GB2225322B - A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide - Google Patents

A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Info

Publication number
GB2225322B
GB2225322B GB8926244A GB8926244A GB2225322B GB 2225322 B GB2225322 B GB 2225322B GB 8926244 A GB8926244 A GB 8926244A GB 8926244 A GB8926244 A GB 8926244A GB 2225322 B GB2225322 B GB 2225322B
Authority
GB
United Kingdom
Prior art keywords
pyrrolidineacetamide
oxo
alpha
ethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8926244A
Other versions
GB2225322A (en
GB8926244D0 (en
Inventor
Eric Cossement
Genevieve Motte
Jean-Pierre Geerts
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of GB8926244D0 publication Critical patent/GB8926244D0/en
Publication of GB2225322A publication Critical patent/GB2225322A/en
Application granted granted Critical
Publication of GB2225322B publication Critical patent/GB2225322B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8926244A 1988-11-23 1989-11-21 A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide Expired - Lifetime GB2225322B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827389A GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Publications (3)

Publication Number Publication Date
GB8926244D0 GB8926244D0 (en) 1990-01-10
GB2225322A GB2225322A (en) 1990-05-30
GB2225322B true GB2225322B (en) 1992-03-25

Family

ID=10647345

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888827389A Pending GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB8926244A Expired - Lifetime GB2225322B (en) 1988-11-23 1989-11-21 A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB888827389A Pending GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Country Status (17)

Country Link
KR (1) KR0157610B1 (en)
CN (1) CN1020604C (en)
AT (1) AT392781B (en)
BG (1) BG51041A3 (en)
CY (1) CY1672A (en)
ES (1) ES2023532A6 (en)
FI (1) FI91961C (en)
GB (2) GB8827389D0 (en)
GR (1) GR1000719B (en)
HK (1) HK102492A (en)
HU (1) HU204508B (en)
NO (1) NO173823C (en)
PH (1) PH26332A (en)
PL (1) PL161781B1 (en)
PT (1) PT92365B (en)
RU (1) RU1797607C (en)
SG (1) SG89392G (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319732D0 (en) 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
ATE361751T1 (en) 1999-12-01 2007-06-15 Ucb Sa A PYRROLIDINE ACETATE DERIVATIVE FOR THE TREATMENT OF CHRONIC OR NEUROPATHIC PAIN
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
EP1517893A2 (en) * 2003-02-03 2005-03-30 Teva Pharmaceutical Industries Limited Process for producing levetiracetam
ES2214147B1 (en) * 2003-02-28 2005-10-01 Farma-Lepori S.A. PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT.
US7629474B2 (en) * 2003-09-24 2009-12-08 Ucb Pharma S.A. Process for preparing 2-oxo-1-pyrrolidine derivatives
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CA2610695A1 (en) 2005-06-01 2006-12-07 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
US8338621B2 (en) 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2009050735A1 (en) * 2007-10-15 2009-04-23 Lupin Limited A novel polymorph of levetiracetam and a process for its preparation
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
ME03518B (en) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
EP0162036A1 (en) * 1984-05-15 1985-11-21 U C B, S.A. (S)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
EP0162036A1 (en) * 1984-05-15 1985-11-21 U C B, S.A. (S)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide

Also Published As

Publication number Publication date
PT92365B (en) 1995-07-18
FI895562A0 (en) 1989-11-22
GR890100769A (en) 1990-12-31
KR900007797A (en) 1990-06-02
AT392781B (en) 1991-06-10
NO173823B (en) 1993-11-01
GB2225322A (en) 1990-05-30
CN1020604C (en) 1993-05-12
GB8926244D0 (en) 1990-01-10
GB8827389D0 (en) 1988-12-29
PT92365A (en) 1990-05-31
RU1797607C (en) 1993-02-23
FI91961C (en) 1994-09-12
NO894649D0 (en) 1989-11-22
CY1672A (en) 1993-05-14
SG89392G (en) 1992-12-04
HU896132D0 (en) 1990-02-28
FI91961B (en) 1994-05-31
NO894649L (en) 1990-05-25
ATA266689A (en) 1990-11-15
PH26332A (en) 1992-04-29
HU204508B (en) 1992-01-28
HUT53072A (en) 1990-09-28
CN1042904A (en) 1990-06-13
ES2023532A6 (en) 1992-01-16
GR1000719B (en) 1992-11-23
NO173823C (en) 1994-02-09
KR0157610B1 (en) 1998-11-16
HK102492A (en) 1992-12-24
BG51041A3 (en) 1993-01-15
PL161781B1 (en) 1993-07-30

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20071121