CN107750156B - 用于制备跨膜pH梯度囊泡的方法 - Google Patents

用于制备跨膜pH梯度囊泡的方法 Download PDF

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Publication number
CN107750156B
CN107750156B CN201680025547.4A CN201680025547A CN107750156B CN 107750156 B CN107750156 B CN 107750156B CN 201680025547 A CN201680025547 A CN 201680025547A CN 107750156 B CN107750156 B CN 107750156B
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vesicles
mosm
buffer
aqueous medium
transmembrane
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CN107750156A (zh
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让-克里斯托弗·勒鲁
文森特·福斯特
瓦伦蒂娜·阿戈斯托尼
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Genfit SA
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Versantis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680025547.4A 2015-05-04 2016-05-03 用于制备跨膜pH梯度囊泡的方法 Active CN107750156B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247 2015-05-04
EP15166247.5 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

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CN107750156A CN107750156A (zh) 2018-03-02
CN107750156B true CN107750156B (zh) 2020-08-21

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US (2) US11376218B2 (https=)
EP (1) EP3291797B1 (https=)
JP (1) JP6715265B2 (https=)
CN (1) CN107750156B (https=)
AU (1) AU2016256979B2 (https=)
DK (1) DK3291797T3 (https=)
ES (1) ES2826896T3 (https=)
MX (1) MX381655B (https=)
PT (1) PT3291797T (https=)
RU (1) RU2717824C2 (https=)
WO (1) WO2016177741A1 (https=)

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Publication number Priority date Publication date Assignee Title
AU2016256979B2 (en) * 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
KR20230110284A (ko) 2020-11-17 2023-07-21 장피트 간부전 치료 방법
EP4618954A1 (en) 2022-11-16 2025-09-24 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism
WO2026078189A1 (en) 2024-10-11 2026-04-16 Genfit Treating endotoxemia with a liposomal suspension
WO2026078188A1 (en) 2024-10-11 2026-04-16 Genfit Reducing a pathological blood level of bile acids with a liposome suspension

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Publication number Publication date
US20180104189A1 (en) 2018-04-19
PT3291797T (pt) 2020-10-19
RU2017141919A3 (https=) 2019-09-20
HK1250663A1 (en) 2019-01-11
MX2017014130A (es) 2018-07-06
RU2717824C2 (ru) 2020-03-26
ES2826896T3 (es) 2021-05-19
WO2016177741A1 (en) 2016-11-10
JP2018519370A (ja) 2018-07-19
EP3291797B1 (en) 2020-09-02
US20220287971A1 (en) 2022-09-15
EP3291797A1 (en) 2018-03-14
CA2987844A1 (en) 2016-11-10
JP6715265B2 (ja) 2020-07-01
AU2016256979A1 (en) 2017-12-07
US12427112B2 (en) 2025-09-30
CN107750156A (zh) 2018-03-02
RU2017141919A (ru) 2019-06-04
AU2016256979B2 (en) 2021-01-28
DK3291797T3 (da) 2020-09-21
US11376218B2 (en) 2022-07-05
BR112017023578A2 (pt) 2018-09-04
MX381655B (es) 2025-03-13

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