - 2060; L.D.MAYER ET AL.: 'influence of ion gradients on the transbilayer distribution of dibucaine in large unilamellar vesicles' *
See also references of WO9014105A1 *

Also Published As

Publication number Publication date
CA2056435A1 (en) 1990-11-16
JPH04505616A (en) 1992-10-01
WO1990014105A1 (en) 1990-11-29
MX9203793A (en) 1992-09-01
EP0472639A1 (en) 1992-03-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19911104

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MADDEN, THOMAS, D.

Inventor name: TAI, LINDA

Inventor name: BALLY, MARCEL, B.

Inventor name: TILCOCK, COLIN, P., S.

Inventor name: HOPE, MICHAEL, J.

Inventor name: CULLIS, PIETER, R.

Inventor name: HARRIGAN, P., RICHARD

Inventor name: MUI, BARBARA, S.

A4 Supplementary search report drawn up and despatched

Effective date: 19920508

AK Designated contracting states

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Effective date: 19930812

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18D Application deemed to be withdrawn

Effective date: 19931223