JP6715265B2 - 膜内外ｐＨ勾配ベシクルを調製する方法 - Google Patents

膜内外ｐＨ勾配ベシクルを調製する方法 Download PDF

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Publication number
JP6715265B2
JP6715265B2 JP2017557435A JP2017557435A JP6715265B2 JP 6715265 B2 JP6715265 B2 JP 6715265B2 JP 2017557435 A JP2017557435 A JP 2017557435A JP 2017557435 A JP2017557435 A JP 2017557435A JP 6715265 B2 JP6715265 B2 JP 6715265B2
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mosm
vesicles
buffer
alkaline
gradient
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JP2018519370A (ja
JP2018519370A5 (https=
Inventor
ルロワ・ジャン−クリストフ
フォルスター・ヴィンセント
アゴストーニ，ヴァレンティナ
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Versantis AG
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Versantis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017557435A 2015-05-04 2016-05-03 膜内外ｐＨ勾配ベシクルを調製する方法 Active JP6715265B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247 2015-05-04
EP15166247.5 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

Publications (3)

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JP2018519370A JP2018519370A (ja) 2018-07-19
JP2018519370A5 JP2018519370A5 (https=) 2019-01-17
JP6715265B2 true JP6715265B2 (ja) 2020-07-01

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US (2) US11376218B2 (https=)
EP (1) EP3291797B1 (https=)
JP (1) JP6715265B2 (https=)
CN (1) CN107750156B (https=)
AU (1) AU2016256979B2 (https=)
DK (1) DK3291797T3 (https=)
ES (1) ES2826896T3 (https=)
MX (1) MX381655B (https=)
PT (1) PT3291797T (https=)
RU (1) RU2717824C2 (https=)
WO (1) WO2016177741A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016256979B2 (en) * 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
CA3196479A1 (en) 2020-11-17 2022-05-27 Philippe Delataille Methods of treatment of liver failure
EP4618954A1 (en) 2022-11-16 2025-09-24 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism
WO2026078188A1 (en) 2024-10-11 2026-04-16 Genfit Reducing a pathological blood level of bile acids with a liposome suspension
WO2026078189A1 (en) 2024-10-11 2026-04-16 Genfit Treating endotoxemia with a liposomal suspension

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Also Published As

Publication number Publication date
US20220287971A1 (en) 2022-09-15
ES2826896T3 (es) 2021-05-19
AU2016256979A1 (en) 2017-12-07
MX381655B (es) 2025-03-13
CN107750156A (zh) 2018-03-02
JP2018519370A (ja) 2018-07-19
DK3291797T3 (da) 2020-09-21
CN107750156B (zh) 2020-08-21
PT3291797T (pt) 2020-10-19
RU2017141919A (ru) 2019-06-04
AU2016256979B2 (en) 2021-01-28
EP3291797A1 (en) 2018-03-14
MX2017014130A (es) 2018-07-06
RU2717824C2 (ru) 2020-03-26
CA2987844A1 (en) 2016-11-10
BR112017023578A2 (pt) 2018-09-04
US11376218B2 (en) 2022-07-05
EP3291797B1 (en) 2020-09-02
US12427112B2 (en) 2025-09-30
HK1250663A1 (en) 2019-01-11
RU2017141919A3 (https=) 2019-09-20
US20180104189A1 (en) 2018-04-19
WO2016177741A1 (en) 2016-11-10

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